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Fein, Miriam R, He, Xue-Yan, Almeida, Ana S, Bružas, Emilis, Pommier, Arnaud, Yan, Ran, Eberhardt, Anaïs, Fearon, Douglas T, Van Aelst, Linda, Wilkinson, John Erby, Dos Santos, Camila O, Egeblad, Mikala (October 2020) Cancer cell CCR2 orchestrates suppression of the adaptive immune response. Journal of Experimental Medicine, 217 (10). ISSN 0022-1007
Miyabayashi, Koji, Baker, Lindsey A, Deschênes, Astrid, Traub, Benno, Caligiuri, Giuseppina, Plenker, Dennis, Alagesan, Brinda, Belleau, Pascal, Li, Siran, Kendall, Jude, Jang, Gun Ho, Kawaguchi, Risa Karakida, Somerville, Tim DD, Tiriac, Hervé, Hwang, Chang-Il, Burkhart, Richard A, Roberts, Nicholas J, Wood, Laura D, Hruban, Ralph H, Gillis, Jesse, Krasnitz, Alexander, Vakoc, Christopher R, Wigler, Michael, Notta, Faiyaz, Gallinger, Steven, Park, Youngkyu, Tuveson, David A (October 2020) Intraductal Transplantation Models of Human Pancreatic Ductal Adenocarcinoma Reveal Progressive Transition of Molecular Subtypes. Cancer Discovery, 10 (10). pp. 1566-1589. ISSN 2159-8274
Cheng, D. K., Oni, T. E., Park, Y., Thalappillil, J. S, Ting, H.-C., Alagesan, B., Prasad, N. V., Rivera, K. D., Pappin, D. J., Van Aelst, L., Tuveson, D. A. (September 2020) Oncogenic KRAS engages an RSK1/NF1 complex in pancreatic cancer. BioRxiv. (Unpublished)
Oni, Tobiloba E, Bautista, Carmelita, Merrill, Joseph R, Goos, Jeroen ACM, Rivera, Keith D, Miyabayashi, Koji, Biffi, Giulia, Garcia, Libia, Plenker, Dennis, Patel, Hardik, Elyada, Ela, Samaritano, Maria, Yu, Kenneth H, Pappin, Darryl J, Goggins, Michael G, Hruban, Ralph H, Lewis, Jason S, Lyons, Scott K, Yeh, Johannes T, Tuveson, David A (September 2020) Detection of incipient pancreatic cancer with novel tumor-specific antibodies in mouse models. BioRxiv. (Unpublished)
Beyaz, S., Roper, J., Bauer-Rowe, K. E., Xifaras, M. E., Ergin, I., Dohnalova, L., Biton, M., Shekar, K., Mou, H. W., Eskiocak, O., Ozata, D., Papciak, K., Chung, C., Almeqdadi, M., Fein, M., Valle-Encinas, E., Erdemir, A., Dogum, K, Garipcan, A., Meyer, H., Fox, J.G., Elinav, E., Kucukural, A., Kumar, P., McAleer, J., Thaiss, C.A., Regev, A., Orkin, S. H., Yilmaz, O. H. (September 2020) Dietary suppression of MHC-II expression in intestinal stem cells enhances intestinal tumorigenesis. BioRxiv. (Unpublished)
Wang, Zhikai, Yan, Ran, Li, Jiayun, Gao, Ya, Moresco, Philip, Yao, Min, Hechtman, Jaclyn F, Weiss, Matthew J, Janowitz, Tobias, Fearon, Douglas T (September 2020) Pancreatic cancer cells assemble a CXCL12-keratin 19 coating to resist immunotherapy. BioRxiv. (Unpublished)
Seppälä, Toni T, Zimmerman, Jacquelyn W, Sereni, Elisabetta, Plenker, Dennis, Suri, Reecha, Rozich, Noah, Blair, Alex, Thomas, Dwayne L, Teinor, Jonathan, Javed, Ammar, Patel, Hardik, Cameron, John L, Burns, William R, He, Jin, Tuveson, David A, Jaffee, Elizabeth M, Eshleman, James, Szabolcs, Annamaria, Ryan, David P, Ting, David T, Wolfgang, Christopher L, Burkhart, Richard A (September 2020) Patient-derived Organoid Pharmacotyping is a Clinically Tractable Strategy for Precision Medicine in Pancreatic Cancer. Annals of Surgery, 272 (3). pp. 427-435. ISSN 0003-4932
