Modeling Pancreatic Cancer with Organoids

Baker, Lindsey A., Tiriac, Hervé, Clevers, Hans, Tuveson, David A. (April 2016) Modeling Pancreatic Cancer with Organoids. Trends in Cancer, 2 (4). pp. 176-190. ISSN 2405-8033

DOI: 10.1016/j.trecan.2016.03.004


Pancreatic ductal adenocarcinoma (PDA) is a highly lethal malignancy for which new treatment and diagnostic approaches are urgently needed. For such breakthroughs to be discovered, researchers require systems that accurately model the development and biology of PDA. While cell lines, genetically engineered murine models, and xenografts have all led to valuable clinical insights, organotypic culture models have emerged as tractable systems to recapitulate the complex 3D organization of PDA. Recently, multiple methods for modeling PDA using organoids have been reported. This review aims to summarize these organoid methods in the context of other PDA models. While each model system has unique benefits and drawbacks, ultimately, organoids hold special promise for the development of personalized medicine approaches.

Item Type: Paper
Subjects: organism description > model organism
diseases & disorders > cancer > cancer types > pancreatic cancer
CSHL Authors:
Communities: CSHL Cancer Center Program > Signal Transduction
CSHL labs > Tuveson lab
CSHL Cancer Center Program > Cellular Communication in Cancer Program
Depositing User: Matt Covey
Date: 1 April 2016
Date Deposited: 07 Apr 2016 15:17
Last Modified: 22 Oct 2020 20:29
PMCID: PMC4847151
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