Items where Community is "Gene Regulation and Inheritance Program"

Paper

Miyabayashi, Koji, Baker, Lindsey A, Deschênes, Astrid, Traub, Benno, Caligiuri, Giuseppina, Plenker, Dennis, Alagesan, Brinda, Belleau, Pascal, Li, Siran, Kendall, Jude, Jang, Gun Ho, Kawaguchi, Risa Karakida, Somerville, Tim DD, Tiriac, Hervé, Hwang, Chang-Il, Burkhart, Richard A, Roberts, Nicholas J, Wood, Laura D, Hruban, Ralph H, Gillis, Jesse, Krasnitz, Alexander, Vakoc, Christopher R, Wigler, Michael, Notta, Faiyaz, Gallinger, Steven, Park, Youngkyu, Tuveson, David A (October 2020) Intraductal Transplantation Models of Human Pancreatic Ductal Adenocarcinoma Reveal Progressive Transition of Molecular Subtypes. Cancer Discovery, 10 (10). pp. 1566-1589. ISSN 2159-8274

Stec, Natalia, Doerfel, Katja, Hills-Muckey, Kelly, Ettorre, Victoria M, Ercan, Sevinc, Keil, Wolfgang, Hammell, CM (September 2020) An Epigenetic Priming Mechanism Mediated by Nutrient Sensing Regulates Transcriptional Output. BioRxiv. (Unpublished)

Ma, Wai Kit, Scharner, Juergen, Costa, Ana SH, Jeong, Hyun Yun, Jackson, Michaela, Rigo, Frank, Bennett, C Frank, Krainer, Adrian R (September 2020) ASO-basedPKMSplice-switching Therapy Inhibits Hepatocellular Carcinoma Cell Growth. BioRxiv. (Unpublished)

Aganezov, S., Goodwin, S., Sherman, R. M., Sedlazeck, F. J., Arun, G., Bhatia, S., Lee, I., Kirsche, M., Wappel, R., Kramer, M., Kostroff, K., Spector, D. L., Timp, W., McCombie, W. R., Schatz, M. C. (September 2020) Comprehensive analysis of structural variants in breast cancer genomes using single-molecule sequencing. Genome Res, 30 (9). pp. 1258-1273. ISSN 1088-9051 (Print)1088-9051

Jaremko, M. J., On, K. F., Thomas, D. R., Stillman, B., Joshua-Tor, L. (August 2020) The dynamic nature of the human origin recognition complex revealed through five cryoEM structures. Elife, 9. e58622. ISSN 2050-084x

Ipsaro, Jonathan J, O’Brien, Paul A, Bhattacharya, Shibani, Palmer, Arthur G, Joshua-Tor, Leemor (August 2020) Asterix/Gtsf1 links tRNAs and piRNA silencing of retrotransposons. BioRxiv. (Unpublished)

Chou, H. C., Bhalla, K., El Demerdash, O., Klingbeil, O., Hanington, Kaarina, Aganezov, S., Andrews, P., Alsudani, H., Chang, K., Vakoc, C. R., Schatz, M. C., McCombie, W. R., Stillman, B. (August 2020) The human Origin Recognition Complex is essential for pre-RC assembly, mitosis and maintenance of nuclear structure. BioRxiv. (Unpublished)

Yuan, Zuanning, Schneider, Sarah, Dodd, Thomas, Riera, A., Bai, Lin, Yan, Chunli, Magdalou, Indiana, Ivanov, Ivaylo, Stillman, Bruce, Li, Huilin, Speck, C. (July 2020) Structural mechanism of helicase loading onto replication origin DNA by ORC-Cdc6. Proceedings of the National Academy of Sciences of the United States of America, 117 (30). pp. 17747-17756. ISSN 0027-8424

Sun, Lijuan, Kees, Tim, Almeida, Ana Santos, Liu, Bodu, He, Xue-Yan, Ng, David, Spector, David, McNeish, Iain A, Gimotty, Phyllis, Adams, Sylvia, Egeblad, Mikala (July 2020) Activating a collaborative innate-adaptive immune response to control breast and ovarian cancer metastasis. BioRxiv. (Unpublished)

Tareen, Ammar, Posfai, Anna, Ireland, William, McCandlish, David, Kinney, Justin (July 2020) MAVE-NN: learning genotype-phenotype maps from multiplex assays of variant effect. BioRxiv. (Unpublished)

Hu, Y, Tareen, A, Sheu, Y-J, Ireland, WT, Speck, C, Li, H, Joshua-Tor, L, Kinney, JB, Stillman, B (July 2020) Evolution of DNA Replication Origin Specification and Gene Silencing Mechanisms. BioRxiv. (Unpublished)

Breschi, A., Muñoz-Aguirre, M., Wucher, V., Davis, C. A., Garrido-Martín, D., Djebali, S., Gillis, J., Pervouchine, D. D., Vlasova, A., Dobin, A., Zaleski, C., Drenkow, J., Danyko, C., Scavelli, A., Reverter, F., Snyder, M. P., Gingeras, T. R., Guigó, R. (July 2020) A limited set of transcriptional programs define major cell types. Genome Res, 30 (7). pp. 1047-1059. ISSN 1088-9051 (Print)1088-9051

Koo, Peter, Ploenzke, Matt (June 2020) Improving representations of genomic sequence motifs in convolutional networks with exponential activations. BioRxiv. (Unpublished)

