Additional materials of the author at
CSHL Institutional Repository

Klingbeil, Olaf, Skopelitis, Damianos, Tonelli, Claudia, Alpsoy, Aktan, Minicozzi, Francesca, Aggarwal, Disha, Russo, Suzanne, Ha, Taehoon, Demerdash, Osama E, Spector, David L, Tuveson, David A, Cifani, Paolo , Vakoc, Christopher R (2024) MARK2/MARK3 kinases are catalytic co-dependencies of YAP/TAZ in human cancer. bioRxiv,

Gao, Yuan , Vakoc, Christopher R (2024) Therapeutic index of targeting select chromatin complexes in human cancer patients. Current Opinion in Genetics and Development, 85 pp. 102162.

He, Xue-Yan, Gao, Yuan, Ng, David, Michalopoulou, Evdokia, George, Shanu, Adrover, Jose M, Sun, Lijuan, Albrengues, Jean, Daßler-Plenker, Juliane, Han, Xiao, Wan, Ledong, Wu, Xiaoli Sky, Shui, Longling S, Huang, Yu-Han, Liu, Bodu, Su, Chang, Spector, David L, Vakoc, Christopher R, Van Aelst, Linda , Egeblad, Mikala (2024) Chronic stress increases metastasis via neutrophil-mediated changes to the microenvironment. Cancer Cell,

He, Tongchen, Xiao, Lanbo, Qiao, Yuanyuan, Klingbeil, Olaf, Young, Eleanor, Wu, Xiaoli S, Mannan, Rahul, Mahapatra, Somnath, Eyunni, Sanjana, Tien, Jean Ching-Yi, Wang, Xiaoju, Zheng, Yang, Kim, NamHoon, Zheng, Heng, Hou, Siyu, Su, Fengyun, Miner, Stephanie J, Mehra, Rohit, Cao, Xuhong, Sekhar, A Chandra, Samajdar, Susanta, Ramachandra, Murali, Parolia, Abhijit, Vakoc, Christopher R , Chinnaiyan, Arul M (2024) Targeting the mSWI/SNF Complex in POU2F-POU2AF Transcription Factor-Driven Malignancies. bioRxiv,

Alpsoy, Aktan, Wu, Xiaoli S, Pal, Sujay, Klingbeil, Olaf, Kumar, Pramod, El Demerdash, Osama, Nalbant, Benan , Vakoc, Christopher R (2024) IκBζ is a dual-use coactivator of NF-κB and POU transcription factors. Molecular Cell, pp. S1097-2765(24)00008.

Tonelli, Claudia, Yordanov, Georgi N, Hao, Yuan, Deschênes, Astrid, Hinds, Juliene, Belleau, Pascal, Klingbeil, Olaf, Brosnan, Erin, Doshi, Abhishek, Park, Youngkyu, Hruban, Ralph H, Vakoc, Christopher R, Dobin, Alexander, Preall, Jonathan , Tuveson, David A (2024) A mucus production programme promotes classical pancreatic ductal adenocarcinoma. Gut,

Xu, Jihao, Roe, Jae-Seok, Lee, EunJung, Tonelli, Claudia, Ji, Keely Y, Younis, Omar W, Somervile, Tim DD, Yao, Melissa, Milazzo, Joseph P, Tiriac, Herve, Kolarzyk, Anna M, Lee, Esak, Grem, Jean L, Lazenby, Audrey J, Grunkemeyer, James A, Hollingsworth, Michael A, Grandgenett, Paul M, Borowsky, Alexander D, Park, Youngkyu, Vakoc, Christopher R, Tuveson, David A , Hwang, Chang-Il (2023) Engrailed-1 Promotes Pancreatic Cancer Metastasis. Advanced Science, pp. e2308537.

Pomella, Silvia, Cassandri, Matteo, D'Archivio, Lucrezia, Porrazzo, Antonella, Cossetti, Cristina, Phelps, Doris, Perrone, Clara, Pezzella, Michele, Cardinale, Antonella, Wachtel, Marco, Aloisi, Sara, Milewski, David, Colletti, Marta, Sreenivas, Prethish, Walters, Zoë S, Barillari, Giovanni, Di Giannatale, Angela, Milano, Giuseppe Maria, De Stefanis, Cristiano, Alaggio, Rita, Rodriguez-Rodriguez, Sonia, Carlesso, Nadia, Vakoc, Christopher R, Velardi, Enrico, Schafer, Beat W, Guccione, Ernesto, Gatz, Susanne A, Wasti, Ajla, Yohe, Marielle, Ignatius, Myron, Quintarelli, Concetta, Shipley, Janet, Miele, Lucio, Khan, Javed, Houghton, Peter J, Marampon, Francesco, Gryder, Berkley E, De Angelis, Biagio, Locatelli, Franco , Rota, Rossella (2023) MYOD-SKP2 axis boosts tumorigenesis in fusion negative rhabdomyosarcoma by preventing differentiation through p57Kip2 targeting. Nature Communications, 14(1) pp. 8373. Springer Science and Business Media LLC.

Maia-Silva, Diogo, Schier, Allison C, Skopelitis, Damianos, Kechejian, Vahag, Alpsoy, Aktan, Liverpool, Jynelle, Taatjes, Dylan J , Vakoc, Christopher R (2023) Marker-based CRISPR screening reveals a MED12-p63 interaction that activates basal identity in pancreatic ductal adenocarcinoma. bioRxiv,

Sroka, Martyna W, Skopelitis, Damianos, Vermunt, Marit W, Preall, Jonathan B, El Demerdash, Osama, de Almeida, Larissa MN, Chang, Kenneth, Utama, Raditya, Gryder, Berkley, Caligiuri, Giuseppina, Ren, Diqiu, Nalbant, Benan, Milazzo, Joseph P, Tuveson, David A, Dobin, Alexander, Hiebert, Scott W, Stengel, Kristy R, Mantovani, Roberto, Khan, Javed, Kohli, Rahul M, Shi, Junwei, Blobel, Gerd A , Vakoc, Christopher R (2023) Myo-differentiation reporter screen reveals NF-Y as an activator of PAX3-FOXO1 in rhabdomyosarcoma. Proceedings of the National Academy of Sciences of USA, 120(36) pp. e2303859120.

Li, Bin E, Li, Grace Y, Cai, Wenqing, Zhu, Qian, Seruggia, Davide, Fujiwara, Yuko, Vakoc, Christopher R , Orkin, Stuart (2023) In vivo CRISPR/Cas9 Screening Identifies Pbrm1 as a Regulator of Mouse Myeloid Leukemia Development. Blood Advances, 7(18) pp. 5281-5293.

Wu, Xiaoli S , Vakoc, Christopher R (2023) Made to order tuft cells by an OCA-T1 isoform switch. Science Immunology, 8(83) pp. eadh3123.

Hur, Stella K, Somerville, Tim DD, Wu, Xiaoli S, Maia-Silva, Diogo, Demerdash, Osama E, Tuveson, David A, Notta, Faiyaz , Vakoc, Christopher R (2023) p73 activates transcriptional signatures of basal lineage identity and ciliogenesis in pancreatic ductal adenocarcinoma. bioRxiv,

Fiskus, Warren, Mill, Christopher P, Birdwell, Christine, Davis, John A, Das, Kaberi, Boettcher, Steffen, Kadia, Tapan M, DiNardo, Courtney D, Takahashi, Koichi, Loghavi, Sanam, Soth, Michael J, Heffernan, Tim, McGeehan, Gerard M, Ruan, Xinjia, Su, Xiaoping, Vakoc, Christopher R, Daver, Naval , Bhalla, Kapil N (2023) Targeting of epigenetic co-dependencies enhances anti-AML efficacy of Menin inhibitor in AML with MLL1-r or mutant NPM1. Blood Cancer Journal, 13(1) pp. 53.

