Wigler, Michael H. Publications

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Wigler, Michael H.

http://wigler.cshl.edu/doku.php

http://orcid.org/0000-0003-4396-1971

Number of items at this level: 263.

Paper

Ye, K., Iossifov, I., Levy, D., Yamrom, B., Buja, A., Krieger, A. M., Wigler, M. (2017) Measuring shared variants in cohorts of discordant siblings with applications to autism. Proc Natl Acad Sci U S A. ISSN 0027-8424

Krasnitz, Alexander, Kendall, Jude, Alexander, Joan, Levy, Dan, Wigler, Michael (2017) Early Detection of Cancer in Blood Using Single-Cell Analysis: A Proposal. Trends in Molecular Medicine. ISSN 1471-4914

Fang, H., Bergmann, E. A., Arora, K., Vacic, V., Zody, M. C., Iossifov, I., O'Rawe, J. A., Wu, Y., Jimenez Barron, L. T., Rosenbaum, J., Ronemus, M., Lee, Y. H., Wang, Z., Dikoglu, E., Jobanputra, V., Lyon, G. J., Wigler, M., Schatz, M. C., Narzisi, G. (2016) Indel variant analysis of short-read sequencing data with Scalpel. Nat Protoc, 11 (12). pp. 2529-2548. ISSN 1750-2799 (Electronic)1750-2799 (Linking)

Wang, Z., Andrews, P., Kendall, J., Ma, B., Hakker, I., Rodgers, L., Ronemus, M., Wigler, M., Levy, D. (2016) SMASH, a fragmentation and sequencing method for genomic copy number analysis. Genome Res, 26 (6). pp. 844-51. ISSN 1549-5469 (Electronic)1088-9051 (Linking)

Garvin, T., Aboukhalil, R., Kendall, J., Baslan, T., Atwal, G. S., Hicks, J., Wigler, M., Schatz, M. C. (2015) Interactive analysis and assessment of single-cell copy-number variations. Nat Methods, 12. pp. 1058-1060. ISSN 1548-7105 (Electronic)1548-7091 (Linking)

Iossifov, I., Levy, D., Allen, J., Ye, K., Ronemus, M., Lee, Y. H., Yamrom, B., Wigler, M. (2015) Low load for disruptive mutations in autism genes and their biased transmission. Proc Natl Acad Sci U S A. ISSN 1091-6490 (Electronic)0027-8424 (Linking)

Baslan, T., Kendall, J., Ward, B., Cox, H., Leotta, A., Rodgers, L., Riggs, M., D'Italia, S., Sun, G., Yong, M., Miskimen, K., Gilmore, H., Saborowski, M., Dimitrova, N., Krasnitz, A., Harris, L., Wigler, M., Hicks, J. (2015) Optimizing sparse sequencing of single cells for highly multiplex copy number profiling. Genome Research, 25 (5). pp. 714-724. ISSN 1088-9051

Rye, I. H., Lundin, P., Maner, S., Fjelldal, R., Naume, B., Wigler, M., Hicks, J., Borresen-Dale, A. L., Zetterberg, A., Russnes, H. G. (2015) Quantitative multigene FISH on breast carcinomas identifies der(1;16)(q10;p10) as an early event in luminal A tumors. Genes, Chromosomes & Cancer, 54 (4). pp. 235-48. ISSN 1045-2257

Jayaprakash, A. D., Benson, E. K., Gone, S., Liang, R., Shim, J., Lambertini, L., Toloue, M. M., Wigler, M., Aaronson, S. A., Sachidanandam, R. (2015) Stable heteroplasmy at the single-cell level is facilitated by intercellular exchange of mtDNA. Nucleic Acids Research, 43 (4). pp. 2177-2187. ISSN 0305-1048

Garvin, Tyler, Aboukhalil, Robert, Kendall, Jude, Baslan, Timour, Atwal, Gurinder S, Hicks, James, Wigler, Michael, Schatz, Michael (2015) Interactive analysis and quality assessment of single-cell copy-number variations. Nature Methods, 12. pp. 1058-1060. ISSN 15487091 (ISSN)

Iossifov, I., O'Roak, B. J., Sanders, S. J., Ronemus, M., Krumm, N., Levy, D., Stessman, H. A., Witherspoon, K. T., Vives, L., Patterson, K. E., Smith, J. D., Paeper, B., Nickerson, D. A., Dea, J., Dong, S., Gonzalez, L. E., Mandell, J. D., Mane, S. M., Murtha, M. T., Sullivan, C. A., Walker, M. F., Waqar, Z., Wei, L., Willsey, A. J., Yamrom, B., Lee, Y. H., Grabowska, E., Dalkic, E., Wang, Z., Marks, S., Andrews, P., Leotta, A., Kendall, J., Hakker, I., Rosenbaum, J., Ma, B., Rodgers, L., Troge, J., Narzisi, G., Yoon, S., Schatz, M. C., Ye, K., McCombie, W. R., Shendure, J., Eichler, E. E., State, M. W., Wigler, M. (2014) The contribution of de novo coding mutations to autism spectrum disorder. Nature, 515 (7526). pp. 216-221. ISSN 0028-0836

Levy, D., Wigler, M. (2014) Facilitated sequence counting and assembly by template mutagenesis. Proceedings of the National Academy of Sciences of the United States of America, 111 (43). E4632-E4637. ISSN 0027-8424

Narzisi, G., O'Rawe, Jason, Iossifov, I., Fang, Han, Lee, Y. H., Wang, Zihua, Wu, Yiyang, Lyon, Gholson J., Wigler, M. H., Schatz, M. C. (2014) Accurate de novo and transmitted indel detection in exome-capture data using microassembly. Nature Methods, 11 (10). pp. 1033-1036.

Dago, A. E., Stepansky, A., Carlsson, A., Luttgen, M., Kendall, J., Baslan, T., Kolatkar, A., Wigler, M., Bethel, K., Gross, M. E., Hicks, J., Kuhn, P. (2014) Rapid phenotypic and genomic change in response to therapeutic pressure in prostate cancer inferred by high content analysis of single circulating tumor cells. PLoS One, 9 (8). e101777. ISSN 1932-6203

Warburton, D., Ronemus, M., Kline, J., Jobanputra, V., Williams, I., Anyane-Yeboa, K., Chung, W., Yu, L., Wong, N., Awad, D., Yu, C. Y., Leotta, A., Kendall, J., Yamrom, B., Lee, Y. H., Wigler, M., Levy, D. (2014) The contribution of de novo and rare inherited copy number changes to congenital heart disease in an unselected sample of children with conotruncal defects or hypoplastic left heart disease. Human Genetics, 133 (1). pp. 11-27. ISSN 1432-1203 (Electronic)0340-6717 (Linking)

Ronemus, M., Iossifov, I., Levy, D., Wigler, M. (2014) The role of de novo mutations in the genetics of autism spectrum disorders. Nature Reviews Genetics, 15 (2). pp. 133-141.

Shi, J., Whyte, W. A., Zepeda-Mendoza, C. J., Milazzo, J. P., Shen, C., Roe, J. S., Minder, J. L., Mercan, F., Wang, E., Eckersley-Maslin, M. A., Campbell, A. E., Kawaoka, S., Shareef, S., Zhu, Z., Kendall, J., Muhar, M., Haslinger, C., Yu, M., Roeder, R. G., Wigler, M. A., Blobel, G. A., Zuber, J., Spector, D. L., Young, R. A., Vakoc, C. R. (2013) Role of SWI/SNF in acute leukemia maintenance and enhancer-mediated Myc regulation. Genes and Development, 27 (24). pp. 264-273. ISSN 08909369 (ISSN)

Krasnitz, A., Sun, G., Andrews, P., Wigler, M. (2013) Target inference from collections of genomic intervals. Proceedings of the National Academy of Sciences of the United States of America, 110 (25). E2271-E2278. ISSN 0027-8424

Donnenberg, A. D., Hicks, J. B., Wigler, M., Donnenberg, V. S. (2013) The Cancer Stem Cell: Cell Type or Cell State? Cytometry Part A, 83A (SI 1). pp. 5-7. ISSN 1552-4922

Wigler, M. (2012) Broad applications of single-cell nucleic acid analysis in biomedical research. Genome Med, 4 (10). p. 79. ISSN 1756-994X (Electronic)

Stadler, Z. K., Esposito, D., Shah, S., Vijai, J., Yamrom, B., Levy, D., Lee, Y. H., Kendall, J., Leotta, A., Ronemus, M., Hansen, N. , Sarrel, K., Rau-Murthy, R., Schrader, K., Kauff, N., Klein, R., Lipkin, S., Murali, R., Robson, M., Sheinfeld, J., Feldman, D., Bosl, G., Norton, L., Wigler, M., Offit, K. (2012) Rare De Novo Germline Copy-Number Variation in Testicular Cancer. The American Journal of Human Genetics, 91 (2). pp. 379-383. ISSN 0002-9297

Kitzing, T., Xue, W., Roessler, S., Krasnitz, A., Schultz, N., Wang, X. W., Wigler, M., Lowe, S. W. (2012) Cooperating Tumor Suppressor Genes on Chromosome 8p Predict Survival Outcome in Hepatocellular Carcinoma. European Journal of Cancer, 48. S139-S139. ISSN 0959-8049

Xue, W., Kitzing, T., Roessler, S., Zuber, J., Krasnitz, A., Schultz, N., Revill, K., Weissmueller, S., Rappaport, A. R., Simon, J., Zhang, J., Luo, W. J., Hicks, J., Zender, L., Wang, X. W., Powers, S., Wigler, M., Lowe, S. W. (2012) A cluster of cooperating tumor-suppressor gene candidates in chromosomal deletions. Proceedings of the National Academy of Sciences of the United States of America, 109 (21). pp. 8212-8217. ISSN 0027-8424

Iossifov, I., Ronemus, M., Levy, D., Wang, Z. H., Hakker, I., Rosenbaum, J., Yamrom, B., Lee, Y. H., Narzisi, G., Leotta, A., Kendall, J., Grabowska, E., Ma, B. C., Marks, S., Rodgers, L., Stepansky, A., Troge, J., Andrews, P., Bekritsky, M., Pradhan, K., Ghiban, E., Kramer, M., Parla, J., Demeter, R., Fulton, L. L., Fulton, R. S., Magrini, V. J., Ye, K., Darnell, J. C., Darnell, R. B., Mardis, E. R., Wilson, R. K., Schatz, M. C., McCombie, W. R., Wigler, M. (2012) De Novo Gene Disruptions in Children on the Autistic Spectrum. Neuron, 74 (2). pp. 285-299. ISSN 0896-6273

