Tuveson, David A. Publications

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Tuveson, David A.

http://tuvesonlab.labsites.cshl.edu/

http://orcid.org/0000-0002-8017-2712

Number of items at this level: 78.

Paper

Feigin, M. E., Garvin, T., Bailey, P., Waddell, N., Chang, D. K., Kelley, D. R., Shuai, S., Gallinger, S., McPherson, J. D., Grimmond, S. M., Khurana, E., Stein, L. D., Biankin, A. V., Schatz, M. C., Tuveson, D. A. (2017) Recurrent noncoding regulatory mutations in pancreatic ductal adenocarcinoma. Nat Genet, 49 (6). pp. 825-833. ISSN 1061-4036

Buscaglia, Jonathan M., Bucobo, Juan Carlos, Tiriac, Herve, Tzimas, Demetrios, Grewal, Suman, LaComb, Joseph, Rowehl, Leahana, Nagula, Satish, Wu, Maoxin, Kim, Joseph, Sasson, Aaron, Li, Ellen, Young, Candice M., Tuveson, David A. (2017) 111 Successful Creation of Pancreatic Cancer Organoids By Means of Eus-Guided Fine-Needle Biopsy (EUS-FNB) for Personalized Cancer Treatment. Gastrointestinal Endoscopy, 85 (5, Sup). AB50-AB51. ISSN 0016-5107

Chio, Iok In Christine, Tuveson, David A. (2017) ROS in Cancer: The Burning Question. Trends in Molecular Medicine, 23 (5). pp. 411-429. ISSN 1471-4914

Sinha, S., Fu, Y. Y., Grimont, A., Ketcham, M., Lafaro, K. J., Saglimbeni, J. A., Askan, G., Bailey, J. M., Melchor, J. P., Zhong, Y., Joo, M. G., Grbovic-Huezo, O., Yang, I. H., Basturk, O., Baker, L., Park, Y., Kurtz, R. C., Tuveson, D. A., Leach, S. D., Pasricha, P. (2017) PanIN neuroendocrine cells promote tumorigenesis via neuronal crosstalk. Cancer Res, 77 (8). pp. 1868-1879. ISSN 1538-7445 (Electronic)0008-5472 (Linking)

Tuveson, D. (2017) Waging war against pancreatic cancer: an interview with David Tuveson. Dis Model Mech, 10 (4). pp. 353-357. ISSN 1754-8403

Feigin, M. E., Tuveson, D. A. (2017) Challenges and Opportunities in Modeling Pancreatic Cancer. Cold Spring Harb Symp Quant Biol, 81. pp. 231-235. ISSN 0091-7451

Ohlund, D., Handly-Santana, A., Biffi, G., Elyada, E., Almeida, A. S., Ponz-Sarvise, M., Corbo, V., Oni, T. E., Hearn, S. A., Lee, E. J., Chio, II, Hwang, C. I., Tiriac, H., Baker, L. A., Engle, D. D., Feig, C., Kultti, A., Egeblad, M., Fearon, D. T., Crawford, J. M., Clevers, H., Park, Y., Tuveson, D. A. (2017) Distinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer. J Exp Med, 214 (3). pp. 579-596. ISSN 0022-1007

Chio, I. I. C., Jafarnejad, S. M., Ponz-Sarvise, M., Park, Y., Rivera, K., Palm, W., Ohlund, D., Hammell, M., Crawford, H., Schmidt, E., Thompson, C., Pappin, D., Sonenberg, N., Tuveson, D. (2017) NRF2 promotes tumor maintenance by modulating mRNA translation in pancreatic cancer. Cancer Research, 77 (Supple). ISSN 0008-54721538-7445

Vakoc, C. R., Tuveson, D. A. (2017) Untangling the genetics from the epigenetics in pancreatic cancer metastasis. Nat Genet, 49 (3). pp. 323-324. ISSN 1061-4036

Senturk, S., Shirole, N. H., Nowak, D. G., Corbo, V., Pal, D., Vaughan, A., Tuveson, D. A., Trotman, L. C., Kinney, J. B., Sordella, R. (2017) Rapid and tunable method to temporally control gene editing based on conditional Cas9 stabilization. Nat Commun, 8. p. 14370. ISSN 2041-1723

