Recapitulating human cancer in a mouse

Chin, L., De Sauvage, F., Egeblad, M., Olive, K. P., Tuveson, D., Weiss, W. (May 2013) Recapitulating human cancer in a mouse. Nature Biotechnology, 31 (5). pp. 392-395. ISSN 10870156

DOI: 10.1038/nbt.2575


Which mouse models are most likely to mimic the genetics and biology of a particular type and stage of human cancer is an open question. Indeed, much has been written about the failure of findings in preclinical mouse models to be translated to clinical success. At the Cold Spring Harbor Laboratory's Mechanisms and Models of Cancer meeting last year, Nature Biotechnology convened a panel of experts from industry and academia to debate the pros and cons of various mouse models, including GEMMs [genetically engineered mouse models], orthotopic, xenograft and allograft transplantation, with a view to improving the utility of these animals in oncology research and drug development.

Item Type: Paper
Subjects: diseases & disorders > cancer
diseases & disorders
organism description > animal > mammal > primates > hominids > human
organism description > model organism
organism description > animal > mammal > rodent > mouse
CSHL Authors:
Communities: CSHL labs > Egeblad lab
CSHL labs > Tuveson lab
Depositing User: Matt Covey
Date: May 2013
Date Deposited: 21 Jun 2013 16:37
Last Modified: 15 Nov 2023 18:40
PMCID: PMC7819848
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