Browse by CSHL Author

Cheng, H., Capponi, S., Wakeling, E., Marchi, E., Li, Q., Zhao, M., Weng, C., Stefan, P. G., Ahlfors, H., Kleyner, R., Rope, A., Lumaka, A., Lukusa, P., Devriendt, K., Vermeesch, J., Posey, J. E., Palmer, E. E., Murray, L., Leon, E., Diaz, J., Worgan, L., Mallawaarachchi, A., Vogt, J., de Munnik, S. A., Dreyer, L., Baynam, G., Ewans, L., Stark, Z., Lunke, S., Goncalves, A. R., Soares, G., Oliveira, J., Fassi, E., Willing, M., Waugh, J. L., Faivre, L., Riviere, J. B., Moutton, S., Mohammed, S., Payne, K., Walsh, L., Begtrup, A., Guillen Sacoto, M. J., Douglas, G., Alexander, N., Buckley, M. F., Mark, P. R., Ades, L. C., Sandaradura, S. A., Lupski, J. R., Roscioli, T., Agrawal, P. B., Kline, A. D., Wang, K., Timmers, H. T. M., Lyon, G. J. (October 2019) Missense variants in TAF1 and developmental phenotypes: challenges of determining pathogenicity. Hum Mutat. ISSN 1059-7794

Paine, I., Posey, J. E., Grochowski, C. M., Jhangiani, S. N., Rosenheck, S., Kleyner, R., Marmorale, T., Yoon, M., Wang, K., Robison, R., Cappuccio, G., Pinelli, M., Magli, A., Coban Akdemir, Z., Hui, J., Yeung, W. L., Wong, B. K. Y., Ortega, L., Bekheirnia, M. R., Bierhals, T., Hempel, M., Johannsen, J., Santer, R., Aktas, D., Alikasifoglu, M., Bozdogan, S., Aydin, H., Karaca, E., Bayram, Y., Ityel, H., Dorschner, M., White, J. J., Wilichowski, E., Wortmann, S. B., Casella, E. B., Kitajima, J. P., Kok, F., Monteiro, F., Muzny, D. M., Bamshad, M., Gibbs, R. A., Sutton, V. R., Van Esch, H., Brunetti-Pierri, N., Hildebrandt, F., Brautbar, A., Van den Veyver, I. B., Glass, I., Lessel, D., Lyon, G. J., Lupski, J. R. (June 2019) Paralog Studies Augment Gene Discovery: DDX and DHX Genes. Am J Hum Genet, 105 (2). pp. 302-316. ISSN 0002-9297

Hsieh, T. C., Mensah, M. A., Pantel, J. T., Aguilar, D., Bar, O., Bayat, A., Becerra-Solano, L., Bentzen, H. B., Biskup, S., Borisov, O., Braaten, O., Ciaccio, C., Coutelier, M., Cremer, K., Danyel, M., Daschkey, S., Eden, H. D., Devriendt, K., Wilson, S., Douzgou, S., Dukic, D., Ehmke, N., Fauth, C., Fischer-Zirnsak, B., Fleischer, N., Gabriel, H., Graul-Neumann, L., Gripp, K. W., Gurovich, Y., Gusina, A., Haddad, N., Hajjir, N., Hanani, Y., Hertzberg, J., Hoertnagel, K., Howell, J., Ivanovski, I., Kaindl, A., Kamphans, T., Kamphausen, S., Karimov, C., Kathom, H., Keryan, A., Knaus, A., Kohler, S., Kornak, U., Lavrov, A., Leitheiser, M., Lyon, G. J., Mangold, E., Reina, P. M., Carrascal, A. M., Mitter, D., Herrador, L. M., Nadav, G., Nothen, M., Orrico, A., Ott, C. E., Park, K., Peterlin, B., Polsler, L., Raas-Rothschild, A., Randolph, L., Revencu, N., Fagerberg, C. R., Robinson, P. N., Rosnev, S., Rudnik, S., Rudolf, G., Schatz, U., Schossig, A., Schubach, M., Shanoon, O., Sheridan, E., Smirin-Yosef, P., Spielmann, M., Suk, E. K., Sznajer, Y., Thiel, C. T., Thiel, G., Verloes, A., Vrecar, I., Wahl, D., Weber, I., Winter, K., Wisniewska, M., Wollnik, B., Yeung, M. W., Zhao, M., Zhu, N., Zschocke, J., Mundlos, S., Horn, D., Krawitz, P. M. (June 2019) PEDIA: prioritization of exome data by image analysis. Genet Med, 21 (12). pp. 2807-2814. ISSN 1098-3600

Cheng, H., Gottlieb, L., Marchi, E., Kleyner, R., Bhardwaj, P., Rope, A. F., Rosenheck, S., Moutton, S., Philippe, C., Eyaid, W., Alkuraya, F. S., Toribio, J., Mena, R., Prada, C. E., Stessman, H., Bernier, R., Wermuth, M., Kauffmann, B., Blaumeiser, B., Kooy, R. F., Baralle, D., Mancini, G. M. S., Conway, S. J., Xia, F., Chen, Z., Meng, L., Mihajlovic, L., Marmorstein, R., Lyon, G. J. (May 2019) Phenotypic and biochemical analysis of an international cohort of individuals with variants in NAA10 and NAA15. Hum Mol Genet, 28 (17). pp. 2900-2919. ISSN 0964-6906

Kline, A. D., Krantz, I. D., Bando, M., Shirahige, K., Chea, S., Sakata, T., Rao, S., Dorsett, D., Singh, V. P., Gerton, J. L., Horsfield, J. A., Calof, A. L., Katz, O., Grados, M., Raible, S., Baranano, K., Lyon, G., Musio, A., Carrico, C. S., Clemens, D. K., Caudill, P., Massa, V., McGill, B. E., Dommestrup, A., O'Connor, J., Haaland, R. E. (March 2019) Cornelia de Lange syndrome, related disorders, and the Cohesin complex: Abstracts from the 8th biennial scientific and educational symposium 2018. Am J Med Genet A, 179 (6). pp. 1080-1090. ISSN 1552-4825

Yu, D., Sul, J. H., Tsetsos, F., Nawaz, M. S., Huang, A. Y., Zelaya, I., Illmann, C., Osiecki, L., Darrow, S. M., Hirschtritt, M. E., Greenberg, E., Muller-Vahl, K. R., Stuhrmann, M., Dion, Y., Rouleau, G., Aschauer, H., Stamenkovic, M., Schlogelhofer, M., Sandor, P., Barr, C. L., Grados, M., Singer, H. S., Nothen, M. M., Hebebrand, J., Hinney, A., King, R. A., Fernandez, T. V., Barta, C., Tarnok, Z., Nagy, P., Depienne, C., Worbe, Y., Hartmann, A., Budman, C. L., Rizzo, R., Lyon, G. J., McMahon, W. M., Batterson, J. R., Cath, D. C., Malaty, I. A., Okun, M. S., Berlin, C., Woods, D. W., Lee, P. C., Jankovic, J., Robertson, M. M., Gilbert, D. L., Brown, L. W., Coffey, B. J., Dietrich, A., Hoekstra, P. J., Kuperman, S., Zinner, S. H., Luethvigsson, P., Saemundsen, E., Thorarensen, O., Atzmon, G., Barzilai, N., Wagner, M., Moessner, R., Ophoff, R., Pato, C. N., Pato, M. T., Knowles, J. A., Roffman, J. L., Smoller, J. W., Buckner, R. L., Willsey, A. J., Tischfield, J. A., Heiman, G. A., Stefansson, H., Stefansson, K., Posthuma, D., Cox, N. J., Pauls, D. L., Freimer, N. B., Neale, B. M., Davis, L. K., Paschou, P., Coppola, G., Mathews, C. A., Scharf, J. M. (March 2019) Interrogating the Genetic Determinants of Tourette's Syndrome and Other Tic Disorders Through Genome-Wide Association Studies. The American Journal of Psychiatry, 176 (3). pp. 217-227. ISSN 0002-953x

Wu, Y., Lyon, G. J. (July 2018) NAA10-related syndrome. Exp Mol Med, 50 (7). p. 85. ISSN 1226-3613

Anttila, V., Bulik-Sullivan, B., Finucane, H. K., Walters, R. K., Bras, J., Duncan, L., Escott-Price, V., Falcone, G. J., Gormley, P., Malik, R., Patsopoulos, N. A., Ripke, S., Wei, Z., Yu, D., Lee, P. H., Turley, P., Grenier-Boley, B., Chouraki, V., Kamatani, Y., Berr, C., Letenneur, L., Hannequin, D., Amouyel, P., Boland, A., Deleuze, J. F., Duron, E., Vardarajan, B. N., Reitz, C., Goate, A. M., Huentelman, M. J., Kamboh, M. I., Larson, E. B., Rogaeva, E., St George-Hyslop, P., Hakonarson, H., Kukull, W. A., Farrer, L. A., Barnes, L. L., Beach, T. G., Demirci, F. Y., Head, E., Hulette, C. M., Jicha, G. A., Kauwe, J. S. K., Kaye, J. A., Leverenz, J. B., Levey, A. I., Lieberman, A. P., Pankratz, V. S., Poon, W. W., Quinn, J. F., Saykin, A. J., Schneider, L. S., Smith, A. G., Sonnen, J. A., Stern, R. A., Van Deerlin, V. M., Van Eldik, L. J., Harold, D., Russo, G., Rubinsztein, D. C., Bayer, A., Tsolaki, M., Proitsi, P., Fox, N. C., Hampel, H., Owen, M. J., Mead, S., Passmore, P., Morgan, K., Nothen, M. M., Rossor, M., Lupton, M. K., Hoffmann, P., Kornhuber, J., Lawlor, B., McQuillin, A., Al-Chalabi, A., Bis, J. C., Ruiz, A., Boada, M., Seshadri, S., Beiser, A., Rice, K., van der Lee, S. J., De Jager, P. L., Geschwind, D. H., Riemenschneider, M., Riedel-Heller, S., Rotter, J. I., Ransmayr, G., Hyman, B. T., Cruchaga, C., Alegret, M., Winsvold, B., Palta, P., Farh, K. H., Cuenca-Leon, E., Furlotte, N., Kurth, T. (June 2018) Analysis of shared heritability in common disorders of the brain. Science, 360 (6395). ISSN 0036-8075

Cheng, H., Dharmadhikari, A. V., Varland, S., Ma, N., Domingo, D., Kleyner, R., Rope, A. F., Yoon, M., Stray-Pedersen, A., Posey, J. E., Crews, S. R., Eldomery, M. K., Akdemir, Z. C., Lewis, A. M., Sutton, V. R., Rosenfeld, J. A., Conboy, E., Agre, K., Xia, F., Walkiewicz, M., Longoni, M., High, F. A., van Slegtenhorst, M. A., Mancini, G. M. S., Finnila, C. R., van Haeringen, A., den Hollander, N., Ruivenkamp, C., Naidu, S., Mahida, S., Palmer, E. E., Murray, L., Lim, D., Jayakar, P., Parker, M. J., Giusto, S., Stracuzzi, E., Romano, C., Beighley, J. S., Bernier, R. A., Kury, S., Nizon, M., Corbett, M. A., Shaw, M., Gardner, A., Barnett, C., Armstrong, R., Kassahn, K. S., Van Dijck, A., Vandeweyer, G., Kleefstra, T., Schieving, J., Jongmans, M. J., de Vries, B. B. A., Pfundt, R., Kerr, B., Rojas, S. K., Boycott, K. M., Person, R., Willaert, R., Eichler, E. E., Kooy, R. F., Yang, Y., Wu, J. C., Lupski, J. R., Arnesen, T., Cooper, G. M., Chung, W. K., Gecz, J., Stessman, H. A. F., Meng, L., Lyon, G. J. (May 2018) Truncating Variants in NAA15 Are Associated with Variable Levels of Intellectual Disability, Autism Spectrum Disorder, and Congenital Anomalies. Am J Hum Genet, 102 (5). pp. 985-994. ISSN 0002-9297