Biffi, G., Tuveson, D. A. (2017) Cancer: Double trouble for tumours. Nature, 542 (7639). pp. 34-35. ISSN 1476-4687 (Electronic)0028-0836 (Linking)

Chio, II, Tuveson, D. A. (2017) ROS in translation: Chink in the armor. Cell Cycle, 16 (4). pp. 297-298. ISSN 1551-4005

Ireland, L., Santos, A., Ahmed, M. S., Rainer, C., Nielsen, S. R., Quaranta, V., Weyer-Czernilofsky, U., Engle, D. D., Perez-Mancera, P., Coupland, S. E., Taktak, A. F., Bogenrieder, T., Tuveson, D. A., Campbell, F., Schmid, M. C., Mielgo, A. (2016) Chemoresistance in pancreatic cancer is driven by stroma-derived insulin-like growth factors. Cancer Res, 76 (23). pp. 6851-6863. ISSN 1538-7445 (Electronic)0008-5472 (Linking)

Tuveson, D. A. (2016) Detecting and killing pancreatic cancer. Human Gene Therapy, 27 (11). A12-A12. ISSN 1043-0342

Chio, Iok In Christine, Jafarnejad, Seyed Mehdi, Ponz-Sarvise, Mariano, Park, Youngkyu, Rivera, Keith, Palm, Wilhelm, Wilson, John, Sangar, Vineet, Hao, Yuan, Öhlund, Daniel, Wright, Kevin, Filippini, Dea, Lee, Eun Jung, Da Silva, Brandon, Schoepfer, Christina, Wilkinson, John Erby, Buscaglia, Jonathan M, DeNicola, Gina M, Tiriac, Herve, Hammell, Molly, Crawford, Howard C, Schmidt, Edward E, Thompson, Craig B, Pappin, Darryl J, Sonenberg, Nahum, Tuveson, David A (2016) NRF2 Promotes Tumor Maintenance by Modulating mRNA Translation in Pancreatic Cancer. Cell, 166 (4). pp. 963-976. ISSN 0092-8674

Biffi, G., Ohlund, D., Tuveson, D. (2016) Building up the tension between the epithelial and stromal compartment in pancreatic ductal adenocarcinoma. Cell Death Differ, 23 (8). pp. 1265-1266. ISSN 1476-5403 (Electronic)1350-9047 (Linking)

Öhlund, Daniel, Handly-Santana, Abram, Elyada, Ela, Biffi, Giulia, Tuveson, David A. (2016) Pancreatic stellate cell heterogeneity in cancer. Pancreatology, 16 (3, Sup). S15. ISSN 1424-3903

Ohman, K. A., Hashim, Y. M., Vangveravong, S., Nywening, T. M., Cullinan, D. R., Goedegebuure, S. P., Liu, J., Van Tine, B. A., Tiriac, H., Tuveson, D. A., DeNardo, D. G., Spitzer, D., Mach, R. H., Hawkins, W. G. (2016) Conjugation to the sigma-2 ligand SV119 overcomes uptake blockade and converts dm-Erastin into a potent pancreatic cancer therapeutic. Oncotarget. ISSN 1949-2553 (Electronic)1949-2553 (Linking)

Kleeff, J., Korc, M., Apte, M., La Vecchia, C., Johnson, C. D., Biankin, A. V., Neale, R. E., Tempero, M., Tuveson, D. A., Hruban, R. H., Neoptolemos, J. P. (2016) Pancreatic cancer. Nat Rev Dis Primers, 2. p. 16022. ISSN 2056-676X (Electronic)2056-676X (Linking)

Nielsen, S. R., Quaranta, V., Linford, A., Emeagi, P., Rainer, C., Santos, A., Ireland, L., Sakai, T., Sakai, K., Kim, Y. S., Engle, D., Campbell, F., Palmer, D., Ko, J. H., Tuveson, D. A., Hirsch, E., Mielgo, A., Schmid, M. C. (2016) Macrophage-secreted granulin supports pancreatic cancer metastasis by inducing liver fibrosis. Nat Cell Biol, 18 (5). pp. 549-60. ISSN 1476-4679 (Electronic)1465-7392 (Linking)