Gao, Yuan, He, Xue-Yan, Wu, Xiaoli S, Huang, Yu-Han, Toneyan, Shushan, Ha, Taehoon, Ipsaro, Jonathan J, Koo, Peter K, Joshua-Tor, Leemor, Bailey, Kelly M, Egeblad, Mikala , Vakoc, Christopher R (2023) ETV6 dependency in Ewing sarcoma by antagonism of EWS-FLI1-mediated enhancer activation. Nature Cell Biology,

Sun, Xueqin, Klingbeil, Olaf, Lu, Bin, Wu, Caizhi, Ballon, Carlos, Ouyang, Meng, Wu, Xiaoli S, Jin, Ying, Hwangbo, Yon, Huang, Yu-Han, Somerville, Tim DD, Chang, Kenneth, Park, Jung, Chung, Taemoon, Lyons, Scott K, Shi, Junwei, Vogel, Hannes, Schulder, Michael, Vakoc, Christopher R , Mills, Alea A (2022) BRD8 maintains glioblastoma by epigenetic reprogramming of the p53 network. Nature,

Mo, Yan, Duan, Shoufu, Zhang, Xu, Hua, Xu, Zhou, Hui, Wei, Hong-Jian, Watanabe, Jun, McQuillan, Nicholas, Su, Zhenyi, Gu, Wei, Wu, Cheng-Chia, Vakoc, Christopher R, Hashizume, Rintaro, Chang, Kenneth , Zhang, Zhiguo (2022) Epigenome programing by H3.3K27M mutation creates a dependence of pediatric glioma on SMARCA4. Cancer Discovery, pp. CD-21.

Xiong, Xiwen, Yang, Chenyan, He, Wei-Qi, Yu, Jiahui, Xin, Yue, Zhang, Xinge, Huang, Rong, Ma, Honghui, Xu, Shaofang, Li, Zun, Ma, Jie, Xu, Lin, Wang, Qunyi, Ren, Kaiqun, Wu, Xiaoli S, Vakoc, Christopher R, Zhong, Jiateng, Zhong, Genshen, Zhu, Xiaofei, Song, Yu, Ruan, Hai-Bin , Wang, Qingzhi (2022) Sirtuin 6 maintains epithelial STAT6 activity to support intestinal tuft cell development and type 2 immunity. Nature Communications, 13(1) pp. 5192.

Doepner, Miriam, Lee, Inyoung, Natale, Christopher A, Brathwaite, Roderick, Venkat, Swati, Kim, Sung Hoon, Wei, Yiliang, Vakoc, Christopher R, Capell, Brian C, Katzenellenbogen, John A, Katzenellenbogen, Benita S, Feigin, Michael E , Ridky, Todd W (2022) Endogenous DOPA inhibits melanoma through suppression of CHRM1 signaling. Science Advances, 8(35) pp. eabn4007.

Orstad, Grace, Fort, Gabriela, Parnell, Timothy J, Jones, Alex, Stubben, Chris, Lohman, Brian, Gillis, Katherine L, Orellana, Walter, Tariq, Rushmeen, Klingbeil, Olaf, Kaestner, Klaus, Vakoc, Christopher R, Spike, Benjamin T , Snyder, Eric L (2022) FoxA1 and FoxA2 control growth and cellular identity in NKX2-1-positive lung adenocarcinoma. Developmental Cell,

Wu, Xiaoli S, He, Xue-Yan, Ipsaro, Jonathan J, Huang, Yu-Han, Preall, Jonathan B, Ng, David, Shue, Yan Ting, Sage, Julien, Egeblad, Mikala, Joshua-Tor, Leemor , Vakoc, Christopher R (2022) OCA-T1 and OCA-T2 are coactivators of POU2F3 in the tuft cell lineage. Nature,

Li, Ruitong, Klingbeil, Olaf, Monducci, Davide, Young, Michael J, Rodriguez, Diego J, Bayyat, Zaid, Dempster, Joshua M, Kesar, Devishi, Yang, Xiaoping, Zamanighomi, Mahdi, Vakoc, Christopher R, Ito, Takahiro , Sellers, William R (2022) Comparative optimization of combinatorial CRISPR screens. Nature Communications, 13(1) pp. 2469.

Bharathy, Narendra, Cleary, Megan M, Kim, Jin-Ah, Nagamori, Kiyo, Crawford, Kenneth A, Wang, Eric, Saha, Debarya, Settelmeyer, Teagan P, Purohit, Reshma, Skopelitis, Damianos, Chang, Kenneth, Doran, Jessica A, Kirschbaum, C Ward, Bharathy, Suriya, Crews, Davis W, Randolph, Matthew E, Karnezis, Anthony N, Hudson-Price, Lisa, Dhawan, Jyotsna, Michalek, Joel E, Ciulli, Alessio, Vakoc, Christopher R , Keller, Charles (2022) SMARCA4 biology in alveolar rhabdomyosarcoma. Oncogene,

Polyanskaya, Sofya A, Moreno, Rosamaria Y, Lu, Bin, Feng, Ruopeng, Yao, Yu, Irani, Seema, Klingbeil, Olaf, Yang, Zhaolin, Wei, Yiliang, Demerdash, Osama E, Benjamin, Lukas A, Weiss, Mitchell J, Zhang, Yan Jessie , Vakoc, Christopher R (2022) SCP4-STK35/PDIK1L complex is a dual phospho-catalytic signaling dependency in acute myeloid leukemia. Cell Reports, 38(2) pp. 110233.

Laubscher, Dominik, Gryder, Berkley E, Sunkel, Benjamin D, Andresson, Thorkell, Wachtel, Marco, Das, Sudipto, Roschitzki, Bernd, Wolski, Witold, Wu, Xiaoli S, Chou, Hsien-Chao, Song, Young K, Wang, Chaoyu, Wei, Jun S, Wang, Meng, Wen, Xinyu, Ngo, Quy Ai, Marques, Joana G, Vakoc, Christopher R, Schäfer, Beat W, Stanton, Benjamin Z , Khan, Javed (2021) BAF complexes drive proliferation and block myogenic differentiation in fusion-positive rhabdomyosarcoma. Nature Communications, 12(1) pp. 6924.

Hutton, Elizabeth R, Vakoc, Christopher R , Siepel, Adam (2021) ACE: a probabilistic model for characterizing gene-level essentiality in CRISPR screens. Genome Biology, 22(1) pp. 278.

Wei, Yiliang, Huang, Yu-Han, Skopelitis, Damianos S, Iyer, Shruti V, Costa, Ana SH, Yang, Zhaolin, Kramer, Melissa, Adelman, Emmalee R, Klingbeil, Olaf, Demerdash, Osama E, Polyanskaya, Sofya A, Chang, Kenneth, Goodwin, Sara, Hodges, Emily, McCombie, W Richard, Figueroa, Maria E , Vakoc, Christopher R (2021) SLC5A3-dependent myo-inositol auxotrophy in acute myeloid leukemia.. Cancer Discovery, pp. candisc.1849.2020-candisc.1849.2020.

Fiskus, Warren, Mill, Christopher P, Nabet, Behnam, Perera, Dimuthu, Birdwell, Christine, Manshouri, Taghi, Lara, Bernardo, Kadia, Tapan M, DiNardo, Courtney, Takahashi, Koichi, Daver, Naval, Bose, Prithviraj, Masarova, Lucia, Pemmaraju, Naveen, Kornblau, Steven, Borthakur, Gautam, Montalban-Bravo, Guillermo, Manero, Guillermo Garcia, Sharma, Sunil, Stubbs, Matthew, Su, Xiaoping, Green, Michael R, Coarfa, Cristian, Verstovsek, Srdan, Khoury, Joseph D, Vakoc, Christopher R , Bhalla, Kapil N (2021) Superior efficacy of co-targeting GFI1/KDM1A and BRD4 against AML and post-MPN secondary AML cells. Blood Cancer Journal, 11(5) pp. 98.

Yang, Zhaolin, Wu, Xiaoli S, Wei, Yiliang, Polyanskaya, Sofya A, Iyer, Shruti V, Jung, Moonjung, Lach, Francis P, Adelman, Emmalee R, Klingbeil, Olaf, Milazzo, Joseph P, Kramer, Melissa, Demerdash, Osama E, Chang, Kenneth, Goodwin, Sara, Hodges, Emily, McCombie, W Richard, Figueroa, Maria E, Smogorzewska, Agata , Vakoc, Christopher R (2021) Transcriptional silencing of ALDH2 confers a dependency on Fanconi anemia proteins in acute myeloid leukemia. Cancer Discovery,

Takao, Sumiko, Forbes, Lauren, Uni, Masahiro, Cheng, Shuyuan, Pineda, Jose Mario Bello, Tarumoto, Yusuke, Cifani, Paolo, Minuesa, Gerard, Chen, Celine, Kharas, Michael G, Bradley, Robert K, Vakoc, Christopher R, Koche, Richard P , Kentsis, Alex (2021) Convergent organization of aberrant MYB complex controls oncogenic gene expression in acute myeloid leukemia. eLife, 10 pp. 1-46.