Lee, Y. H., Ronemus, M., Kendall, J., Lakshmi, B., Leotta, A., Levy, D., Esposito, D., Grubor, V., Ye, K., Wigler, M., Yamrom, B. (2012) Reducing system noise in copy number data using principal components of self-self hybridizations. Proceedings of the National Academy of Sciences of the United States of America, 109 (3). E103-E110. ISSN 0027-8424

Horev, G., Ellegood, J., Lerch, J. P., Son, Y. E., Muthuswamy, L., Vogel, H., Krieger, A. M., Buja, A., Henkelman, R. M., Wigler, M. H., Mills, A. A. (2011) Dosage-dependent phenotypes in models of 16p11.2 lesions found in autism. Proceedings of the National Academy of Sciences of the United States of America, 108 (41). pp. 17076-81. ISSN 0027-8424

Gilman, S. R, Iossifov, I., Levy, D., Ronemus, M., Wigler, M. H., Vitkup, D. (2011) Rare De Novo Variants Associated with Autism Implicate a Large Functional Network of Genes Involved in Formation and Function of Synapses. Neuron, 70 (5). pp. 898-907. ISSN 0896-6273

Levy, D., Ronemus, M., Yamrom, B., Lee, Y. H., Leotta, A., Kendall, J. T., Marks, S., Lakshmi, B., Pai, D., Ye, Kenny, Buja, Andreas, Krieger, Abba, Yoon, S., Troge, J. E., Rodgers,  L., Iossifov, I., Wigler, M. H. (2011) Rare De Novo and Transmitted Copy-Number Variation in Autistic Spectrum Disorders. Neuron, 70 (5). pp. 886-897. ISSN 0896-6273

Kamalakaran, S., Varadan, V., Giercksky Russnes, H. E., Levy, D., Kendall, J. T., Janevski, A., Riggs, M., Banerjee, N., Synnestvedt, M., Schlichting, E., Kåresen, R., Shama Prasada, K., Rotti, H., Rao, R., Rao, L., Eric Tang, M. H., Satyamoorthy, K., Lucito, R., Wigler, M. H., Dimitrova, N., Naume, B., Borresen-Dale, A. L., Hicks, J. B. (2011) DNA methylation patterns in luminal breast cancers differ from non-luminal subtypes and can identify relapse risk independent of other clinical variables. Molecular Oncology, 5 (1). pp. 77-92.

Navin, N. E., Kendall, J. T., Troge, J. E., Andrews, P., Rodgers,  L., McIndoo, J., Cook, K., Stepansky,  A., Levy, D., Esposito, D., Muthuswamy, L., Krasnitz, A., McCombie, W. R., Hicks, J. B., Wigler, M. H. (2011) Tumour evolution inferred by single-cell sequencing. Nature, 472 (7341). pp. 90-94. ISSN 00280836 (ISSN)

Russnes, H. G., Vollan, H. K. M., Lingjærde, O. C., Krasnitz, A., Lundin, P., Naume, B., Sørlie, T., Borgen, E., Rye, I. H., Langerød, A., Chin, S. F., Teschendorff, A. E., Stephens, P. J., Månér, S., Schlichting, E., Baumbusch, L. O., Kåresen, R., Stratton, M. P., Wigler, M. H., Caldas, C., Zetterberg, A., Hicks, J. B., Børresen-Dale, A. L. (2010) Genomic architecture characterizes tumor progression paths and fate in breast cancer patients. Science Translational Medicine, 2 (38).

Hicks, J. B., Navin, N. E., Kendall, J. T., Levy, D., Wigler, M. H. (2010) Tracing Tumor Lineage and Progression through Genomic Copy Number Profiling at the Single Cell Level. Annals of Oncology, 21 (S4). iv49. ISSN 0923-7534

Navin, N. E., Krasnitz, A., Rodgers, L., Cook, K., Meth, J. L., Kendall, J. T., Riggs, M., Eberling, Y., Troge, J. E., Grubor, V., Levy, D., Lundin, P., Månér, S., Zetterberg, A., Hicks, J. B., Wigler, M. H. (2010) Inferring tumor progression from genomic heterogeneity. Genome Research, 20 (1). pp. 68-80.

Bric, A., Miething, C., Bialucha, C. U., Scuoppo, C., Zender, L., Krasnitz, A., Xuan, Z., Zuber, J., Wigler, M. H., Hicks, J. B., McCombie, W. R., Hemann, M. T., Hannon, G. J., Powers, S., Lowe, S. W. (2009) Functional identification of tumor-suppressor genes through an in vivo RNA interference screen in a mouse lymphoma model. Cancer Cell, 16 (4). pp. 324-35. ISSN 1535-6108

Hodges, E., Smith, A. D., Kendall, J. T., Xuan, Z., Ravi, K., Rooks, M., Zhang, M. Q., Ye, K., Bhattacharjee, A., Brizuela, L., McCombie, W. R., Wigler, M. H., Hannon, G. J., Hicks, J. B. (2009) High definition profiling of mammalian DNA methylation by array capture and single molecule bisulfite sequencing. Genome Research, 19 (9). pp. 1593-1605. ISSN 1088-9051

McArthur, H. L., Brogi, E., Patil, S., Wigler, M. H., Norton, L., Hicks, J. B., Hudis, C. A. (2009) High resolution microarray copy number analysis (array CGH) suggests that determination of HER2 amplification by FISH (FISH plus ) is inaccurate in human breast cancer specimens that are HER2 2+by immunohistochemistry (IHC2+). European Journal of Cancer Supplements, 7 (2). p. 88. ISSN 1359-6349

Hicks, J. B., McArthur, H., Tan, L. K., Patil, S., Wigler, M. H., Hudis, C., Norton, L. (2009) Topo2a and Her2 Co-Amplification Is Uncommon by High Resolution Representational Oligonucleotide Microarray Analysis (Roma) in Human Breast Cancer. Annals of Oncology, 20 (S2). ii22-23. ISSN 0923-7534

Russnes, H. G., Vollan, H. K. M., Sorlie, T., Krasnitz, A., Zetterberg, A., Naume, B., Borgen, E., Nesland, J. M., Wigler, M. H., Borresen-Dale, A. L., Hicks, J. B. (2009) Molecular subclassification of breast carcinomas based on aCGH reveals two major groups of tumors with common genomic, transcriptomic and clinicopathological characteristics. APMIS, 117 (3). pp. 238-239. ISSN 0903-4641

Grubor, V., Krasnitz, A., Troge, J. E., Meth, J. L., Lakshmi, B., Kendall, J. T., Yamrom, B., Alex, G., Pai, D., Navin, N. E., Hufnagel, L. A., Lee, Y. H., Cook, K., Allen, S. L., Rai, K. R., Damle, R. N., Calissano, C., Chiorazzi, N., Wigler, M. H., Esposito, D. (2009) Novel genomic alterations and clonal evolution in chronic lymphocytic leukemia revealed by representational oligonucleotide microarray analysis (ROMA). Blood, 113 (6). pp. 1294-1303. ISSN 0006-4971

McArthur, H. L., Tan, L. K., Patil, S., Wigler, M. H., Hudis, C. A., Hicks, J. B., Norton, L. (2009) High resolution representational oligonucleotide microarray analysis (ROMA) suggests that TOPO2 and HER2 co-amplification is uncommon in human breast cancer. Cancer Res, 69 (2, Sup). 163S-163S. ISSN 0008-5472

Gupta, L., Kumar, S., Singh, R., Shaik, R., Dimitrova, N., Gorthi, A., Lakshmi, B., Pai, D., Kamalakaran, S., Zhao, X., Wigler, M. H. (2008) Classification method for microarray probe selection using sequence, thermodynamics and secondary structure parameters. 19th International Conference on Pattern Recognition. ISSN 1051-4651

Zender, L., Xue, W., Zuber, J., Semighini, C. P., Krasnitz, A., Ma, B., Zender, P., Kubicka, S., Luk, J. M., Schirmacher, P., McCombie, W. R., Wigler, M. H., Hicks, J. B., Hannon, G. J., Powers, S., Lowe, S. W. (2008) An Oncogenomics-Based In Vivo RNAi Screen Identifies Tumor Suppressors in Liver Cancer. Cell, 135 (5). pp. 852-864. ISSN 0092-8674

Grubor, V., Krasnitz, A., Troge, J. E., Meth, J. L., Lakshmi, B., Kendall, J. T., Yamrom, B., Alex, G., Pai, D., Navin, N. E., Hufnagel, L. A., Lee, Y. H., Cook, K., Allen, S. L., Rai, K. R., Damle, R., Calissano, C., Chiorazzi, N., Wigler, M. H., Esposito, D. (2008) High-Resolution Array-Based Comparative Genome Hybridization (CGH) Identifies Novel and Recurrent Regions in CLL. Blood, 112 (11). p. 717. ISSN 0006-4971

Russnes, H. G., Sorlie, T., Krasnitz, A., Zetterberg, A., Naume, B., Borgen, E., Nesland, J. M., Wigler, M. H., Borresen-Dale, A. L., Hicks, J. B. (2008) Molecular subclassification of breast carcinomas based on aCGH, gene expression, IHC and ploidy - relevance for clinical outcome. European Journal of Cancer Supplements, 6 (9). p. 9. ISSN 1359-6349

Xue, W., Krasnitz, A., Lucito, R., Sordella, R., Van Aelst, L., Cordon-Cardo, C., Singer, S., Kuehnel, F., Wigler, M. H., Powers, S., Zender, L., Lowe, S. W. (2008) DLC1 is a chromosome 8p tumor suppressor whose loss promotes hepatocellular carcinoma. Genes & Development, 22 (11). pp. 1439-44. ISSN 0890-9369

Alarcon, M., Abrahams, B. S., Stone, J. L., Duvall, J. A., Perederiy, J. V., Bomar, J. M., Sebat, J., Wigler, M. H., Martin, C. L., Ledbetter, D. H., Nelson, S. F., Cantor, R. M., Geschwind, D. H. (2008) Linkage, Association, and Gene-Expression Analyses Identify CNTNAP2 as an Autism-Susceptibility Gene. Am J Hum Genet, 82 (1). pp. 150-159.