Jenkinson, C., Elliott, V., Evans, A., Oldfield, L., Jenkins, R. E., O'Brien, D. P., Apostolidou, S., Gentry-Maharaj, A., Fourkala, E. O., Jacobs, I., Menon, U., Cox, T. F., Campbell, F., Pereira, S. P., Tuveson, D. A., Park, P. K., Greenhalf, W., Sutton, R. Professor, Timms, J. F., Neoptolemos, J., Costello, E. (2016) Decreased serum thrombospondin-1 levels in pancreatic cancer patients up to 24 months prior to clinical diagnosis: association with diabetes mellitus. Clin Cancer Res, 22 (7). pp. 1734-43. ISSN 1078-0432 (Electronic)1078-0432 (Linking)

Baker, Lindsey A., Tiriac, Hervé, Clevers, Hans, Tuveson, David A. (2016) Modeling Pancreatic Cancer with Organoids. Trends in Cancer, 2 (4). pp. 176-190. ISSN 2405-8033

Serrao, E. M., Kettunen, M. I., Rodrigues, T. B., Dzien, P., Wright, A. J., Gopinathan, A., Gallagher, F. A., Lewis, D. Y., Frese, K. K., Almeida, J., Howat, W. J., Tuveson, D. A., Brindle, K. M. (2016) MRI with hyperpolarised [1-13C]pyruvate detects advanced pancreatic preneoplasia prior to invasive disease in a mouse model. Gut, 65 (3). pp. 465-75. ISSN 1468-3288 (Electronic)0017-5749 (Linking)

Espana-Agusti, J., Zou, X. G., Wong, K., Fu, B. Y., Yang, F. T., Tuveson, D. A., Adams, D. J., Matakidou, A. (2016) Generation and Characterisation of a Pax8-CreER(T2) Transgenic Line and a Slc22a6-CreER(T2) Knock-In Line for Inducible and Specific Genetic Manipulation of Renal Tubular Epithelial Cells. Plos One, 11 (2). ISSN 1932-6203

Boj, S. F., Hwang, C. I., Baker, L. A., Engle, D. D., Tuveson, D. A., Clevers, H. (2016) Model organoids provide new research opportunities for ductal pancreatic cancer. Mol Cell Oncol, 3 (1). e1014757. ISSN 2372-3556 (Electronic)2372-3556 (Linking)

Hwang, C. I., Boj, S. F., Clevers, H., Tuveson, D. A. (2016) Pre-clinical Models of Pancreatic Ductal Adenocarcinoma. J Pathol, 238 (2). pp. 197-204. ISSN 1096-9896 (Electronic)0022-3417 (Linking)

Rosati, A., Basile, A., D'Auria, R., d'Avenia, M., De Marco, M., Falco, A., Festa, M., Guerriero, L., Iorio, V., Parente, R., Pascale, M., Marzullo, L., Franco, R., Arra, C., Barbieri, A., Rea, D., Menichini, G., Hahne, M., Bijlsma, M., Barcaroli, D., Sala, G., di Mola, F. F., di Sebastiano, P., Todoric, J., Antonucci, L., Corvest, V., Jawhari, A., Firpo, M. A., Tuveson, D. A., Capunzo, M., Karin, M., De Laurenzi, V., Turco, M. C. (2015) BAG3 promotes pancreatic ductal adenocarcinoma growth by activating stromal macrophages. Nat Commun, 6. p. 8695. ISSN 2041-1723 (Electronic)2041-1723 (Linking)

Jenkinson, C., Elliott, V. L., Evans, A., Oldfield, L., Timms, J. F., Gentry-Maharaj, A., Menon, U., Cox, T., Campbell, F., Sutton, R., Pereira, S. P., Tuveson, D. A., Greenhalf, W., Neoptolemos, J. P., Costello, E. (2015) Decreased Serum Thrombospondin-1 Levels in Pancreatic Ductal Adenocarcinoma Patients: An Early Indicator of Cancer or Diabetes Development? Pancreas, 44 (8). p. 1383. ISSN 0885-3177

Zambirinis, C. P., Levie, E., Nguy, S., Avanzi, A., Barilla, R., Xu, Y., Seifert, L., Daley, D., Greco, S. H., Deutsch, M., Jonnadula, S., Torres-Hernandez, A., Tippens, D., Pushalkar, S., Eisenthal, A., Saxena, D., Ahn, J., Hajdu, C., Engle, D. D., Tuveson, D., Miller, G. (2015) TLR9 ligation in pancreatic stellate cells promotes tumorigenesis. J Exp Med. ISSN 1540-9538 (Electronic)0022-1007 (Linking)