Chou, Hsiang-Chen, Bhalla, Kuhulika, Demerdesh, Osama El, Klingbeil, Olaf, Hanington, Kaarina, Aganezov, Sergey, Andrews, Peter, Alsudani, Habeeb, Chang, Kenneth, Vakoc, Christopher R, Schatz, Michael C, McCombie, W Richard , Stillman, Bruce (2021) The human Origin Recognition Complex is essential for pre-RC assembly, mitosis and maintenance of nuclear structure.. eLife, 10

Sroka, Martyna W , Vakoc, Christopher R (2021) An epigenetic tipping point in cancer comes under the microscope.. Nature, 590(7846) pp. 399-400.

Miyabayashi, Koji, Baker, Lindsey A, Deschênes, Astrid, Traub, Benno, Caligiuri, Giuseppina, Plenker, Dennis, Alagesan, Brinda, Belleau, Pascal, Li, Siran, Kendall, Jude, Jang, Gun Ho, Kawaguchi, Risa Karakida, Somerville, Tim DD, Tiriac, Hervé, Hwang, Chang-Il, Burkhart, Richard A, Roberts, Nicholas J, Wood, Laura D, Hruban, Ralph H, Gillis, Jesse, Krasnitz, Alexander, Vakoc, Christopher R, Wigler, Michael, Notta, Faiyaz, Gallinger, Steven, Park, Youngkyu , Tuveson, David A (2020) Intraductal Transplantation Models of Human Pancreatic Ductal Adenocarcinoma Reveal Progressive Transition of Molecular Subtypes.. Cancer Discovery, 10(10) pp. 1566-1589. American Association for Cancer Research (AACR).

Chou, H. C., Bhalla, K., El Demerdash, O., Klingbeil, O., Hanington, Kaarina, Aganezov, S., Andrews, P., Alsudani, H., Chang, K., Vakoc, C. R., Schatz, M. C., McCombie, W. R. , Stillman, B. (2020) The human Origin Recognition Complex is essential for pre-RC assembly, mitosis and maintenance of nuclear structure. BioRxiv,

Oni, T. E., Biffi, G., Baker, L. A., Hao, Y., Tonelli, C., Somerville, T. D. D., Deschênes, A., Belleau, P., Hwang, C. I., Sánchez-Rivera, F. J., Cox, H., Brosnan, E., Doshi, A., Lumia, R. P., Khaledi, K., Park, Y., Trotman, L. C., Lowe, S. W., Krasnitz, A., Vakoc, C. R. , Tuveson, D. A. (2020) SOAT1 promotes mevalonate pathway dependency in pancreatic cancer. J Exp Med, 217(9)

Somerville, T. D. D., Xu, Y., Wu, X. S., Maia-Silva, D., Hur, S. K., de Almeida, L. M. N., Preall, J. B., Koo, P. K. , Vakoc, C. R. (2020) ZBED2 is an antagonist of interferon regulatory factor 1 and modifies cell identity in pancreatic cancer. Proc Natl Acad Sci U S A, 117(21) pp. 11471-11482.

Gryder, B. E., Wachtel, M., Chang, K., El Demerdash, O., Aboreden, N.G., Mohammed, W., Ewert, W., Pomella, S., Rota, R., Wei, J.S., Song, Y., Stanton, B. Z., Schafer, B., Vakoc, C.R. , Khan, J. (2020) Miswired Enhancer Logic Drives a Cancer of the Muscle Lineage. iScience, 23(5) pp. 101103.

Wu, X.S. , Vakoc, C. R. (2020) A Pliable ERα Cistrome Evades Therapy. Nat Cell Biol, 22(6) pp. 619-620.

Somerville, T. D. D., Biffi, G., DaBler-Plenker, J., Hur, S.K., He, X.-Y., Vance, K.E., Miyabayashi, K., Xu, Y., Maia-Silva, D., Klingbeil, O., Demerdash, O. E., Preall, J. B., Hollingsworth, M. A., Egeblad, M., Tuveson, D. A. , Vakoc, C. R. (2020) Squamous trans-differentiation of pancreatic cancer cells promotes stromal inflammation. Elife, 9 pp. e53381.

Poirier, J. T., George, J., Owonikoko, T. K., Berns, A., Brambilla, E., Byers, L. A., Carbone, D., Chen, H. J., Christensen, C. L., Dive, C., Farago, A. F., Govindan, R., Hann, C., Hellmann, M. D., Horn, L., Johnson, J. E., Ju, Y. S., Kang, S., Krasnow, M., Lee, J., Lee, S. H., Lehman, J., Lok, B., Lovly, C., MacPherson, D., McFadden, D., Minna, J., Oser, M., Park, K., Park, K. S., Pommier, Y., Quaranta, V., Ready, N., Sage, J., Scagliotti, G., Sos, M. L., Sutherland, K. D., Travis, W. D., Vakoc, C. R., Wait, S. J., Wistuba, I., Wong, K. K., Zhang, H., Daigneault, J., Wiens, J., Rudin, C. M. , Oliver, T. G. (2020) New Approaches to SCLC Therapy: From the Laboratory to the Clinic. J Thorac Oncol, 15(4) pp. 520-540.

Poirier, J. T., George, J., Owonikoko, T. K., Berns, A., Brambilla, E., Byers, L. A., Carbone, D., Chen, H. J., Christensen, C. L., Dive, C., Farago, A. F., Govindan, R., Hann, C., Hellmann, M. D., Horn, L., Johnson, J. E., Ju, Y. S., Kang, S., Krasnow, M., Lee, J., Lee, S. H., Lehman, J., Lok, B., Lovly, C., MacPherson, D., McFadden, D., Minna, J., Oser, M., Park, K., Park, K. S., Pommier, Y., Quaranta, V., Ready, N., Sage, J., Scagliotti, G., Sos, M. L., Sutherland, K. D., Travis, W. D., Vakoc, C. R., Wait, S. J., Wistuba, I., Wong, K. K., Zhang, H., Daigneault, J., Wiens, J., Rudin, C. M. , Oliver, T. G. (2020) New approaches to small cell lung cancer therapy : from the laboratory to the clinic. J Thorac Oncol,

Foronda, M., Tarumoto, Y., Schatoff, E. M., Leach, B. I., Diaz, B. J., Zimmerman, J., Goswami, S., Shusterman, M., Vakoc, C. R. , Dow, L. E. (2019) Tankyrase inhibition sensitizes cells to CDK4 blockade. PLoS One, 14(12) pp. e0226645.

Hutton, Elizabeth, Vakoc, Christopher , Siepel, Adam (2019) ACE: A Probabilistic Model for Characterizing Gene-Level Essentiality in CRISPR Screens. bioRxiv,

Gryder, B. E., Pomella, S., Sayers, C., Wu, X. S., Song, Y., Chiarella, A. M., Bagchi, S., Chou, H. C., Sinniah, R. S., Walton, A., Wen, X., Rota, R., Hathaway, N. A., Zhao, K., Chen, J., Vakoc, C. R., Shern, J. F., Stanton, B. Z. , Khan, J. (2019) Histone hyperacetylation disrupts core gene regulatory architecture in rhabdomyosarcoma. Nat Genet, 51(12) pp. 1714-1722.

Caiado, F., Maia-Silva, D., Jardim, C., Schmolka, N., Carvalho, T., Reforco, C., Faria, R., Kolundzija, B., Simoes, A. E., Baubec, T., Vakoc, C. R., da Silva, M. G., Manz, M. G., Schumacher, T. N., Norell, H. , Silva-Santos, B. (2019) Lineage tracing of acute myeloid leukemia reveals the impact of hypomethylating agents on chemoresistance selection. Nat Commun, 10(1) pp. 4986.

Tarumoto, Y., Lin, S., Wang, J., Milazzo, J. P., Xu, Y., Lu, B., Yang, Z., Wei, Y., Polyanskaya, S., Wunderlich, M., Gray, N. S., Stegmaier, K. , Vakoc, C. R. (2019) Salt-Inducible Kinase inhibition suppresses acute myeloid leukemia progression in vivo. Blood,

Li, F., Deng, Z., Zhang, L., Wu, C., Jin, Y., Hwang, I., Vladimirova, O., Xu, L., Yang, L., Lu, B., Dheekollu, J., Li, J. Y., Feng, H., Hu, J., Vakoc, C. R., Ying, H., Paik, J., Lieberman, P. M. , Zheng, H. (2019) ATRX loss induces telomere dysfunction and necessitates induction of alternative lengthening of telomeres during human cell immortalization. Embo j, 38(19) pp. e96659.

