Cancer: Double trouble for tumours

Biffi, G., Tuveson, D. A. (February 2017) Cancer: Double trouble for tumours. Nature, 542 (7639). pp. 34-35. ISSN 1476-4687 (Electronic)0028-0836 (Linking)

DOI: 10.1038/nature21117


When some cancer cells delete a tumour-suppressor gene, they also delete nearby genes. It emerges that one of these latter genes has a key metabolic role, revealing a therapeutic opportunity that might be relevant for many tumours. During cancer progression, many cancer cells delete tumour-suppressor genes that block tumour development. This deletion process often also removes some neighbouring genes. The partial or complete loss of these neighbouring genes can make cancer cells vulnerable to therapeutic targeting — a concept known as collateral lethality1. In a paper online in Nature, Dey et al.2 reveal an example of collateral lethality in pancreatic cancer that exploits changes in cellular metabolism.

Item Type: Paper
Subjects: diseases & disorders > cancer > cancer types > pancreatic cancer
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > genes: types > tumor suppressor
CSHL Authors:
Communities: CSHL labs > Tuveson lab
Depositing User: Matt Covey
Date: 2 February 2017
Date Deposited: 26 Jan 2017 17:29
Last Modified: 24 Mar 2017 16:44
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