Neesse, A., Algul, H., Tuveson, D. A., Gress, T. M. (2015) Stromal biology and therapy in pancreatic cancer: a changing paradigm. Gut, 64 (9). pp. 1476-1484. ISSN 1468-3288 (Electronic)0017-5749 (Linking)

Rosati, A., Basile, A., D'Auria, R., d'Avenia, M., De Marco, M., Falco, A., Festa, M., Guerriero, L., Iorio, V., Pascale, M., Franco, R., Arra, C., Barbieri, A., Rea, D., Menichini, G., Hahne, M., Bijlsma, M., Barcaroli, D., Tuveson, D. A., Todoric, J., Karin, M., De Laurenzi, V., Turco, M. C. (2015) PDAC cells release BAG3 that activates a paracrine loop with stromal macrophages. Cancer Research, 75 (Supple). Abstract 2393. ISSN 0008-5472

Ponz-Sarvise, Mariano, Tuveson, David A., Yu, Kenneth H. (2015) Mouse Models of Pancreatic Ductal Adenocarcinoma. Hematology/Oncology Clinics of North America, 29 (4). pp. 609-617. ISSN 0889-8588

Tian, C. X., Ohlund, D., Clauser, K., Carr, S. A., Tuveson, D. A., Hynes, R. O. (2015) Profiling of extracellular matrix proteins in pancreatic ductal adenocarcinoma progression and metastasis. Cancer Research, 75 (Supple). ISSN 0008-5472

Palm, W., Park, Y., Wright, K., Pavlova, N. N., Tuveson, D. A., Thompson, C. B. (2015) The Utilization of Extracellular Proteins as Nutrients Is Suppressed by mTORC1. Cell, 162 (2). pp. 259-270. ISSN 1097-4172 (Electronic)0092-8674 (Linking)

Roy, I., McAllister, D., Gorse, E., Dixon, K., Cheng, G., Getschman, A., Engle, D., Tsai, S., Tuveson, D., Evans, D., Volkman, B., Kalyanaraman, B., Dwinell, M. (2015) Chemokine biased agonists regulate pancreatic cancer migration and metastasis through bioenergetic signaling. Cancer Research, 75 (Supple). B55. ISSN 0008-5472

Carapua, E. F., Gemenetzidis, E., Feig, C., Tuveson, D., Kocher, H. (2015) Developing drug combinations to co-target pancreatic cancer and its supporting stroma. Cancer Research, 75 (Supple). B72. ISSN 0008-5472

Tian, C. X., Olund, D., Tuveson, D., Hynes, R. O. (2015) Understanding the roles of extracellular matrix proteins in pancreatic ductal adenocarcinoma progression and metastasis. Cancer Research, 75 (Supple). A45. ISSN 0008-5472

Espana-Agusti, J., Tuveson, D. A., Adams, D. J., Matakidou, A. (2015) A minimally invasive, lentiviral based method for the rapid and sustained genetic manipulation of renal tubules. Sci Rep, 5. p. 11061. ISSN 2045-2322 (Electronic)2045-2322 (Linking)

Tuveson, D., Rai, K. R. (2015) Augmenting NF-kappaB in poor-risk CLL: A general paradigm for other cancers? J Exp Med, 212 (6). pp. 830-1. ISSN 1540-9538 (Electronic)0022-1007 (Linking)

Jenkinson, Claire, Elliott, Victoria, Evans, Anthony, Oldfield, Lucy, O'Brien, Darragh, Apostolidou, Sophia, Gentry-Maharaj, Aleksandra, Fourkala, Evangelia- O., Jacobs, Ian, Menon, Usha, Cox, Trevor, Campbell, Fiona, Tuveson, David, Greenhalf, William, Sutton, Robert, Pereira, Stephen, Timms, John, Neoptolemos, John, Costello, Eithne (2015) Decreased serum thrombospondin-1 levels in pancreatic ductal adenocarcinoma patients: an early indicator of disease or diabetes mellitus development? Pancreatology, 15 (3, Sup). S28. ISSN 1424-3903

Saiyin, H., Ardito-Abraham, C. M., Wu, Y., Wei, Y., Fang, Y., Han, X., Li, J., Zhou, P., Yi, Q., Maitra, A., Liu, J. O., Tuveson, D. A., Lou, W., Yu, L. (2015) Identification of novel vascular projections with cellular trafficking abilities on the microvasculature of pancreatic ductal adenocarcinoma. J Pathol, 236 (2). pp. 142-154. ISSN 0022-3417