Greenberg, E., Tung, E. S., Gauvin, C., Osiecki, L., Yang, K. G., Curley, E., Essa, A., Illmann, C., Sandor, P., Dion, Y., Lyon, G. J., King, R. A., Darrow, S., Hirschtritt, M. E., Budman, C. L., Grados, M., Pauls, D. L., Keuthen, N. J., Mathews, C. A., Scharf, J. M. (May 2018) Prevalence and predictors of hair pulling disorder and excoriation disorder in Tourette syndrome. Eur Child Adolesc Psychiatry, 27 (5). pp. 569-579. ISSN 1018-8827

Fang, Han, Huang, Yi-Fei, Radhakrishnan, Aditya, Siepel, Adam, Lyon, Gholson J., Schatz, Michael C. (February 2018) Scikit-ribo Enables Accurate Estimation and Robust Modeling of Translation Dynamics at Codon Resolution. Cell Systems, 6 (2). pp. 180-191. ISSN 2405-4712

Darrow, Sabrina M., Grados, Marco, Sandor, Paul, Hirschtritt, Matthew E., Illmann, Cornelia, Osiecki, Lisa, Dion, Yves, King, Robert, Pauls, David, Budman, Cathy L., Cath, Danielle C., Greenberg, Erica, Lyon, Gholson J., McMahon, William M., Lee, Paul C., Delucchi, Kevin L., Scharf, Jeremiah M., Mathews, Carol A. (July 2017) Autism Spectrum Symptoms in a Tourette Syndrome Sample. Journal of the American Academy of Child & Adolescent Psychiatry, 56 (7). pp. 610-617. ISSN 0890-8567

Hirschtritt, M. E., Darrow, S. M., Illmann, C., Osiecki, L., Grados, M., Sandor, P., Dion, Y., King, R. A., Pauls, D., Budman, C. L., Cath, D. C., Greenberg, E., Lyon, G. J., Yu, D., McGrath, L. M., McMahon, W. M., Lee, P. C., Delucchi, K. L., Scharf, J. M., Mathews, C. A. (June 2017) Genetic and phenotypic overlap of specific obsessive-compulsive and attention-deficit/hyperactive subtypes with Tourette syndrome. Psychol Med. pp. 1-15. ISSN 0033-2917

Huang, A. Y., Yu, D., Davis, L. K., Sul, J. H., Tsetsos, F., Ramensky, V., Zelaya, I., Ramos, E. M., Osiecki, L., Chen, J. A., McGrath, L. M., Illmann, C., Sandor, P., Barr, C. L., Grados, M., Singer, H. S., Nothen, M. M., Hebebrand, J., King, R. A., Dion, Y., Rouleau, G., Budman, C. L., Depienne, C., Worbe, Y., Hartmann, A., Muller-Vahl, K. R., Stuhrmann, M., Aschauer, H., Stamenkovic, M., Schloegelhofer, M., Konstantinidis, A., Lyon, G. J., McMahon, W. M., Barta, C., Tarnok, Z., Nagy, P., Batterson, J. R., Rizzo, R., Cath, D. C., Wolanczyk, T., Berlin, C., Malaty, I. A., Okun, M. S., Woods, D. W., Rees, E., Pato, C. N., Pato, M. T., Knowles, J. A., Posthuma, D., Pauls, D. L., Cox, N. J., Neale, B. M., Freimer, N. B., Paschou, P., Mathews, C. A., Scharf, J. M., Coppola, G. (June 2017) Rare Copy Number Variants in NRXN1 and CNTN6 Increase Risk for Tourette Syndrome. Neuron, 94 (6). 1101-1111.e7. ISSN 0896-6273

Hirschtritt, Matthew, Darrow, Sabrina M., Illmann, Cornelia, Osiecki, Lisa, Grados, Marco, Sandor, Paul, Dion, Yves, King, Robert A., Pauls, David, Budman, Cathy L., Cath, Danielle C., Greenberg, Erica, Lyon, Gholson J., Yu, Dongmei, McGrath, Lauren M., McMahon, William M., Lee, Paul C., Delucchi, Kevin L., Scharf, Jeremiah M., Mathews, Carol A. (May 2017) Genetic and Phenotypic Overlap of Specific Obsessive-Compulsive Subtypes with Tourette Syndrome. Biological Psychiatry, 81 (10, Su). S361-S362. ISSN 0006-3223

Willsey, A. J., Fernandez, T. V., Yu, D., King, R. A., Dietrich, A., Xing, J., Sanders, S. J., Mandell, J. D., Huang, A. Y., Richer, P., Smith, L., Dong, S., Samocha, K. E., Neale, B. M., Coppola, G., Mathews, C. A., Tischfield, J. A., Scharf, J. M., State, M. W., Heiman, G. A. (May 2017) De Novo Coding Variants Are Strongly Associated with Tourette Disorder. Neuron, 94 (3). 486-499.e9. ISSN 0896-6273

Darrow, S. M., Hirschtritt, M. E., Davis, L. K., Illmann, C., Osiecki, L., Grados, M., Sandor, P., Dion, Y., King, R., Pauls, D., Budman, C. L., Cath, D. C., Greenberg, E., Lyon, G. J., Yu, D., McGrath, L. M., McMahon, W. M., Lee, P. C., Delucchi, K. L., Scharf, J. M., Mathews, C. A. (April 2017) Identification of Two Heritable Cross-Disorder Endophenotypes for Tourette Syndrome. Am J Psychiatry, 174 (4). pp. 387-396. ISSN 1535-7228 (Electronic)0002-953X (Linking)

Fang, H., Wu, Y., Yang, H., Yoon, M., Jimenez-Barron, L. T., Mittelman, D., Robison, R., Wang, K., Lyon, G. J. (February 2017) Whole genome sequencing of one complex pedigree illustrates challenges with genomic medicine. BMC Med Genomics, 10 (1). p. 10. ISSN 1755-8794

Dorfel, M. J., Fang, H., Crain, J., Klingener, M., Weiser, J., Lyon, G. J. (January 2017) Proteomic and genomic characterization of a yeast model for Ogden syndrome. Yeast, 34 (1). pp. 19-37. ISSN 1097-0061 (Electronic)0749-503X (Linking)

Fang, H., Bergmann, E. A., Arora, K., Vacic, V., Zody, M. C., Iossifov, I., O'Rawe, J. A., Wu, Y., Jimenez Barron, L. T., Rosenbaum, J., Ronemus, M., Lee, Y. H., Wang, Z., Dikoglu, E., Jobanputra, V., Lyon, G. J., Wigler, M., Schatz, M. C., Narzisi, G. (December 2016) Indel variant analysis of short-read sequencing data with Scalpel. Nat Protoc, 11 (12). pp. 2529-2548. ISSN 1750-2799 (Electronic)1750-2799 (Linking)

Lyon, Gholson J. (November 2016) Human Genetics and Rare Diseases. In: CSHL In-House Symposium, November 21th-22nd 2016, Cold Spring Harbor Laboratory. (Unpublished)

Kleyner, R., Malcolmson, J., Tegay, D., Ward, K., Maughan, A., Maughan, G., Nelson, L., Wang, K., Robison, R., Lyon, G. J. (November 2016) KBG syndrome involving a single-nucleotide duplication in ANKRD11. Cold Spring Harb Mol Case Stud, 2 (6). a001131. ISSN 2373-2873 (Linking)

Malcolmson, J., Kleyner, R., Tegay, D., Adams, W., Ward, K., Coppinger, J., Nelson, L., Meisler, M. H., Wang, K., Robison, R., Lyon, G. J. (November 2016) SCN8A mutation in a child presenting with seizures and developmental delays. Cold Spring Harb Mol Case Stud, 2 (6). a001073. ISSN 2373-2873

Hirschtritt, M. E., Darrow, S. M., Illmann, C., Osiecki, L., Grados, M., Sandor, P., Dion, Y., King, R. A., Pauls, D. L., Budman, C. L., Cath, D. C., Greenberg, E., Lyon, G. J., Yu, D., McGrath, L. M., McMahon, W. M., Lee, P. C., Delucchi, K. L., Scharf, J. M., Mathews, C. A. (August 2016) Social disinhibition is a heritable subphenotype of tics in Tourette syndrome. Neurology, 87 (5). pp. 497-504. ISSN 0028-3878

Shi, L., Guo, Y., Dong, C., Huddleston, J., Yang, H., Han, X., Fu, A., Li, Q., Li, N., Gong, S., Lintner, K. E., Ding, Q., Wang, Z., Hu, J., Wang, D., Wang, F., Wang, L., Lyon, G. J., Guan, Y., Shen, Y., Evgrafov, O. V., Knowles, J. A., Thibaud-Nissen, F., Schneider, V., Yu, C. Y., Zhou, L., Eichler, E. E., So, K. F., Wang, K. (June 2016) Long-read sequencing and de novo assembly of a Chinese genome. Nat Commun, 7. p. 12065. ISSN 2041-1723 (Electronic)2041-1723 (Linking)

Lyon, Gholson J. (April 2016) New human neurologic and intellectual disability syndromes involving transcription, translation, and protein degradation. In: Computational Genomics Seminar Series, Icahn School of Medicine at Mount Sinai, NY. (Unpublished)

Lyon, Gholson J. (February 2016) New human neurologic and intellectual disability syndromes involving transcription, translation, and protein degradation. In: Columbia Child Neurology and Institute of Genomic Medicine, Columbia University, New York, NY. (Unpublished)

Lyon, G. J. (February 2016) Speaker in Diagnostic Odyssey Session. In: Utah Rare Disease Symposium,, Salt Lake City, UT. (Unpublished)

Desai, A., Connelly, J. J., March, M., Hou, C., Chiavacci, R. , Kim, C., Lyon, G., Hadley, D., Hakonarson, H. (February 2016) Systematic data-querying of large pediatric biorepository identifies novel Ehlers-Danlos Syndrome variant. BMC Musculoskelet Disord, 17 (1). p. 80.

