Tumor Promotor Induces Plasminogen Activator

Wigler, M. H., Weinstein, I. B. (1976) Tumor Promotor Induces Plasminogen Activator. Nature, 259 (5540). pp. 232-233. ISSN 0028-0836

URL: http://www.ncbi.nlm.nih.gov/pubmed/1250353
DOI: 10.1038/259232a0


INFECTION of chick embryo fibroblasts with Rous sarcoma virus (RSV) induces a cell-specified plasminogen activator 1. Induction occurs with transforming viruses but not with lytic viruses or with oncornaviruses which are not themselves transforming 2. Similarly, many mammalian cell lines and embryo cultures transformed with either viruses or chemical carcinogens may be high producers of plasminogen activator in contrast to their untransformed counterparts 3–6. A correlation has been demonstrated between production of plasminogen activator and various features of the transformed phenotype, such as cell locomotion, morphology and loss of anchorage-dependent growth 4,7. Several established cell lines which are not highly tumorigenic or transformed by the usual criteria are, however, active producers of plasminogen activator; there are examples also of transformed or tumorigenic cell lines which do not produce significant levels of plasminogen activator 3,8–10.

Item Type: Paper
Subjects: diseases & disorders > cancer
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > DNA expression > promoter
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > tissue plasminogen activator
CSHL Authors:
Communities: CSHL labs > Wigler lab
Depositing User: CSHL Librarian
Date: 1976
Date Deposited: 10 Apr 2012 13:46
Last Modified: 22 Apr 2016 20:15
Related URLs:
URI: https://repository.cshl.edu/id/eprint/25953

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