Tournier, Cathy, Davies, Clare C., Harvey, Emma, McMahon, Raymond F. T., Finegan, Katherine G., Connor, Frances, Davis, Roger J., Tuveson, David A. (2015) Impaired JNK signaling cooperates with KrasG12D expression to accelerate pancreatic ductal adenocarcinoma. Pancreatology, 15 (3, Sup). S36. ISSN 1424-3903

Perna, D., Karreth, F. A., Rust, A. G., Perez-Mancera, P. A., Rashid, M., Iorio, F., Alifrangis, C., Arends, M. J., Bosenberg, M. W., Bollag, G., Tuveson, D. A., Adams, D. J. (2015) BRAF inhibitor resistance mediated by the AKT pathway in an oncogenic BRAF mouse melanoma model. Proceedings of the National Academy of Sciences of the United States of America, 112 (6). E536-E545. ISSN 0027-8424

Boj, Sylvia F, Hwang, Chang-Il, Baker, Lindsey A, Chio, Iok In Christine, Engle, Dannielle D, Corbo, Vincenzo, Jager, Myrthe, Ponz-Sarvise, Mariano, Tiriac, Hervé, Spector, Mona S, Gracanin, Ana, Oni, Tobiloba, Yu, Kenneth H, van Boxtel, Ruben, Huch, Meritxell, Rivera, Keith D, Wilson, John P, Feigin, Michael E, Öhlund, Daniel, Handly-Santana, Abram, Ardito-Abraham, Christine M, Ludwig, Michael, Elyada, Ela, Alagesan, Brinda, Biffi, Giulia, Yordanov, Georgi N, Delcuze, Bethany, Creighton, Brianna, Wright, Kevin, Park, Youngkyu, Morsink, Folkert H M., Molenaar, I.  Quintus, Borel Rinkes, Inne H, Cuppen, Edwin, Hao, Yuan, Jin, Ying, Nijman, Isaac J, Iacobuzio-Donahue, Christine, Leach, Steven D, Pappin, Darryl J, Hammell, Molly, Klimstra, David S, Basturk, Olca, Hruban, Ralph H, Offerhaus, George Johan, Vries, Robert G J., Clevers, Hans, Tuveson, David A (2015) Organoid Models of Human and Mouse Ductal Pancreatic Cancer. Cell, 160 (1-2). pp. 324-338. ISSN 0092-8674

Schlomann, U., Koller, G., Conrad, C., Ferdous, T., Golfi, P., Garcia, A. M., Hofling, S., Parsons, M., Costa, P., Soper, R., Bossard, M., Hagemann, T., Roshani, R., Sewald, N., Ketchem, R. R., Moss, M. L., Rasmussen, F. H., Miller, M. A., Lauffenburger, D. A., Tuveson, D. A., Nimsky, C., Bartsch, J. W. (2015) ADAM8 as a drug target in pancreatic cancer. Nature Communications, 6. p. 6175. ISSN 2041-1723

Naguib, A., Bencze, G., Engle, D. D., Chio, II, Herzka, T., Watrud, K., Bencze, S., Tuveson, D. A., Pappin, D. J., Trotman, L. C. (2014) P53 Mutations Change Phosphatidylinositol Acyl Chain Composition. Cell Reports, 10 (1). pp. 8-19. ISSN 2211-1247

Tuveson, D. (2014) Progress in pancreatic cancer modeling. Molecular Cancer Research, 12. ISSN 1541-7786

Chio, II, Yordanov, G., Tuveson, D. (2014) MAX-ing out MYC: a novel small molecule inhibitor against MYC-dependent tumors. Journal of the National Cancer Institute, 106 (12). ISSN 0027-8874

Tuveson, D. A. (2014) Modeling pancreatic cancer biology and medicine. Molecular Cancer Research, 12 (Supple). ISSN 1541-7786

Ponz-Sarvise, M., Corbo, V., Ohlund, D., Oni, T., Handly-Santana, A., Engle, D., Tiriac, H., Chio, C., Feigin, M., Baker, L., Ardito-Abraham, C., Park, Y., Hwang, C., Elyada, E., Yu, K., Clevers, H., Tuveson, D. A. (2014) Pancreatic ductal organoids as a new platform for drug discovery. European Journal of Cancer, 50. p. 63. ISSN 0959-8049