Egan, C. M., Sridhar, S., Wigler, M. H., Hall, I. M. (2007) Recurrent DNA copy number variation in the laboratory mouse. Nat Genet, 39 (11). pp. 1384-9. ISSN 1061-4036 (Print)

Lucito, R., Suresh, S., Walter, K., Pandey, A., Lakshmi, B., Krasnitz, A., Sebat, J., Wigler, M. H., Klein, A. P., Brune, K., Palmisano, E., Maitra, A., Goggins, M., Hruban, R. H. (2007) Copy-Number Variants in Patients with a Strong Family History of Pancreatic Cancer. Cancer Biol Ther, 6 (10). pp. 1592-9. ISSN 1538-4047 (Print)

Zhao, X., Leotta, A., Kustanovich, V., Lajonchere, C., Geschwind, D. H., Law, K., Law, P., Qiu, S., Lord, C., Sebat, J., Ye, K., Wigler, M. H. (2007) A unified genetic theory for sporadic and inherited autism. Proc Natl Acad Sci U S A, 104 (31). pp. 12831-12836. ISSN 0027-8424 (Print)

Sebat, J., Lakshmi, B., Malhotra, D., Troge, J. E., Lese-Martin, C., Walsh, T., Yamrom, B., Yoon, S., Krasnitz, A., Kendall, J. T., Leotta, A., Pai, D., Zhang, R., Lee, Y. H., Hicks, J. B., Spence, S. J., Lee, A. T., Puura, K., Lehtimaki, T., Ledbetter, D., Gregersen, P. K., Bregman, J., Sutcliffe, J. S., Jobanputra, V., Chung, W., Warburton, D., King, M. C., Skuse, D., Geschwind, D. H., Gilliam, T. C., Ye, K., Wigler, M. H. (2007) Strong Association of De Novo Copy Number Mutations with Autism. Science, 316 (5823). pp. 445-449.

Sebat, J., Lakshmi, B., Troge, J., Martin, C., Spence, S., Ledbetter, D., Gilliam, T. C., Ye, K., Geschwind, D., Sutcliffe, J., Wigler, M. H. (2006) High-resolution analysis of genome copy number variation in autism. International Journal of Developmental Neuroscience, 24 (8). p. 474. ISSN 0736-5748

Pelham, R. J., Rodgers, L., Hall, I. M., Lucito, R., Nguyen, K. C. Q., Navin, N. E., Hicks, J. B., Mu, D., Powers, S., Wigler, M. H., Botstein, D. (2006) Identification of alterations in DNA copy number in host stromal cells during tumor progression. Proc Natl Acad Sci U S A, 103 (52). pp. 19848-19853. ISSN 0027-8424

Hicks, J. B., Krasnitz, A., Lakshmi, B., Navin, N. E., Riggs, M., Leibu, E., Esposito, D., Alexander, J., Troge, J. E., Grubor, V., Yoon, S., Wigler, M. H., Ye, K., Borresen-Dale, A. L., Naume, B., Schlicting, E., Norton, L., Hagerstrom, T., Skoog, L., Auer, G., Månér, S., Lundin, P., Zetterberg, A. (2006) Novel patterns of genome rearrangement and their association with survival in breast cancer. Genome Research, 16 (12). pp. 1465-79. ISSN 1088-9051

Grubor, V. D., Troge, J. E., Meth, J. L., Lakshmi, B., Yamron, B., Hufnagel, L. A., Lee, Y. H., Kendall, J. T., Pai, D., Lee, A., Gregersen, P., Yancopoulos, S., Allen, S., Rai, K. R., Chiorazzi, N., Wigler, M. H., Esposito, D. (2006) Genome Analysis of CLL by Representational Oligonucleotide Microarray Analysis (ROMA). ASH Annual Meeting Abstracts, 108 (11). p. 2085.

Navin, N. E., Grubor, V., Hicks, J. B., Leibu, E., Thomas, E., Troge, J., Riggs, M., Lundin, P., Månér, S., Sebat, J., Zetterberg, A., Wigler, M. H. (2006) PROBER: oligonucleotide FISH probe design software. Bioinformatics, 22 (19). pp. 2437-8. ISSN 1460-2059 (Electronic)

Lakshmi, B., Hall, I. M., Egan, C., Alexander, J., Leotta, A., Healy, J., Zender, L., Spector, M. S., Xue, W., Lowe, S. W., Wigler, M. H., Lucito, R. (2006) Mouse genomic representational oligonucleotide microarray analysis: detection of copy number variations in normal and tumor specimens. Proc Natl Acad Sci U S A, 103 (30). pp. 11234-9. ISSN 0027-8424 (Print)

Zender, L., Spector, M. S., Xue, W., Flemming, P., Cordon-Cardo, C., Silke, J., Fan, S. T., Luk, J. M., Wigler, M. H., Hannon, G. J., Mu, D., Lucito, R., Powers, S., Lowe, S. W. (2006) Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approach. Cell, 125 (7). pp. 1253-67. ISSN 0092-8674 (Print)

West, J., Healy, J., Wigler, M. H., Casey, W., Mishra, B. (2006) Validation of S. Pombe sequence assembly by microarray hybridization. J Comput Biol, 13 (1). pp. 1-20. ISSN 1066-5277 (Print)

Sachs, N. A., Holmes, S. E., Cowell, J. K., Conroy, J., Nowak, N. J., McQuaid, D., Rossi, M. R., Gaile, D. P., Christian, S. L., Wigler, M. H., Sebat, J., Ross, C. A., DeLisi, L. E., Margolis, R. L. (2005) Assessment of schizophrenia genomes for DNA copy number alterations. American Journal of Medical Genetics Part B-Neuropsychiatric Genetics, 138B (1). pp. 90-91. ISSN 1552-4841

Jobanputra, V., Sebat, J., Troge, J., Chung, W., Anyane-Yeboa, K., Wigler, M. H., Warburton, D. (2005) Application of ROMA (representational oligonucleotide microarray analysis) to patients with cytogenetic rearrangements. Genetics in Medicine, 7 (2). pp. 111-118. ISSN 1098-3600

Hicks, J. B., Muthuswamy, L., Krasnitz, A., Navin, N. E., Riggs, M., Grubor, V., Esposito, D., Alexander, J., Troge, J. E., Wigler, M. H., Maner, S., Lundin, P., Zetterberg, A. (2005) High-resolution ROMA CGH and FISH analysis of aneuploid and diploid breast tumors. Cold Spring Harb Symp Quant Biol, 70. pp. 51-63. ISSN 1943-4456 (Electronic) 0091-7451 (Linking)

Daruwala, R. S., Rudra, A., Ostrer, H., Lucito, R., Wigler, M. H., Mishra, B. (2004) A versatile statistical analysis algorithm to detect genome copy number variation. Proceedings of the National Academy of Sciences of the United States of America, 101 (46). pp. 16292-16297. ISSN 0027-8424

Olshen, A. B., Venkatraman, E. S., Lucito, R., Wigler, M. H. (2004) Circular binary segmentation for the analysis of array-based DNA copy number data. Biostatistics, 5 (4). pp. 557-572. ISSN 1465-4644

Sebat, J., Lakshmi, B., Troge, J. E., Alexander, J., Young, J., Lundin, P., Maner, S., Massa, H., Walker, M., Chi, M., Navin, N. E., Lucito, R., Healy, J., Hicks, J. B., Ye, K., Reiner, A., Gilliam, T. C., Trask, B., Patterson, N., Zetterberg, A., Wigler, M. H. (2004) Large-scale copy number polymorphism in the human genome. Science, 305 (5683). pp. 525-8. ISSN 1095-9203 (Electronic)

Thomas, E. E., Srebro, N., Sebat, J., Navin, N., Healy, J., Mishra, B., Wigler, M. H. (2004) Distribution of short paired duplications in mammalian genomes. Proc Natl Acad Sci U S A, 101 (28). pp. 10349-54. ISSN 0027-8424 (Print)

Healy, J., Thomas, E. E., Schwartz, J. T., Wigler, M. H. (2003) Annotating large genomes with exact word matches. Genome Research, 13 (10). pp. 2306-2315. ISSN 1088-9051

Lucito, R., Healy, J., Alexander, J., Reiner, A., Esposito, D., Chi, M. Y., Rodgers, L., Brady, A., Sebat, J., Troge, J. E., West, J. A., Rostan, S., Nguyen, K. C. Q., Powers, S., Ye, K. Q., Olshen, A., Venkatraman, E., Norton, L., Wigler, M. H. (2003) Representational oligonucleotide microarray analysis: A high-resolution method to detect genome copy number variation. Genome Research, 13 (10). pp. 2291-2305. ISSN 1088-9051

Mu, D., Chen, L. Y., Zhang, X. P., See, L. H., Koch, C. M., Yen, C., Tong, J. J., Spiegel, L., Nguyen, K. C. Q., Servoss, A., Peng, Y., Pei, L., Marks, J. R., Lowe, S. W., Hoey, T., Jan, L. Y., McCombie, W. R., Wigler, M. H., Powers, S. (2003) Genomic amplification and oncogenic properties of the KCNK9 potassium channel gene. Cancer Cell, 3 (3). pp. 297-302. ISSN 1535-6108

Hamaguchi, M., Meth, J. L., von Klitzing, C., Wei, W., Esposito, D., Rodgers, L., Walsh, T., Welcsh, P., King, M. C., Wigler, M. H. (2002) DBC2, a candidate for a tumor suppressor gene involved in breast cancer. Proceedings of the National Academy of Sciences of the United States of America, 99 (21). pp. 13647-13652. ISSN 0027-8424

Wigler, M. H., Mishra, B. (2002) Genetics. Wild by nature. Science, 296 (5572). pp. 1407-1408. ISSN 0036-8075

