Somerville, Tim D D., Vakoc, Christopher R (July 2016) Modeling the Epigenetic Chain Reaction Downstream of DNMT3A(R882H). Cancer Cell, 30 (1). pp. 9-10. ISSN 1535-6108
Abstract
In this issue of Cancer Cell, Lu et al. use a mouse model of DNMT3AR882H/NRASG12D acute myeloid leukemia to define a cascade of chromatin changes that emanate from DNMT3A-bound enhancers to initiate disease. The authors also reveal a chemical strategy to interrupt this process.
| Item Type: | Paper |
|---|---|
| Subjects: | diseases & disorders > cancer bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > DNA methylation diseases & disorders > cancer > cancer types > leukemia bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > methyltransferase |
| CSHL Authors: | |
| Communities: | CSHL labs > Vakoc lab CSHL Cancer Center Program > Cancer Genetics and Genomics Program |
| Depositing User: | Matt Covey |
| Date: | 11 July 2016 |
| Date Deposited: | 22 Jul 2016 19:07 |
| Last Modified: | 05 Nov 2020 19:08 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/32975 |
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