Somerville, T. D. D., Xu, Y., Wu, X. S., Maia-Silva, D., Hur, S. K., de Almeida, L. M. N., Preall, J. B., Koo, P. K., Vakoc, C. R. (May 2020) ZBED2 is an antagonist of interferon regulatory factor 1 and modifies cell identity in pancreatic cancer. Proc Natl Acad Sci U S A, 117 (21). pp. 11471-11482. ISSN 0027-8424 (Print)0027-8424

Lee, J., Shah, M., Ballouz, S., Crow, M., Gillis, J. (May 2020) CoCoCoNet: conserved and comparative co-expression across a diverse set of species. Nucleic Acids Research. ISSN 0305-1048

Gutbrod, M. J., Martienssen, R. A. (May 2020) Conserved chromosomal functions of RNA interference. Nat Rev Genet, 21 (5). pp. 311-331. ISSN 1471-0056

Somerville, T. D. D., Biffi, G., DaBler-Plenker, J., Hur, S.K., He, X.-Y., Vance, K.E., Miyabayashi, K., Xu, Y., Maia-Silva, D., Klingbeil, O., Demerdash, O. E., Preall, J. B., Hollingsworth, M. A., Egeblad, M., Tuveson, D. A., Vakoc, C. R. (April 2020) Squamous trans-differentiation of pancreatic cancer cells promotes stromal inflammation. Elife, 9. e53381. ISSN 2050-084x (Public Dataset)

Lee, S.C., Ernst, E., Berube, B., Borges, F., Parent, J. S., Ledon, P., Schorn, A., Martienssen, R. A. (April 2020) Arabidopsis Retrotransposon Virus-Like Particles and Their Regulation by Epigenetically Activated Small RNA. Genome Research, 30 (4). pp. 576-588. ISSN 1088-9051

Sheng, L., Rigo, F., Bennett, C. F., Krainer, A. R., Hua, Y. (April 2020) Comparison of the Efficacy of MOE and PMO Modifications of Systemic Antisense Oligonucleotides in a Severe SMA Mouse Model. Nucleic Acids Research, 6 (48). pp. 2853-2865. ISSN 0305-1048 (Public Dataset)

Wheeler, E., Brooks, A.M., Concia, L., Vera, D., Wear, E. E., LeBlanc, C., Ramu, U., Vaughn, M. W., Bass, H., Martienssen, R. A., Thompson, W.F., Hanley-Bowdoin, L. (March 2020) Arabidopsis DNA Replication Initiates in Intergenic, AT-rich Open Chromatin. Plant Physiology. ISSN 0032-0889 (Public Dataset)

Rahman, M. A., Lin, K. T., Bradley, R. K., Abdel-Wahab, O., Krainer, A. R. (March 2020) Recurrent SRSF2 mutations in MDS affect both splicing and NMD. Genes Dev, 34 (5-6). pp. 413-427. ISSN 0890-9369

Sinnakannu, J. R., Lee, K. L., Cheng, S., Li, J., Yu, M., Tan, S. P., Ong, C. C. H., Li, H., Than, H., Anczukow-Camarda, O., Krainer, A. R., Roca, X., Rozen, S. G., Iqbal, J., Yang, H., Chuah, C., Ong, S. T. (February 2020) SRSF1 mediates cytokine-induced impaired imatinib sensitivity in chronic myeloid leukemia. Leukemia, 34 (7). pp. 1787-1798. ISSN 0887-6924

Chang, K. C., Diermeier, S. D., Yu, A. T., Brine, L. D., Russo, S., Bhatia, S., Alsudani, H., Kostroff, K., Bhuiya, T., Brogi, E., Bennett, C. F., Rigo, F., Spector, D. L. (February 2020) MaTAR25 LncRNA Regulates the Tensin1 Gene to Impact Breast Cancer Progression. BioRxiv. (Unpublished)

Koo, PK, Ploenzke, M (February 2020) Deep learning for inferring transcription factor binding sites. Current Opinion in Systems Biology, 19. pp. 16-23. ISSN 2452-3100

Rey-Suarez, Ivan, Wheatley, Brittany A, Koo, Peter, Bhanja, Anshuman, Shu, Zhou, Mochrie, Simon, Song, Wenxia, Shroff, Hari, Upadhyaya, Arpita (January 2020) WASP family proteins regulate the mobility of the B cell receptor during signaling activation. Nature Communications, 11 (1). p. 439. ISSN 2041-1723

Chen, C. C., Li, B., Millman, S. E., Chen, C., Li, X., Morris, J. P. Iv, Mayle, A., Ho, Y. J., Loizou, E., Liu, H., Qin, W., Shah, H., Violante, S., Cross, J. R., Lowe, S. W., Zhang, L. (January 2020) Vitamin B6 Addiction in Acute Myeloid Leukemia. Cancer Cell, 37 (1). pp. 71-84. ISSN 15356108 (ISSN) (Public Dataset)

Rahman, M. A., Krainer, A. R., Abdel-Wahab, O. (January 2020) SnapShot: Splicing Alterations in Cancer. Cell, 180 (1). 208-208.e1. ISSN 0092-8674

Martinez, M. A. Q., Kinney, B. A., Medwig-Kinney, T. N., Ashley, G., Ragle, J. M., Johnson, L., Aguilera, J., Hammell, C. M., Ward, J. D., Matus, D. Q. (January 2020) Rapid Degradation of Caenorhabditis elegans Proteins at Single-Cell Resolution with a Synthetic Auxin. G3 (Bethesda, Md.), 10 (1). pp. 267-280. ISSN 21601836 (ISSN) (Public Dataset)

Tareen, A., Kinney, J. B. (December 2019) Logomaker: beautiful sequence logos in Python. Bioinformatics. ISSN 1367-4803 (Public Dataset)