Stolarov, J., Chang, K., Reiner, A., Rodgers, L., Hannon, G. J., Wigler, M. H., Mittal, V. (2001) Design of a retroviral-mediated ecdysone-inducible system and its application to the expression profiling of the PTEN tumor suppressor. Proceedings of the National Academy of Sciences of the United States of America, 98 (23). pp. 13043-13048. ISSN 0027-8424

Scheffzek, K., Grunewald, P., Wohlgemuth, S., Kabsch, W., Tu, H., Wigler, M. H., Wittinghofer, A., Herrmann, C. (2001) The Ras-Byr2RBD complex: Structural basis for Ras effector recognition in yeast. Structure, 9 (11). pp. 1043-1050. ISSN 0969-2126

Wen, S. H., Stolarov, J., Myers, M. P., Su, J. D., Wigler, M. H., Tonks, N. K., Durden, D. L. (2001) PTEN controls tumor-induced angiogenesis. Proceedings of the National Academy of Sciences of the United States of America, 98 (8). pp. 4622-4627. ISSN 0027-8424

Lucito, R., West, J., Reiner, A., Alexander, J., Esposito, D., Mishra, B., Powers, S., Norton, L., Wigler, M. H. (2000) Detecting gene copy number fluctuations in tumor cells by microarray analysis of genomic representations. Genome Research, 10 (11). pp. 1726-1736. ISSN 1088-9051

Dong, D. L., Liu, R., Sherlock, R., Wigler, M. H., Nestler, H. P. (1999) Molecular forceps from combinatorial libraries prevent the farnesylation of Ras by binding to its carboxyl terminus. Chem Biol, 6 (3). pp. 133-41. ISSN 1074-5521 (Print)

Tu, H., Wigler, M. H. (1999) Genetic evidence for Pak1 autoinhibition and its release by Cdc42. Mol Cell Biol, 19 (1). pp. 602-11. ISSN 0270-7306 (Print)

Myers, M. P., Pass, I., Batty, I. H., Van der Kaay, J., Stolarov, J. P., Hemmings, B. A., Wigler, M. H., Downes, C. P., Tonks, N. K. (1998) The lipid phosphatase activity of PTEN is critical for its tumor supressor function. Proc Natl Acad Sci U S A, 95 (23). pp. 13513-8. ISSN 0027-8424 (Print)

Webb, C. P., Van Aelst, L., Wigler, M. H., Woude, G. F. (1998) Signaling pathways in Ras-mediated tumorigenicity and metastasis. Proc Natl Acad Sci U S A, 95 (15). pp. 8773-8. ISSN 0027-8424 (Print)

Lucito, R., Nakimura, M., West, J. A., Han, Y., Chin, K., Jensen, K. R., McCombie, R. W., Gray, J. W., Wigler, M. H. (1998) Genetic analysis using genomic representations. Proceedings of the National Academy of Sciences of the United States of America, 95 (8). pp. 4487-92. ISSN 0027-8424

Hamaguchi, M., O'Connor, E. A., Chen, T., Parnell, L., McCombie, R. W., Wigler, M. H. (1998) Rapid isolation of cDNA by hybridization. Proceedings of the National Academy of Sciences of the United States of America, 95 (7). pp. 3764-9. ISSN 0027-8424

Tu, H., Barr, M., Dong, D. L., Wigler, M. H. (1997) Multiple regulatory domains on the Byr2 protein kinase. Mol Cell Biol, 17 (10). pp. 5876-87. ISSN 0270-7306 (Print)

Myers, M. P., Stolarov, J. P., Eng, C., Li, J., Wang, S. I., Wigler, M. H., Parsons, R., Tonks, N. K. (1997) P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphatase. Proc Natl Acad Sci U S A, 94 (17). pp. 9052-7. ISSN 0027-8424 (Print)

Li, J., Yen, C., Liaw, D., Podsypanina, K., Bose, S., Wang, S. I., Puc, J., Miliaresis, C., Rodgers, L., McCombie, R., Bigner, S. H., Giovanella, B. C., Ittmann, M., Tycko, B., Hibshoosh, H., Wigler, M. H., Parsons, R. (1997) PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer. Science, 275 (5308). pp. 1943-7. ISSN 0036-8075 (Print)

Barr, M. M., Tu, H., Van Aelst, L., Wigler, M. H. (1996) Identification of Ste4 as a potential regulator of Byr2 in the sexual response pathway of Schizosaccharomyces pombe. Mol Cell Biol, 16 (10). pp. 5597-603. ISSN 0270-7306 (Print)

White, M. A., Vale, T., Camonis, J. H., Schaefer, E., Wigler, M. H. (1996) A role for the Ral guanine nucleotide dissociation stimulator in mediating Ras-induced transformation. J Biol Chem, 271 (28). pp. 16439-42. ISSN 0021-9258 (Print)

Thiagalingam, S., Lisitsyn, N. A., Hamaguchi, M., Wigler, M. H., Willson, J. K., Markowitz, S. D., Leach, F. S., Kinzler, K. W., Vogelstein, B. (1996) Evaluation of the FHIT gene in colorectal cancers. Cancer Res, 56 (13). pp. 2936-9. ISSN 0008-5472 (Print)

Khosravi-Far, R., White, M. A., Westwick, J. K., Solski, P. A., Chrzanowska-Wodnicka, M., Van Aelst, L., Wigler, M. H., Der, C. J. (1996) Oncogenic Ras activation of Raf/mitogen-activated protein kinase-independent pathways is sufficient to cause tumorigenic transformation. Mol Cell Biol, 16 (7). pp. 3923-33. ISSN 0270-7306 (Print)

Joneson, T., White, M. A., Wigler, M. H., Bar-Sagi, D. (1996) Stimulation of membrane ruffling and MAP kinase activation by distinct effectors of RAS. Science, 271 (5250). pp. 810-812. ISSN 0036-8075

Xu, H. P., Yanak, B. L., Wigler, M. H., Gorin, M. B. (1996) New polymorphic markers in the vicinity of the pearl locus on mouse chromosome 13. Mamm Genome, 7 (1). pp. 16-9. ISSN 0938-8990 (Print)

Marcus, S., Polverino, A., Chang, E., Robbins, D., Cobb, M. H., Wigler, M. H. (1995) Shk1, a homolog of the Saccharomyces cerevisiae Ste20 and mammalian p65PAK protein kinases, is a component of a Ras/Cdc42 signaling module in the fission yeast Schizosaccharomyces pombe. Proc Natl Acad Sci U S A, 92 (13). pp. 6180-4. ISSN 0027-8424 (Print)

Jung, V., Chen, L., Hofmann, S. L., Wigler, M. H., Powers, S. (1995) Mutations in the SHR5 gene of Saccharomyces cerevisiae suppress Ras function and block membrane attachment and palmitoylation of Ras proteins. Mol Cell Biol, 15 (3). pp. 1333-42. ISSN 0270-7306 (Print)

White, M. A., Nicolette, C., Minden, A., Polverino, A., Van Aelst, L., Karin, M., Wigler, M. H. (1995) Multiple Ras functions can contribute to mammalian cell transformation. Cell, 80 (4). pp. 533-41. ISSN 0092-8674 (Print)

Lisitsyn, N. A., Lisitsina, N. M., Dalbagni, G., Barker, P., Sanchez, C. A., Gnarra, J., Linehan, W. M., Reid, B. J., Wigler, M. H. (1995) Comparative genomic analysis of tumors: detection of DNA losses and amplification. Proc Natl Acad Sci U S A, 92 (1). pp. 151-5. ISSN 0027-8424 (Print)

Lisitsyn, N., Wigler, M. H. (1995) Representational difference analysis in detection of genetic lesions in cancer. Methods Enzymol, 254. pp. 291-304. ISSN 0076-6879 (Print)

Chang, E. C., Barr, M., Wang, Y., Jung, V., Xu, H. P., Wigler, M. H. (1994) Cooperative interaction of S. pombe proteins required for mating and morphogenesis. Cell, 79 (1). pp. 131-41. ISSN 0092-8674 (Print)

Marcus, S., Polverino, A., Barr, M., Wigler, M. H. (1994) Complexes between STE5 and components of the pheromone-responsive mitogen-activated protein kinase module. Proc Natl Acad Sci U S A, 91 (16). pp. 7762-6. ISSN 0027-8424 (Print)

Jung, V., Wei, W., Ballester, R., Camonis, J., Mi, S., Van Aelst, L., Wigler, M. H., Broek, D. (1994) Two types of RAS mutants that dominantly interfere with activators of RAS. Mol Cell Biol, 14 (6). pp. 3707-18. ISSN 0270-7306 (Print)

Marcus, S., Polverino, A., Robbins, D., Cobb, M., Wigler, M. H. (1994) Conservation of Ste20-Related Protein-Kinases in Eukaryotes. Faseb Journal, 8 (7). A1431-A1431. ISSN 0892-6638

Xu, H. P., White, M., Marcus, S., Wigler, M. H. (1994) Concerted action of RAS and G proteins in the sexual response pathways of Schizosaccharomyces pombe. Mol Cell Biol, 14 (1). pp. 50-8. ISSN 0270-7306 (Print)

Lisitsyn, N. A., Segre, J. A., Kusumi, K., Lisitsyn, N. M., Nadeau, J. H., Frankel, W. N., Wigler, M. H., Lander, E. S. (1994) Direct isolation of polymorphic markers linked to a trait by genetically directed representational difference analysis. Nat Genet, 6 (1). pp. 57-63. ISSN 1061-4036 (Print)

Lisitsyn, N. A., Leach, F. S., Vogelstein, B., Wigler, M. H. (1994) Detection of genetic loss in tumors by representational difference analysis. Cold Spring Harbor Symposia on Quantitative Biology, 59. pp. 585-7. ISSN 00917451 (ISSN)

Van Aelst, L., White, M., Wigler, M. H. (1994) Ras partners. Cold Spring Harbor Symposia on Quantitative Biology, 59. pp. 181-186. ISSN 00917451 (ISSN)

Ohlmeyer, M. H. J., Swanson, R. N., Dillard, L. W., Reader, J. C., Asouline, G., Kobayashi, R., Wigler, M. H., Still, W. C. (1993) Complex synthetic chemical libraries indexed with molecular tags. Proceedings of the National Academy of Sciences of the United States of America, 90 (23). pp. 10922-10926. ISSN 0027-8424

Bolger, G., Michaeli, T., Martins, T., St John, T., Steiner, B., Rodgers, L., Riggs, M., Wigler, M. H., Ferguson, K. (1993) A family of human phosphodiesterases homologous to the dunce learning and memory gene product of Drosophila melanogaster are potential targets for antidepressant drugs. Mol Cell Biol, 13 (10). pp. 6558-71. ISSN 0270-7306 (Print)

Van Aelst, L., Barr, M., Marcus, S., Polverino, A., Wigler, M. H. (1993) Complex formation between RAS and RAF and other protein kinases. Proc Natl Acad Sci U S A, 90 (13). pp. 6213-7. ISSN 0027-8424 (Print)

Michaeli, T., Bloom, T. J., Martins, T., Loughney, K., Ferguson, K., Riggs, M., Rodgers, L., Beavo, J. A., Wigler, M. H. (1993) Isolation and characterization of a previously undetected human cAMP phosphodiesterase by complementation of cAMP phosphodiesterase- deficient Saccharomyces cerevisiae. Journal of Biological Chemistry, 268 (17). pp. 12925-12932. ISSN 0021-9258

Chardin, P., Camonis, J. H., Gale, N. W., van Aelst, L., Schlessinger, J., Wigler, M. H., Bar-Sagi, D. (1993) Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2. Science, 260 (5112). pp. 1338-1343.