Ehrenhofer-Wolfer, K., Puchner, T., Schwarz, C., Rippka, J., Blaha-Ostermann, S., Strobl, U., Hormann, A., Bader, G., Kornigg, S., Zahn, S., Sommergruber, W., Schweifer, N., Zichner, T., Schlattl, A., Neumuller, R. A., Shi, J., Vakoc, C. R., Kogl, M., Petronczki, M., Kraut, N., Pearson, M. A. , Wohrle, S. (2019) SMARCA2-deficiency confers sensitivity to targeted inhibition of SMARCA4 in esophageal squamous cell carcinoma cell lines. Sci Rep, 9(1) pp. 11661.

Bottcher, J., Dilworth, D., Reiser, U., Neumuller, R. A., Schleicher, M., Petronczki, M., Zeeb, M., Mischerikow, N., Allali-Hassani, A., Szewczyk, M. M., Li, F., Kennedy, S., Vedadi, M., Barsyte-Lovejoy, D., Brown, P. J., Huber, K. V. M., Rogers, C. M., Wells, C. I., Fedorov, O., Rumpel, K., Zoephel, A., Mayer, M., Wunberg, T., Bose, D., Zahn, S., Arnhof, H., Berger, H., Reiser, C., Hormann, A., Krammer, T., Corcokovic, M., Sharps, B., Winkler, S., Haring, D., Cockcroft, X. L., Fuchs, J. E., Mullauer, B., Weiss-Puxbaum, A., Gerstberger, T., Boehmelt, G., Vakoc, C. R., Arrowsmith, C. H., Pearson, M. , McConnell, D. B. (2019) Fragment-based discovery of a chemical probe for the PWWP1 domain of NSD3. Nat Chem Biol, 15(8) pp. 822-829.

Wei, Y. L. , Vakoc, C. (2019) Probing leukemia vulnerabilities in vivousing domain-focused CRISPR screening. Cancer Research, 79(13) pp. Meeting Abstract 5161.

Yohe, M. E., Heske, C. M., Stewart, E., Adamson, P. C., Ahmed, N., Antonescu, C. R., Chen, E., Collins, N., Ehrlich, A., Galindo, R. L., Gryder, B. E., Hahn, H., Hammond, S., Hatley, M. E., Hawkins, D. S., Hayes, M. N., Hayes-Jordan, A., Helman, L. J., Hettmer, S., Ignatius, M. S., Keller, C., Khan, J., Kirsch, D. G., Linardic, C. M., Lupo, P. J., Rota, R., Shern, J. F., Shipley, J., Sindiri, S., Tapscott, S. J., Vakoc, C. R., Wexler, L. H. , Langenau, D. M. (2019) Insights into pediatric rhabdomyosarcoma research: Challenges and goals. Pediatr Blood Cancer, 66(10) pp. article no. e27869.

Bell, C. C., Fennell, K. A., Chan, Y. C., Rambow, F., Yeung, M. M., Vassiliadis, D., Lara, L., Yeh, P., Martelotto, L. G., Rogiers, A., Kremer, B. E., Barbash, O., Mohammad, H. P., Johanson, T. M., Burr, M. L., Dhar, A., Karpinich, N., Tian, L., Tyler, D. S., MacPherson, L., Shi, J., Pinnawala, N., Yew Fong, C., Papenfuss, A. T., Grimmond, S. M., Dawson, S. J., Allan, R. S., Kruger, R. G., Vakoc, C. R., Goode, D. L., Naik, S. H., Gilan, O., Lam, E. Y. N., Marine, J. C., Prinjha, R. K. , Dawson, M. A. (2019) Targeting enhancer switching overcomes non-genetic drug resistance in acute myeloid leukaemia. Nat Commun, 10(1) pp. 2723.

Rudin, C. M., Poirier, J. T., Byers, L. A., Dive, C., Dowlati, A., George, J., Heymach, J. V., Johnson, J. E., Lehman, J. M., MacPherson, D., Massion, P. P., Minna, J. D., Oliver, T. G., Quaranta, V., Sage, J., Thomas, R. K., Vakoc, C. R. , Gazdar, A. F. (2019) Author Correction: Molecular subtypes of small cell lung cancer: a synthesis of human and mouse model data. Nat Rev Cancer, 19(5) pp. 289-297.

Lan, X., Khandros, E., Huang, P., Peslak, S. A., Bhardwaj, S. K., Grevet, J. D., Abdulmalik, O., Wang, H., Keller, C. A., Giardine, B., Baeza, J., Duffner, E. R., El Demerdash, O., Wu, X. S., Vakoc, C. R., Garcia, B. A., Hardison, R. C., Shi, J. , Blobel, G. A. (2019) The E3 ligase adaptor molecule SPOP regulates fetal hemoglobin levels in adult erythroid cells. Blood Adv, 3(10) pp. 1586-1597.

Bharathy, N., Berlow, N. E., Wang, E., Abraham, J., Settelmeyer, T. P., Hooper, J. E., Svalina, M. N., Bajwa, Z., Goros, M. W., Hernandez, B. S., Wolff, J. E., Pal, R., Davies, A. M., Ashok, A., Bushby, D., Mancini, M., Noakes, C., Goodwin, N. C., Ordentlich, P., Keck, J., Hawkins, D. S., Rudzinski, E. R., Mansoor, A., Perkins, T. J., Vakoc, C. R., Michalek, J. E. , Keller, C. (2019) Preclinical rationale for entinostat in embryonal rhabdomyosarcoma. Skelet Muscle, 9(1) pp. 12.

Stripay, J., Morfouace, M., Vakoc, C. , Roussel, M. (2019) INTERROGATING THE ROLE OF EPIGENETIC REGULATORS IN MYC-DRIVEN MEDULLOBLASTOMA. Neuro-Oncology, 21 pp. 108-108.

Rudin, C. M., Poirier, J. T., Byers, L. A., Dive, C., Dowlati, A., George, J., Heymach, J. V., Johnson, J. E., Lehman, J. M., MacPherson, D., Massion, P. P., Minna, J. D., Oliver, T. G., Quaranta, V., Sage, J., Thomas, R. K., Vakoc, C. R. , Gazdar, A. F. (2019) Molecular subtypes of small cell lung cancer: a synthesis of human and mouse model data. Nat Rev Cancer, 19(5) pp. 289-297.

Aho, E. R., Wang, J., Gogliotti, R. D., Howard, G. C., Phan, J., Acharya, P., Macdonald, J. D., Cheng, K., Lorey, S. L., Lu, B., Wenzel, S., Foshage, A. M., Alvarado, J., Wang, F., Shaw, J. G., Zhao, B., Weissmiller, A. M., Thomas, L. R., Vakoc, C. R., Hall, M. D., Hiebert, S. W., Liu, Q., Stauffer, S. R., Fesik, S. W. , Tansey, W. P. (2019) Displacement of WDR5 from Chromatin by a WIN Site Inhibitor with Picomolar Affinity. Cell Reports, 26(11) pp. 2916-2928.e13.

Somerville, Tim DD, Biffi, Giulia, Daßler-Plenker, Juliane, Miyabayashi, Koji, Xu, Yali, Maia-Silva, Diogo, Klingbeil, Olaf, Demerdash, Osama, Egeblad, Mikala, Tuveson, David , Vakoc, Christopher (2019) Squamous trans-differentiation of pancreatic cancer cells promotes stromal inflammation. eLife,

Bharathy, N., Berlow, N. E., Wang, E., Abraham, J., Settelmeyer, T. P., Hooper, J. E., Svalina, M. N., Ishikawa, Y., Zientek, K., Bajwa, Z., Goros, M. W., Hernandez, B. S., Wolff, J. E., Rudek, M. A., Xu, L., Anders, N. M., Pal, R., Harrold, A. P., Davies, A. M., Ashok, A., Bushby, D., Mancini, M., Noakes, C., Goodwin, N. C., Ordentlich, P., Keck, J., Hawkins, D. S., Rudzinski, E. R., Chatterjee, B., Bachinger, H. P., Barr, F. G., Liddle, J., Garcia, B. A., Mansoor, A., Perkins, T. J., Vakoc, C. R., Michalek, J. E. , Keller, C. (2018) The HDAC3-SMARCA4-miR-27a axis promotes expression of the PAX3:FOXO1 fusion oncogene in rhabdomyosarcoma. Sci Signal, 11(557)

Brien, G. L., Remillard, D., Shi, J., Hemming, M. L., Chabon, J., Wynne, K., Dillon, E. T., Cagney, G., Van Mierlo, G., Baltissen, M. P., Vermeulen, M., Qi, J., Frohling, S., Gray, N. S., Bradner, J. E., Vakoc, C. R. , Armstrong, S. A. (2018) Targeted degradation of BRD9 reverses oncogenic gene expression in synovial sarcoma. Elife, 7

Lu, B., Klingbeil, O., Tarumoto, Y., Somerville, T. D. D., Huang, Y. H., Wei, Y., Wai, D. C., Low, J. K. K., Milazzo, J. P., Wu, X. S., Cao, Z., Yan, X., Demerdash, O. E., Huang, G., Mackay, J. P., Kinney, J. B., Shi, J. , Vakoc, C. R. (2018) A Transcription Factor Addiction in Leukemia Imposed by the MLL Promoter Sequence. Cancer Cell, 34(6) pp. 970-981.