Kohler, S., Vasilevsky, N. A., Engelstad, M., Foster, E., McMurry, J., Ayme, S., Baynam, G., Bello, S. M., Boerkoel, C. F., Boycott, K. M., Brudno, M., Buske, O. J., Chinnery, P. F., Cipriani, V., Connell, L. E., Dawkins, H. J., DeMare, L. E., Devereau, A. D., de Vries, B. B., Firth, H. V., Freson, K., Greene, D., Hamosh, A., Helbig, I., Hum, C., Jahn, J. A., James, R., Krause, R., Laulederkind, S. J., Lochmuller, H., Lyon, G. J., Ogishima, S., Olry, A., Ouwehand, W. H., Pontikos, N., Rath, A., Schaefer, F., Scott, R. H., Segal, M., Sergouniotis, P. I., Sever, R., Smith, C. L., Straub, V., Thompson, R., Turner, C., Turro, E., Veltman, M. W., Vulliamy, T., Yu, J., von Ziegenweidt, J., Zankl, A., Zuchner, S., Zemojtel, T., Jacobsen, J. O., Groza, T., Smedley, D., Mungall, C. J., Haendel, M., Robinson, P. N. (January 2016) The Human Phenotype Ontology in 2017. Nucleic Acids Res, 45 (D1). D865-D876. ISSN 1362-4962 (Electronic)0305-1048 (Linking)

Lyon, Gholson J. (January 2016) A rare genetic “transcriptomopathy” syndrome leading to insights into more common neurologic disorders. In: New York City Wide Human Genetics Meeting 2016, Rockefeller University, New York City, NY. (Unpublished)

Lyon, Gholson J. (2016) Human Genetic Variation and the Genotype-Phenotype Problem. [Teaching Resource] (Unpublished)

Lyon, Gholson J. (2016) N-terminal acetyltransferases and Translation. [Teaching Resource] (Unpublished)

O’Rawe, Jason A, Wu, Yiyang, Dörfel, Max J, Rope, Alan F, Au, P. Y.  Billie, Parboosingh, Jillian S, Moon, Sungjin, Kousi, Maria, Kosma, Konstantina, Smith, Christopher S, Tzetis, Maria, Schuette, Jane L, Hufnagel, Robert B, Prada, Carlos E, Martinez, Francisco, Orellana, Carmen, Crain, Jonathan, Caro-Llopis, Alfonso, Oltra, Silvestre, Monfort, Sandra, Jiménez-Barrón, Laura T, Swensen, Jeffrey, Ellingwood, Sara, Smith, Rosemarie, Fang, Han, Ospina, Sandra, Stegmann, Sander, Den Hollander, Nicolette, Mittelman, David, Highnam, Gareth, Robison, Reid, Yang, Edward, Faivre, Laurence, Roubertie, Agathe, Rivière, Jean-Baptiste, Monaghan, Kristin G, Wang, Kai, Davis, Erica E, Katsanis, Nicholas, Kalscheuer, Vera M, Wang, Edith H, Metcalfe, Kay, Kleefstra, Tjitske, Innes, A.  Micheil, Kitsiou-Tzeli, Sophia, Rosello, Monica, Keegan, Catherine E, Lyon, Gholson J (December 2015) TAF1 Variants Are Associated with Dysmorphic Features, Intellectual Disability, and Neurological Manifestations. The American Journal of Human Genetics, 97 (6). pp. 922-932. ISSN 0002-9297

Jiménez-Barrón, Laura T., O'Rawe, Jason A., Wu, Yiyang, Yoon, Margaret, Fang, Han, Iossifov, Ivan, Lyon, Gholson J. (October 2015) Genome-wide variant analysis of simplex autism families with an integrative clinical-bioinformatics pipeline. Molecular Case Studies, 1 (1).

Lyon, Gholson J. (October 2015) Variants in TAF1 are associated with a new syndrome with severe intellectual disability and characteristic dysmorphic features. In: he American Society of Human Genetics (ASHG) 2015, Baltimore, MD. (Unpublished)

Lyon, Gholson J. (October 2015) A new intellectual disability syndrome. In: Seminar, Cold Spring Harbor Laboratory In-House Seminar Series, Cold Spring Harbor, NY. (Unpublished)

Guo, Y., Ding, X., Shen, Y., Lyon, G. J., Wang, K. (September 2015) SeqMule: automated pipeline for analysis of human exome/genome sequencing data. Sci Rep, 5. p. 14283. ISSN 2045-2322 (Electronic)2045-2322 (Linking)

Lyon, Gholson J. (September 2015) Ogden Syndrome and the role of Nα-acetylation in human health and disease. In: 2015 Symposium of National Creative Initiatives Center for Immune and Vascular Cell Network (NCIC-IVCN), Ewha Womans University, Seoul, Korea. (Unpublished)

Lyon, Gholson J. (September 2015) Optimized sequencing leading to new human genetic syndromes involving transcription, translation, and protein degradation. In: The 24th KOGO Annual Conference 2015 & The 10th Asian Epigenomics Meeting, The Korea Science and Technology Center, Seoul, Korea. (Unpublished)

Lyon, Gholson J. (September 2015) Optimized sequencing leading to new human genetic syndromes involving transcription, translation, and protein degradation. In: Seminar, Pohang University of Science and Technology (POSTECH), Pohang, South Korea. (Unpublished)

Lyon, Gholson J. (September 2015) Variants in TAF1 are associated with a new syndrome with severe intellectual disability and characteristic dysmorphic features. In: 17th International Fragile X and Other Early-Onset Cognitive Disorders Workshop, Strasbourg, France. (Unpublished)

Doerfel, Max, Lyon, Gholson J. (August 2015) The biological functions of Naa10 – from amino-terminal acetylation to human disease. Gene, 567 (2). pp. 103-131. ISSN 0378-1119

Lyon, Gholson J., O'Rawe, Jason (July 2015) Human genetics and clinical aspects of neurodevelopmental disorders. In: The Genetics of Neurodevelopmental Disorders. Wiley, pp. 289-317.

Lyon, Gholson J. (July 2015) Human genetic variation and the genotype-phenotype problem - part 1 of 2. In: Topical Talks: Talks of interest in the biomedical and life sciences. Henry Stewart Talks.

Lyon, Gholson J. (June 2015) (Hyper)tension release by N-terminal acetylation / Control of mammalian G protein signaling by N-terminal acetylation and the N-end rule pathway. Journal Club . (Unpublished)

Lyon, Gholson J. (June 2015) Sporulation in the Budding Yeast Saccharomyces cerevisiae. Journal Club . (Unpublished)

Lyon, Gholson J. (June 2015) Genetic Complexity and Neuropsychiatric Disorders. In: Institute of Medical Genetics and Functional Genomics, Hosted by Svetlana Gorokhova, Marseille, France. (Unpublished)

Lyon, G. J. (May 2015) Discovery and genetic characterization of new neuropsychiatric syndromes from family-based studies. In: Cold Spring Harbor Laboratory: The Biology of Genomes Meeting, Cold Spring Harbor, NY. (Unpublished)

Lyon, G. J. (May 2015) New human genetic syndromes leading to the discovery of new biology. In: Cold Spring Harbor Laboratory: 80th CSHL Symposium on Quantitative Biology – 21st Century Genetics: Genes at Work, Cold Spring Harbor, NY. (Unpublished)

Lyon, G. J. (May 2015) Using next generation sequencing to discover new human genetic syndromes and reveal new biology. In: GTCbio: 5th Next Generation Sequencing Conference, Boston, MA. (Unpublished)

Lyon, Gholson J. (April 2015) Association of Protein Biogenesis Factors at the Yeast Ribosomal Tunnel Exit Is Affected by the Translational Status and Nascent Polypeptide Sequence. Journal Club. (Unpublished)

Hirschtritt, M. E., Lee, P. C., Pauls, D. L., Dion, Y., Grados, M. A., Illmann, C., King, R. A., Sandor, P., McMahon, W. M., Lyon, G. J., Cath, D. C., Kurlan, R., Robertson, M. M., Osiecki, L., Scharf, J. M., Mathews, C. A. (April 2015) Lifetime Prevalence, Age of Risk, and Genetic Relationships of Comorbid Psychiatric Disorders in Tourette Syndrome. JAMA Psychiatry, 72 (4). p. 325. ISSN 2168-622x

Lyon, G. J. (April 2015) Variants in TAF1 are associated with a new syndrome with severe intellectual disability and characteristic dysmorphic features. In: 10th International Meeting on Copy Variants and Genes in Intellectual Disability and Autism, Troina, Italy. (Unpublished)

Lyon, Gholson J. (April 2015) The principle of antagonism ensures protein targeting specificity at the endoplasmic reticulum. Journal Club. (Unpublished)

Lyon, Gholson J. (March 2015) Cut the Hype. Accuracy and Standards Come First. Frontline Genomics, 2. pp. 19-23.

Lyon, Gholson J. (March 2015) An Organellar Na-Acetyltransferase, Naa60, Acetylates Cytosolic N Termini of Transmembrane Proteins and Maintains Goli Integrity. Journal Club. (Unpublished)

Lyon, G. J. (March 2015) Speaker, Rare Human Diseases as a Window into New Biology. In: Rare Human Diseases as a Window into New Biology, Lawrence, KS. (Unpublished)

Lyon, G. J. (March 2015) Variants in TAF1 are associated with a new syndrome with severe intellectual disability and characteristic dysmorphic features. In: Cold Spring Harbor Laboratory: Wiring the Brain, Cold Spring Harbor, NY. (Unpublished)

Hirschtritt, ME, Lee, PC, Pauls, DL, Dion, Yves, Grados, MA, Illmann, C, King, RA, Sandor, P., McMahon, W. M., Lyon, Gholson J., Cath, Danielle C., Kurlan, Roger, Robertson, M. M., Osiecki, L., Scharf, Jeremiah M., Matthews, Carol A. (February 2015) Lifetime Prevalence, Age of Risk, and Etiology of Comorbid Psychiatric Disorders in Tourette Syndrome. Tourette Syndrome Association International Consortium for Genetics.

Lyon, Gholson J. (February 2015) Autoacetylation regulates differentially the roles of ARD1 variants in tumorigenesis. Journal Club. (Unpublished)

Fang, Han, Lyon, Gholson J. (February 2015) Causal signals between codon bias, mRNA structure, and the efficiency of translation and elongation. Journal Club . (Unpublished)

Lyon, Gholson J. (February 2015) Different subcellular localizations and functions of human ARD1 variants. Journal Club . (Unpublished)

Lyon, Gholson J. (February 2015) Massively parallel single-amino-acid mutagenesis. Journal Club. (Unpublished)

Lyon, Gholson J. (February 2015) The Molecular Basis for Histone H4- and H2A Specific Amino-Terminal Acetylation by NatD. Journal Club . (Unpublished)

Lyon, Gholson J. (February 2015) NAA10 controls osteoblast differentiation and bone formation as a feedback regulator of Runx2. Journal Club . (Unpublished)

Lyon, G. J. (February 2015) Speaker, Utah’s Inaugural Rare Disease Day Symposium. In: Utah’s Inaugural Rare Disease Day Symposium, Salt Lake City, UT. (Unpublished)

Lyon, Gholson J. (February 2015) Translation inhibitors cause abnormalities in ribosome profiling experiments. Journal Club. (Unpublished)

He, M., Person, T. N., Hebbring, S. J., Heinzen, E., Ye, Z., Schrodi, S. J., McPherson, E. W., Lin, S. M., Peissig, P. L., Brilliant, M. H., O'Rawe, J., Robison, R. J., Lyon, G. J., Wang, K. (January 2015) SeqHBase: a big data toolset for family based sequencing data analysis. Journal of Medical Genetics, 52 (4). pp. 282-288. ISSN 0022-2593