Wigler, M. H., Xu, H. P., Vanaelst, L., Jung, V., Marcus, S., Polverino, T., Oneill, K., Chang, E., Camonis, J., Nicolette, C., White, M., Ballester, R. (1993) Evolution of Ras Signal Transduction Pathways. Faseb Journal, 7 (7). A1124-A1124. ISSN 0892-6638

Gutmann, D. H., Boguski, M., Marchuk, D., Wigler, M. H., Collins, F. S., Ballester, R. (1993) Analysis of the neurofibromatosis type-1 (NF1) GAP-related domain by site-directed mutagenesis. Oncogene, 8 (3). pp. 761-769. ISSN 0950-9232

Lisitsyn, N., Lisitsyn, N., Wigler, M. H. (1993) Cloning the differences between two complex genomes. Science, 259 (5097). pp. 946-51. ISSN 0036-8075 (Print)

Neiman, A. M., Stevenson, B. J., Xu, H. P., Sprague, G. F., Herskowitz, I., Wigler, M. H., Marcus, S. (1993) Functional homology of protein kinases required for sexual differentiation in Schizosaccharomyces pombe and Saccharomyces cerevisiae suggests a conserved signal transduction module in eukaryotic organisms. Molecular Biology of the Cell, 4 (1). pp. 107-120. ISSN 1059-1524

Andersen, L. B., Ballester, R., Marchuk, D. A., Chang, E., Gutmann, D. H., Saulino, A. M., Camonis, J., Wigler, M. H., Collins, F. S. (1993) A conserved alternative splice in the von Recklinghausen neurofibromatosis (NF1) gene produces two neurofibromin isoforms, both of which have GTPase-activating protein activity. Molecular and Cellular Biology, 13 (1). pp. 487-495. ISSN 0270-7306

Marcus, S., Wigler, M. H., Xu, H. P., Ballester, R., Kawamukai, M., Polverino, A. (1993) RAS function and protein kinase cascades. Ciba Found Symp, 176. 53-61; discussion 61. ISSN 0300-5208 (Print)

Shibuya, E. K., Polverino, A. J., Chang, E., Wigler, M. H., Ruderman, J. V. (1992) Oncogenic Ras triggers the activation of 42-kDa mitogen-activated protein kinase in extracts of quiescent Xenopus oocytes. Proceedings of the National Academy of Sciences of the United States of America, 89 (20). pp. 9831-9835. ISSN 0027-8424

Xu, H. P., Rajavashisth, T., Grewal, N., Jung, V., Riggs, M., Rodgers, L., Wigler, M. H. (1992) A gene encoding a protein with seven zinc finger domains acts on the sexual differentiation pathways of Schizosaccharomyces pombe. Mol Biol Cell, 3 (7). pp. 721-34. ISSN 1059-1524 (Print)

Gerst, J. E., Rodgers, L., Riggs, M., Wigler, M. (1992) SNC1, a yeast homolog of the synaptic vesicle-associated membrane protein/synaptobrevin gene family: genetic interactions with the RAS and CAP genes. Proc Natl Acad Sci U S A, 89 (10). pp. 4338-42. ISSN 0027-8424 (Print)0027-8424 (Linking)

Gerst, J. E., Rodgers, L., Riggs, M., Wigler, M. H. (1992) Snc1, a Yeast Homolog of the Synaptic Vesicle-Associated Membrane-Protein Synaptobrevin Gene Family - Genetic Interactions with the Ras and Cap Genes. Proceedings of the National Academy of Sciences of the United States of America, 89 (10). pp. 4338-4342. ISSN 0027-8424

Kawamukai, M., Gerst, J., Field, J., Riggs, M., Rodgers, L., Wigler, M. H., Young, D. (1992) Genetic and biochemical analysis of the adenylyl cyclase-associated protein, cap, in Schizosaccharomyces pombe. Molecular Biology of the Cell, 3 (2). pp. 167-180. ISSN 1059-1524

Andersen, L., Ballester, R., Marchuk, D., Saulino, A., Wigler, M. H., Collins, F. (1991) Alternative Splicing in the Proposed Catalytic Domain of the Type-1 Neurofibromatosis Gene. American Journal of Human Genetics, 49 (4). p. 21. ISSN 0002-9297

Vojtek, A., Haarer, B., Field, J., Gerst, J., Pollard, T. D., Brown, S., Wigler, M. H. (1991) Evidence for a functional link between profilin and CAP in the yeast S. cerevisiae. Cell, 66 (3). pp. 497-505. ISSN 0092-8674

Daar, I., Nebreda, A. R., Yew, N., Sass, P., Paules, R., Santos, E., Wigler, M. H., Vandewoude, G. F. (1991) The Ras Oncoprotein and M-Phase Activity. Science, 253 (5015). pp. 74-76. ISSN 0036-8075

Wang, Y., Xu, H. P., Riggs, M., Rodgers, L., Wigler, M. H. (1991) byr2, a Schizosaccharomyces pombe gene encoding a protein kinase capable of partial suppression of the ras1 mutant phenotype. Molecular & Cellular Biology, 11 (7). pp. 3554-63. ISSN 0270-7306

Young, D., O'Neill, K., Broek, D., Wigler, M. H. (1991) The adenylyl cyclase-encoding gene from Saccharomyces kluyveri. Gene, 102 (1). pp. 129-32. ISSN 0378-1119

Colicelli, J., Nicolette, C., Birchmeier, C., Rodgers, L., Riggs, M., Wigler, M. H. (1991) Expression of three mammalian cDNAs that interfere with RAS function in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A, 88 (7). pp. 2913-7. ISSN 0027-8424

Gerst, J. E., Ferguson, K., Vojtek, A., Wigler, M. H., Field, J. (1991) CAP is a bifunctional component of the Saccharomyces cerevisiae adenylyl cyclase complex. Molecular & Cellular Biology, 11 (3). pp. 1248-57. ISSN 0270-7306

Kawamukai, M., Ferguson, K., Wigler, M. H., Young, D. (1991) Genetic and biochemical analysis of the adenylyl cyclase of Schizosaccharomyces pombe. Cell Regulation, 2 (2). pp. 155-64. ISSN 1044-2030

Vojtek, A., Field, J., Gerst, J., Wigler, M. H. (1991) The Ras Signalling Pathway in Yeast. Journal of Cellular Biochemistry - Supplement.(15 PART B). p. 84.

Wigler, M. H., Ballester, R., Chang, E., Colicelli, J., Field, J., Gerst, J., Kawamukai, M., Michaeli, T., Nicolette, C. (1991) The Ways of Ras. Proceedings American Association for Cancer Research Annual Meeting. p. 435.

Wang, Y., Boguski, M., Riggs, M., Rodgers, L., Wigler, M. (1991) sar1, a gene from Schizosaccharomyces pombe encoding a protein that regulates ras1. Cell Regulation, 2 (6). pp. 453-465. ISSN 10442030 (ISSN)

Ballester, R., Marchuk, D., Boguski, M., Saulino, A., Letcher, R., Wigler, M. H., Collins, F. (1990) The NF1 locus encodes a protein functionally related to mammalian GAP and yeast IRA proteins. Cell, 63 (4). pp. 851-9. ISSN 0092-8674

Xu, H. P., Wang, Y., Riggs, M., Rodgers, L., Wigler, M. H. (1990) Biological activity of the mammalian RAP genes in yeast. Cell Regulation, 1 (10). pp. 763-769. ISSN 1044-2030

Wigler, M. H. (1990) Oncoproteins. Gaps in Understanding Ras. Nature, 346 (6286). pp. 696-697. ISSN 0028-0836

Colicelli, J., Field, J., Ballester, R., Chester, N., Young, D., Wigler, M. H. (1990) Mutational mapping of RAS-responsive domains of the Saccharomyces cerevisiae adenylyl cyclase. Molecular & Cellular Biology, 10 (6). pp. 2539-43. ISSN 0270-7306

Field, J., Vojtek, A., Ballester, R., Bolger, G., Colicelli, J., Ferguson, K., Gerst, J., Kataoka, T., Michaeli, T., Powers, S., Riggs, M., Rodgers, L., Wieland, I., Wheland, B., Wigler, M. H. (1990) Cloning and characterization of CAP, the S. cerevisiae gene encoding the 70 kd adenylyl cyclase-associated protein. Cell, 61 (2). pp. 319-327. ISSN 0092-8674

Wieland, I., Bolger, G., Asouline, G., Wigler, M. H. (1990) A method for difference cloning: gene amplification following subtractive hybridization. Proc Natl Acad Sci U S A, 87 (7). pp. 2720-4. ISSN 0027-8424

Field, J., Xu, H. P., Michaeli, T., Ballester, R., Sass, P., Wigler, M. H., Colicelli, J. (1990) Mutations of the adenylyl cyclase gene that block RAS function in Saccharomyces cerevisiae. Science, 247 (4941). pp. 464-7. ISSN 0036-8075

Birchmeier, C., O'Neill, K., Riggs, M., Wigler, M. H. (1990) Characterization of Ros1 cDNA from a Human Glioblastoma Cell Line. Proceedings of the National Academy of Sciences of the United States of America, 87 (12). pp. 4799-4803.