Scharner, J., Ma, W. K., Zhang, Q., Lin, K. T., Rigo, F., Bennett, C. F., Krainer, A. R. (December 2019) Hybridization-mediated off-target effects of splice-switching antisense oligonucleotides. Nucleic Acids Res, 48 (2). ISSN 0305-1048 (Public Dataset)

Hershlag, A., Peyser, A., Bristow, S. L., Puig, O., Pollock, A., Niknazar, M., Mills, A. A. (December 2019) The potential impact of tumor suppressor genes on human gametogenesis: a case-control study. J Assist Reprod Genet. ISSN 1058-0468

Park, S., Brugiolo, M., Akerman, M., Das, S., Urbanski, L., Geier, A., Kesarwani, A. K., Fan, M., Leclair, N., Lin, K. T., Hu, L., Hua, I., George, J., Muthuswamy, S. K., Krainer, A. R., Anczukow, O. (November 2019) Differential Functions of Splicing Factors in Mammary Transformation and Breast Cancer Metastasis. Cell Rep, 29 (9). 2672-2688.e7. ISSN 2211-1247 (Public Dataset)

Li, S., Kendall, J., Park, S., Wang, Z., Alexander, J., Moffitt, A., Ranade, N., Danyko, C., Gegenhuber, B., Fischer, S., Robinson, B. D., Lepor, H., Tollkuhn, J., Gillis, J., Brouzes, E., Krasnitz, A., Levy, D., Wigler, M. (November 2019) Copolymerization of single-cell nucleic acids into balls of acrylamide gel. Genome Res, 30 (1). pp. 49-61. ISSN 1088-9051 (Public Dataset)

Carter, J. A., Preall, J. B., Atwal, G. S. (October 2019) Bayesian Inference of Allelic Inclusion Rates in the Human T Cell Receptor Repertoire. Cell Syst, 9 (5). pp. 475-482. ISSN 2405-4712 (Public Dataset)

Chen, X., Sun, Y. C., Zhan, H., Kebschull, J. M., Fischer, S., Matho, K., Huang, Z. J., Gillis, J., Zador, A. M. (October 2019) High-Throughput Mapping of Long-Range Neuronal Projection Using In Situ Sequencing. Cell, 179 (3). 772-786.e19. ISSN 0092-8674 (Public Dataset)

Yoshimi, A., Lin, K. T., Wiseman, D. H., Rahman, M. A., Pastore, A., Wang, B., Lee, S. C., Micol, J. B., Zhang, X. J., de Botton, S., Penard-Lacronique, V., Stein, E. M., Cho, H., Miles, R. E., Inoue, D., Albrecht, T. R., Somervaille, T. C. P., Batta, K., Amaral, F., Simeoni, F., Wilks, D. P., Cargo, C., Intlekofer, A. M., Levine, R. L., Dvinge, H., Bradley, R. K., Wagner, E. J., Krainer, A. R., Abdel-Wahab, O. (October 2019) Coordinated alterations in RNA splicing and epigenetic regulation drive leukaemogenesis. Nature, 574 (7777). pp. 273-277. ISSN 0028-0836

Kneuss, E., Munafo, M., Eastwood, E. L., Deumer, U. S., Preall, J. B., Hannon, G. J., Czech, B. (August 2019) Specialization of the Drosophila nuclear export family protein Nxf3 for piRNA precursor export. Genes Dev, 33 (17-18). pp. 1208-1220. ISSN 0890-9369

Carter, J. A., Preall, J. B., Grigaityte, K., Goldfless, S. J., Jeffery, E., Briggs, A. W., Vigneault, F., Atwal, G. S. (July 2019) Single T Cell Sequencing Demonstrates the Functional Role alpha beta TCR Pairing in Cell Lineage and Antigen Specificity. Frontiers in Immunology, 10. Article Number:1516. ISSN 1664-3224

Jung, J., Grant, T., Thomas, D. R., Diehnelt, C. W., Grigorieff, N., Joshua-Tor, L. (June 2019) High-resolution cryo-EM structures of outbreak strain human norovirus shells reveal size variations. Proc Natl Acad Sci U S A, 116 (26). pp. 12828-12832. ISSN 0027-8424

Hossain, Manzar, Bhalla, Kuhulika, Stillman, Bruce (June 2019) Cyclin binding Cy motifs have multiple activities in the initiation of DNA replication. bioRxiv. (Unpublished)

Feng, H., Bao, S., Rahman, M. A., Weyn-Vanhentenryck, S. M., Khan, A., Wong, J., Shah, A., Flynn, E. D., Krainer, A. R., Zhang, C. (June 2019) Modeling RNA-Binding Protein Specificity In Vivo by Precisely Registering Protein-RNA Crosslink Sites. Mol Cell, 74 (6). 1189-1204.e6. ISSN 1097-2765

Elyada, E., Bolisetty, M., Laise, P., Flynn, W. F., Courtois, E. T., Burkhart, R. A., Teinor, J. A., Belleau, P., Biffi, G., Lucito, M. S., Sivajothi, S., Armstrong, T. D., Engle, D. D., Yu, K. H., Hao, Y., Wolfgang, C. L., Park, Y., Preall, J., Jaffee, E. M., Califano, A., Robson, P., Tuveson, D. A. (June 2019) Cross-species single-cell analysis of pancreatic ductal adenocarcinoma reveals antigen-presenting cancer-associated fibroblasts. Cancer Discov, 9 (8). pp. 1102-1123. ISSN 2159-8274