O'Rawe, J. A., Ferson, S., Lyon, G. J. (January 2015) Accounting for uncertainty in DNA sequencing data. Trends Genet, 31 (2). pp. 61-68. ISSN 0168-9525

Lyon, Gholson J. (January 2015) A Ribosome-Bound Quality Control Complex Triggers Degradation of Nascent Peptides and Signals Translation Stress. Journal Club. (Unpublished)

Lyon, Gholson J. (January 2015) Rqc2p and 60S ribosomal subunits mediate mRNA-independent elongation of nascent chains. Journal Club. (Unpublished)

Lyon, Gholson J. (2015) Human genetic variation and the genotype-phenotype problem - part 2 of 2. [Video]

O'Rawe, Jason, Wu, Yiyang, Rope, Alan, Jimenez Barron, Laura, Swensen, Jeffrey J., Fang, Han, Mittelman, David, Highnam, Gareth, Robison, Reid J., Yang, Edward, Wang, Kai, Lyon, Gholson (2015) A variant in TAF1 is associated with a new syndrome with severe intellectual disability and characteristic dysmorphic features. bioRxiv. (Unpublished)

Myklebust, L. M., Van Damme, P., Stove, S. I., Dorfel, M. J., Abboud, A., Kalvik, T. V., Grauffel, C., Jonckheere, V., Wu, Y., Swensen, J., Kaasa, H., Liszczak, G., Marmorstein, R., Reuter, N., Lyon, G. J., Gevaert, K., Arnesen, T. (December 2014) Biochemical and cellular analysis of Ogden syndrome reveals downstream Nt-acetylation defects. Human Molecular Genetics, 24 (7). pp. 1956-1976. ISSN 0964-6906

Lyon, Gholson J. (December 2014) Crystal structure of a TAF1-TAF7 complex in human transcription factor IID reveals a promoter binding module. Journal Club. (Unpublished)

Lyon, Gholson J. (December 2014) Human Genetic Variation and the Genotype-Phenotype Problem. In: Lecture to GE510: Graduate Genetics Course, December 4, 2014, Stony Brook University, Stony Brook, NY . (Unpublished)

Barash, Carol Isaacson, Lyon, Gholson (November 2014) Open access and data sharing: Easier said than done. Applied & Translational Genomics. ISSN 2212-0661

Fang, Han, Lyon, Gholson J. (November 2014) Reducing INDEL calling errors in whole genome and exome sequencing data. In: Cold Spring Harbor Laboratory Biological Data Science Meeting, November 8, 2014, Cold Spring Harbor, NY. (Unpublished)

Jimenez Barron, Laura, Lyon, Gholson J. (November 2014) Genome Wide Variant Analysis of families with Autism Spectrum Disorder (ASD) using an Integrative Bioinformatics Pipeline. In: Cold Spring Harbor Laboratory Personal Genomes Meeting , November 2014, Cold Spring Harbor, NY . (Unpublished)

Lyon, Gholson J. (November 2014) Human Genetic Variation and the Genotype-Phenotype Problem. In: Lecture to Stony Brook University Psychology Students on "Molecular Psychology", Stony Brook University, Stony Brook, NY . (Unpublished)

Lyon, Gholson J. (November 2014) Human Genetics and Orphan Diseases. In: Cold Spring Harbor Laboratory In-House Symposium XXVIII, November 24 - 25, 2014, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY. (Unpublished)

O'Rawe, Jason, Lyon, Gholson J. (November 2014) Large pedigrees in human sequencing studies: toward a more resolved and accurate picture of genetic disease. In: Cold Spring Harbor Laboratory Personal Genomes Meeting, November 2014, Cold Spring Harbor, NY. (Unpublished)

Fang, Han, Lyon, Gholson J. (November 2014) Reducing INDEL calling errors in whole genome and exome sequencing data. In: Cold Spring Harbor Laboratory Personal Genomes Meeting, November 2014, Cold Spring Harbor, NY . (Unpublished)

Fang, Han, Lyon, Gholson J. (November 2014) Whole genome analysis of an extended pedigree with Prader-Willi Syndrome, Hereditary Hemochromatosis, Familial Dysautonomia, Tourette Syndrome and other illnesses. In: Cold Spring Harbor Laboratory Personal Genomes Meeting, November 2014, Cold Spring Harbor, NY. (Unpublished)

Lyon, Gholson J. (October 2014) N-terminal acetyltransferases and Translation. In: Lecture to Stony Brook Chemical Biology Graduate Students, October 30, 2014 , Stony Brook University, Stony Brook, NY. (Unpublished)

O'Rawe, Jason, Lyon, Gholson J. (October 2014) Large pedigrees in human sequencing studies: toward a more resolved and accurate picture of genetic disease. In: 64th Annual Meeting of the American Society of Human Genetics (ASHG), October 2014, San Diego, California. (Unpublished)

Doerfel, Max, Lyon, Gholson J. (October 2014) Molecular and cellular effects of the Ogden syndrome S37P mutation on the function of the N-terminal acetyltransferase Naa10. In: 64th Annual Meeting of the American Society of Human Genetics (ASHG), October 2014, San Diego, California. (Unpublished)

Fang, Han, Lyon, Gholson J. (October 2014) Reducing INDEL calling errors in whole-genome and exome sequencing. In: 64th Annual Meeting of the American Society of Human Genetics (ASHG), October 2014, San Diego, California. (Unpublished)

Lyon, Gholson J. (September 2014) Human Genetic Variation and the Genotype-Phenotype Problem. In: Lecture to Watson School Graduate Students , September 22, 2014, Cold Spring Harbor Laboratory. (Unpublished)

Fang, Han, Lyon, Gholson J. (September 2014) Genetic influences on translation in yeast. [Teaching Resource] (Unpublished)

Narzisi, G., O'Rawe, Jason, Iossifov, I., Fang, Han, Lee, Y. H., Wang, Zihua, Wu, Yiyang, Lyon, Gholson J., Wigler, M. H., Schatz, M. C. (August 2014) Accurate de novo and transmitted indel detection in exome-capture data using microassembly. Nature Methods, 11 (10). pp. 1033-1036.

Lyon, Gholson J. (July 2014) "Genetic Research, and its Application in Today's Health Care System". [Audio]

Lyon, Gholson J. (July 2014) "Ogden Syndrome and the Amino-Terminal Acetylation of Proteins". In: NIGMS Medical Scientist Training Program 50th Anniversary Symposium, July 17th 2014, NIH Campus - Bethesda, Maryland. (Unpublished)

Lyon, Gholson J. (June 2014) "Genetic Complexity and Neuropsychiatric Disorders". In: Nurturing Genetics: Reflections on a Century of Scientific and Social Change - An International and Interdisciplinary Symposium, June 29th - July 2nd 2014, University of Leeds, UK. (Unpublished)

Gholson, Lyon (June 2014) "Clinical genetics of neurodevelopmental disorders". In: Mount Sinai Medical Center - Invited Speaker, June 20th 2014, Department of Genetics and Genomic Sciences and the Institute for Genomics and Multiscale Biology at the Mount Sinai Medical Center. (Unpublished)

Jimenez Barron, Laura, Lyon, Gholson J. (June 2014) "Variant Analysis of Simplex Autism Families". In: CSHL Woodbury Genomic In-House Seminar, June 16th 2014, CSHL Woodbury Genome Center. (Unpublished)

Lyon, Gholson J. (June 2014) "The ARD1 Gene of Yeast Functions in the Switch between the Mitotic Cell Cycle and Alternative Developmental Pathways". Journal Club. (Unpublished)

Lyon, Gholson J. (June 2014) "ARD1 and NAT1 proteins from a complex that has N-terminal acetyltransferase activity". Journal Club. (Unpublished)

Lyon, Gholson J. (June 2014) "Genome sequencing identifies major causes of severe intellectual disability". Journal Club. (Unpublished)

Lyon, Gholson J. (June 2014) "Identification and characterization of genes and mutants for an N-terminal acetyltransferase from yeast". Journal Club. (Unpublished)

Lyon, Gholson J. (June 2014) "Identification of Methionine Na-Acetyltransferase from Saccharomyces cerevisiae". Journal Club. (Unpublished)

Lyon, Gholson J. (June 2014) "Model Peptides Reveal Specificity of Na-Acetyltransferase from Saccharomyces cerevisiae". Journal Club. (Unpublished)

Lyon, Gholson J. (June 2014) "Molecular Cloning and Sequencing of a cDNA Encoding Na-Acetyltransferase from Saccharomyces cerevisiae". Journal Club. (Unpublished)

Lyon, Gholson J. (June 2014) "NAT2, an Essential Gene Encoding Methionine Na-Acetyltransferase in the Yeast Saccharomyces cerevisiae". Journal Club. (Unpublished)

Lyon, Gholson J. (June 2014) "Na Acetylation Is Required for Normal Growth and Mating of Saccharomyces cerevisiae". Journal Club. (Unpublished)

Lyon, Gholson J. (June 2014) "Purification and Characterization of an Na-Acetyltransferase from Saccharomyces cerevisiae". Journal Club. (Unpublished)

Lyon, Gholson J. (June 2014) "The Yeast ARD1 Gene Product Is Required for Repression of Cryptic Mating-Type Information at the HML Locus". Journal Club. (Unpublished)

Lyon, Gholson J. (May 2014) Challenges for Clinical Implementation of Genomic Medicine. In: Ancestry.com, May 27th 2014, Provo, Utah. (Unpublished)

Lyon, Gholson J. (May 2014) Challenges for Clinical Implementation of Genomic Medicine. In: New York Genome Center Lecture Series, May 22nd 2014, New York Genome Center - NYC . (Unpublished)

Jimenez-Barron, Laura (May 2014) "Quantifying Absolute Protein Synthesis Rates Reveals Principles Underlying Allocation of Cellular Resources". Journal Club. (Unpublished)