Bencze, G., Bencze, S., Rivera, K. D., Watson, J. D., Orfi, L., Tonks, N. K., Pappin, D. J. (August 2020) Mito-oncology agent: fermented extract suppresses the Warburg effect, restores oxidative mitochondrial activity, and inhibits in vivo tumor growth. Sci Rep, 10 (1). p. 14174. ISSN 2045-2322
Barth, N. D., Subiros-Funosas, R., Mendive-Tapia, L., Duffin, R., Shields, M. A., Cartwright, J. A., Henriques, S. T., Sot, J., Goñi, F. M., Lavilla, R., Marwick, J. A., Vermeren, S., Rossi, A. G., Egeblad, M., Dransfield, I., Vendrell, M. (August 2020) A fluorogenic cyclic peptide for imaging and quantification of drug-induced apoptosis. Nat Commun, 11 (1). p. 4027. ISSN 2041-1723
Wilson, J., Palmeri, J., Pappin, D. (August 2020) SimpliFi: a data-to-meaning analytics engine to bring omics understanding to all. J Biomol Tech, 31 (Suppl). S1. ISSN 1524-0215 (Print)1524-0215
Sun, Lijuan, Kees, Tim, Almeida, Ana Santos, Liu, Bodu, He, Xue-Yan, Ng, David, Spector, David, McNeish, Iain A, Gimotty, Phyllis, Adams, Sylvia, Egeblad, Mikala (July 2020) Activating a collaborative innate-adaptive immune response to control breast and ovarian cancer metastasis. BioRxiv. (Unpublished)
Biasci, D., Smoragiewicz, M., Connell, C. M., Wang, Z., Gao, Y., Thaventhiran, J. E., Basu, B., Magiera, L., Johnson, I. T., Bax, L., Gopinathan, A., Isherwood, C., Gallagher, F., Pawula, M., Hudecova, I., Gale, D., Rosenfeld, N., Barmpounakis, P., Popa, E. C., Brais, R., Godfrey, E., Mir, F., Richards, F., Fearon, D. T., Janowitz, T., Jodrell, D. (July 2020) CXCR4 inhibition in human pancreatic and colorectal cancers induces an integrated immune response. medRxiv. (Unpublished)
Lau, A. N., Li, Z., Danai, L. V., Westermark, A. M., Darnell, A. M., Ferreira, R., Gocheva, V., Sivanand, S., Lien, E. C., Sapp, K. M., Mayers, J. R., Biffi, G., Chin, C. R., Davidson, S. M., Tuveson, D. A., Jacks, T., Matheson, N. J., Yilmaz, O., Vander Heiden, M. G. (July 2020) Dissecting cell-type-specific metabolism in pancreatic ductal adenocarcinoma. Elife, 9. ISSN 2050-084x
Oni, T. E., Biffi, G., Baker, L. A., Hao, Y., Tonelli, C., Somerville, T. D. D., Deschênes, A., Belleau, P., Hwang, C. I., Sánchez-Rivera, F. J., Cox, H., Brosnan, E., Doshi, A., Lumia, R. P., Khaledi, K., Park, Y., Trotman, L. C., Lowe, S. W., Krasnitz, A., Vakoc, C. R., Tuveson, D. A. (July 2020) SOAT1 promotes mevalonate pathway dependency in pancreatic cancer. J Exp Med, 217 (9). ISSN 0022-1007
Dasgupta, A., Shukla, S.K., Vernucci, E., King, R.J., Abrego, J., Mulder, S.E., Mullen, N.J., Graves, G., Buettner, K., Thakur, R., Murthy, D., Attri, K.S., Wang, D., Chaika, N.V., Pacheco, C.G., Rai, I., Engle, D. D., Grandgenett, P. M., Punsoni, M., Reames, B.N., Teoh-Fitzgerald, M., Oberley-Deegan, R., Yu, F., Klute, K.A., Hollingsworth, M.A., Zimmerman, M.C., Mehla, K., Sadoshima, J., Tuveson, D. A., Singh, P.K. (July 2020) SIRT1-NOX4 Signaling Axis Regulates Cancer Cachexia. J Exp Med, 217 (7). e20190745. ISSN 0022-1007