Lin, K. T., Krainer, A. R. (May 2019) PSI-Sigma: a comprehensive splicing-detection method for short-read and long-read RNA-seq analysis. Bioinformatics, 35 (23). pp. 5048-5054. ISSN 1367-4803

Kinney, J. B., McCandlish, D. M. (May 2019) Massively Parallel Assays and Quantitative Sequence-Function Relationships. Annu Rev Genomics Hum Genet, 20. pp. 99-127. ISSN 1527-8204

Schorn, A. J., Martienssen, R. (May 2019) Getting in LINE with Replication. Molecular Cell, 74 (3). pp. 415-417. ISSN 10972765 (ISSN)

Arun, G., Spector, D. L. (March 2019) MALAT1 Long Non-Coding RNA and Breast Cancer. RNA Biol, 16 (6). pp. 860-863. ISSN 1547-6286

Scharner, J., Qi, S., Rigo, F., Bennett, C. F., Krainer, A. R. (March 2019) Delivery of GalNAc-Conjugated Splice-Switching ASOs to Non-hepatic Cells through Ectopic Expression of Asialoglycoprotein Receptor. Mol Ther Nucleic Acids, 16. pp. 313-325. ISSN 2162-2531 (Print)

Crow, M., Lim, N., Ballouz, S., Pavlidis, P., Gillis, J. (March 2019) Predictability of human differential gene expression. Proc Natl Acad Sci U S A. ISSN 0027-8424

Stein, C. B., Genzor, P., Mitra, S., Elchert, A. R., Ipsaro, J. J., Benner, L., Sobti, S., Su, Y., Hammell, M., Joshua-Tor, L., Haase, A. D. (February 2019) Decoding the 5' nucleotide bias of PIWI-interacting RNAs. Nat Commun, 10 (1). p. 828. ISSN 2041-1723

Abulwerdi, F. A., Xu, W., Ageeli, A. A., Yonkunas, M. J., Arun, G., Nam, H., Schneekloth, J. S., Dayie, T. K., Spector, D., Baird, N., Le Grice, S. F. J. (February 2019) Selective Small-Molecule Targeting of a Triple Helix Encoded by the Long Noncoding RNA, MALAT1. ACS Chemical Biology, 14 (2). pp. 223-235. ISSN 15548929 (ISSN) (Public Dataset)

Barnes, S. L., Belliveau, N. M., Ireland, W. T., Kinney, J. B., Phillips, R. (February 2019) Mapping DNA sequence to transcription factor binding energy in vivo. PLoS Comput Biol, 15 (2). e1006226. ISSN 1553-734x

Wang, E., Lu, S. X., Pastore, A., Chen, X., Imig, J., Chun-Wei Lee, S., Hockemeyer, K., Ghebrechristos, Y. E., Yoshimi, A., Inoue, D., Ki, M., Cho, H., Bitner, L., Kloetgen, A., Lin, K. T., Uehara, T., Owa, T., Tibes, R., Krainer, A. R., Abdel-Wahab, O., Aifantis, I. (February 2019) Targeting an RNA-Binding Protein Network in Acute Myeloid Leukemia. Cancer Cell, 35 (3). 359-384.e7. ISSN 1535-6108

Ando, Y., Elkayam, E., McPherson, R. L., Dasovich, M., Cheng, S. J., Voorneveld, J., Filippov, D. V., Ong, S. E., Joshua-Tor, L., Leung, A. K. L. (January 2019) ELTA: Enzymatic Labeling of Terminal ADP-Ribose. Mol Cell, 73 (4). 845-856 e5. ISSN 1097-2765

Trivedi, Gaurang, Inoue, Daichi, Chen, Cynthia, Bitner, Lillian, Chung, Young Rock, Taylor, Justin, Gönen, Mithat, Wess, Jürgen, Abdel-Wahab, Omar, Zhang, Lingbo (2019) Muscarinic acetylcholine receptor regulates self-renewal of early erythroid progenitors. Science Translational Medicine, 11 (511).

Adams, R. M., Kinney, J. B., Walczak, A. M., Mora, T. (December 2018) Epistasis in a Fitness Landscape Defined by Antibody-Antigen Binding Free Energy. Cell Syst, 8 (1). pp. 86-93. ISSN 2405-4712 (Print)2405-4712

Forcier, T. L., Ayaz, A., Gill, M. S., Jones, D., Phillips, R., Kinney, J. B. (December 2018) Measuring cis-regulatory energetics in living cells using allelic manifolds. eLife, 7. ISSN 2050084X (ISSN)

Lu, H. C., Pollack, H., Lefante, J. J., Mills, A. A., Tian, D. (December 2018) Altered sleep architecture, rapid eye movement (REM) sleep, and neural oscillation in a mouse model of human chromosome 16p11.2 microdeletion. Sleep, 42 (3). ISSN 0161-8105

On, Kin Fan, Jaremko, Matt, Stillman, Bruce, Joshua-Tor, Leemor (December 2018) A structural view of the initiators for chromosome replication. Current Opinion in Structural Biology, 53. pp. 131-139. ISSN 0959-440X

Lu, B., Klingbeil, O., Tarumoto, Y., Somerville, T. D. D., Huang, Y. H., Wei, Y., Wai, D. C., Low, J. K. K., Milazzo, J. P., Wu, X. S., Cao, Z., Yan, X., Demerdash, O. E., Huang, G., Mackay, J. P., Kinney, J. B., Shi, J., Vakoc, C. R. (November 2018) A Transcription Factor Addiction in Leukemia Imposed by the MLL Promoter Sequence. Cancer Cell, 34 (6). pp. 970-981. ISSN 1535-6108

