Splicing-factor alterations in cancers

Anczukow, O., Krainer, A. R. (September 2016) Splicing-factor alterations in cancers. RNA, 22 (9). pp. 1285-301. ISSN 1469-9001 (Electronic)1355-8382 (Linking)

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URL: http://www.ncbi.nlm.nih.gov/pubmed/27530828
DOI: 10.1261/rna.057919.116


Tumor-associated alterations in RNA splicing result either from mutations in splicing-regulatory elements or changes in components of the splicing machinery. This review summarizes our current understanding of the role of splicing-factor alterations in human cancers. We describe splicing-factor alterations detected in human tumors and the resulting changes in splicing, highlighting cell-type-specific similarities and differences. We review the mechanisms of splicing-factor regulation in normal and cancer cells. Finally, we summarize recent efforts to develop novel cancer therapies, based on targeting either the oncogenic splicing events or their upstream splicing regulators.

Item Type: Paper
Subjects: diseases & disorders > cancer
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > RNA splicing
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > splicing factor
CSHL Authors:
Communities: CSHL labs > Krainer lab
CSHL Cancer Center Program > Gene Regulation and Inheritance Program
Depositing User: Matt Covey
Date: September 2016
Date Deposited: 26 Aug 2016 21:04
Last Modified: 26 Oct 2020 20:46
PMCID: PMC4986885
Related URLs:
URI: https://repository.cshl.edu/id/eprint/33405

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