Middleton, EA, He, X.-Y., Denorme, F, Campbell, RA, Ng, D., Salvatore, S., Mostyka, M, Baxter-Stoltzfus, A., Borczuk, A., Loda, M., Cody, MJ, Manne, BK, Portier, I, Harris, E, Petrey, AC, Beswick, EJ, Caulin, AF, Iovino, A, Abegglen, LM, Weyrich, AS, Rondina, MT, Egeblad, M., Schiffman, JD, Con Yost, C (June 2020) Neutrophil Extracellular Traps (NETs) Contribute to Immunothrombosis in COVID-19 Acute Respiratory Distress Syndrome. Blood. ISSN 0006-4971
Janowitz, T., Gablenz, E., Pattinson, D., Wang, T.C., Conigliaro, J., Tracey, K., Tuveson, D. (June 2020) Famotidine Use and Quantitative Symptom Tracking for COVID-19 in Non-Hospitalised Patients: A Case Series. Gut, 69 (9). pp. 1592-1597. ISSN 1468-3288
Zuo, Y., Yalavarthi, S., Shi, H., Gockman, K., Zuo, M., Madison, J.A., Blair, C.N., Weber, A., Barnes, B.J., Egeblad, M., Woods, R.J., Kanthi, Y., Knight, J.S. (June 2020) Neutrophil Extracellular Traps in COVID-19. JCI Insight, 5 (11). p. 138999. ISSN 2379-3708
Barnes, B.J., Adrover, J.M., Baxter-Stoltzfus, A., Borczuk, A., Cools-Lartigue, J., Crawford, J.M., DaBler-Plenker, J., Guerci, P., Huynh, C., Knight, J.S., Loda, M., Looney, M.R., McAllister, F., Rayes, R., Renaud, S., Rousseau, S., Salvatore, S., Schwartz, R.E., Spicer, J.D., Yost, C.C., Weber, A., Zuo, Y., Egeblad, M. (June 2020) Targeting Potential Drivers of COVID-19: Neutrophil Extracellular Traps. J Exp Med, 217 (6). e20200652. ISSN 1540-9538
Feigman, M.J., Moss, M.A., Chen, C., Cyrill, S.L., Cicone, M.F., Trousdell, M.C., Yang, S.-T., Frey, W.D., Wilkinson, J.E., Dos Santos, C. O. (May 2020) Pregnancy Reprograms the Epigenome of Mammary Epithelial Cells and Blocks the Development of Premalignant Lesions. Nat Commun, 11 (1). p. 2649. ISSN 2041-1723
Weber, Andrew G, Chau, Alice S, Egeblad, Mikala, Barnes, Betsy J, Janowitz, Tobias (May 2020) Nebulized in-line endotracheal dornase alfa and albuterol administered to mechanically ventilated COVID-19 patients: A case series. MedRxiv. (Unpublished)
Janowitz, T., Tuveson, D. A. (May 2020) The Era of COVID-19 and the Rise of Science Collectivism in Cancer Research. Cancer Discov, 10 (7). pp. 913-915. ISSN 2159-8274
Yamamoto, K., Venida, A., Yano, J., Biancur, D.E., Kakiuchi, M., Gupta, S., Sohn, A.S.W., Mukhopadhyay, S., Lin, E.Y., Parker, S.J., Banh, R.S., Paulo, J.A., Wen, K.W., Debnath, J., Kim, G.E., Mancias, J.D., Fearon, D. T., Perera, R.M., Kimmelman, A.C. (May 2020) Autophagy Promotes Immune Evasion of Pancreatic Cancer by Degrading MHC-I. Nature, 581 (7806). pp. 100-105. ISSN 0028-0836
Corrie, P.G., Qian, W., Basu, B., Valle, J.W., Falk, S., Lwuji, C., Wasan, H., Palmer, D., Scott-Brown, M., Wadsley, J., Arif, S., Bridgewater, J., Propper, D., Gillmore, R., Gopinathan, A., Skells, R., Bundi, P., Brais, R., Dalchau, K., Bax, L., Chhabra, A., Machin, A., Dayim, A., McAdam, K., Cummins, S., Wall, L., Ellis, R., Anthoney, A., Evans, J., Ma, Y.T., Isherwood, C., Neesse, A., Tuveson, D., Jodrell, D. I. (April 2020) Scheduling Nab-Paclitaxel Combined With Gemcitabine as First-Line Treatment for Metastatic Pancreatic Adenocarcinoma. Br J Cancer. ISSN 0007-0920
Somerville, T. D. D., Biffi, G., DaBler-Plenker, J., Hur, S.K., He, X.-Y., Vance, K.E., Miyabayashi, K., Xu, Y., Maia-Silva, D., Klingbeil, O., Demerdash, O. E., Preall, J. B., Hollingsworth, M. A., Egeblad, M., Tuveson, D. A., Vakoc, C. R. (April 2020) Squamous trans-differentiation of pancreatic cancer cells promotes stromal inflammation. Elife, 9. e53381. ISSN 2050-084x (Public Dataset)
