Chromosomal Assignment of a Family of Human Oncogenes

Ryan, J., Barker, P. E., Shimizu, K., Wigler, M. H., Ruddle, F. H. (1983) Chromosomal Assignment of a Family of Human Oncogenes. Proc Natl Acad Sci U S A, 80 (14). pp. 4460-4463. ISSN 0027-8424

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A family of human transforming genes, previously shown to share homology with the ras family of viral oncogenes, maps to three different human chromosomes. A well-characterized mouse-human hybrid cell panel, combined with Southern blotting, was used in this study. The transforming gene of the T24 bladder carcinoma cell line maps to human chromosome 11. An oncogene isolated from the lung carcinoma cell line SK-Calu-1 maps to human chromosome 12. The third ras-related gene, cloned from SK-N-SH, a neuroblastoma cell line, maps to human chromosome 1.

Item Type: Paper
Subjects: organism description > animal > mammal > primates > hominids > human
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > genes: types > oncogene
CSHL Authors:
Communities: CSHL labs > Wigler lab
Depositing User: CSHL Librarian
Date: 1983
Date Deposited: 05 Apr 2012 18:11
Last Modified: 09 Nov 2017 20:52
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