Ballester, R., Wigler, M. H. (1990) Isolation and Characterization of Genes That Regulate Ras Function in the Yeast Saccharomyces-Cerevisiae. Yeast, 6 (SPEC. ). S212.

Gerst, J. E., Field, J., Ferguson, K., Wigler, M. H. (1990) Molecular and Phenotypic Analysis of Cap a Regulatory Element Involved in Mediating Both Ras Action and Amino Acid Balance. Yeast, 6 (SPEC. ). S174.

Xu, H. P., Riggs, M., Rodgers, L., Wigler, M. H. (1990) A gene from Schizosaccharomyces-Pombe with homology to Escherichia-Coli RNAse III blocks conjugation and sporulation when overexpressed in wild type cells. Nucleic Acids Research, 18 (17). p. 5304.

Ballester, R., Michaeli, T., Ferguson, K., Xu, H. P., McCormick, F., Wigler, M. H. (1989) Genetic analysis of mammalian GAP expressed in yeast. Cell, 59 (4). pp. 681-6. ISSN 0092-8674

Michaeli, T., Field, J., Ballester, R., O'Neill, K., Wigler, M. H. (1989) Mutants of H-ras that interfere with RAS effector function in Saccharomyces cerevisiae. Embo J, 8 (10). pp. 3039-44. ISSN 0261-4189

Young, D., Riggs, M., Field, J., Vojtek, A., Broek, D., Wigler, M. H. (1989) The adenylyl cyclase gene from Schizosaccharomyces pombe. Proc Natl Acad Sci U S A, 86 (20). pp. 7989-93. ISSN 0027-8424

Colicelli, J., Birchmeier, C., Michaeli, T., O'Neill, K., Riggs, M., Wigler, M. H. (1989) Isolation and characterization of a mammalian gene encoding a high-affinity cAMP phosphodiesterase. Proc Natl Acad Sci U S A, 86 (10). pp. 3599-603. ISSN 0027-8424

Powers, S., O'Neill, K., Wigler, M. H. (1989) Dominant yeast and mammalian RAS mutants that interfere with the CDC25-dependent activation of wild-type RAS in Saccharomyces cerevisiae. Molecular & Cellular Biology, 9 (2). pp. 390-5. ISSN 0270-7306

Sharma, S., Birchmeier, C., Nikawa, J., O'Neill, K., Rodgers, L., Wigler, M. H. (1989) Characterization of the ros1-gene products expressed in human glioblastoma cell lines. Oncogene Res, 5 (2). pp. 91-100. ISSN 0890-6467

Young, D., O'Neill, K., Jessell, T., Wigler, M. H. (1988) Characterization of the rat mas oncogene and its high-level expression in the hippocampus and cerebral cortex of rat brain. Proc Natl Acad Sci U S A, 85 (14). pp. 5339-42. ISSN 0027-8424

Cameron, S., Levin, L., Zoller, M., Wigler, M. H. (1988) cAMP-independent control of sporulation, glycogen metabolism, and heat shock resistance in S. cerevisiae. Cell, 53 (4). pp. 555-66. ISSN 0092-8674

Field, J., Nikawa, J., Broek, D., MacDonald, B., Rodgers, L., Wilson, I. A., Lerner, R. A., Wigler, M. H. (1988) Purification of a RAS-responsive adenylyl cyclase complex from Saccharomyces cerevisiae by use of an epitope addition method. Molecular & Cellular Biology, 8 (5). pp. 2159-65. ISSN 0270-7306

Toda, T., Cameron, S., Sass, P., Wigler, M. H. (1988) SCH9, a gene of Saccharomyces cerevisiae that encodes a protein distinct from, but functionally and structurally related to, cAMP-dependent protein kinase catalytic subunits. Genes Dev, 2 (5). pp. 517-27. ISSN 0890-9369

Levin, L. R., Kuret, J., Johnson, K. E., Powers, S., Cameron, S., Michaeli, T., Wigler, M. H., Zoller, M. J. (1988) A mutation in the catalytic subunit of cAMP-dependent protein kinase that disrupts regulation. Science, 240 (4848). pp. 68-70.

Wigler, M. H., Cameron, S., Powers, S., Field, J., Toda, T., Broek, D., Nikawa, J., Michaelis, T., Colicelli, J. (1988) Integration of Ras and Adenylate Cyclase Pathways in Yeast. Journal of Cell Biology, 107 (6 PART). 4A.

Wigler, M. H., Field, J., Powers, S., Broek, D., Toda, T., Cameron, S., Nikawa, J., Michaeli, T., Colicelli, J., Ferguson, K. (1988) Studies of RAS function in the yeast Saccharomyces cerevisiae. Cold Spring Harbor Symposia on Quantitative Biology, 53 (2). pp. 649-55. ISSN 00917451 (ISSN)

Birchmeier, C., Sharma, S., Wigler, M. H. (1987) Expression and rearrangement of the ROS1 gene in human glioblastoma cells. Proc Natl Acad Sci U S A, 84 (24). pp. 9270-4. ISSN 0027-8424

Nikawa, J., Cameron, S., Toda, T., Ferguson, K. M., Wigler, M. H. (1987) Rigorous feedback control of cAMP levels in Saccharomyces cerevisiae. Genes & Development, 1 (9). pp. 931-937.

Nikawa, J., Sass, P., Wigler, M. H. (1987) Cloning and characterization of the low-affinity cyclic AMP phosphodiesterase gene of Saccharomyces cerevisiae. Molecular & Cellular Biology, 7 (10). pp. 3629-36. ISSN 0270-7306

Rabin, M., Birnbaum, D., Young, D., Birchmeier, C., Wigler, M. H., Ruddle, F. H. (1987) Human ROS1 and MAS1 oncogenes located in regions of chromosome 6 associated with tumor-specific rearrangements. Oncogene Res, 1 (2). pp. 169-78. ISSN 0890-6467 (Print)

Toda, T., Cameron, S., Sass, P., Zoller, M., Scott, J. D., McMullen, B., Hurwitz, M., Krebs, E. G., Wigler, M. H. (1987) Cloning and characterization of BCY1, a locus encoding a regulatory subunit of the cyclic AMP-dependent protein kinase in Saccharomyces cerevisiae. Molecular & Cellular Biology, 7 (4). pp. 1371-1377.

Broek, D., Toda, T., Michaeli, T., Levin, L., Birchmeier, C., Zoller, M., Powers, S., Wigler, M. H. (1987) The S. cerevisiae CDC25 gene product regulates the RAS/adenylate cyclase pathway. Cell, 48 (5). pp. 789-800.

Johnson, K. E., Cameron, S., Toda, T., Wigler, M. H., Zoller, M. J. (1987) Expression in Escherichia coli of BCY1, the regulatory subunit of cyclic AMP-dependent protein kinase from Saccharomyces cerevisiae. Journal of Biological Chemistry, 262 (18). pp. 8636-8642.

Field, J., Broek, D., Kataoka, T., Wigler, M. H. (1987) Guanine nucleotide activation of, and competition between, RAS proteins from Saccharomyces cerevisiae. Molecular & Cellular Biology, 7 (6). pp. 2128-2133.

Toda, T., Cameron, S., Sass, P., Zoller, M., Wigler, M. H. (1987) Three different genes in Saccharomyces cerevisiae encode the catalytic subunits of the cAMP-dependent protein kinase. Cell, 50 (2). pp. 277-288.

Michaelis, S., Anna, S. S., Powers, S., Wigler, M. H., Herskowitz, I. (1987) Yeast Mating Pheromone a-Factor and Its Relationship to Ras Proteins. Journal of Cellular Biochemistry. p. 261. ISSN 0730-2312

Herlands, L., Kishimoto, T., Birchmeier, C., Wigler, M. H., Koide, S. S. (1986) Induction of Oocyte Maturation by Injection of Oncogenic H-Ras Protein in the Starfish. Zoological Science, 3 (6). p. 1036. ISSN 0289-0003

Birchmeier, C., Young, D., Wigler, M. H. (1986) Characterization of two new human oncogenes. Cold Spring Harbor Symposia on Quantitative Biology, 51 (2). pp. 993-1000. ISSN 00917451 (ISSN)

Birchmeier, C., Birnbaum, D., Waitches, G., Fasano, O., Wigler, M. H. (1986) Characterization of an activated human ros gene. Molecular & Cellular Biology, 6 (9). pp. 3109-3116.

Sass, P., Field, J., Nikawa, J., Toda, T., Wigler, M. H. (1986) Cloning and characterization of the high-affinity cAMP phosphodiesterase of Saccharomyces cerevisiae. Proceedings of the National Academy of Sciences of the United States of America, 83 (24). pp. 9303-9307.

Young, D., Waitches, G., Birchmeier, C., Fasano, O., Wigler, M. H. (1986) Isolation and characterization of a new cellular oncogene encoding a protein with multiple potential transmembrane domains. Cell, 45 (5). pp. 711-720.

Powers, S., Michaelis, S., Broek, D., Ann-A, S. S., Field, J., Herskowitz, I., Wigler, M. H. (1986) RAM, a gene of yeast required for a functional modification of RAS proteins and for production of mating pheromone a-factor. Cell, 47 (3). pp. 413-422.

Kataoka, T., Broek, D., Wigler, M. H. (1985) DNA sequence and characterization of the S. cerevisiae gene encoding adenylate cyclase. Cell, 43 (2). pp. 493-505. ISSN 0092-8674

Birchmeier, C., Broek, D., Wigler, M. H. (1985) RAS proteins can induce meiosis in Xenopus oocytes. Cell, 43 (3 PART). pp. 615-622.