McGrath, Lauren M., Yu, Dongmei, Marshall, Christian, Davis, Lea K., Thiruvahindrapuram, Bhooma, Li, Bingbin, Cappi, Carolina, Geber, Gloria, Wolf, Aaron, Schroeder, Frederick A., Osiecki, Lisa, O'Dushlaine, Colm, Kirby, Andrew, Illman, Cornelia, Haddad, Stephen, Gallagher, Patience, Fagerness, Jesen A., Barr, Cathy L., Bellodi, Laura, Benarroch, Fortu, Bienvenu, O. Joseph, Black, Donald W., Bloch, Michael H. , Bruun, Ruth D., Budman, Cathy L., Camarena, Beatriz, Cath, Danielle C., Cavallini, Maria C,, Chouinard, Sylvain, Coric , Vladimir, Cullen, Bernadette, Delomre, Richard, Denys, Damiaan, Derks, Eske M., Dion, Yves, Rosario, Maria C., Eapen, Valsama, Evans, Patrick, Falkai, Peter, Fernanadez , Thomas, Garrido, Helena, Geller, Daniel, Grabe, Hans J., Grados, Marco A., Greenberg, Benjamin D., Gross-Tsur, Varda, Grunblatt, Edna, Heiman , Gary A, Hemmings, Sian M.J., Herrera, Luis D., Hounie, Ana G., Jankovic, Joseph, Kennedy, James L., King, Robert A., Kurlan, Roger, Lanzagorta, Nuria, Leboyer, Marion, Leckman, James F., Lennertz, Leonhard, Lochner , Christine, Lowe, Thomas L., Lyon, Gholson J,, Maccaiardi, Fabio, Maier, Wolfgang, McCracken, James T., McMahon, William, Murphy, Dennis L., Naarden, Allan L., Neale, Benjamin M., Nurmi, Erika, Pakstis , Andrew J,, Pato, Michele T., Pato, Carlos N., Piacentini, John, Pittenger, Christopher, Pollak, Yehuda, Reus, Victor I., Richter, Maragret A., Riddle, Mark, Robertson, Mary M., Rosenberg, David , Rouleau, Guy A., Ruhrmann, Stephan, Sampaio, Aline S., Samuels, Jack, Sandor, Paul, Sheppard, Brooke, Singer, Harvey S., Smit, Jan H., Stein , Dan J., Tishfield, Jay A., Vallada, Homero, Veenstra-VanderWeele, Jeremy, Walitza, Susanne, Wang, Ying, Wendland, Jens R., Shugart , Yin Yao, Miguel, Euripedes C., Nicolini, Humberto, Oostra, Ben A., Moessner, Rainald, Wagner, Michael, Ruiz-Linares, Andres, Heutink, Peter, Nestadt, Gerald, Freimer, Nelson, Petryshen, Tracey, Posthuma, Danielle, Jenike, Michael A., Cox, Nancy J., Hanna, Gregory L., Brentani, Helena, Schrerer , Stephen W., Arnold, Paul D., Stewart, S. Evelyn, Matthews, Carol A., Knowles, James A., Cook, Edwin H., Pauls, David L., Wang, Kai, Scharf, Jeremiah M. (April 2014) Copy Number Variation in Obsessive-Compulsive Disorder and Tourette Syndrome: A Cross-Disorder Study. Journal of American Academy of Child & Adolescent Psychiatry, 53 (8). pp. 910-9. (In Press)

Fang, Han (April 2014) "Towards Better Understanding of Artifacts in Variant Calling from High-Coverage Samples". Journal Club. (Unpublished)

Lyon, Gholson J. (April 2014) "Whole genome sequencing, clinical interpretation, and deep brain stimulation in a severely mentally ill person". In: CSHL Neuronal Circuits Meeting, April 2nd-5th 2014, Cold Spring Harbor Laboratory. (Unpublished)

Brownstein, C. A., Beggs, A. H., Homer, N., Merriman, B., Yu, T. W., Flannery, K. C., Dechene, E. T., Towne, M. C., Savage, S. K., Price, E. N., Holm, I. A., Luquette, L. J., Lyon, E., Majzoub, J., Neupert, P., McCallie, D., Szolovits, P., Willard, H. F., Mendelsohn, N. J., Temme, R., Finkel, R. S., Yum, S. W., Medne, L., Sunyaev, S. R., Adzhubey, I., Cassa, C. A., de Bakker, P. I., Duzkale, H., Dworzy Ski, P., Fairbrother, W., Francioli, L., Funke, B. H., Giovanni, M. A., Handsaker, R. E., Lage, K., Lebo, M. S., Lek, M., Leshchiner, I., Macarthur, D. G., McLaughlin, H. M., Murray, M. F., Pers, T. H., Polak, P. P., Raychaudhuri, S., Rehm, H. L., Soemedi, R., Stitziel, N. O., Vestecka, S., Supper, J., Gugenmus, C., Klocke, B., Hahn, A., Schubach, M., Menzel, M., Biskup, S., Freisinger, P., Deng, M., Braun, M., Perner, S., Smith, R. J., Andorf, J. L., Huang, J., Ryckman, K., Sheffield, V. C., Stone, E. M., Bair, T., Black-Ziegelbein, E. A., Braun, T. A., Darbro, B., Deluca, A. P., Kolbe, D. L., Scheetz, T. E., Shearer, A. E., Sompallae, R., Wang, K., Bassuk, A. G., Edens, E., Mathews, K., Moore, S. A., Shchelochkov, O. A., Trapane, P., Bossler, A., Campbell, C. A., Heusel, J. W., Kwitek, A., Maga, T., Panzer, K., Wassink, T., Van Daele, D., Azaiez, H., Booth, K., Meyer, N., Segal, M. M., Williams, M. S., Tromp, G., White, P., Corsmeier, D., Fitzgerald-Butt, S., Herman, G., Lamb-Thrush, D. (March 2014) An international effort towards developing standards for best practices in analysis, interpretation and reporting of clinical genome sequencing results in the CLARITY Challenge. Genome Biology, 15 (3). R53. ISSN 1465-6906

Lyon, Gholson J. (March 2014) "Inefficient SRP interaction with a nascent chain triggers a mRNA quality control pathway". Journal Club. (Unpublished)

Lyon, Gholson J. (March 2014) "N-Terminal Acetylation Inhibits Protein Targeting to the Endoplasmic Reticulum". Journal Club. (Unpublished)

Lyon, Gholson J. (March 2014) National Academy of Sciences Journal Summit - Invited Panelist. In: National Academy of Sciences Journal Summit, March 2014, National Academy of Sciences, Washington D.C.. (Unpublished)

Lyon, Gholson J. (January 2014) Deep Brain Stimulation, Psychiatric Genetics, and iPS cell models of disease. In: CSHL In-House Seminar Series, Jan 24th 2014, Cold Spring Harbor Laboratory . (Unpublished)

Fang, Han, Lyon, Gholson J. (January 2014) Chromosome-scale scaffolding of de novo genome assemblies based on chromatin interactions. Journal Club. (Unpublished)

Lyon, Gholson J. (January 2014) Clinical Genomics of Neuropsychiatric Illnesses. In: Stony Brook University Division of Child and Adolescent Psychiatry, Seminar, Invited Speaker, January 2014, Stony Brook, NY. (Unpublished)

Lyon, Gholson J. (January 2014) "N(α)-Acetylation of yeast ribosomal proteins and its effect on protein synthesis". Journal Club. (Unpublished)

Kota, Prashant, Lyon, Gholson J. (January 2014) "The N-Terminal Methionine of Cellular Proteins as a Degradation Signal". Journal Club. (Unpublished)

Lyon, Gholson J. (January 2014) "Whole-genome haplotype reconstruction using proximity-ligation and shotgun sequencing". Journal Club. (Unpublished)

Wu, Yiyang, Lyon, Gholson J. (January 2014) A splice donor mutation in NAA10 results in the dysregulation of the retinoic acid signalling pathway and causes Lenz microphthalmia syndrome. Journal Club. (Unpublished)

Shi, L, Li, Bingbin, Huang, Y., Liu, T, Lyon, Gholson J., Xu, A, Wang, Kai (2014) "Genotype-first" approaches on a curious case of idiopathic progressive cognitive decline. BMC Med Genomics, 7 (1). p. 66.

Lyon, Gholson J., Doerfel, Max, O'Rawe, Jason, Fang, Han, Jimenez Barron, Laura (2014) Human Genetics and Genomic Medicine. Cold Spring Harbor Laboratory.

Fang, Han, Wu, Yiyang, Narzisi, G., O'Rawe, Jason, Jimenez Barron, Laura, Rosenbaum, J., Ronemus, M., Iossifov, I., Schatz, M. C., Lyon, Gholson J. (2014) Reducing INDEL calling errors in whole genome and exome sequencing data. Genome Med, 6 (10). p. 89.

Lyon, Gholson J. (December 2013) "FDA Crackdown on 23ndMe Delays a Revolution in Medicine, says Medical Geneticist, Gholson Lyon". [Audio]

Lyon, Gholson J. (December 2013) "Epidemiology, epigenetics and the ‘Gloomy Prospect’: embracing randomness in population health research and practice". Journal Club. (Unpublished)

Lyon, Gholson J. (December 2013) FDA Crackdown on 23andMe Delays a Revolution in Medicine. [Audio] (Unpublished)

Lyon, Gholson J. (December 2013) Increasing Accuracy for Exome and Whole Genome Sequencing. In: Bio-IT World and Cambridge Healthtech Institute's Inaugural- Clinical Exome Sequencing, December 4-5th 2013, Lisbon, Portugal. (Unpublished)

Lyon, Gholson J. (November 2013) Advancing Precision Medicine through clinical grade whole genome sequencing, return of results and deep brain stimulation. [Video] (Unpublished)

Lyon, Gholson J. (November 2013) Advancing Precision Medicine through clinical grade whole genome sequencing, return of results and deep brain stimulation. In: Precision Medicine: Personal Genomes & Pharmacogenomics, Nov 13th - Nov 16th 2103, Cold Spring Harbor, NY . (Unpublished)

Lyon, Gholson J. (November 2013) Cambridge HealthTech Institute Clinical Genomics Podcast: Highlights from the Upcoming Clinical Exome Sequencing Conference. [Audio]

Lyon, Gholson J. (November 2013) Stopping 23andMe will only delay the revolution medicine needs. In: The Conversation.

O'Rawe, Jason, Wu, Yiyang, Mittelman, David, Fang, Han, Lyon, Gholson J. (November 2013) Uncovering genetic components of a previously un-described syndrome. In: Cold Spring Harbor Laboratory: Precision Medicine Meeting, November 2013, Cold Spring Harbor, New York. (Unpublished)

Fang, Han, Wu, Yiyang, O'Rawe, Jason, Mittelman, David, Lyon, Gholson J. (November 2013) Whole genome sequencing analysis of a family with familial dysautonomia and neuropsychiatric symptoms. In: Cold Spring Harbor Laboratory Precision Medicine Meeting, November 2013, Cold Spring Harbor, New York. (Unpublished)

Lyon, Gholson J. (November 2013) "The ubiquitin reference technique and tandem fluorescence timers". Journal Club. (Unpublished)

Lyon, Gholson J. (October 2013) Amino-terminal acetylation of proteins by N-terminal acetyltransferases: mechanisms and relevance to human genetic diseases. In: Stony Brook University Department of Chemistry Seminar Series, Oct 3rd 2013, Stony Brook, NY. (Unpublished)

Lyon, Gholson J. (October 2013) Amino-terminal acetylation of proteins: role in human disease and biology. In: Stony Brook University Department of Pharmacology Seminar Series, Oct 29th 2013, Stony Brook, NY. (Unpublished)

Lyon, Gholson J. (October 2013) "Control of protein quality and stoichiometries by N-terminal acetylation and the N-end rule pathway". Journal Club. (Unpublished)

O'Rawe, Jason, Fang, Han, Rynearson, Shawn, Robison, Reid J., Kiruluta, Edward S., Higgins, Gerald, Eilbeck, Karen, Reese, Martin G., Lyon, Gholson J. (October 2013) Integrating precision medicine in the study and clinical treatment of a severely mentally ill person. PeerJ, 1. e177.