Biffi, G., Oni, T. E., Spielman, B., Hao, Y., Elyada, E., Park, Y., Preall, J., Tuveson, D. A. (October 2018) IL-1-induced JAK/STAT signaling is antagonized by TGF-beta to shape CAF heterogeneity in pancreatic ductal adenocarcinoma. Cancer Discov, 9 (2). pp. 282-301. ISSN 2159-8274

Chen, W. C., Tareen, A., Kinney, J. B. (October 2018) Density Estimation on Small Data Sets. Physical Review Letters, 121 (16). p. 160605. ISSN 00319007 (ISSN)

Hwang, D. W., Jaganathan, A., Shrestha, P., Jin, Y., El-Amine, N., Wang, S. H., Hammell, M., Mills, A. A. (August 2018) Chromatin-mediated translational control is essential for neural cell fate specification. Life Sci Alliance, 1 (4). e201700016. ISSN 2575-1077

Crow, M., Gillis, J. (August 2018) Co-expression in Single-Cell Analysis: Saving Grace or Original Sin? Trends Genet, 34 (11). pp. 823-831. ISSN 0168-9525 (Print)0168-9525

Posfai, A., Zhou, J., Plotkin, J. B., Kinney, J. B., McCandlish, D. M. (August 2018) Selection for Protein Stability Enriches for Epistatic Interactions. Genes (Basel), 9 (9). ISSN 2073-4425 (Print)2073-4425

Wong, M. S., Kinney, J. B., Krainer, A. R. (August 2018) Quantitative Activity Profile and Context Dependence of All Human 5' Splice Sites. Mol Cell, 71 (6). 1012-1026.e3. ISSN 1097-2765

Tramentozzi, E., Ferraro, P., Hossain, M., Stillman, B., Bianchi, V., Pontarin, G. (July 2018) The dNTP triphosphohydrolase activity of SAMHD1 persists during S-phase when the enzyme is phosphorylated at T592. Cell Cycle, 17 (9). pp. 1102-1114. ISSN 1551-4005

Huang, Y. H., Klingbeil, O., He, X. Y., Wu, X. S., Arun, G., Lu, B., Somerville, T. D. D., Milazzo, J. P., Wilkinson, J. E., Demerdash, O. E., Spector, D. L., Egeblad, M., Shi, J., Vakoc, C. R. (July 2018) POU2F3 is a master regulator of a tuft cell-like variant of small cell lung cancer. Genes Dev, 32 (13-14). pp. 915-928. ISSN 0890-9369

Aznarez, Isabel, Nomakuchi, Tomoki T., Tetenbaum-Novatt, Jaclyn, Rahman, Mohammad Alinoor, Fregoso, Oliver, Rees, Holly, Krainer, Adrian R. (May 2018) Mechanism of Nonsense-Mediated mRNA Decay Stimulation by Splicing Factor SRSF1. Cell Reports, 23 (7). pp. 2186-2198. ISSN 2211-1247

Ballouz, S., Dobin, A., Gingeras, T. R., Gillis, J. (May 2018) The fractured landscape of RNA-seq alignment: the default in our STARs. Nucleic Acids Res. ISSN 0305-1048

Zhang, T., Wu, Y. C., Mullane, P., Ji, Y. J., Liu, H., He, L., Arora, A., Hwang, H. Y., Alessi, A. F., Niaki, A. G., Periz, G., Guo, L., Wang, H., Elkayam, E., Joshua-Tor, L., Myong, S., Kim, J. K., Shorter, J., Ong, S. E., Leung, A. K. L., Wang, J. (March 2018) FUS Regulates Activity of MicroRNA-Mediated Gene Silencing. Mol Cell, 69 (5). 787-801.e8. ISSN 1097-2765 (Public Dataset)

Crow, M., Paul, A., Ballouz, S., Huang, Z. J., Gillis, J. (February 2018) Characterizing the replicability of cell types defined by single cell RNA-sequencing data using MetaNeighbor. Nat Commun, 9 (1). p. 884. ISSN 2041-1723

Lin, K. T., Ma, W. K., Scharner, J., Liu, Y. R., Krainer, A. R. (February 2018) A human-specific switch of alternatively spliced AFMID isoforms contributes to TP53 mutations and tumor recurrence in hepatocellular carcinoma. Genome Res, 28 (3). pp. 275-284. ISSN 1088-9051

Arun, G., Diermeier, S. D., Spector, D. L. (February 2018) Therapeutic Targeting of Long Non-Coding RNAs in Cancer. Trends Mol Med, 24 (3). pp. 257-277. ISSN 1471-4914

Li, J., Wu, C., Wang, W., He, Y., Elkayam, E., Joshua-Tor, L., Hammond, P. T. (February 2018) Structurally modulated codelivery of siRNA and Argonaute 2 for enhanced RNA interference. Proc Natl Acad Sci U S A, 115 (12). E2696-E2705. ISSN 0027-8424

Krishnan, N., Bonham, C. A., Rus, I. A., Shrestha, O. K., Gauss, C. M., Haque, A., Tocilj, A., Joshua-Tor, L., Tonks, N. K. (January 2018) Harnessing insulin- and leptin-induced oxidation of PTP1B for therapeutic development. Nat Commun, 9 (1). p. 283. ISSN 2041-1723