Birchmeier, C., Broek, D., Toda, T., Powers, S., Kataoka, T., Wigler, M. H. (1985) Conservation and divergence of RAS protein function during evolution. Cold Spring Harbor Symposia on Quantitative Biology, 50. pp. 721-725. ISSN 00917451 (ISSN)

Powers, S., Kataoka, T., Toda, T., Fasano, O., Wigler, M. H. (1985) Control of Yeast Adenyl-Cyclase by Ras Proteins. Federation Proceedings, 44 (3). R8-R8. ISSN 0014-9446

Broek, D., Samily, N., Fasano, O., Fujiyama, A., Tamanoi, F., Northup, J., Wigler, M. H. (1985) Differential activation of yeast adenylate cyclase by wild type and mutant RAS proteins. Cell, 41 (3). pp. 763-770.

Kataoka, T., Powers, S., Cameron, S., Fasano, O., Goldfarb, M., Broach, J., Wigler, M. H. (1985) Functional homology of mammalian and yeast RAS genes. Cell, 40 (1). pp. 19-26.

Toda, T., Uno, I., Ishikawa, T., Powers, S., Kataoka, T., Broek, D., Cameron, S., Broach, J., Matsumoto, K., Wigler, M. H. (1985) In yeast, RAS proteins are controlling elements of adenylate cyclase. Cell, 40 (1). pp. 27-36.

Feramisco, J., Sullivan, N., Kamata, T., Barsagi, D., Welch, W., Gross, M., Sweet, R., Rosenberg, M., Sathe, G., Fasano, O., Goldfarb, M., Wigler, M. H., Nitecki, D., Clark, R., Arnheim, N., McCormick, F. (1985) Microinjection of Ras Oncogene Proteins and Inhibitory Antibodies Specific for the Ras Oncogene Proteins into Living Normal and Transformed-Cells. Federation Proceedings, 44 (5). p. 1768. ISSN 0014-9446

Gross, M., Sweet, R. W., Sathe, G., Yokoyama, S., Fasano, O., Goldfarb, M., Wigler, M. H., Rosenberg, M. (1985) Purification and characterization of human H-RAS proteins expressed in Escherichia coli. Molecular and Cellular Biology, 5 (5). pp. 1015-1024. ISSN 0270-7306

Broach, J., Toda, T., Kataoka, T., Powers, S., Broek, D., Wigler, M. H. (1985) Ras Proteins Function Exclusively to Modulate Adenylate-Cyclase Activity in the Yeast Saccharomyces. DNA-a Journal of Molecular & Cellular Biology, 4 (1). p. 64. ISSN 0198-0238

Fasano, O., Birnbaum, D., Edlund, L., Fogh, J., Wigler, M. H. (1984) New human transforming genes detected by a tumorigenicity assay. Molecular & Cellular Biology, 4 (9). pp. 1695-1705.

Kataoka, T., Powers, S., McGill, C., Fasano, O., Strathern, J., Broach, J., Wigler, M. H. (1984) Genetic analysis of yeast RAS1 and RAS2 genes. Cell, 37 (2). pp. 437-445. ISSN 0092-8674

Powers, S., Kataoka, T., Fasano, O., Goldfarb, M., Strathern, J., Broach, J., Wigler, M. H. (1984) Genes in Saccharomyces cerevisiae encoding proteins with domains homologous to the mammalian ras proteins. Cell, 36 (3). pp. 607-612.

Fasano, O., Aldrich, T., Tamanoi, F., Taparowsky, E., Furth, M., Wigler, M. H. (1984) Analysis of the transforming potential of the human H-ras gene by random mutagenesis. Proceedings of the National Academy of Sciences of the United States of America, 81 (13). pp. 4008-4012.

Wigler, M. H., Fasano, O., Taparowsky, E., Birnbaum, D., Goldfarb, M., Fogh, J. (1984) Human Transforming Genes. DNA-a Journal of Molecular & Cellular Biology, 3 (1). p. 65. ISSN 0198-0238

Meyers, D. A., Antonarakis, S. E., Fearon, E. R., Mallonee, R. L., Waber, P. G., Phillips, J. A., Kazazian, H. H., Levine, M., Kronenberg, H. M., Wigler, M. H., Ullrich, A. (1984) Use of DNA Polymorphisms to Establish the Linkage Map of the Pth, Beta-Globin, C-Ha-Ras-1, and Insulin Loci on 11p. Cytogenetics and Cell Genetics, 37 (1-4). pp. 540-541. ISSN 0301-0171

Tamanoi, F., Walsh, M., Kataoka, T., Wigler, M. H. (1984) A product of yeast RAS-2 gene is a guanine nucleotide binding protein. Proceedings of the National Academy of Sciences of the United States of America, 81 (22). pp. 6924-6928.

Barker, D., McCoy, M., Weinberg, R., Goldfarb, M., Wigler, M. H., Burt, R., Gardner, E., White, R. (1983) A test of the role of two oncogenes in inherited predisposition to colon cancer. Mol Biol Med, 1 (2). pp. 199-206. ISSN 0735-1313 (Print)

Shimizu, K., Birnbaum, D., Ruley, M. A., Fasano, O., Suard, Y., Edlund, L., Taparowsky, E., Goldfarb, M., Wigler, M. H. (1983) Structure of the Ki-Ras Gene of the Human-Lung Carcinoma Cell-Line Calu-1. Nature, 304 (5926). pp. 497-500. ISSN 0028-0836

Shimizu, K., Goldfarb, M., Suard, Y., Perucho, M., Li, Y., Kamata, T., Feramisco, J., Stavnezer, E., Fogh, J., Wigler, M. H. (1983) Three human transforming genes are related to the viral ras oncogenes. Proceedings of the National Academy of Sciences of the United States of America, 80 (8). pp. 2112-2116. ISSN 0027-8424

Shimizu, K., Goldfarb, M., Perucho, M., Wigler, M. H. (1983) Isolation and preliminary characterization of the transforming gene of a human neuroblastoma cell line. Proc Natl Acad Sci U S A, 80 (2). pp. 383-387.

Ryan, J., Barker, P. E., Shimizu, K., Wigler, M. H., Ruddle, F. H. (1983) Chromosomal Assignment of a Family of Human Oncogenes. Proc Natl Acad Sci U S A, 80 (14). pp. 4460-4463. ISSN 0027-8424

Wigler, M. H., Shimizu, K., Goldfarb, M., Taparowsky, E., Suard, Y., Fasano, O. (1983) Human Transforming Genes. DNA-a Journal of Molecular & Cellular Biology, 2 (1). p. 64. ISSN 0198-0238

Kwoh, T. J., Zipser, D., Wigler, M. H. (1983) Mutational analysis of the cloned chicken thymidine kinase gene. J Mol Appl Genet, 2 (2). pp. 191-200. ISSN 0271-6801 (Print)

Fasano, O., Taparowsky, E., Fiddes, J., Wigler, M. H., Goldfarb, M. (1983) Sequence and Structure of the Coding Regions of the Human H-Ras-1 Gene from T-24 Bladder Carcinoma Cells. Journal of Molecular & Applied Genetics, 2 (2). pp. 173-180. ISSN 0271-6801

Taparowsky, E., Shimizu, K., Goldfarb, M., Wigler, M. H. (1983) Structure and Activation of the Human N-Ras Gene. Cell, 34 (2). pp. 581-586.

Shimizu, K., Taparowsky, E., Fasano, O., Suard, Y., Birnbaum, D., Ruley, M. A., Goldfarb, M., Wigler, M. H. (1983) Structures of 3 Ras Genes Activated in Human-Tumor Cell-Lines. Journal of Cell Biology, 97 (5). A69-A69. ISSN 0021-9525

Taparowsky, E., Suard, Y., Fasano, O., Shimizu, K., Goldfarb, M., Wigler, M. H. (1982) Activation of the T24 Bladder-Carcinoma Transforming Gene Is Linked to a Single Amino-Acid Change. Nature, 300 (5894). pp. 762-765. ISSN 0028-0836

Goldfarb, M., Shimizu, K., Perucho, M., Wigler, M. H. (1982) Isolation and Preliminary Characterization of a Human Transforming Gene from T24 Bladder-Carcinoma Cells. Nature, 296 (5856). pp. 404-409. ISSN 0028-0836

Perucho, M., Goldfarb, M., Shimizu, K., Lama, C., Fogh, J., Wigler, M. H. (1981) Human-tumor-derived cell lines contain common and different transforming genes. Cell, 27 (3 Pt 2). pp. 467-76. ISSN 0092-8674

Perucho, M., Wigler, M. H. (1981) Linkage and expression of foreign DNA in cultured animal cells. Cold Spring Harb Symp Quant Biol, 45 (2). pp. 829-838. ISSN 0091-7451 (Print)0091-7451 (Linking)

Wigler, M. H. (1981) The inheritance of methylation patterns in vertebrates. Cell, 24 (2). pp. 285-286.

Wigler, M. H., Levy, D., Perucho, M. (1981) The somatic replication of DNA methylation. Cell, 24 (1). pp. 33-40.

Hanahan, D., Lane, D., Lipsich, L., Wigler, M. H., Botchan, M. (1980) Characteristics of an Sv40-Plasmid Recombinant and Its Movement into and out of the Genome of a Murine Cell. Cell, 21 (1). pp. 127-139. ISSN 0092-8674

Wigler, M. H., Perucho, M., Kurtz, D., Dana, S., Pellicer, A., Axel, R., Silverstein, S. (1980) Transformation of mammalian cells with an amplifiable dominant acting gene. Proceedings of the National Academy of Sciences of the United States of America, 77 (6). pp. 3567-3570. ISSN 0027-8424

Perucho, M., Hanahan, D., Lipsich, L., Wigler, M. H. (1980) Isolation of the chicken thymidine kinase gene by plasmid rescue. Nature, 285 (5762). pp. 207-210.

Klessig, D. F., Wigler, M. H., Grodzicker, T. (1980) Construction of Co Transformation of Human Cell Lines Which Express Segments of the Adenovirus Genome. Journal of Supramolecular Structure, 9 (SUPPL.). p. 256.