Somerville, T. D. D., Xu, Y., Miyabayashi, K., Tiriac, H., Cleary, C. R., Maia-Silva, D., Milazzo, J. P., Tuveson, D. A. , Vakoc, C. R. (2018) TP63-Mediated Enhancer Reprogramming Drives the Squamous Subtype of Pancreatic Ductal Adenocarcinoma. Cell Rep, 25(7) pp. 1741-1755.e7.

Zafra, M. P., Schatoff, E. M., Katti, A., Foronda, M., Breinig, M., Schweitzer, A. Y., Simon, A., Han, T., Goswami, S., Montgomery, E., Thibado, J., Kastenhuber, E. R., Sanchez-Rivera, F. J., Shi, J., Vakoc, C. R., Lowe, S. W., Tschaharganeh, D. F. , Dow, L. E. (2018) Optimized base editors enable efficient editing in cells, organoids and mice. Nat Biotechnol, 36(9) pp. 888-896.

Vakoc, C. R. , Kentsis, A. (2018) Disabling an oncogenic transcription factor by targeting of control kinases. Oncotarget, 9(64) pp. 32276-32277.

Huang, Y. H., Klingbeil, O., He, X. Y., Wu, X. S., Arun, G., Lu, B., Somerville, T. D. D., Milazzo, J. P., Wilkinson, J. E., Demerdash, O. E., Spector, D. L., Egeblad, M., Shi, J. , Vakoc, C. R. (2018) POU2F3 is a master regulator of a tuft cell-like variant of small cell lung cancer. Genes Dev, 32(13-14) pp. 915-928.

Hörmann, A., Hopfgartner, B., Köcher, T., Corcokovic, M., Krammer, T., Reiser, C., Bader, G., Shi, J., Ehrenhöfer, K., Wöhrle, S., Schweifer, N., Vakoc, C. R., Kraut, N., Pearson, M., Petronczki, M. , Neumüller, R. A. (2018) RIOK1 kinase activity is required for cell survival irrespective of MTAP status. Oncotarget, 9(47) pp. 28625-28637.

Tiriac, H., Belleau, P., Engle, D. D., Plenker, D., Deschenes, A., Somerville, T., Froeling, F. E. M., Burkhart, R. A., Denroche, R. E., Jang, G. H., Miyabayashi, K., Young, C. M., Patel, H., Ma, M., LaComb, J. F., Palmaira, R. L. D., Javed, A. A., Huynh, J. A., Johnson, M., Arora, K., Robine, N., Shah, M., Sanghvi, R., Goetz, A. B., Lowder, C. Y., Martello, L., Driehuis, E., Lecomte, N., Askan, G., Iacobuzio-Donahue, C. A., Clevers, H., Wood, L. D., Hruban, R. H., Thompson, E. D., Aguirre, A. J., Wolpin, B. M., Sasson, A., Kim, J., Wu, M., Bucobo, J. C., Allen, P. J., Sejpal, D. V., Nealon, W., Sullivan, J. D., Winter, J. M., Gimotty, P. A., Grem, J. L., DiMaio, D. J., Buscaglia, J. M., Grandgenett, P. M., Brody, J. R., Hollingsworth, M. A., O'Kane, G. M., Notta, F., Kim, E. J., Crawford, J. M., Devoe, C. E., Ocean, A., Wolfgang, C. L., Yu, K. H., Li, E., Vakoc, C. R., Hubert, B., Fischer, S. E., Wilson, J. M., Moffitt, R. A., Knox, J. J., Krasnitz, A., Gallinger, S. , Tuveson, D. A. (2018) Organoid profiling identifies common responders to chemotherapy in pancreatic cancer. Cancer Discovery, 8(9) pp. 1112-1129.

Skucha, A., Ebner, J., Schmöllerl, J., Roth, M., Eder, T., César-Razquin, A., Stukalov, A., Vittori, S., Muhar, M., Lu, B., Aichinger, M., Jude, J., Müller, A. C., Győrffy, B., Vakoc, C. R., Valent, P., Bennett, K. L., Zuber, J., Superti-Furga, G. , Grebien, F. (2018) MLL-fusion-driven leukemia requires SETD2 to safeguard genomic integrity. Nat Commun, 9(1) pp. 1983.

Tuveson, D., Engle, D., Hwang, C., Vakoc, C. , Roe, J. S. (2018) GEMMs and GEOs to characterize pancreatic cancer initiation and progression. Cancer Research,

Wai, D. C., Szyszka, T. N., Campbell, A. E., Kwong, C., Wilkinson-White, L. E., Silva, A. P. G., Low, J. K. K., Kwan, A. H., Gamsjaeger, R., Chalmers, J. N., Patrick, W. M., Lu, B., Vakoc, C. R., Blobel, G. , Mackay, J. P. (2018) The BRD3 ET domain recognizes a short peptide motif through a mechanism that is conserved across chromatin remodelers and transcriptional regulators. J Biol Chem, 293(19) pp. 7160-7175.

Bhagwat, A. S., Lu, B. , Vakoc, C. R. (2018) Enhancer dysfunction in leukemia. Blood, 131(16) pp. 1795-1804.

Tarumoto, Y., Lu, B., Somerville, T. D. D., Huang, Y. H., Milazzo, J. P., Wu, X. S., Klingbeil, O., El Demerdash, O., Shi, J. , Vakoc, C. R. (2018) LKB1, Salt-Inducible Kinases, and MEF2C Are Linked Dependencies in Acute Myeloid Leukemia. Mol Cell, 69(6) pp. 1017-1027.

Banito, Ana, Li, Xiang, Laporte, Aimée N., Roe, Jae-Seok, Sanchez-Vega, Francisco, Huang, Chun-Hao, Dancsok, Amanda R., Hatzi, Katerina, Chen, Chi-Chao, Tschaharganeh, Darjus F., Chandwani, Rohit, Tasdemir, Nilgun, Jones, Kevin B., Capecchi, Mario R., Vakoc, Christopher R., Schultz, Nikolaus, Ladanyi, Marc, Nielsen, Torsten O. , Lowe, Scott W. (2018) The SS18-SSX Oncoprotein Hijacks KDM2B-PRC1.1 to Drive Synovial Sarcoma. Cancer Cell, 33(3) pp. 527-541.

Xu, Y., Milazzo, J. P., Somerville, T. D. D., Tarumoto, Y., Huang, Y. H., Ostrander, E. L., Wilkinson, J. E., Challen, G. A. , Vakoc, C. R. (2018) A TFIID-SAGA Perturbation that Targets MYB and Suppresses Acute Myeloid Leukemia. Cancer Cell, 33(1) pp. 13-28 e8.

Vakoc, C. (2018) Cancer drug target identification using domain-focused CRISPR screening. Clinical Cancer Research, 24(2 Supp) pp. 19-19.

Barbieri, I., Tzelepis, K., Pandolfini, L., Shi, J., Millan-Zambrano, G., Robson, S. C., Aspris, D., Migliori, V., Bannister, A. J., Han, N., De Braekeleer, E., Ponstingl, H., Hendrick, A., Vakoc, C. R., Vassiliou, G. S. , Kouzarides, T. (2017) Promoter-bound METTL3 maintains myeloid leukaemia by m(6)A-dependent translation control. Nature, 552(7683) pp. 126-131.

Fontanals-Cirera, B., Hasson, D., Vardabasso, C., Di Micco, R., Agrawal, P., Chowdhury, A., Gantz, M., de Pablos-Aragoneses, A., Morgenstern, A., Wu, P., Filipescu, D., Valle-Garcia, D., Darvishian, F., Roe, J. S., Davies, M. A., Vakoc, C. R., Hernando, E. , Bernstein, E. (2017) Harnessing BET Inhibitor Sensitivity Reveals AMIGO2 as a Melanoma Survival Gene. Mol Cell, 68(4) pp. 731-744.e9.