Kultti, A., Zhao, C. M., Zimmerman, S., Osgood, R. J., Chen, Y. L., Symons, R., Jiang, P., Thompson, C. B., Tuveson, D. A., Frost, G. I., Shepard, H. M., Huang, Z. D. (2014) Extracellular hyaluronan accumulation by hyaluronan synthase 3 promotes pancreatic cancer growth and modulates tumor microenvironment via epithelial-mesenchymal transition. Cancer Research, 74 (19). ISSN 0008-5472

Espana-Agusti, J., Tuveson, D. A., Adams, D. J., Matakidou, A. (2014) A minimally invasive, lentiviral based method for the rapid and sustained genetic manipulation of mouse tubular epithelial cells. BJU International, 114 (Supple). p. 11. ISSN 1464-4096

Corbo, V., Ponz-Sarvise, M., Tuveson, D. A. (2014) The RAS and YAP1 dance, who is leading? EMBO journal, 33 (21). pp. 3437-2438. ISSN 0261-4189

Sherman, Mara H, Yu, Ruth T, Engle, Dannielle D, Ding, Ning, Atkins, Annette R, Tiriac, Herve, Collisson, Eric A, Connor, Frances, Van Dyke, Terry, Kozlov, Serguei, Martin, Philip, Tseng, Tiffany W, Dawson, David W, Donahue, Timothy R, Masamune, Atsushi, Shimosegawa, Tooru, Apte, Minoti V, Wilson, Jeremy S, Ng, Beverly, Lau, Sue Lynn, Gunton, Jenny E, Wahl, Geoffrey M, Hunter, Tony, Drebin, Jeffrey A, O’Dwyer, Peter J, Liddle, Christopher, Tuveson, David A, Downes, Michael, Evans, Ronald M (2014) Vitamin D Receptor-Mediated Stromal Reprogramming Suppresses Pancreatitis and Enhances Pancreatic Cancer Therapy. Cell, 159 (1). pp. 80-93. ISSN 0092-8674

Ohlund, D., Elyada, E., Tuveson, D. (2014) Fibroblast heterogeneity in the cancer wound. Journal of Experimental Medicine, 211 (8). pp. 1503-23. ISSN 0022-1007

Kultti, A., Zhao, C. M., Singha, N. C., Zimmerman, S., Osgood, R. J., Symons, R., Jiang, P., Li, X. M., Thompson, C. B., Infante, J. R., Jacobetz, M. A., Tuveson, D. A., Frost, G. I., Shepard, H. M., Huang, Z. D. (2014) Accumulation of Extracellular Hyaluronan by Hyaluronan Synthase 3 Promotes Tumor Growth and Modulates the Pancreatic Cancer Microenvironment. Biomed Research International. p. 15. ISSN 2314-6133

Chandel, N. S., Tuveson, D. A. (2014) The Promise and Perils of Antioxidants for Cancer Patients. New England Journal of Medicine, 371 (2). pp. 177-178. ISSN 0028-4793

Baumgart, S., Chen, N. M., Siveke, J. T., Konig, A., Zhang, J. S., Singh, S. K., Wolf, E., Bartkuhn, M., Esposito, I., Hessmann, E., Reinecke, J., Nikorowitsch, J., Brunner, M., Singh, G., Fernandez-Zapico, M. E., Smyrk, T., Bamlet, W. R., Eilers, M., Neesse, A., Gress, T. M., Billadeau, D. D., Tuveson, D., Urrutia, R., Ellenrieder, V. (2014) Inflammation-Induced NFATc1-STAT3 Transcription Complex Promotes Pancreatic Cancer Initiation by Kras(G12D). Cancer Discovery, 4 (6). pp. 688-701. ISSN 2159-8274

Bapiro, T. E., Frese, K. K., Courtin, A., Bramhall, J. L., Madhu, B., Cook, N., Neesse, A., Griffiths, J. R., Tuveson, D. A., Jodrell, D. I., Richards, F. M. (2014) Gemcitabine diphosphate choline is a major metabolite linked to the Kennedy pathway in pancreatic cancer models in vivo. British Journal of Cancer, 111 (2). pp. 318-325. ISSN 0007-0920

