MALAT1 Long Non-Coding RNA: Functional Implications

Arun, G., Aggarwal, D., Spector, D. L. (June 2020) MALAT1 Long Non-Coding RNA: Functional Implications. Noncoding RNA, 6 (2). E22.

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Abstract

The mammalian genome is pervasively transcribed and the functional significance of many long non-coding RNA (lncRNA) transcripts are gradually being elucidated. Metastasis Associated Lung Adenocarcinoma Transcript 1 (MALAT1) is one of the most well-studied lncRNAs. MALAT1 is a highly conserved nuclear retained lncRNA that is abundantly expressed in cells and tissues and has been shown to play a role in regulating genes at both the transcriptional and post-transcriptional levels in a context-dependent manner. However, Malat1 has been shown to be dispensable for normal development and viability in mice. Interestingly, accumulating evidence suggests that MALAT1 plays an important role in numerous diseases including cancer. Here, we discuss the current state-of-knowledge in regard to MALAT1 with respect to its function, role in diseases, and the potential therapeutic opportunities for targeting MALAT1 using antisense oligonucleotides and small molecules.

Item Type:	Paper
Subjects:	bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > long non-coding RNA bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > RNA splicing
CSHL Authors:	Spector, David L. Arun, Gayatri Aggarwal, Disha
Communities:	CSHL labs > Spector lab CSHL Cancer Center Program CSHL Cancer Center Program > Gene Regulation and Inheritance Program
Depositing User:	Adrian Gomez
Date:	3 June 2020
Date Deposited:	08 Jun 2020 15:08
Last Modified:	13 Feb 2024 19:49
PMCID:	PMC7344863
Related URLs:	Publisher
URI:	https://repository.cshl.edu/id/eprint/39490

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