Noguchi, Y., Yuan, Z., Bai, L., Schneider, S., Zhao, G., Stillman, B., Speck, C., Li, H. (November 2017) Cryo-EM structure of Mcm2-7 double hexamer on DNA suggests a lagging-strand DNA extrusion model. Proc Natl Acad Sci U S A, 114 (45). E9529-9538. ISSN 0027-8424

He, H., Li, Y., Dong, Q., Chang, A. Y., Gao, F., Chi, Z., Su, M., Zhang, F., Ban, H., Martienssen, R., Chen, Y. H., Li, F. (November 2017) Coordinated regulation of heterochromatin inheritance by Dpb3-Dpb4 complex. Proc Natl Acad Sci U S A. ISSN 0027-8424

Roche, B., Arcangioli, B., Martienssen, R. (September 2017) New roles for Dicer in the nucleolus and its relevance to cancer. Cell Cycle, 16 (18). pp. 1643-1653. ISSN 1551-4005

Diermeier, S. D., Spector, D. L. (August 2017) Antisense Oligonucleotide-mediated Knockdown in Mammary Tumor Organoids. Bio Protoc, 7 (16). ISSN 2331-8325 (Print)2331-8325

Li, M. A., Amaral, P. P., Cheung, P., Bergmann, J. H., Kinoshita, M., Kalkan, T., Ralser, M., Robson, S., Meyenn, F. V., Paramor, M., Yang, F., Chen, C., Nichols, J., Spector, D. L., Kouzarides, T., He, L., Smith, A. (August 2017) A lncRNA fine tunes the dynamics of a cell state transition involving Lin28, let-7 and de novo DNA methylation. Elife, 6. ISSN 2050-084x

Elkayam, Elad, Faehnle, Christopher R., Morales, Marjorie, Sun, Jingchuan, Li, Huilin, Joshua-Tor, Leemor (August 2017) Multivalent Recruitment of Human Argonaute by GW182. Molecular Cell, 67 (4). pp. 646-658. ISSN 1097-2765 (Public Dataset)

Faehnle, C. R., Walleshauser, J., Joshua-Tor, L. (August 2017) Multi-domain utilization by TUT4 and TUT7 in control of let-7 biogenesis. Nat Struct Mol Biol, 24 (8). pp. 658-665. ISSN 1545-9985 (Public Dataset)

Roche, B., Arcangioli, B., Martienssen, R. A. (July 2017) Transcriptional reprogramming in cellular quiescence. RNA Biol, 14 (7). pp. 843-853. ISSN 1547-6286

Schorn, A. J., Gutbrod, M. J., LeBlanc, C., Martienssen, R. (June 2017) LTR-Retrotransposon Control by tRNA-Derived Small RNAs. Cell, 170 (1). pp. 61-71. ISSN 0092-8674 (Public Dataset)

Chang, An-Yun, Castel, Stephane E., Ernst, Evan, Kim, Hyun Soo, Martienssen, Robert A. (June 2017) The Conserved RNA Binding Cyclophilin, Rct1, Regulates Small RNA Biogenesis and Splicing Independent of Heterochromatin Assembly. Cell Reports, 19 (12). pp. 2477-2489. ISSN 2211-1247

Elkayam, E., Parmar, R., Brown, C. R., Willoughby, J. L., Theile, C. S., Manoharan, M., Joshua-Tor, L. (April 2017) siRNA carrying an (E)-vinylphosphonate moiety at the 5' end of the guide strand augments gene silencing by enhanced binding to human Argonaute-2. Nucleic Acids Res, 45 (6). pp. 3528-3536. ISSN 1362-4962 (Electronic)0305-1048 (Linking) (Public Dataset)

Taniguchi, Y., Kawata, M., Ho Chang, S., Mori, D., Okada, K., Kobayashi, H., Sugita, S., Hosaka, Y., Inui, H., Taketomi, S., Yano, F., Ikeda, T., Akiyama, H., Mills, A. A., Chung, U. I., Tanaka, S., Kawaguchi, H., Saito, T. (March 2017) Regulation of Chondrocyte Survival in Mouse Articular Cartilage by p63. Arthritis and Rheumatology, 69 (3). pp. 598-609. ISSN 2326-5205

Yuan, Z., Riera, A., Bai, L., Sun, J., Nandi, S., Spanos, C., Chen, Z. A., Barbon, M., Rappsilber, J., Stillman, B., Speck, C., Li, H. (March 2017) Structural basis of Mcm2-7 replicative helicase loading by ORC-Cdc6 and Cdt1. Nat Struct Mol Biol, 24 (3). pp. 316-324. ISSN 1545-9985 (Public Dataset)

Ipsaro, J. J., Shen, C., Arai, E., Xu, Y., Kinney, J. B., Joshua-Tor, L., Vakoc, C. R., Shi, J. (February 2017) Rapid generation of drug-resistance alleles at endogenous loci using CRISPR-Cas9 indel mutagenesis. PLoS One, 12 (2). e0172177. ISSN 1932-6203

Senturk, S., Shirole, N. H., Nowak, D. G., Corbo, V., Pal, D., Vaughan, A., Tuveson, D. A., Trotman, L. C., Kinney, J. B., Sordella, R. (February 2017) Rapid and tunable method to temporally control gene editing based on conditional Cas9 stabilization. Nat Commun, 8. p. 14370. ISSN 2041-1723 (Public Dataset)

Tocilj, A., On, K. F., Yuan, Z., Sun, J., Elkayam, E., Li, H., Stillman, B., Joshua-Tor, L. (January 2017) Structure of the active form of human Origin Recognition Complex and its ATPase motor module. Elife, 6. ISSN 2050-084X (Electronic)2050-084X (Linking) (Public Dataset)

