A path to translation: How 3D patient tumor avatars enable next generation precision oncology

Bose, Shree, Barroso, Margarida, Chheda, Milan G, Clevers, Hans, Elez, Elena, Kaochar, Salma, Kopetz, Scott E, Li, Xiao-Nan, Meric-Bernstam, Funda, Meyer, Clifford A, Mou, Haiwei, Naegle, Kristen M, Pera, Martin F, Perova, Zinaida, Politi, Katerina A, Raphael, Benjamin J, Robson, Paul, Sears, Rosalie C, Tabernero, Josep, Tuveson, David A, Welm, Alana L, Welm, Bryan E, Willey, Christopher D, Salnikow, Konstantin, Chuang, Jeffrey H, Shen, Xiling (October 2022) A path to translation: How 3D patient tumor avatars enable next generation precision oncology. Cancer Cell. ISSN 1535-6108

URL: https://www.ncbi.nlm.nih.gov/pubmed/36270276
DOI: 10.1016/j.ccell.2022.09.017


3D patient tumor avatars (3D-PTAs) hold promise for next-generation precision medicine. Here, we describe the benefits and challenges of 3D-PTA technologies and necessary future steps to realize their potential for clinical decision making. 3D-PTAs require standardization criteria and prospective trials to establish clinical benefits. Innovative trial designs that combine omics and 3D-PTA readouts may lead to more accurate clinical predictors, and an integrated platform that combines diagnostic and therapeutic development will accelerate new treatments for patients with refractory disease.

Item Type: Paper
Subjects: diseases & disorders > cancer
diseases & disorders
diseases & disorders > neoplasms
diseases & disorders > cancer > drugs and therapies
diseases & disorders > cancer > drugs and therapies > precision medicine
CSHL Authors:
Communities: CSHL labs > Tuveson lab
SWORD Depositor: CSHL Elements
Depositing User: CSHL Elements
Date: 18 October 2022
Date Deposited: 27 Oct 2022 01:13
Last Modified: 11 Jan 2024 18:54
PMCID: PMC10576652
URI: https://repository.cshl.edu/id/eprint/40740

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