Wigler, M. H., Perucho, M., Lipsich, L., Lane, D., Klessig, D., Grodzicker, T., Botchan, M., Hanahan, D. (1980) DNA Mediated Gene Transfer: Theory and Application. Journal of Supramolecular Structure, 9 (SUPPL.). p. 229. ISSN 0161-3294

Perucho, M., Hanahan, D., Wigler, M. H. (1980) Genetic and Physical Linkage of Exogenous Sequences in Transformed-Cells. Cell, 22 (1). pp. 309-317. ISSN 0092-8674

Wold, B., Wigler, M. H., Lacy, E., Maniatis, T., Silverstein, S., Axel, R. (1979) Introduction and expression of a rabbit Beta-globin gene in mouse fibroblasts. Proceedings of the National Academy of Sciences of the United States of America, 76 (11). pp. 5684-5688. ISSN 0027-8424

Wigler, M. H., Pellicer, A., Silverstein, S., Axel, R., Urlaub, G., Chasin, L. (1979) DNA-Mediated Transfer of the Adenine Phosphoribosyltransferase Locus into Mammalian Cells. Proc Natl Acad Sci U S A, 76 (3). pp. 1373-1376.

Wigler, M. H., Sweet, R., Sim, G. K., Wold, B., Pellicer, A., Lacy, E., Maniatis, T., Silverstein, S., Axel, R. (1979) Transformation of mammalian cells with genes from procaryotes and eucaryotes. Cell, 16 (4). pp. 777-785. ISSN 0092-8674

Wigler, M. H., Pellicer, A., Silverstein, S., Axel, R. (1978) Biochemical transfer of single-copy eucaryotic genes using total cellular DNA as donor. Cell, 14 (3). pp. 725-731.

Wigler, M. H., DeFeo, D., Weinstein, I. B. (1978) Induction of Plasminogen Activator in Cultured Cells by Macrocyclic Plant Diterpene Esters and Other Agents Related to Tumor Promotion. Cancer Res, 38 (5). pp. 1434-1437.

Pellicer, A., Wigler, M. H., Axel, R., Silverstein, S. (1978) The transfer and stable integration of HSV thymidine kinase gene into mouse cells. Cell, 14 (1). pp. 133-141. ISSN 0092-8674

Weinstein, I. B., Wigler, M. H. (1977) Cell culture studies provide new information on tumour promoters. Nature, 270 (5639). pp. 659-550.

Wigler, M. H., Silverstein, S., Lee, L. S., Pellicer, A., Cheng, Y. C., Axel, R. (1977) Transfer of Purified Herpes-Virus Thymidine Kinase Gene to Cultured Mouse Cells. Cell, 11 (1). pp. 223-232. ISSN 0092-8674

Wigler, M. H., Axel, R. (1976) Nucleosomes in metaphase chromosomes. Nucleic Acids Res, 3 (6). pp. 1463-1461.

Wigler, M. H., Weinstein, I. B. (1976) Tumor Promotor Induces Plasminogen Activator. Nature, 259 (5540). pp. 232-233. ISSN 0028-0836

Wigler, M. H., Weinstein, I. B. (1975) Preparative Method for Obtaining Enucleated Mammalian-Cells. Biochemical and Biophysical Research Communications, 63 (3). pp. 669-674. ISSN 0006-291X

Book Section

Lucito, R., Wigler, M. H. (2003) Preparation of slides and hybridization. In: DNA microarrays : a molecular cloning manual. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, pp. 394-399. ISBN 0879696257

Lucito, R., Wigler, M. H. (2003) Preparation of target DNA. In: DNA microarrays : a molecular cloning manual. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, pp. 386-393. ISBN 0879696257

Casey, W., Mishra, B., Wigler, M. H. (2001) Placing Probes along the Genome Using Pairwise Distance Data. In: Algorithms in Bioinformatics: First International Workshop, WABI 2001, Aarhus, Denmark, August 28-31, 2001, Proceedings. Lecture Notes in Computer Science, 2149 . Springer-Verlag, Berlin / Heidelberg, pp. 52-68. ISBN 0302-9743

Toda, T., Broek, D., Field, J., Michaeli, T., Cameron, S., Nikawa, J., Sass, P., Birchmeier, C., Powers, S., Wigler, M. H. (1987) Exploring the function of RAS oncogenes by studying the yeast Saccharomyces cerevisiae. In: Oncogenes and cancer : proceedings of the 17th International Symposium of the Princess Takamatsu Cancer Research Fund, Tokyo, 1986. Princess Takamatsu Symposia , 17 . Japan Scientific Societies Press, Tokyo, pp. 253-260. ISBN 4762205176

Wigler, M. H., Powers, S., Kataoka, T., Toda, T., Fasano, O., Matsumoto, K., Uno, I., Ishikawa, T., Broach, J. (1985) Function of Yeast Ras Genes. In: Genetics, cell differentiation, and cancer. Bristol-Myers cancer symposia, 7 (ED.). Academic Press, Orlando, pp. 153-164.

Wigler, M. H., Shimizu, K., Goldfarb, M., Perucho, M., Taparowski, E., Kamata, T., Feramisco, J. (1984) Identification Isolation and Preliminary Characterization of 3 Human Transforming Genes. In: Cell fusion : gene transfer and transformation. Miles international symposium series , 14 (ED.). Raven Press, New York, pp. 101-112.

Wigler, M. H., Fasano, O., Taparowsky, E., Powers, S., Kataoka, T., Birnbaum, D., Shimizu, K., Goldfarb, M. (1984) Structure and Activation of Ras Genes. In: Oncogenes and viral genes. Cancer cells, 2 (ED.). Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, pp. 419-424. ISBN 0879691697

Taparowsky, E., Suard, Y., Fasano, O., Shimizu, K., Goldfarb, M., Wigler, M. H. (1983) Activation of the Human H-Ras Gene. In: Recombinant DNA applications to human disease. Banbury report, 14 (ED.). Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, pp. 123-134. ISBN 0879692146

Wigler, M. H., Goldfarb, M., Shimizu, K., Perucho, M., Suard, Y., Fasano, O., Taparowsky, E., Fogh, J. (1983) Identification Isolation and Characterization of 3 Distinct Human Transforming Genes. In: Genes and proteins in oncogenesis. P & S biomedical sciences symposia series (ED.). Academic Press, New York, pp. 285-292. ISBN 0127424202

Wigler, M. H., Ford, J. P., Weinstein, I. B. (1975) Glucocorticoid inhibition of the fibrinolytic activity of tumor cells. In: Proteases and Biological Control. Cold Spring Harbor Conferences on Cell Proliferation, 2 . Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, 849−856 . ISBN 0097-5230

Monograph

Wigler, M. H. (2013) Cold Spring Harbor Laboratory Annual Reports Excerpts: Wigler Laboratory 1979-2011. Project Report. Cold Spring Harbor Laboratory.

Patent

Michael Wigler (2014) Use of representations of DNA for genetic analysis. United States Patent 8663917. .

Michael Wigler (2013) Determining a probabilistic diagnosis of autism by analysis of genomic copy number variations. United States Patent 8554488. .

Michael Wigler (2009) Use of representations of DNA for genetic analysis. United States Patent 7531307. .

Michael Wigler (2005) Complex combinatorial chemical libraries encoded with tags. United States Patent 6936477. .

Michael Wigler (2003) Complex combinatorial chemical libraries encoded with tags. United States Patent 6503759. .

Michael Wigler (2003) Method for generating libaries of antibody genes comprising amplification of diverse antibody DNAs and methods for using these libraries for the production of diverse antigen combining molecules. United States Patent 6635424. .

Michael Wigler (2003) Methods for identifying modulators of gene expression. United States Patent 6569617. .

Michael Wigler (2002) Cancer detection probes. United States Patent 6350576. .

Michael Wigler (2002) DNA construct for producing proteinaceous materials in eucaryotic cells. United States Patent 6455275. .

Michael Wigler (2002) Method for generating libaries of antibody genes comprising amplification of diverse antibody DNAs and methods for using these libraries for the production of diverse antigen combining molecules. United States Patent 6479243. .

Michael Wigler (2001) Method for generating libaries of antibody genes comprising amplification of diverse antibody DNAs and methods for using these libraries for the production of diverse antigen combining molecules. United States Patent 6303313. .

Michael Wigler (2001) Representational approach to DNA analysis. United States Patent 6277606. .

Michael Wigler (2000) Cloning by complementation and related processes. United States Patent 6069240. .

Michael Wigler (2000) Cloning by complementation and related processes. United States Patent 6100025. .

Michael Wigler (2000) Cloning of mammalian genes in microbial organisms and methods for pharmacological screening. United States Patent 6080540. .

Michael Wigler (2000) Methods for producing probes capable of distinguishing DNA from related sources. United States Patent 6159713. .

Michael Wigler (1999) Cloning by complementation and related processes. United States Patent 5977305. .

Michael Wigler (1999) Supports and combinatorial chemical libraries thereof encoded by non-sequencable tags. United States Patent 6001579. .

Michael Wigler (1998) Complex combinatorial chemical libraries encoded with tags. United States Patent 5721099. .

Michael Wigler (1998) Method for generating libaries of antibody genes comprising amplification of diverse antibody DNAs and methods for using these libraries for the production of diverse antigen combining molecules. United States Patent 5780225. .

Michael Wigler (1996) Cancer detection probes. United States Patent 5569753. .

Michael Wigler (1996) Cloning by complementation and related processes. United States Patent 5527896. .

Michael Wigler (1996) Complex combinatorial chemical libraries encoded with tags. United States Patent 5565324. .

Michael Wigler (1996) Methods for producing probes capable of distinguishing DNA from related sources. United States Patent 5501964. .

Michael Wigler (1996) Methods for recording the reaction history of a solid support. United States Patent 5968736. .

Michael Wigler (1996) Representational approach to DNA analysis. United States Patent 5876929. .

Michael Wigler (1995) Methods for producing probes capable of distingushing variant genomic sequences. United States Patent 5436142. .

Michael Wigler (1994) DNA sequence encoding mas onhcogene, polypeptides encoded therefrom and diagnostic and other methods based therefrom. United States Patent 5320941. .

Michael Wigler (1994) DNA sequence encoding mas onhcogene, polypeptides encoded therefrom and diagnostic and other methods based therefrom. United States Patent 5320941. .

Michael Wigler (1993) Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials. United States Patent 5179017. .

Michael Wigler (1989) Bioassay for transforming genes and genes detected thereby. United States Patent 4866166. .

Michael Wigler (1987) Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials. United States Patent 4634665. .

Video

Wigler, M. H. (2011) Talk from Mike Wigler at the Cold Spring Harbor Laboratory In-House Symposium (2011). [Video] (Unpublished)

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