Mills, A. A. (January 2017) The Chromodomain Helicase DNA-Binding Chromatin Remodelers: Family Traits that Protect from and Promote Cancer. Cold Spring Harb Perspect Med. ISSN 2157-1422 (Electronic)2157-1422 (Linking)

Kawata, M., Taniguchi, Y., Mori, D., Yano, F., Ohba, S., Chung, U. I., Shimogori, T., Mills, A. A., Tanaka, S., Saito, T. (2017) Different regulation of limb development by p63 transcript variants. PLoS One, 12 (3). e0174122. ISSN 1932-6203

Zhang, Bin, Mao, Yuntao S., Diermeier, Sarah D., Novikova, Irina V., Nawrocki, Eric P., Jones, Tom A., Lazar, Zsolt, Tung, Chang-Shung, Luo, Weijun, Eddy, Sean R., Sanbonmatsu, Karissa Y., Spector, David L. (2017) Identification and Characterization of a Class of MALAT1-like Genomic Loci. Cell Reports, 19 (8). pp. 1723-1738. ISSN 2211-1247 (Public Dataset)

Adams, R. M., Mora, T., Walczak, A. M., Kinney, J. B. (December 2016) Measuring the sequence-affinity landscape of antibodies with massively parallel titration curves. Elife, 5. ISSN 2050-084X (Electronic)2050-084X (Linking) (Public Dataset)

Roche, B., Arcangioli, B., Martienssen, R. A. (October 2016) RNA interference is essential for cellular quiescence. Science, 354 (6313). ISSN 1095-9203 (Electronic)0036-8075 (Linking)

Diermeier, Sarah D, Chang, Kung-Chi, Freier, Susan M, Song, Junyan, El Demerdash, Osama, Krasnitz, Alexander, Rigo, Frank, Bennett, C.  Frank, Spector, David L (September 2016) Mammary Tumor-Associated RNAs Impact Tumor Cell Proliferation, Invasion, and Migration. Cell Reports, 17 (1). pp. 261-274. ISSN 2211-1247 (Public Dataset)

Allemand, E., Myers, M. P., Garcia-Bernardo, J., Harel-Bellan, A., Krainer, A. R., Muchardt, C. (September 2016) A Broad Set of Chromatin Factors Influences Splicing. PLoS Genet, 12 (9). e1006318. ISSN 1553-7404 (Electronic)1553-7390 (Linking)

Anczukow, O., Krainer, A. R. (September 2016) Splicing-factor alterations in cancers. RNA, 22 (9). pp. 1285-301. ISSN 1469-9001 (Electronic)1355-8382 (Linking)

Hossain, M., Stillman, B. (July 2016) Opposing roles for DNA replication initiator proteins ORC1 and CDC6 in control of Cyclin E gene transcription. Elife, 5. ISSN 2050-084X (Electronic)2050-084X (Linking) (Public Dataset)

Bruun, G. H., Doktor, T. K., Borch-Jensen, J., Masuda, A., Krainer, A. R., Ohno, K., Andresen, B. S. (July 2016) Global identification of hnRNP A1 binding sites for SSO-based splicing modulation. BMC Biol, 14 (1). p. 54. ISSN 1741-7007 (Electronic)1741-7007 (Linking)

Ireland, William, Kinney, Justin (May 2016) MPAthic: Quantitative Modeling of Sequence-Function Relationships for massively parallel assays. BioRxiv. (Unpublished)

MacDiarmid, J. A., Langova, V., Bailey, D., Pattison, S. T., Pattison, S. L., Christensen, N., Armstrong, L. R., Brahmbhatt, V. N., Smolarczyk, K., Harrison, M. T., Costa, M., Mugridge, N. B., Sedliarou, I., Grimes, N. A., Kiss, D. L., Stillman, B., Hann, C. L., Gallia, G. L., Graham, R. M., Brahmbhatt, H. (April 2016) Targeted Doxorubicin Delivery to Brain Tumors via Minicells: Proof of Principle Using Dogs with Spontaneously Occurring Tumors as a Model. PLoS One, 11 (4). e0151832. ISSN 1932-6203 (Electronic)1932-6203 (Linking)

Liu, Y., Chen, C., Xu, Z., Scuoppo, C., Rillahan, C. D., Gao, J., Spitzer, B., Bosbach, B., Kastenhuber, E. R., Baslan, T., Ackermann, S., Cheng, L., Wang, Q., Niu, T., Schultz, N., Levine, R. L., Mills, A. A., Lowe, S. W. (March 2016) Deletions linked to TP53 loss drive cancer through p53-independent mechanisms. Nature, 531 (7595). pp. 471-475. ISSN 1476-4687 (Electronic)0028-0836 (Linking)

Sheu, Y. J., Kinney, J. B., Stillman, B. (March 2016) Concerted activities of Mcm4, Sld3 and Dbf4 in control of origin activation and DNA replication fork progression. Genome Res, 26 (3). pp. 315-330. ISSN 1549-5469 (Electronic)1088-9051 (Linking) (Public Dataset)

Atwal, G. S., Kinney, J. B. (March 2016) Learning Quantitative Sequence–Function Relationships from Massively Parallel Experiments. Journal of Statistical Physics, 162 (5). pp. 1203-1243. ISSN 00224715

Nomakuchi, T. T., Rigo, F., Aznarez, I., Krainer, A. R. (February 2016) Antisense oligonucleotide-directed inhibition of nonsense-mediated mRNA decay. Nat Biotechnol, 34 (2). pp. 164-166. ISSN 1546-1696 (Electronic)1087-0156 (Linking)

