Vakoc, C. R., Tuveson, D. A. (February 2017) Untangling the genetics from the epigenetics in pancreatic cancer metastasis. Nat Genet, 49 (3). pp. 323-324. ISSN 1061-4036
DOI: 10.1038/ng.3798
Abstract
Comparative genomic analyses of primary tumors and metastases within individuals with pancreatic cancer have exposed the complex clonal dynamics that underlie the dissemination of cancer cells to distant sites. Recent studies implicate non-genetic mechanisms in this process, particularly fluctuations in chromatin states and metabolism, which can endow rare cells within a primary tumor with metastatic potential.
| Item Type: | Paper |
|---|---|
| Subjects: | bioinformatics > genomics and proteomics > genetics & nucleic acid processing bioinformatics > genomics and proteomics > genetics & nucleic acid processing > epigenetics bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > epigenetics diseases & disorders > cancer > metastasis diseases & disorders > cancer > cancer types > pancreatic cancer |
| CSHL Authors: | |
| Communities: | CSHL labs > Tuveson lab CSHL labs > Vakoc lab CSHL Cancer Center Program > Cancer Genetics and Genomics Program CSHL Cancer Center Program > Cellular Communication in Cancer Program |
| Depositing User: | Matt Covey |
| Date: | 24 February 2017 |
| Date Deposited: | 02 Mar 2017 16:31 |
| Last Modified: | 26 Oct 2020 15:43 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/34141 |
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