Lyon, Gholson J. (September 2013) Childhood-­onset Neuropsychiatric Disorders. In: FarGen Summit (Faroe Genome Project), Sept 19th-20th 2013, Tórshavn, The Faroe Islands. (Unpublished)

Lyon, Gholson J. (September 2013) N=1 Human Study in Clinical Neurosciences: Genomics Guided Medicine and Deep Brain Stimulation. In: 5th Annual Consumer Genetics Conference, Sept 25th-27th 2013, Boston, MA. (Unpublished)

Levine, Jesse (September 2013) Pluripotent Stem Cells Induced from Mouse Somatic Cells by Small- Molecule Compounds. Journal Club. (Unpublished)

O'Rawe, Jason, Fang, Han, Rynearson, Shawn, Robison, Reid J., Kiruluta, Edward S., Higgins, Gerald, Eilbeck, Karen, Reese, Martin G., Lyon, Gholson J. (August 2013) Supplemental figure 1 for "Integrating precision medicine in the study and clinical treatment of a severely mentally ill person.". [Image] (Unpublished)

O'Rawe, Jason, Fang, Han, Rynearson, Shawn, Robison, Reid J., Kiruluta, Edward S., Higgins, Gerald, Eilbeck, Karen, Reese, Martin G., Lyon, Gholson J. (August 2013) Supplemental figure 2 for "Integrating precision medicine in the study and clinical treatment of a severely mentally ill person.". [Image] (Unpublished)

O'Rawe, Jason, Fang, Han, Rynearson, Shawn, Robison, Reid J., Kiruluta, Edward S., Higgins, Gerald, Eilbeck, Karen, Reese, Martin G., Lyon, Gholson J. (August 2013) Supplemental figure 4 for "Integrating precision medicine in the study and clinical treatment of a severely mentally ill person.". [Image] (Unpublished)

O'Rawe, Jason, Fang, Han, Rynearson, Shawn, Robison, Reid J., Kiruluta, Edward S., Higgins, Gerald, Eilbeck, Karen, Reese, Martin G., Lyon, Gholson J. (August 2013) Supplemental figure 5 for "Integrating precision medicine in the study and clinical treatment of a severely mentally ill person.". [Image] (Unpublished)

O'Rawe, Jason, Fang, Han, Rynearson, Shawn, Robison, Reid J., Kiruluta, Edward S., Higgins, Gerald, Eilbeck, Karen, Reese, Martin G., Lyon, Gholson J. (August 2013) Supplemental file 10 for "Integrating precision medicine in the study and clinical treatment of a severely mentally ill person.". [Dataset] (Unpublished)

O'Rawe, Jason, Fang, Han, Rynearson, Shawn, Robison, Reid J., Kiruluta, Edward S., Higgins, Gerald, Eilbeck, Karen, Reese, Martin G., Lyon, Gholson J. (August 2013) Supplemental file 11 for "Integrating precision medicine in the study and clinical treatment of a severely mentally ill person.". UNSPECIFIED. (Unpublished)

O'Rawe, Jason, Fang, Han, Rynearson, Shawn, Robison, Reid J., Kiruluta, Edward S., Higgins, Gerald, Eilbeck, Karen, Reese, Martin G., Lyon, Gholson J. (August 2013) Supplemental file 12 for "Integrating precision medicine in the study and clinical treatment of a severely mentally ill person.". [Dataset] (Unpublished)

Lyon, Gholson J., O'Rawe, Jason, Robison, Reid J., Kiruluta, Edward S., Higgins, Gerald, Reese, Martin G. (August 2013) Supplemental file 1 for "Integrating precision medicine in the study and clinical treatment of a severely mentally ill person.". [Dataset] (Unpublished)

O'Rawe, Jason, Fang, Han, Rynearson, Shawn, Robison, Reid J., Kiruluta, Edward S., Higgins, Gerald, Eilbeck, Karen, Reese, Martin G., Lyon, Gholson J. (August 2013) Supplemental file 2 for "Integrating precision medicine in the study and clinical treatment of a severely mentally ill person.". [Dataset] (Unpublished)

O'Rawe, Jason, Fang, Han, Rynearson, Shawn, Robison, Reid J., Kiruluta, Edward S., Higgins, Gerald, Eilbeck, Karen, Reese, Martin G., Lyon, Gholson J. (August 2013) Supplemental file 3 for "Integrating precision medicine in the study and clinical treatment of a severely mentally ill person.". [Dataset] (Unpublished)

O'Rawe, Jason, Fang, Han, Rynearson, Shawn, Robison, Reid J., Kiruluta, Edward S., Higgins, Gerald, Eilbeck, Karen, Reese, Martin G., Lyon, Gholson J. (August 2013) Supplemental file 4 for "Integrating precision medicine in the study and clinical treatment of a severely mentally ill person.". [Dataset] (Unpublished)

O'Rawe, Jason, Fang, Han, Rynearson, Shawn, Robison, Reid J., Kiruluta, Edward S., Higgins, Gerald, Eilbeck, Karen, Reese, Martin G., Lyon, Gholson J. (August 2013) Supplemental file 5 for "Integrating precision medicine in the study and clinical treatment of a severely mentally ill person.". [Dataset] (Unpublished)

O'Rawe, Jason, Fang, Han, Rynearson, Shawn, Robison, Reid J., Kiruluta, Edward S., Higgins, Gerald, Eilbeck, Karen, Reese, Martin G., Lyon, Gholson J. (August 2013) Supplemental file 6 for "Integrating precision medicine in the study and clinical treatment of a severely mentally ill person.". [Dataset] (Unpublished)

O'Rawe, Jason, Fang, Han, Rynearson, Shawn, Robison, Reid J., Kiruluta, Edward S., Higgins, Gerald, Eilbeck, Karen, Reese, Martin G., Lyon, Gholson J. (August 2013) Supplemental file 7 for "Integrating precision medicine in the study and clinical treatment of a severely mentally ill person.". [Dataset] (Unpublished)

O'Rawe, Jason, Fang, Han, Rynearson, Shawn, Robison, Reid J., Kiruluta, Edward S., Higgins, Gerald, Eilbeck, Karen, Reese, Martin G., Lyon, Gholson J. (August 2013) Supplemental file 8 for "Integrating precision medicine in the study and clinical treatment of a severely mentally ill person.". [Dataset] (Unpublished)

O'Rawe, Jason, Fang, Han, Rynearson, Shawn, Robison, Reid J., Kiruluta, Edward S., Higgins, Gerald, Eilbeck, Karen, Reese, Martin G., Lyon, Gholson J. (August 2013) Supplemental file 9 for "Integrating precision medicine in the study and clinical treatment of a severely mentally ill person.". [Dataset] (Unpublished)

Fang, Han (August 2013) Finding the sources of missing heritability in a yeast cross. Journal Club. (Unpublished)

Lyon, Gholson J. (August 2013) Molecular basis for N-terminal acetylation by the heterodimeric NatA complex. Journal Club. (Unpublished)

Fang, Han (July 2013) Whole Genome Sequencing in support of Wellness and Health Maintenance. Journal Club. (Unpublished)

Lyon, Gholson J. (July 2013) Whole genome sequencing, clinical interpretation, and deep brain stimulation in a severely mentally ill person. In: Gordon Research Conference, Human Genetics and Genomics, July 7th-12th 2013, Bryant University, Smithfield, RI . (Unpublished)

Lyon, Gholson J. (July 2013) Whole genome sequencing, clinical interpretation, and deep brain stimulation in a severely mentally ill person. In: Wiring the Brain - Cold Spring Harbor Laboratory, July 18th-22nd 2013, Cold Spring Harbor, New York. (Unpublished)

Wang, K., Kim, C., Bradfield, J., Guo, Y. F., Toskala, E., Otieno, F. G., Hou, C. P., Thomas, K., Cardinale, C., Lyon, G. J., Golhar, R., Hakonarson, H. (July 2013) Whole-genome DNA/RNA sequencing identifies truncating mutations in RBCK1 in a novel Mendelian disease with neuromuscular and cardiac involvement. Genome Medicine, 5. ISSN 1756-994X

Lyon, Gholson J. (June 2013) The Chaperone-Like Protein HYPK Acts Together with NatA in Cotranslational N-Terminal Acetylation and Prevention of Huntingtin Aggregation. Journal Club. (Unpublished)

Lyon, Gholson J. (June 2013) Toward more accurate variant calling for personal genomes. In: The Clinical Genome Conference, June 25th-26th 2013, San Francisco, CA. (Unpublished)

O'Rawe, Jason, Fang, Han, Rynearson, Shawn, Robison, Reid J., Kiruluta, Edward S., Higgins, Gerald, Eilbeck, Karen, Reese, Martin G., Lyon, Gholson J. (May 2013) Supplemental figure 3 for "Integrating precision medicine in the study and clinical treatment of a severely mentally ill person.". [Image] (Unpublished)

Lyon, Gholson J. (May 2013) Clinical genetics and other aspects of neuropsychiatric disorders. In: The International Behavioural and Neural Genetics Society (IBANGS), Genes, Brain & Behavior 15th Annual Meeting, May 20th-24th 2013, Leuven, Belgium. (Unpublished)

Lyon, Gholson J. (May 2013) Clinical genetics and other aspects of neuropsychiatric disorders. In: NGS Translate World Forum, May 28th-31st 2013, Boston, MA. (Unpublished)

Lyon, Gholson J. (May 2013) Exome and Genome Sequencing. [Teaching Resource] (Unpublished)

O'Rawe, Jason, Jiang, Tao, Sun, Guangqing, Wu, Yiyang, Wang, Wei, Hu, Jingchu, Bodily, Paul, Tian, Lifeng, Hakonarson, Hakon, Johnson, W. Evan, Robison, Reid J., Wei, Zhi, Wang, Kai, Lyon, Gholson J. (May 2013) Low concordance of multiple variant-calling pipelines: practical implications for exome and genome sequencing. In: The Biology of Genomes , May 2013, Cold Spring Harbor Laboratory. (Unpublished)

Lyon, Gholson J. (April 2013) Low concordance of multiple variant-calling pipelines: practical implications for exome and genome sequencing. In: COMPUTATIONAL BIOLOGY & BIOINFORMATICS SEMINAR SERIES, April 10th 2013, Cold Spring Harbor Laboratory. (Unpublished)

Lyon, Gholson J. (April 2013) Exome and Genome Sequencing. [Teaching Resource] (Unpublished)

Lyon, Gholson J. (April 2013) Genome Engineering Using CRISPR. Journal Club. (Unpublished)

O'Rawe, J., Jiang, T., Sun, G., Wu, Y., Wang, W., Hu, J., Bodily, P., Tian, L., Hakonarson, H., Johnson, W. E., Wei, Z., Wang, K., Lyon, G. J. (March 2013) Low concordance of multiple variant-calling pipelines: practical implications for exome and genome sequencing. Genome Med, 5 (3). p. 28. ISSN 1756-994X (Print)

Lyon, Gholson J. (March 2013) Controversies in Giving Data Back. In: The Future of Genomic Medicine VI, March 7th-8th 2013, La Jolla, CA. (Unpublished)

Lyon, Gholson J., Robison, Reid J., Wang, Kai (March 2013) The Implementation of Clinical Genomics: Ethical, Societal and Regulatory Considerations. In: ACMG Annual Clinical Genetics Meeting, March 19th-23rd 2013, Phoenix, AZ. (Unpublished)

O'Rawe, Jason, Jiang, Tao, Sun, Guangqing, Wu, Yiyang, Wang, Wei, Hu, Jingchu, Bodily, Paul, Tian, Lifeng, Harkonarson, Hakon, Johnson, W. Evan, Robison, Reid J., Wei, Zhi, Wang, Kai, Lyon, Gholson J. (March 2013) Toward more accurate variant calling for “personal genomes”. In: ACMG Annual Clinical Genetics Meeting, March 19th-23rd 2013, Phoenix, AZ. (Unpublished)