Pichugina, T., Sugawara, T., Kaykov, A., Schierding, W., Masuda, K., Uewaki, J., Grand, R. S., Allison, J. R., Martienssen, R. A., Nurse, P., Ueno, M., O'Sullivan, J. M. (January 2016) A diffusion model for the coordination of DNA replication in Schizosaccharomyces pombe. Sci Rep, 6. p. 18757. ISSN 2045-2322 (Electronic)2045-2322 (Linking)

Hammell, Christopher M, Hannon, Gregory J (January 2016) Inducing RNAi in Caenorhabditis elegans by Injection of dsRNA. Cold Spring Harbor protocols, 2016 (1). pdb.prot086306. ISSN 1940-3402

Arun, G., Diermeier, S., Akerman, M., Chang, K. C., Wilkinson, J. E., Hearn, S., Kim, Y., MacLeod, A. R., Krainer, A. R., Norton, L., Brogi, E., Egeblad, M., Spector, D. L. (January 2016) Differentiation of mammary tumors and reduction in metastasis upon Malat1 lncRNA loss. Genes Dev, 30 (1). pp. 34-51. ISSN 1549-5477 (Electronic)0890-9369 (Linking) (Public Dataset)

Breschi, A., Djebali, S., Gillis, J., Pervouchine, D. D., Dobin, A., Davis, C. A., Gingeras, T. R., Guigo, R. (2016) Gene-specific patterns of expression variation across organs and species. Genome Biol, 17 (1). p. 151. ISSN 1474-760X (Electronic)1474-7596 (Linking)

Shen, Chen, Ipsaro, Jonathan J, Shi, Junwei, Milazzo, Joseph P, Wang, Eric, Roe, Jae-Seok, Suzuki, Yutaka, Pappin, Darryl J, Joshua-Tor, Leemor, Vakoc, Christopher R (December 2015) NSD3-Short Is an Adaptor Protein that Couples BRD4 to the CHD8 Chromatin Remodeler. Molecular Cell, 60 (6). pp. 847-859. ISSN 1097-2765

Sanchez, Carlos G, Teixeira, Felipe Karam, Czech, Benjamin, Preall, Jonathan B, Zamparini, Andrea L, Seifert, Jessica R K., Malone, Colin D, Hannon, Gregory J, Lehmann, Ruth (December 2015) Regulation of Ribosome Biogenesis and Protein Synthesis Controls Germline Stem Cell Differentiation. Cell Stem Cell, 18 (2). pp. 276-290. ISSN 1934-5909

Zepeda-Mendoza, C. J., Mukhopadhyay, S., Wong, E. S., Harder, N., Splinter, E., de Wit, E., Eckersley-Maslin, M. A., Ried, T., Eils, R., Rohr, K., Mills, A., de Laat, W., Flicek, P., Sengupta, A. M., Spector, D. L. (November 2015) Quantitative analysis of chromatin interaction changes upon a 4.3 Mb deletion at mouse 4E2. BMC Genomics, 16 (1). p. 982. ISSN 1471-2164 (Electronic)1471-2164 (Linking)

Anczukow, O., Krainer, A. R. (October 2015) The spliceosome, a potential Achilles heel of MYC-driven tumors. Genome Med, 7 (1). p. 107. ISSN 1756-994X (Electronic)1756-994X (Linking)

Yu, Y., Gu, J., Jin, Y., Luo, Y., Preall, J. B., Ma, J., Czech, B., Hannon, G. J. (October 2015) Panoramix enforces piRNA-dependent cotranscriptional silencing. Science, 350 (6258). pp. 339-42. ISSN 1095-9203 (Electronic)0036-8075 (Linking)

Anczukow, O., Akerman, M., Clery, A., Wu, J., Shen, C., Shirole, N. H., Raimer, A., Sun, S., Jensen, M. A., Hua, Y., Allain, F. H., Krainer, A. R. (October 2015) SRSF1-Regulated Alternative Splicing in Breast Cancer. Mol Cell, 60 (1). pp. 105-17. ISSN 1097-4164 (Electronic)1097-2765 (Linking)

Stillman, B. (July 2015) Reconsidering DNA Polymerases at the Replication Fork in Eukaryotes. Molecular Cell, 59 (2). pp. 139-141. ISSN 1097-2765

Ren, J., Castel, S. E., Martienssen, R. A. (July 2015) Dicer in action at replication-transcription collisions. Mol Cell Oncol, 2 (3). e991224. ISSN 2372-3556 (Electronic)2372-3556 (Linking)

Tian, D., Stoppel, L. J., Heynen, A. J., Lindemann, L., Jaeschke, G., Mills, A. A., Bear, M. F. (January 2015) Contribution of mGluR5 to pathophysiology in a mouse model of human chromosome 16p11.2 microdeletion. Nature Neuroscience, 18. pp. 182-184. ISSN 1097-6256

Guo, Ya, Xu, Quan, Canzio, Daniele, Shou, Jia, Li, Jinhuan, Gorkin, David U, Jung, Inkyung, Wu, Haiyang, Zhai, Yanan, Tang, Yuanxiao, Lu, Yichao, Wu, Yonghu, Jia, Zhilian, Li, Wei, Zhang, Michael Q, Ren, Bing, Krainer, Adrian R, Maniatis, Tom, Wu, Qiang (2015) CRISPR Inversion of CTCF Sites Alters Genome Topology and Enhancer/Promoter Function. Cell, 162 (4). pp. 900-910. ISSN 0092-8674