Vakoc, C. R. , Tuveson, D. A. (2017) Soils and Seeds That Initiate Pancreatic Cancer Metastasis. Cancer Discov, 7(10) pp. 1067-1068.

Roe, J. S., Hwang, C. I., Somerville, T. D. D., Milazzo, J. P., Lee, E. J., Da Silva, B., Maiorino, L., Tiriac, H., Young, C. M., Miyabayashi, K., Filippini, D., Creighton, B., Burkhart, R. A., Buscaglia, J. M., Kim, E. J., Grem, J. L., Lazenby, A. J., Grunkemeyer, J. A., Hollingsworth, M. A., Grandgenett, P. M., Egeblad, M., Park, Y., Tuveson, D. A. , Vakoc, C. R. (2017) Enhancer Reprogramming Promotes Pancreatic Cancer Metastasis. Cell, 170(5) pp. 875-888.

Xu, Y. , Vakoc, C. R. (2017) Targeting Cancer Cells with BET Bromodomain Inhibitors. Cold Spring Harb Perspect Med, 7(7)

Tzelepis, K., Barbieri, I., Pandolfini, L., Shi, J., Robson, S. C., Migliori, V., Bannister, A. J., Han, N., De Braekeleer, E., Ponstingl, H., Vakoc, C. R., Vassiliou, G. S. , Kouzarides, T. (2017) Mettl3 controls translation of target mRNAs by n6 methylation of adenosine residues in their coding sequence and constitutes a novel therapeutic vulnerability of acute myeloid leukaemia. Haematologica, 102(Supple) pp. 154-155.

Lanning, B. R. , Vakoc, C. R. (2017) Single-minded CRISPR screening. Nat Biotechnol, 35(4) pp. 339-340.

Vakoc, C. R. , Tuveson, D. A. (2017) Untangling the genetics from the epigenetics in pancreatic cancer metastasis. Nat Genet, 49(3) pp. 323-324.

Ipsaro, J. J., Shen, C., Arai, E., Xu, Y., Kinney, J. B., Joshua-Tor, L., Vakoc, C. R. , Shi, J. (2017) Rapid generation of drug-resistance alleles at endogenous loci using CRISPR-Cas9 indel mutagenesis. PLoS One, 12(2) pp. e0172177.

Roe, J. S. , Vakoc, C. R. (2017) The Essential Transcriptional Function of BRD4 in Acute Myeloid Leukemia. Cold Spring Harb Symp Quant Biol, 81 pp. 61-66.

Oran, A. R., Adams, C. M., Zhang, X. Y., Gennaro, V. J., Pfeiffer, H. K., Mellert, H. S., Seidel, H. E., Mascioli, K., Kaplan, J., Gaballa, M. R., Shen, C., Rigoutsos, I., King, M. P., Cotney, J. L., Arnold, J. J., Sharma, S. D., Martinez-Outschoorn, U. E., Vakoc, C. R., Chodosh, L. A., Thompson, J. E., Bradner, J. E., Cameron, C. E., Shadel, G. S., Eischen, C. M. , McMahon, S. B. (2016) Multi-focal control of mitochondrial gene expression by oncogenic MYC provides potential therapeutic targets in cancer. Oncotarget, 7(45) pp. 72395-72414.

Hohmann, A. F., Martin, L. J., Minder, J. L., Roe, J. S., Shi, J., Steurer, S., Bader, G., McConnell, D., Pearson, M., Gerstberger, T., Gottschamel, T., Thompson, D., Suzuki, Y., Koegl, M. , Vakoc, C. R. (2016) Sensitivity and engineered resistance of myeloid leukemia cells to BRD9 inhibition. Nat Chem Biol, 12(9) pp. 672-9.

Huang, Yu-Han , Vakoc, Christopher R (2016) A Biomarker Harvest from One Thousand Cancer Cell Lines. Cell, 166(3) pp. 536-537.

Somerville, Tim D D. , Vakoc, Christopher R (2016) Modeling the Epigenetic Chain Reaction Downstream of DNMT3A(R882H). Cancer Cell, 30(1) pp. 9-10.

Zhang, Qiang, Zeng, Lei, Shen, Chen, Ju, Ying, Konuma, Tsuyoshi, Zhao, Chengcheng, Vakoc, Christopher R , Zhou, Ming-Ming (2016) Structural Mechanism of Transcriptional Regulator NSD3 Recognition by the ET Domain of BRD4. Structure,

Tasdemir, N., Banito, A., Roe, J. S., Alonso-Curbelo, D., Camiolo, M., Tschaharganeh, D. F., Huang, C. H., Aksoy, O., Bolden, J. E., Chen, C. C., Fennell, M., Thapar, V., Chicas, A., Vakoc, C. R. , Lowe, S. W. (2016) BRD4 connects enhancer remodeling to senescence immune surveillance. Cancer Discov, 6(6) pp. 612-629.

Martin, L. J., Koegl, M., Bader, G., Cockcroft, X. L., Fedorov, O., Fiegen, D., Gerstberger, T., Hofmann, M. H., Hohmann, A. F., Kessler, D., Knapp, S., Knesl, P., Kornigg, S., Muller, S., Nar, H., Rogers, C., Rumpel, K., Schaaf, O., Steurer, S., Tallant, C., Vakoc, C. R., Zeeb, M., Zoephel, A., Pearson, M., Boehmelt, G. , McConnell, D. (2016) Structure-Based Design of an in Vivo Active Selective BRD9 Inhibitor. J Med Chem, 59(10) pp. 4462-75.

Bhagwat, A. S., Roe, J. S., Mok, B. Y., Hohmann, A. F., Shi, J. , Vakoc, C. R. (2016) BET Bromodomain Inhibition Releases the Mediator Complex from Select cis-Regulatory Elements. Cell Rep, 15(3) pp. 519-30.

Bhagwat, A. S., Roe, J. S., Mok, B. A. , Vakoc, C. R. (2016) BET bromodomain inhibitors antagonize Brd4-Mediator complexes to undermine the acute myeloid leukemia cell state. Cancer Research, 76(2)

Shen, Chen, Ipsaro, Jonathan J, Shi, Junwei, Milazzo, Joseph P, Wang, Eric, Roe, Jae-Seok, Suzuki, Yutaka, Pappin, Darryl J, Joshua-Tor, Leemor , Vakoc, Christopher R (2015) NSD3-Short Is an Adaptor Protein that Couples BRD4 to the CHD8 Chromatin Remodeler. Molecular Cell, 60(6) pp. 847-859.

Matthews, G. M., Mehdipour, P., Cluse, L. A., Falkenberg, K. J., Wang, E., Roth, M., Santoro, F., Vidacs, E., Stanley, K., House, C. M., Rusche, J. R., Vakoc, C. R., Zuber, J., Minucci, S. , Johnstone, R. W. (2015) Functional-genetic dissection of HDAC dependencies in mouse lymphoid and myeloid malignancies. Blood, 126(21) pp. 2392-2403.

Rathert, P., Roth, M., Neumann, T., Muerdter, F., Roe, J. S., Muhar, M., Deswal, S., Cerny-Reiterer, S., Peter, B., Jude, J., Hoffmann, T., Boryn, L. M., Axelsson, E., Schweifer, N., Tontsch-Grunt, U., Dow, L. E., Gianni, D., Pearson, M., Valent, P., Stark, A., Kraut, N., Vakoc, C. R. , Zuber, J. (2015) Transcriptional plasticity promotes primary and acquired resistance to BET inhibition. Nature, 525 pp. 543-547.

Bhagwat, A. S. , Vakoc, C. R. (2015) Targeting Transcription Factors in Cancer. Trends Cancer, 1(1) pp. 53-65.

Roe, Jae-Seok, Mercan, Fatih, Rivera, Keith, Pappin, Darryl J , Vakoc, Christopher R (2015) BET Bromodomain Inhibition Suppresses the Function of Hematopoietic Transcription Factors in Acute Myeloid Leukemia. Molecular Cell, 58(6) pp. 1028-1036.

Shi, J., Wang, E., Milazzo, J. P., Wang, Z., Kinney, J. B. , Vakoc, C. R. (2015) Discovery of cancer drug targets by CRISPR-Cas9 screening of protein domains. Nat Biotechnol, 33(6) pp. 661-67.