Fu, P., Ramchandran, R., Shaaya, M., Huang, L., Ebenezer, D.L., Jiang, Y., Komarova, Y., Vogel, S.M., Malik, A.B., Minshall, R.D., Du, G., Tonks, N. K., Natarajan, V. (April 2020) Phospholipase D2 Restores Endothelial Barrier Function by Promoting PTPN14-mediated VE-cadherin Dephosphorylation. Journal of Biological Chemistry, 295 (22). pp. 7669-7685. ISSN 0021-9258
Monje, M., Borniger, J., D'Silva, N.J., Deneen, B., Dirks, P.B., Fattahi, F., Frenette, P.S., Garzia, L., Gutmann, D.H., Hanahan, D., Hervey-Jumper, S.L., Hondermarck, H., Hurov, J.B., Kepecs, A., Knox, S.M., Lloyd, A.C., Magnon, C., Saloman, J.L., Segal, R.A., Sloan, E.K., Sun, X., Taylor, M.D., Tracey, K.J., Trotman, L. C., Tuveson, D. A., Wang, T.C., White, R.A., Winkler, F. (April 2020) Roadmap for the Emerging Field of Cancer Neuroscience. Cell, 181 (2). pp. 219-222. ISSN 0092-8674
Sahai, E., Astsaturov, I., Cukierman, E., DeNardo, D. G., Egeblad, M., Evans, R. M., Fearon, D., Greten, F. R., Hingorani, S. R., Hunter, T., Hynes, R. O., Jain, R. K., Janowitz, T., Jorgensen, C., Kimmelman, A. C., Kolonin, M. G., Maki, R. G., Powers, R. S., Pure, E., Ramirez, D. C., Scherz-Shouval, R., Sherman, M. H., Stewart, S., Tlsty, T. D., Tuveson, D. A., Watt, F. M., Weaver, V., Weeraratna, A. T., Werb, Z. (March 2020) A framework for advancing our understanding of cancer-associated fibroblasts. Nat Rev Cancer, 20 (3). pp. 174-186. ISSN 1474-175x
Wilson, J.P., Ipsaro, J. J., Del Giudice, S.N., Turna, N. S., Gauss, C. M., Dusenbury, K.H., Marquart, K., Rivera, K. D., Pappin, D. J. (March 2020) Tryp-N: A Thermostable Protease for the Production of N-terminal Argininyl and Lysinyl Peptides. J Proteome Res, 19 (4). pp. 1459-1469. ISSN 1535-3893 (Public Dataset)
LaComb, J. F., Plenker, D., Tiriac, H., Bucobo, J. C., D'Souza, L.S., Khokhar, A.S., Patel, H., Channer, B., Joseph, D., Wu, M., Tuveson, D. A., Li, E., Buscaglia, J. M. (February 2020) Single-Pass vs 2-Pass Endoscopic Ultrasound-Guided Fine-Needle Biopsy Sample Collection for Creation of Pancreatic Adenocarcinoma Organoids. Clin Gastroenterol Hepatol. ISSN 1542-3565
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Tian, C., Ohlund, D., Rickelt, S., Lidstrom, T., Huang, Y., Hao, L., Zhao, R. T., Franklin, O., Bhatia, S. N., Tuveson, D. A., Hynes, R. O. (February 2020) Cancer-cell-derived matrisome proteins promote metastasis in pancreatic ductal adenocarcinoma. Cancer Res, 80 (7). pp. 1461-1474. ISSN 0008-5472
Ordovas-Montanes, J., Beyaz, S., Rakoff-Nahoum, S., Shalek, A. K. (February 2020) Distribution and storage of inflammatory memory in barrier tissues. Nat Rev Immunol, 20 (5). pp. 308-320. ISSN 1474-1733
Connell, Claire M, Brais, Rebecca, Whitaker, Hayley, Upponi, Sara, Beh, Ian, Risdall, Jane, Corrie, Pippa, Janowitz, Tobias, Jodrell, Duncan I (January 2020) Early relapse on adjuvant gemcitabine associated with an exceptional response to 2nd line capecitabine chemotherapy in a patient with pancreatic adenosquamous carcinoma with strong intra-tumoural expression of cytidine deaminase: a case report. BMC Cancer, 20 (1). p. 38. ISSN 1471-2407
