Presynaptic regulation of dopamine transmission in schizophrenia

Lyon, Gholson J., Abi-Dargham, Anissa, Moore, Holly, Lieberman, Jeffrey A., Javitch, Jonathan A., Sulzer, David (2011) Presynaptic regulation of dopamine transmission in schizophrenia. Schizophrenia Bulletin, 37 (1). pp. 108-117. ISSN 1745-1701

DOI: 10.1093/schbul/sbp010


A role for dopamine (DA) release in the hallucinations and other positive symptoms associated with schizophrenia has long been inferred from the antipsychotic response to D2 DA receptor antagonists and because the DA releaser amphetamine can be psychotogenic. Recent studies suggest that patients with schizophrenia, including those never exposed to antipsychotic drugs, maintain high presynaptic DA accumulation in the striatum. New laboratory approaches are elucidating mechanisms that control the level of presynaptic DA stores, thus contributing to fundamental understanding of the basic pathophysiologic mechanism in schizophrenia.

Item Type: Paper
Uncontrolled Keywords: Animals Corpus Striatum Disease Models, Animal Dopamine Humans Presynaptic Terminals Receptors, Dopamine D2 Schizophrenia
Subjects: diseases & disorders > mental disorders
organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > synaptic transmission
CSHL Authors:
Communities: CSHL labs > Lyon lab
Depositing User: Matt Covey
Date: 2011
Date Deposited: 10 Dec 2012 20:14
Last Modified: 10 Dec 2012 21:16
PMCID: PMC3004182

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