Wang, E., Kawaoka, S., Roe, J. S., Shi, J., Hohmann, A. F., Xu, Y., Bhagwat, A. S., Suzuki, Y., Kinney, J. B. , Vakoc, C. R. (2015) The transcriptional cofactor TRIM33 prevents apoptosis in B lymphoblastic leukemia by deactivating a single enhancer. Elife, 4

Yu, J. R., Tai, Y., Jin, Y., Hammell, M. C., Wilkinson, J. E., Roe, J. S., Vakoc, C. R. , Van Aelst, L. (2015) TGF-beta/Smad signaling through DOCK4 facilitates lung adenocarcinoma metastasis. Genes Dev, 29(3) pp. 250-61.

Shen, C. , Vakoc, C. R. (2015) Gain-of-function mutations in chromatin regulators as a tumorigenic mechanism and opportunity for therapeutic intervention. Current Opinion in Oncology, 27(1) pp. 57-63.

Xu, Y. , Vakoc, C. R. (2014) Brd4 is on the move during inflammation. Trends in Cell Biology, 24(11) pp. 615-616.

Matthews, G. M., Cluse, L., Wang, E., Roth, M., Vakoc, C., Miao, W. Y., Rusche, J., Zuber, J. , Johnstone, R. W. (2014) RNAi-mediated depletion of histone deacetylases highlights the potential for isoform-specific inhibitors in B-cell lymphoma and acute myeloid leukemia. Cancer Research, 74(19)

Hohmann, A. F. , Vakoc, C. R. (2014) A rationale to target the SWI/SNF complex for cancer therapy. Trends in Genetics, 30(8) pp. 356-363.

Shi, J. , Vakoc, C. R. (2014) The Mechanisms behind the Therapeutic Activity of BET Bromodomain Inhibition. Molecular Cell, 54(5) pp. 728-736.

Mazurek, A., Park, Y., Miething, C., Wilkinson, J. E., Gillis, J., Lowe, S. W, Vakoc, C. R , Stillman, B. (2014) Acquired Dependence of Acute Myeloid Leukemia on the DEAD-Box RNA Helicase DDX5. Cell Reports, 7(6) pp. 1887-1899.

Wedeh, G., Cerny-Reiterer, S., Hadzijusufovic, E., Herrmann, H., Blatt, K., Eisenwort, G., Hoermann, G., Sperr, W. R., Muellauer, L., Vakoc, C. R., Bradner, J. E., Horny, H., Zuber, J., Arock, M. , Valent, P. (2014) The epigenetic reader brd4 serves as a novel marker and target in aggressive systemic mastocytosis and mast cell leukemia. Haematologica, 99 pp. 514-515.

Alpatov, R., Lesch, B. J., Nakamoto-Kinoshita, M., Blanco, A., Chen, S., Stutzer, A., Armache, K. J., Simon, M. D., Xu, C., Ali, M., Murn, J., Prisic, S., Kutateladze, T. G., Vakoc, C. R., Min, J., Kingston, R. E., Fischle, W., Warren, S. T., Page, D. C. , Shi, Y. (2014) A Chromatin-Dependent Role of the Fragile X Mental Retardation Protein FMRP in the DNA Damage Response. Cell, 157(4) pp. 869-81.

Chen, C., Liu, Y., Rappaport, A. R., Kitzing, T., Schultz, N., Zhao, Z., Shroff, A. S., Dickins, R. A., Vakoc, C. R., Bradner, J. E., Stock, W., Lebeau, M. M., Shannon, K. M., Kogan, S., Zuber, J. , Lowe, S. W. (2014) MLL3 Is a Haploinsufficient 7q Tumor Suppressor in Acute Myeloid Leukemia. Cancer Cell, 25(5) pp. 652-665.

Vakoc, C. R., Garcia-Manero, G. , Look, A. T. (2014) Cancer therapy resistance: chasing epigenetics. Nature Medicine, 20(4) pp. 340-341.

Bhagwat, A. S. , Vakoc, C. R. (2014) A new bump in the epigenetic landscape. Molecular Cell, 53(6) pp. 857-8.

Roe, J. S. , Vakoc, C. R. (2014) C/EBPalpha: critical at the origin of leukemic transformation. Journal of Experimental Medicine, 211(1) pp. 1-4.

Shi, J., Whyte, W. A., Zepeda-Mendoza, C. J., Milazzo, J. P., Shen, C., Roe, J. S., Minder, J. L., Mercan, F., Wang, E., Eckersley-Maslin, M. A., Campbell, A. E., Kawaoka, S., Shareef, S., Zhu, Z., Kendall, J., Muhar, M., Haslinger, C., Yu, M., Roeder, R. G., Wigler, M. A., Blobel, G. A., Zuber, J., Spector, D. L., Young, R. A. , Vakoc, C. R. (2013) Role of SWI/SNF in acute leukemia maintenance and enhancer-mediated Myc regulation. Genes and Development, 27(24) pp. 264-273.

King, Bryan, Trimarchi, Thomas, Reavie, Linsey, Xu, Luyao, Mullenders, Jasper, Ntziachristos, Panagiotis, Aranda-Orgilles, Beatriz, Perez-Garcia, Arianne, Shi, Junwei, Vakoc, Christopher, Sandy, Peter, Shen, Steven S, Ferrando, Adolfo , Aifantis, Iannis (2013) The Ubiquitin Ligase FBXW7 Modulates Leukemia-Initiating Cell Activity by Regulating MYC Stability. Cell, 153(7) pp. 1552-1566.

Lovén, J., Hoke, H. A, Lin, C. Y., Lau, A. W., Orlando, D. A., Vakoc, C. R., Bradner, J. E., Lee, T. I. , Young, R. A. (2013) Selective Inhibition of Tumor Oncogenes by Disruption of Super-Enhancers. Cell, 153(2) pp. 320-334.

Wang, E., Kawaoka, S., Yu, M., Shi, J., Ni, T., Yang, W., Zhu, J., Roeder, R. G. , Vakoc, C. R. (2013) Histone H2B ubiquitin ligase RNF20 is required for MLL-rearranged leukemia. Proceedings of the National Academy of Sciences of the United States of America, 110(10) pp. 3901-6.

Roe, J. S. , Vakoc, C. R. (2013) Oncogene interference through targeting of chromatin regulators. Cell Cycle, 12(10) pp. 1475-1476.

Shi, J., Wang, E., Zuber, J., Rappaport, A., Taylor, M., Johns, C., Lowe, S. W. , Vakoc, C. R. (2013) The Polycomb complex PRC2 supports aberrant self-renewal in a mouse model of MLL-AF9;Nras(G12D) acute myeloid leukemia. Oncogene, 32(7) pp. 930-938.

Herrmann, H., Blatt, K., Shi, J., Gleixner, K. V., Cerny-Reiterer, S., Mullauer, L., Vakoc, C. R., Sperr, W. R., Horny, H. P., Bradner, J. E., Zuber, J. , Valent, P. (2012) Small-molecule inhibition of BRD4 as a new potent approach to eliminate leukemic stem- and progenitor cells in acute myeloid leukemia AML. Oncotarget, 3(12) pp. 1588-99.

Ernst, P. , Vakoc, C. R. (2012) WRAD: enabler of the SET1-family of H3K4 methyltransferases. Briefings in Functional Genomics, 11(3) pp. 217-226.

Shi, Y., Alpatov, R., Wagner, U., Nakamoto-Kinoshita, M., Ye, Z., Luu, Y., Armache, K. J., Simon, M. D., Stuetzer, A., Greer, E. L., Wang, Z. B., Hu, G. Q., Wu, F. Z., Xu, C., Beavers, W. N., Guo, Y. H., Bian, C. B., Morrison, P. T., Vakoc, C. R., Min, J. R., Fischle, W., Kingston, R. E., Zhao, K. J., Ren, B. , Warren, S. T. (2012) The fragile X mental retardation protein FMRP plays a role in the DNA damage response. Faseb Journal, 26

Herrmann, H., Blatt, K., Shi, J. W., Rappaport, A. R., Gleixner, K. V., Cerny-Reiterer, S., Peter, B., Wang, E., Sperr, W. R., Bradner, J. E., Lowe, S. W., Vakoc, C. R., Zuber, J. , Valent, P. (2011) Small-Molecule Inhibition of BRD4 Is a Novel Promising Approach to Therapeutically Target Leukemia Stem Cells in AML. Blood, 118(21) pp. 3484.