Davies, C. C., Harvey, E., McMahon, R. F. T., Finegan, K. G., Connor, F., Davis, R. J., Tuveson, D. A., Tournier, C. (2014) Impaired JNK signaling cooperates with KrasG12D expression to accelerate pancreatic ductal adenocarcinoma. Cancer Research, 74 (12). pp. 3344-3356. ISSN 15387445

Neesse, A., Michl, P., Tuveson, D. A., Ellenrieder, V. (2014) nab-Paclitaxel: Novel Clinical and Experimental Evidence in Pancreatic Cancer. Zeitschrift fur Gastroenterologie, 52 (4). pp. 360-366. ISSN 0044-2771

Feig, C., Jones, J. O., Kraman, M., Wells, R. J. B., Deonarine, A., Chan, D. S., Connell, C. M., Roberts, E. W., Zhao, Q., Caballero, O. L., Teichmann, S. A., Janowitz, T., Jodrell, D. I., Tuveson, D. A., Fearon, D. T. (2013) Targeting CXCL12 from FAP-expressing carcinoma-associated fibroblasts synergizes with anti-PD-L1 immunotherapy in pancreatic cancer. Proceedings of the National Academy of Sciences of the United States of America, 110 (50). pp. 20212-20217. ISSN 00278424 (ISSN)

Neesse, A., Frese, K. K., Chan, D. S., Bapiro, T. E., Howat, W. J., Richards, F. M., Ellenrieder, V., Jodrell, D. I., Tuveson, D. A. (2013) SPARC independent drug delivery and antitumour effects of nab-paclitaxel in genetically engineered mice. Gut, 63 (6). pp. 974-983. ISSN 00175749 (ISSN)

Neesse, A., Frese, K. K., Bapiro, T. E., Nakagawa, T., Sternlicht, M. D., Seeley, T. W., Pilarsky, C., Jodrell, D. I., Spong, S. M., Tuveson, D. A. (2013) CTGF antagonism with mAb FG-3019 enhances chemotherapy response without increasing drug delivery in murine ductal pancreas cancer. Proceedings of the National Academy of Sciences of the United States of America, 110 (30). pp. 12325-30. ISSN 0027-8424

Roberts, E. W., Deonarine, A., Jones, J. O., Denton, A. E., Feig, C., Lyons, S. K., Espeli, M., Kraman, M., McKenna, B., Wells, R. J. B., Zhao, Q., Caballero, O. L., Larder, R., Coll, A. P., O'Rahilly, S., Brindle, K. M., Teichmann, S. A., Tuveson, D. A., Fearon, D. T. (2013) Depletion of stromal cells expressing fibroblast activation protein-alpha from skeletal muscle and bone marrow results in cachexia and anemia. Journal of Experimental Medicine, 210 (6). pp. 1137-1151. ISSN 0022-1007

Mahajan, Ujwal Mukund, Teller, Steffen, Sendler, Matthias, Schwaiger, Theresa, Glöckl, Gunner, Aurich, Konstanze, Partecke, Lars Ivo, Hadlich, Steffen, Weiss, Frank Ulrich, Kühn, Jens P., Tuveson, David, Lerch, Markus M., Mayerle, Julia (2013) In vivo imaging and targeted siRNA delivery using superparamagnetic nanoparticles in pancreatic ductal adenocarcinoma. Pancreatology, 13 (3, Sup). S19. ISSN 1424-3903

Chin, L., De Sauvage, F., Egeblad, M., Olive, K. P., Tuveson, D., Weiss, W. (2013) Recapitulating human cancer in a mouse. Nature Biotechnology, 31 (5). pp. 392-395. ISSN 10870156

Jacobetz, M. A., Chan, D. S., Neesse, A., Bapiro, T. E., Cook, N., Frese, K. K., Feig, C., Nakagawa, T., Caldwell, M. E., Zecchini, H. I., Lolkema, M. P., Jiang, P., Kultti, A., Thompson, C. B., Maneval, D. C., Jodrell, D. I., Frost, G. I., Shepard, H. M., Skepper, J. N., Tuveson, D. A. (2013) Hyaluronan impairs vascular function and drug delivery in a mouse model of pancreatic cancer. Gut, 62 (1). pp. 112-20. ISSN 1468-3288 (Electronic)0017-5749 (Linking)