Marchione, D. M., Ilieva, I., Devins, K., Sharpe, D., Pappin, D. J., Garcia, B. A., Wilson, J. P., Wojcik, J. B. (January 2020) HYPERsol: High-Quality Data from Archival FFPE Tissue for Clinical Proteomics. J Proteome Res, 19 (2). pp. 973-983. ISSN 1535-3893 (Public Dataset)
Cheung, E. C., DeNicola, G. M., Nixon, C., Blyth, K., Labuschagne, C. F., Tuveson, D. A., Vousden, K. H. (January 2020) Dynamic ROS Control by TIGAR Regulates the Initiation and Progression of Pancreatic Cancer. Cancer Cell. ISSN 1535-6108
Chan-Seng-Yue, M., Kim, J. C., Wilson, G. W., Ng, K., Figueroa, E. F., O'Kane, G. M., Connor, A. A., Denroche, R. E., Grant, R. C., McLeod, J., Wilson, J. M., Jang, G. H., Zhang, A., Liang, S. B., Borgida, A., Chadwick, D., Kalimuthu, S., Lungu, I., Bartlett, J. M. S., Krzyzanowski, P. M., Sandhu, V., Tiriac, H., Froeling, F. E. M., Karasinska, J. M., Topham, J. T., Renouf, D. J., Schaeffer, D. F., Jones, S. J. M., Marra, M. A., Laskin, J., Chetty, R., Stein, L. D., Zogopoulos, G., Haibe-Kains, B., Campbell, P. J., Tuveson, D. A., Knox, J. J., Fischer, S. E., Gallinger, S., Notta, F. (January 2020) Transcription phenotypes of pancreatic cancer are driven by genomic events during tumor evolution. Nat Genet. ISSN 1061-4036 (Public Dataset)
Sindhwani, S., Syed, A.M., Ngai, J., Kingston, B.R., Maiorino, L., Rothschild, J., MacMillan, P., Zhang, Y., Rajesh, N.U., Hoang, T., Wu, J.L.Y., Wilhelm, S., Zilman, A., Gadde, S., Sulaiman, A., Ouyang, B., Lin, Z., Wang, L., Egeblad, M., Chan, W.C.W. (January 2020) The entry of nanoparticles into solid tumours. Nat Mater. ISSN 1476-1122 (Public Dataset)
Munir, Hafsa, Jones, James O, Janowitz, Tobias, Martins, Carla P, Welsh, Sarah J, Shields, Jacqueline D (January 2020) Stromal Amyloid β drives Neutrophil extracellular trap formation to augment tumour growth. BioRxiv. (Unpublished)
Londhe, A. D., Bergeron, A., Curley, S. M., Zhang, F., Rivera, K. D., Kannan, A., Coulis, G., Rizvi, S. H. M., Kim, S. J., Pappin, D. J., Tonks, N. K., Linhardt, R. J., Boivin, B. (December 2019) Regulation of PTP1B activation through disruption of redox-complex formation. Nat Chem Biol, 16 (2). pp. 122-125. ISSN 1552-4450
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Carbonetti, G., Converso, C., Clement, T., Wang, C., Trotman, L., Ojima, I., Kaczocha, M. (October 2019) Docetaxel/cabazitaxel and fatty acid binding protein 5 inhibitors produce synergistic inhibition of prostate cancer growth. Prostate. ISSN 0270-4137
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Tian, C., Clauser, K. R., Ohlund, D., Rickelt, S., Huang, Y., Gupta, M., Mani, D. R., Carr, S. A., Tuveson, D. A., Hynes, R. O. (September 2019) Proteomic analyses of ECM during pancreatic ductal adenocarcinoma progression reveal different contributions by tumor and stromal cells. Proc Natl Acad Sci U S A, 116 (39). pp. 19609-19618. ISSN 0027-8424
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Denton, A. E., Carr, E. J., Magiera, L. P., Watts, A. J. B., Fearon, D. T. (July 2019) Embryonic FAP(+) lymphoid tissue organizer cells generate the reticular network of adult lymph nodes. J Exp Med, 216 (10). pp. 2242-2252. ISSN 0022-1007