Issa, G. C., Delmore, J. E., McKeown, M. R., Lemieux, M. E., Rahl, P. B., Jacobs, H. M., Kastritis, E., Gilpatrick, T., Paranal, R. M., Qi, J., Shi, J. W., Chesi, M., Schinzel, A. C., Vakoc, C. R., Bergsagel, P. L., Richardson, P. G., Young, R., Hahn, W. C., Ghobrial, I. M., Anderson, K. C., Kung, A. L., Mitsiades, C. S. , Bradner, J. E. (2011) Inhibition of c-Myc Expression and Function in Hematologic Malignancies. Blood, 118(21) pp. 1409.

Delmore, J. E., Issa, G. C., Lemieux, M. E., Rahl, P. B., Shi, J. W., Jacobs, H. M., Kastritis, E., Gilpatrick, T., Paranal, R. M., Qi, J., Chesi, M., Schinzel, A. C., McKeown, M. R., Heffernan, T. P., Vakoc, C. R., Bergsagel, P.  , Ghobrial, I. M., Richardson, P. G., Young, R. A., Hahn, W. C., Anderson, K. C., Kung, A. L., Bradner, J. E. , Mitsiades, C. S. (2011) BET Bromodomain Inhibition as a Therapeutic Strategy to Target c-Myc. Cell, 146(6) pp. 904-917.

Zuber, J., Shi, J., Wang, E., Rappaport, A. R., Herrmann, H., Sison, E. A., Magoon, D., Qi, J., Blatt, K., Wunderlich, M., Taylor, M. J., Johns, C., Chicas, A., Mulloy, J. C., Kogan, S. C., Brown, P., Valent, P., Bradner, J. E., Lowe, S. W. , Vakoc, C. R. (2011) RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia. Nature, 478(7370) pp. 524-528.

Zuber, J., Rappaport, A. R., Luo, W., Wang, E., Chen, C., Vaseva, A. V., Shi, J., Weissmueller, S., Fellman, C., Taylor, M. J., Weissenboeck, M., Graeber, T. G., Kogan, S. C., Vakoc, C. R. , Lowe, S. W. (2011) An integrated approach to dissecting oncogene addiction implicates a Myb-coordinated self-renewal program as essential for leukemia maintenance. Genes & Development, 25(15) pp. 1628-1640.

Vakoc, C. R., Zuber, J., Lowe, S., Wang, E., Rappaport, A. R. , Shi, J. W. (2010) An RNA1 Screen Reveals a Pattern of Addiction to Epigenetic Pathways That Distinguishes MLL AF9 Leukemia From Normal Hematopoietic Cells. Blood, 116(21) pp. 35-35.

Speck, N. A. , Vakoc, C. R. (2010) PAF Is in the Cabal of MLL1-Interacting Proteins that Promote Leukemia. Cancer Cell, 17(6) pp. 531-532.

Blobel, G. A., Kadauke, S., Wang, E., Lau, A. W., Zuber, J., Chou, M. M. , Vakoc, C. R. (2009) A Reconfigured Pattern of MLL Occupancy within Mitotic Chromatin Promotes Rapid Transcriptional Reactivation Following Mitotic Exit. Molecular Cell, 36(6) pp. 970-983.

Chou, S. T., Khandros, E., Bailey, L. C., Nichols, K. E., Vakoc, C. R., Yao, Y., Huang, Z., Crispino, J. D., Hardison, R. C., Blobel, G. A. , Weiss, M. J. (2009) Graded repression of PU.1/Sfpi1 gene transcription by GATA factors regulates hematopoietic cell fate. Blood, 114(5) pp. 983-994.

Vakoc, C. R., Blobel, G. A., Wen, Y.-Y., Gibbs, R. A., Johnstone, C. N. , Rustgi, A. K. (2009) Low frequency of MLL3 mutations in colorectal carcinoma. Cancer Genetics and Cytogenetics, 189(2) pp. 140-141.

Tripic, T., Deng, W., Cheng, Y., Zhang, Y., Vakoc, C. R., Gregory, G. D., Hardison, R. C. , Blobel, G. A. (2009) SCL and associated proteins distinguish active from repressive GATA transcription factor complexes. Blood, 113(10) pp. 2191-2201.

Jing, H., Vakoc, C. R., Ying, L., Mandat, S., Wang, H., Zheng, X. , Blobel, G. A. (2008) Exchange of GATA Factors Mediates Transitions in Looped Chromatin Organization at a Developmentally Regulated Gene Locus. Molecular Cell, 29(2) pp. 232-242.

Steger, D. J., Lefterova, M. I., Ying, L., Stonestrom, A. J., Schupp, M., Zhuo, D., Vakoc, A. L., Kim, J. E., Chen, J., Lazar, M. A., Blobel, G. A. , Vakoc, C. R. (2008) DOT1L/KMT4 recruitment and H3K79 methylation are ubiquitously coupled with gene transcription in mammalian cells. Molecular and Cellular Biology, 28(8) pp. 2825-2839.

Chou, S. T., Bailey, C. L., Hardison, R. C., Blobel, G. A., Vakoc, C. R. , Weiss, M. J. (2007) GATA-1 represses PU.1/Sfpi-1 gene transcription in erythroMegakaryocytic progenitors. Blood, 110(11) pp. 371A-371A.

Jing, H., Vakoc, C. R., Wang, H., Mandat, S., Miller, J., Gregory, P. D., Reik, A. , Blobel, G. A. (2007) Regulation of higher order chromatin organization by GATA-1. Blood Cells Molecules and Diseases, 38(2) pp. 126-126.

Gregory, G. D., Vakoc, C. R., Rozovskaia, T., Zheng, X., Patel, S., Nakamura, T., Canaani, E. , Blobel, G. A. (2007) Mammalian ASH1L is a histone methyltransferase that occupies the transcribed region of active genes. Molecular and Cellular Biology, 27(24) pp. 8466-8479.

Lamonica, J. M., Vakoc, C. R. , Blobel, G. A. (2006) Acetylation of GATA-1 is required for chromatin occupancy. Blood, 108(11) pp. 348A-348A.

Lamonica, J. M., Vakoc, C. R. , Blobel, G. A. (2006) Acetylation of GATA-1 is required for chromatin occupancy. Blood, 108(12) pp. 3736-3738.

Vakoc, C. R., Sachdeva, M. M., Wang, H. , Blobel, G. A. (2006) Profile of histone lysine methylation across transcribed mammalian chromatin. Molecular and Cellular Biology, 26(24) pp. 9185-9195.

Zeng, P. Y., Vakoc, C. R., Chen, Z. C., Blobel, G. A. , Berger, S. L. (2006) In vivo dual cross-linking for identification of indirect DNA-associated proteins by chromatin immunoprecipitation. Biotechniques, 41(6) pp. 694-698.

Dore, L. C., Vakoc, C. R., Blobel, G. A., Hardison, R. C., Bodine, D. M., Gallagher, P. G. , Weiss, M. J. (2005) Genomic organization, chromatin structure, and transcriptional regulation of the murine Alpha Hemoglobin Stabilizing Protein (AHSP) gene. Blood, 106(11) pp. 1012A-1012A.

Vakoc, C. R., Mandat, S. A., Olenschock, B. A. , Blobel, G. A. (2005) Histone H3 lysine 9 methylation and HP1 gamma are associated with transcription elongation through mammalian chromatin. Blood, 106(11) pp. 493A-493A.

Hong, W., Nakazawa, M., Chen, Y. Y., Kori, R., Vakoc, C. R., Rakowski, C. , Blobel, G. A. (2005) FOG-1 recruits the NuRD repressor complex to mediate transcriptional repression by GATA-1. Embo Journal, 24(13) pp. 2367-2378.

Vakoc, C. R., Letting, D. L., Gheldof, N., Sawado, T., Bender, M. A., Groudine, M., Weiss, M. J., Dekker, J. , Blobel, G. A. (2005) Proximity among distant regulatory elements at the β-globin locus requires GATA-1 and FOG-1. Molecular Cell, 17(3) pp. 453-462.

Vakoc, C. R., Mandat, S. A., Olenchock, B. A. , Blobel, G. A. (2005) Histone H3 lysine 9 methylation and HP1γ are associated with transcription elongation through mammalian chromatin. Molecular Cell, 19(3) pp. 381-391.

Welch, J. J., Watts, J. A., Vakoc, C. R., Yao, Y., Wang, H., Hardison, R. C., Blobel, G. A., Chodosh, L. A. , Weiss, M. J. (2004) Global regulation of erythroid gene expression by transcription factor GATA-1. Blood, 104(10) pp. 3136-3147.