Untangling the genetics from the epigenetics in pancreatic cancer metastasis

Vakoc, C. R., Tuveson, D. A. (February 2017) Untangling the genetics from the epigenetics in pancreatic cancer metastasis. Nat Genet, 49 (3). pp. 323-324. ISSN 1061-4036

URL: https://www.ncbi.nlm.nih.gov/pubmed/28232730
DOI: 10.1038/ng.3798

Abstract

Comparative genomic analyses of primary tumors and metastases within individuals with pancreatic cancer have exposed the complex clonal dynamics that underlie the dissemination of cancer cells to distant sites. Recent studies implicate non-genetic mechanisms in this process, particularly fluctuations in chromatin states and metabolism, which can endow rare cells within a primary tumor with metastatic potential.

Item Type: Paper
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > epigenetics
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > epigenetics
diseases & disorders > cancer > metastasis
diseases & disorders > cancer > cancer types > pancreatic cancer
CSHL Authors:
Communities: CSHL labs > Tuveson lab
CSHL labs > Vakoc lab
CSHL Cancer Center Program > Cancer Genetics and Genomics Program
CSHL Cancer Center Program > Cellular Communication in Cancer Program
Depositing User: Matt Covey
Date: 24 February 2017
Date Deposited: 02 Mar 2017 16:31
Last Modified: 26 Oct 2020 15:43
Related URLs:
URI: https://repository.cshl.edu/id/eprint/34141

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