Neesse, A., Krug, S., Gress, T. M., Tuveson, D. A., Michl, P. (2013) Emerging concepts in pancreatic cancer medicine: targeting the tumor stroma. Onco Targets Ther, 7. pp. 33-43. ISSN 1178-6930 (Print)1178-6930

Feig, C., Gopinathan, A., Neesse, A., Chan, D. S., Cook, N., Tuveson, D. A. (2012) The pancreas cancer microenvironment. Clin Cancer Res, 18 (16). pp. 4266-76. ISSN 1078-0432 (Print)1078-0432 (Linking)

Perez-Mancera, P. A., Rust, A. G., van der Weyden, L., Kristiansen, G., Li, A., Sarver, A. L., Silverstein, K. A., Grutzmann, R., Aust, D., Rummele, P., Knosel, T., Herd, C., Stemple, D. L., Kettleborough, R., Brosnan, J. A., Li, A., Morgan, R., Knight, S., Yu, J., Stegeman, S., Collier, L. S., ten Hoeve, J. J., de Ridder, J., Klein, A. P., Goggins, M., Hruban, R. H., Chang, D. K., Biankin, A. V., Grimmond, S. M., Wessels, L. F., Wood, S. A., Iacobuzio-Donahue, C. A., Pilarsky, C., Largaespada, D. A., Adams, D. J., Tuveson, D. A. (2012) The deubiquitinase USP9X suppresses pancreatic ductal adenocarcinoma. Nature, 486 (7402). pp. 266-70. ISSN 1476-4687 (Electronic)0028-0836 (Linking)

Cook, N., Frese, K. K., Bapiro, T. E., Jacobetz, M. A., Gopinathan, A., Miller, J. L., Rao, S. S., Demuth, T., Howat, W. J., Jodrell, D. I., Tuveson, D. A. (2012) Gamma secretase inhibition promotes hypoxic necrosis in mouse pancreatic ductal adenocarcinoma. J Exp Med, 209 (3). pp. 437-44. ISSN 1540-9538 (Electronic)0022-1007 (Linking)

Frese, K. K., Neesse, A., Cook, N., Bapiro, T. E., Lolkema, M. P., Jodrell, D. I., Tuveson, D. A. (2012) nab-Paclitaxel potentiates gemcitabine activity by reducing cytidine deaminase levels in a mouse model of pancreatic cancer. Cancer Discov, 2 (3). pp. 260-9. ISSN 2159-8290 (Electronic)2159-8274 (Linking)

Tuveson, David A, Neoptolemos, John P (2012) Understanding Metastasis in Pancreatic Cancer: A Call for New Clinical Approaches. Cell, 148 (1–2). pp. 21-23. ISSN 0092-8674

Pearson, H. B., Perez-Mancera, P. A., Dow, L. E., Ryan, A., Tennstedt, P., Bogani, D., Elsum, I., Greenfield, A., Tuveson, D. A., Simon, R., Humbert, P. O. (2011) SCRIB expression is deregulated in human prostate cancer, and its deficiency in mice promotes prostate neoplasia. Journal of Clinical Investigation, 121 (11). pp. 4257-4267. ISSN 0021-9738

DeNicola, G. M., Karreth, F. A., Humpton, T. J., Gopinathan, A., Wei, C., Frese, K., Mangal, D., Yu, K. H., Yeo, C. J., Calhoun, E. S., Scrimieri, F., Winter, J. M., Hruban, R. H., Iacobuzio-Donahue, C., Kern, S. E., Blair, I. A., Tuveson, D. A. (2011) Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis. Nature, 475 (7354). pp. 106-9. ISSN 1476-4687 (Electronic)0028-0836 (Linking)

Kraman, M., Bambrough, P. J., Arnold, J. N., Roberts, E. W., Magiera, L., Jones, J. O., Gopinathan, A., Tuveson, D. A., Fearon, D. T. (2010) Suppression of antitumor immunity by stromal cells expressing fibroblast activation protein-alpha. Science, 330 (6005). pp. 827-30. ISSN 1095-9203 (Electronic)0036-8075 (Linking)

Video

Tuveson, D. A. (2012) Talk from David Tuveson at the Cold Spring Harbor Laboratory In-House Symposium (2012). [Video] (Unpublished)

This list was generated on Tue Jul 25 04:56:19 2017 EDT.
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