Lyon, Gholson J., O'Rawe, Jason, Wu, Yiyang, Rope, Alan, Robison, Reid J., Wang, Kai, Swensen, Jeffrey J. (March 2013) Whole Genome Sequencing Analysis of an Idiopathic Intellectual Disability Syndrome. In: ACMG Annual Clinical Genetics Meeting, March 19th-23rd 2013, Phoenix, AZ. (Unpublished)

Wu, Yiyang (March 2013) The evolution of MIP technology. Journal Club. (Unpublished)

Lyon, Gholson J., Segal, Jeremy P. (February 2013) Practical, ethical and regulatory considerations for the evolving medical and research genomics landscape. Applied & Translational Genomics, 2 (1). pp. 34-40. ISSN 2212-0661 (In Press)

Lyon, Gholson J. (February 2013) Whole Genome Sequencing Analysis of a severe Idiopathic Intellectual Disability Syndrome or "limitations of theory may not be revealed when the facts are too few" - Knox 1958. In: 20th Annual Molecular Psychiatry Meeting, Feb 3rd-5th 2013, Park City, UT. (Unpublished)

Lyon, Gholson J. (2013) Genetic and Biochemical Analysis of Childhood-­Onset Idiopathic Neuropsychiatric Disorders. In: Institute for Computational Biomedicine and Department of Physiology and Biophysics Seminar Series, Feb 13th 2013, Weill Cornell Medical College, New York, NY. (Unpublished)

Lyon, Gholson J., Doerfel, Max, O'Rawe, Jason, Wu, Yiyang, Fang, Han, Kota, Prashant, Jimenez Barron, Laura (2013) Human Genetics and Genomic Medicine. Cold Spring Harbor Laboratory.

Lyon, Gholson J. (2013) Human Subject Research Protocol. Gholson Lyon. (Unpublished)

Lyon, Gholson J. (2013) Informed Consent for Human Subject Research Project. Gholson Lyon. (Unpublished)

O'Rawe, Jason, Fang, Han, Rynearson, Shawn, Robison, Reid J., Kiruluta, Edward S., Higgins, Gerald, Eilbeck, Karen, Reese, Martin G., Lyon, Gholson J. (2013) Supplementary video of subject M.A for Integrating precision medicine in the study and clinical treatment of a severely mentally ill person. PeerJ 1:e177. [Video]

Shi, L., Zhang, X., Golhar, R., Otieno, F. G., He, M., Hou, C., Kim, C., Keating, B., Lyon, G. J., Wang, K., Hakonarson, H. (2013) Whole-genome sequencing in an autism multiplex family. Molecular Autism, 4 (1). p. 8. ISSN 2040-2392 (Electronic)

Lyon, Gholson J., Bird, Lynne M., Rope, Alan (2013) X-linked Malformation and Infantile Lethality Syndrome (provisionally named Ogden Syndrome). In: Inborn errors of development. Oxford University Press, Oxford; New York. ISBN 9780195306910 (Submitted)

Lyon, Gholson J. (November 2012) Software Considerations for Processing, Analyzing and Interpreting Exome & Genome Sequence Data in Clinical Settings. In: World Genome Data Analysis Summit: Pre Conference Workshop, Nov 27th 2012, San Francisco. (Unpublished)

Lyon, Gholson J. (November 2012) Talk from Gholson Lyon at the Cold Spring Harbor Laboratory In-House Symposium (2012). [Video] (Unpublished)

Lyon, Gholson J. (October 2012) The Implementation of Clinical Genomics: Ethical, Societal and Regulatory Considerations. In: Consumer Genetics Conference, Oct 5th 2012, Boston, MA. (Unpublished)

Lyon, Gholson J. (October 2012) Implementation of Variant Calling Algorithms in Clinical Genome Sequencing. In: Bio-IT Europe The Road to the Clinic: Applying Genomics in a Clinical Setting , Oct 10th 2012, Vienna, Austria. (Unpublished)

Lyon, Gholson J. (October 2012) Summary of Efforts to Achieve and Evaluate High-Quality Exomes and Genomes. In: Bio-IT Europe Pre-Conference Short Courses: Software Considerations for Processing, Analyzing and Interpreting Sequence Data , Oct 8th 2012, Vienna, Austria. (Unpublished)

Lyon, Gholson J. (September 2012) Clinical Genomics Perspective in Psychiatry. In: 3rd Annual Child and Adolescent Psychotherapy and Psychopharmacology Conference, Sept 2012, Philadelphia, PA. (Unpublished)

Lyon, Gholson J. (August 2012) Humanizing the Human Genome Project. In: Project Syndicate: The World's Opinion Page, August 2, 2012.

Lyon, Gholson J. (August 2012) Taking NGS into the Clinic. In: Cambridge Healthtech Institute Next Gen Seq Meeting, Aug 16th 2012, Providence, RI. (Unpublished)

Lyon, Gholson J. (July 2012) The Implementation of Clinical Genomics: Ethical, Societal and Regulatory Considerations. In: 20th Annual International Conference on Intelligent Systems for Molecular Biology: High Throughput Sequencing Special Interest Group Meeting, July 13th-14th 2012, Long Beach, CA. (Unpublished)

Lyon, Gholson J. (2012) Challenges of Clinical Implementation of Genomic Medicine. In: Invited Presentation at New York Genome Center, Dec 2012, New York Genome Center. (Unpublished)

Lyon, Gholson J. (2012) Challenges of Clinical Implementation of Genomic Medicine. In: Cold Spring Harbor Laboratory In House Seminar , Nov 20th 2012, Cold Spring Harbor Laboratory. (Unpublished)

Lyon, Gholson J. (2012) Clinical Issues with the Return of Next-­Generation Sequencing Results. In: The Clinical Genome Conference, June 12th-13th 2012, San Francisco, CA. (Unpublished)

Lyon, Gholson J. (2012) Clinical progress in autism genetics and treatment. In: Systems biology of autism: from basic science to therapeutic strategies , Sept 9-­12, 2012. (Unpublished)

Lyon, Gholson J. (2012) Ethics Panel: Challenges of Clinical Implementation of Genomic Medicine. In: Personal Genomes & Medical Genomics Meeting, Nov 16th 2012, Cold Spring Harbor Laboratory. (Unpublished)

Lyon, Gholson J. (2012) Genetics and Genome Sequencing of Childhood-Onset Neuropsychiatric Disorders. In: Department of Psychiatry and Behavioral Science Grand Rounds, Dec 18th 2012, Stony Brook University . (Unpublished)

Scharf, J. M., Yu, D., Mathews, C. A., Neale, B. M., Stewart, S. E., Fagerness, J. A., Evans, P., Gamazon, E., Edlund, C. K., Service, S. K., Tikhomirov, A., Osiecki, L., Illmann, C., Pluzhnikov, A., Konkashbaev, A., Davis, L. K., Han, B., Crane, J., Moorjani, P., Crenshaw, A. T., Parkin, M. A., Reus, V. I., Lowe, T. L., Rangel-Lugo, M., Chouinard, S., Dion, Y., Girard, S., Cath, D. C., Smit, J. H., King, R. A., Fernandez, T. V., Leckman, J. F., Kidd, K. K., Kidd, J. R., Pakstis, A. J., State, M. W., Herrera, L. D., Romero, R., Fournier, E., Sandor, P., Barr, C. L., Phan, N., Gross-Tsur, V., Benarroch, F., Pollak, Y., Budman, C. L., Bruun, R. D., Erenberg, G., Naarden, A. L., Lee, P. C., Weiss, N., Kremeyer, B., Berrio, G. B., Campbell, D. D., Cardona Silgado, J. C., Ochoa, W. C., Mesa Restrepo, S. C., Muller, H., Valencia Duarte, A. V., Lyon, G. J., Leppert, M., Morgan, J., Weiss, R., Grados, M. A., Anderson, K., Davarya, S., Singer, H., Walkup, J., Jankovic, J., Tischfield, J. A., Heiman, G. A., Gilbert, D. L., Hoekstra, P. J., Robertson, M. M., Kurlan, R., Liu, C., Gibbs, J. R., Singleton, A., Hardy, J., Strengman, E., Ophoff, R. A., Wagner, M., Moessner, R., Mirel, D. B., Posthuma, D., Sabatti, C., Eskin, E., Conti, D. V., Knowles, J. A., Ruiz-Linares, A., Rouleau, G. A., Purcell, S., Heutink, P., Oostra, B. A., McMahon, W. M., Freimer, N. B., Cox, N. J., Pauls, D. L. (2012) Genome-wide association study of Tourette's syndrome. Molecular Psychiatry, 18 (6). pp. 721-728. ISSN 1476-5578

Elia, J., Glessner, J. T., Wang, K., Takahashi, N., Shtir, C. J., Hadley, D., Sleiman, P. M. A., Zhang, H., Kim, C. E., Robison, R., Lyon, G. J., Flory, J. H., Bradfield, J. P., Imielinski, M., Hou, C., Frackelton, E. C., Chiavacci, R. M., Sakurai, T., Rabin, C., Middleton, F. A., Thomas, K. A., Garris, M., Mentch, F., Freitag, C. M., Steinhausen, H. C., Todorov, A. A., Reif, A., Rothenberger, A., Franke, B., Mick, E. O., Roeyers, H., Buitelaar, J., Lesch, K. P., Banaschewski, T., Ebstein, R. P., Mulas, F., Oades, R. D., Sergeant, J., Sonuga-Barke, E., Renner, T. J., Romanos, M., Romanos, J., Warnke, A., Walitza, S., Meyer, J., Pálmason, H., Seitz, C., Loo, S. K., Smalley, S. L., Biederman, J., Kent, L., Asherson, P., Anney, R. J. L., Gaynor, J. W., Shaw, P., Devoto, M., White, P. S., Grant, S. F. A., Buxbaum, J. D., Rapoport, J. L., Williams, N. M., Nelson, S. F., Faraone, S. V., Hakonarson, H. (2012) Genome-wide copy number variation study associates metabotropic glutamate receptor gene networks with attention deficit hyperactivity disorder. Nature Genetics, 44 (1). pp. 78-84. ISSN 1061-4036

Badner, J. A., Koller, D., Foroud, T., Edenberg, H., Nurnberger, J. I., Zandi, P. P., Willour, V. L., McMahon, F. J., Potash, J. B., Hamshere, M., Grozeva, D., Green, E., Kirov, G., Jones, I., Jones, L., Craddock, N., Morris, D., Segurado, R., Gill, M., Sadovnick, D., Remick, R., Keck, P., Kelsoe, J., Ayub, M., MacLean, A., Blackwood, D., Liu, C. Y., Gershon, E. S., McMahon, W., Lyon, G. J., Robinson, R., Ross, J., Byerley, W. (2012) Genome-wide linkage analysis of 972 bipolar pedigrees using single-nucleotide polymorphisms. Molecular Psychiatry, 17 (8). pp. 818-826. ISSN 1476-5578

Lyon, Gholson J. (2012) Guest post: Time to bring human genome sequencing into the clinic. Discussion Paper. genomesunzipped.org.

Lyon, Gholson J., Doerfel, Max, O'Rawe, Jason, Wu, Yiyang, Kota, Prashant (2012) Human Genetics and Genomic Medicine. Cold Spring Harbor Laboratory.