Slepicka, P. F., Cyrill, S. L., Dos Santos, C. O. (July 2019) Pregnancy and Breast Cancer: Pathways to Understand Risk and Prevention. Trends Mol Med, 25 (10). pp. 866-881. ISSN 1471-4914
Nayar, Saba, Campos, Joana, Smith, Charlotte G, Iannizzotto, Valentina, Gardner, David H, Mourcin, Frédéric, Roulois, David, Turner, Jason, Sylvestre, Marvin, Asam, Saba, Glaysher, Bridget, Bowman, Simon J, Fearon, Douglas T, Filer, Andrew, Tarte, Karin, Luther, Sanjiv A, Fisher, Benjamin A, Buckley, Christopher D, Coles, Mark C, Barone, Francesca (July 2019) Immunofibroblasts are pivotal drivers of tertiary lymphoid structure formation and local pathology. Proceedings of the National Academy of Sciences of USA, 116 (27). pp. 13490-13497. ISSN 0027-8424
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Elyada, E., Bolisetty, M., Laise, P., Flynn, W. F., Courtois, E. T., Burkhart, R. A., Teinor, J. A., Belleau, P., Biffi, G., Lucito, M. S., Sivajothi, S., Armstrong, T. D., Engle, D. D., Yu, K. H., Hao, Y., Wolfgang, C. L., Park, Y., Preall, J., Jaffee, E. M., Califano, A., Robson, P., Tuveson, D. A. (June 2019) Cross-species single-cell analysis of pancreatic ductal adenocarcinoma reveals antigen-presenting cancer-associated fibroblasts. Cancer Discov, 9 (8). pp. 1102-1123. ISSN 2159-8274
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Tai, Y., Gallo, N. B., Wang, M., Yu, J. R., Van Aelst, L. (February 2019) Axo-axonic Innervation of Neocortical Pyramidal Neurons by GABAergic Chandelier Cells Requires AnkyrinG-Associated L1CAM. Neuron, 102 (2). pp. 267-270. ISSN 0896-6273
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Cheng, D., Tuveson, D. (January 2018) Kras in Organoids. Cold Spring Harb Perspect Med, 8 (10). ISSN 2157-1422
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Zhang, S., Fan, G., Hao, Y., Hammell, M., Wilkinson, J. E., Tonks, N. K. (October 2017) Suppression of protein tyrosine phosphatase N23 predisposes to breast tumorigenesis via activation of FYN kinase. Genes Dev, 31 (19). pp. 1939-57. ISSN 0890-9369
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Flint, Thomas R., Fearon, Douglas T., Janowitz, Tobias (May 2017) Connecting the Metabolic and Immune Responses to Cancer. Trends in Molecular Medicine, 23 (5). pp. 451-464. ISSN 1471-4914
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Fearon, D. T. (April 2017) Explaining the Paucity of Intratumoral T Cells: A Construction Out of Known Entities. Cold Spring Harb Symp Quant Biol, 81. pp. 219-226. ISSN 0091-7451
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Ohlund, D., Handly-Santana, A., Biffi, G., Elyada, E., Almeida, A. S., Ponz-Sarvise, M., Corbo, V., Oni, T. E., Hearn, S. A., Lee, E. J., Chio, II, Hwang, C. I., Tiriac, H., Baker, L. A., Engle, D. D., Feig, C., Kultti, A., Egeblad, M., Fearon, D. T., Crawford, J. M., Clevers, H., Park, Y., Tuveson, D. A. (March 2017) Distinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer. J Exp Med, 214 (3). pp. 579-596. ISSN 0022-1007
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