Gramza, Joyce, Lyon, Gholson J. (2012) Humane Treatment for Patients: How to Handle Genetic Information. [Audio]

Lyon, Gholson J., Wang, Kai (2012) Identifying disease mutations in genomic medicine settings: current challenges and how to accelerate progress. Genome Medicine, 4 (7). p. 58. ISSN 1756-994X (Electronic)

Lyon, Gholson J. (2012) A New Tool for Personal Genomics. [Audio]

Lyon, G. J. (2012) Personalized medicine: Bring clinical standards to human-genetics research. Nature, 482 (7385). pp. 300-301. ISSN 00280836 (ISSN)

Lyon, G. J. (2012) There is nothing 'incidental' about unrelated findings. Personalized Medicine, 9 (2). pp. 163-166. ISSN 17410541 (ISSN)

Lyon, Gholson J. (October 2011) The 2011 William Allan Award of the American Society of Human Genetics to the Right Person "J.M. Opitz"? [Teaching Resource] (Unpublished)

Lyon, Gholson J. (September 2011) Returning Research Results from Next‐Generation Sequencing and Analysis to Patients with Idiopathic Disorders? In: Personal Genomes Meeting, Sept 30th - Oct 2nd 2011, Cold Spring Harbor Laboratory. (Unpublished)

Lyon, Gholson J., Jiang, Tao, Van Wijk, Richard, Wang, Wei, Bodily, Paul Mark, Xing, Jinchuan, Tian, Lifeng, Robison, Reid J., Clement, Mark, Lin, Yang, Zhang, Peng, Liu, Ying, Moore, Barry, Glessner, Joseph T., Elia, Josephine, Reimherr, Fred, van Solinge, Wouter W., Yandell, Mark, Hakonarson, Hakon, Wang, Jun, Johnson, William Evan, Wei, Zhi, Wang, Kai (2011) Exome sequencing and unrelated findings in the context of complex disease research: ethical and clinical implications. Dscovery Medicine, 12 (62). pp. 41-55. ISSN 1944-7930

Lyon, Gholson J. (2011) Finding and Analyzing Human Genetic Variation in Neuropsychiatric Disorders. In: Faculty Recruitment Talk, Dec 2011, Cold Spring Harbor Laboratory. (Unpublished)

Lyon, Gholson J. (2011) Personal account of the discovery of a new disease using next-generation sequencing. Interview by Natalie Harrison. Pharmacogenomics, 12 (11). pp. 1519-1523. ISSN 1744-8042

Lyon, Gholson J., Abi-Dargham, Anissa, Moore, Holly, Lieberman, Jeffrey A., Javitch, Jonathan A., Sulzer, David (2011) Presynaptic regulation of dopamine transmission in schizophrenia. Schizophrenia Bulletin, 37 (1). pp. 108-117. ISSN 1745-1701

Wei, Zhi, Wang, Wei, Hu, Pingzhao, Lyon, Gholson J., Hakonarson, Hakon (2011) SNVer: a statistical tool for variant calling in analysis of pooled or individual next-generation sequencing data. Nucleic Acids Research, 39 (19). e132. ISSN 03051048 (ISSN)

Rope, Alan F., Wang, Kai, Evjenth, Rune, Xing, Jinchuan, Johnston, Jennifer J., Swensen, Jeffrey J., Johnson, W. Evan, Moore, Barry, Huff, Chad D., Bird, Lynne M., Carey, John C., Opitz, John M., Stevens, Cathy A., Jiang, Tao, Schank, Christa, Fain, Heidi Deborah, Robison, Reid, Dalley, Brian, Chin, Steven, South, Sarah T., Pysher, Theodore J., Jorde, Lynn B., Hakonarson, Hakon, Lillehaug, Johan R., Biesecker, Leslie G., Yandell, Mark, Arnesen, Thomas, Lyon, Gholson J. (2011) Using VAAST to identify an X-linked disorder resulting in lethality in male infants due to N-terminal acetyltransferase deficiency. American Journal of Human Genetics, 89 (1). pp. 28-43. ISSN 0002-9297

Lyon, Gholson J., Samar, Stephanie M., Conelea, Christine, Trujillo, Marcel R., Lipinski, Christina M., Bauer, Christopher C., Brandt, Bryan C., Kemp, Joshua J., Lawrence, Zoe E., Howard, Jonathan, Castellanos, F. Xavier, Woods, Douglas, Coffey, Barbara J. (2010) Testing tic suppression: comparing the effects of dexmethylphenidate to no medication in children and adolescents with attention-deficit/hyperactivity disorder and Tourette's disorder. Journal of Child and Adolescent Psychopharmacology, 20 (4). pp. 283-289. ISSN 1557-8992

Lyon, Gholson J., Shprecher, David, Coffey, Barbara, Kurlan, Roger (2010) Tourette's Disorder. Current Treatment Options in Neurology, 12 (4). pp. 274-286. ISSN 1534-3138

Robison, R. J., Reimherr, F. W., Marchant, B. K., Kondo, D, Lyon, G. J., Olsen, J, Christopherson, D, Pommerville, C, Tuya, S, Johnson, A, Coon, H (2010) The Use of Emotional Dysregulation as an Endophenotype for Genetic studies in Adults with Attention-Deficit Hyperactivity Disorder. Journal of ADHD and Related Disorders, 1 (4). pp. 29-38.

Lyon, G. J., Coffey, B. J. (August 2009) Complex tics and complex management in a case of severe Tourette's disorder (TD) in an adolescent. Journal of Child and Adolescent Psychopharmacology, 19 (4). pp. 469-74. ISSN 1557-8992 (Electronic)1044-5463 (Linking)

Lyon, Gholson J., Samar, Stephanie, Jummani, Rahil, Hirsch, Scott, Spirgel, Arie, Goldman, Rachel, Coffey, Barbara J. (2009) Aripiprazole in children and adolescents with Tourette's disorder: an open-label safety and tolerability study. Journal of Child and Adolescent Psychopharmacology, 19 (6). pp. 623-633. ISSN 1557-8992

Lyon, G. J., Coffey, B. (2008) Book Review: Attention-Deficit Hyperactivity Disorder: A Handbook for Diagnosis and Treatment, 3rd ed. Journal of Clinical Psychiatry, 69 (6). p. 1023. ISSN 1555-2101 (online)

Lyon, G. J., Coffey, B. (2008) Book Review: Treating Tourette Syndrome and Tic Disorders: A Guide for Practitioners. Journal of Child and Adolescent Psychopharmacology, 18 (4). pp. 411-412.

Lyon, Gholson J. (2008) Possible varenicline-induced paranoia and irritability in a patient with major depressive disorder, borderline personality disorder, and methamphetamine abuse in remission. Journal of Clinical Psychopharmacology, 28 (6). pp. 720-721. ISSN 0271-0749

Lyon, Gholson J., Coffey, Barbara, Silva, Raul (2008) Postraumatic stress disorder and reactive attachment disorder: outcome in an adolescent. Journal of Child and Adolescent Psychopharmacology, 18 (6). pp. 641-646. ISSN 1557-8992

Lyon, G. J., Koplewicz, H. S. (December 2007) Schizophrenia in childhood. The Scientist, 21 (12 SUP). pp. 22-25. ISSN 08903670 (ISSN)

Wright, Jesse S., Lyon, Gholson J., George, Elizabeth A., Muir, Tom W., Novick, Richard P. (2004) Hydrophobic interactions drive ligand-receptor recognition for activation and inhibition of staphylococcal quorum sensing. Proceedings of the National Academy of Sciences of the United States of America, 101 (46). pp. 16168-16173. ISSN 0027-8424

Lyon, Gholson J., Novick, Richard P. (2004) Peptide signaling in Staphylococcus aureus and other Gram-positive bacteria. Peptides, 25 (9). pp. 1389-1403. ISSN 0196-9781

Lyon, Gholson J., Muir, Tom W. (2003) Chemical signaling among bacteria and its inhibition. Chemistry & Biology, 10 (11). pp. 1007-1021. ISSN 1074-5521

Kalkum, Markus, Lyon, Gholson J., Chait, Brian T. (2003) Detection of secreted peptides by using hypothesis-driven multistage mass spectrometry. Proceedings of the National Academy of Sciences of the United States of America, 100 (5). pp. 2795-2800. ISSN 0027-8424

Miller, Justin S., Dudkin, Vadim Y., Lyon, Gholson J., Muir, Tom W., Danishefsky, Samuel J. (2003) Toward fully synthetic N-linked glycoproteins. Angewandte Chemie International Edition, 42 (4). pp. 431-434. ISSN 1433-7851

Lyon, Gholson J., Wright, Jesse S., Muir, Tom W., Novick, Richard P. (2002) Key determinants of receptor activation in the agr autoinducing peptides of Staphylococcus aureus. Biochemistry, 41 (31). pp. 10095-10104. ISSN 0006-2960 (Print)

Lyon, Gholson J., Wright, Jesse S., Christopoulos, Arthur, Novick, Richard P., Muir, Tom W. (2002) Reversible and specific extracellular antagonism of receptor-histidine kinase signaling. Journal of Biological Chemistry, 277 (8). pp. 6247-6253. ISSN 0021-9258

Jarraud, S., Lyon, G. J., Figueiredo, A. M., Lina, G., Gerard, L., Vandenesch, F., Etienne, J., Muir, T. W., Novick, R. P. (2000) Exfoliatin-producing strains define a fourth agr specificity group in Staphylococcus aureus. Journal of Bacteriology, 182 (22). pp. 6517-6522. ISSN 0021-9193

Lyon, G. J., Mayville, P., Muir, T. W., Novick, R. P. (2000) Rational design of a global inhibitor of the virulence response in Staphylococcus aureus, based in part on localization of the site of inhibition to the receptor-histidine kinase, AgrC. Proceedings of the National Academy of Sciences of the United States of America, 97 (24). pp. 13330-13335. ISSN 0027-8424

Fuortes, M., Melchior, M., Han, H., Lyon, G. J., Nathan, C. (August 1999) Role of the tyrosine kinase pyk2 in the integrin-dependent activation of human neutrophils by TNF. Journal of Clinical Investigation, 104 (3). pp. 327-335. ISSN 0021-9738

Hernandez, A., Lyon, G. J., Schneider, M. J., St Germain, D. L. (1999) Isolation and characterization of the mouse gene for the type 3 iodothyronine deiodinase. Endocrinology, 140 (1). pp. 124-130. ISSN 0013-7227

Hernandez, A., Park, J. P., Lyon, G. J., Mohandas, T. K., St Germain, D. L. (1998) Localization of the type 3 iodothyronine deiodinase (DIO3) gene to human chromosome 14q32 and mouse chromosome 12F1. Genomics, 53 (1). pp. 119-121. ISSN 08887543 (ISSN)

Gilmour, D. T., Lyon, G. J., Carlton, M. B., Sanes, J. R., Cunningham, J. M., Anderson, J. R., Hogan, B. L., Evans, M. J., Colledge, W. H. (1998) Mice deficient for the secreted glycoprotein SPARC/osteonectin/BM40 develop normally but show severe age-onset cataract formation and disruption of the lens. Embo Journal, 17 (7). pp. 1860-1870. ISSN 0261-4189