ROR2 Regulates Cellular Plasticity in Pancreatic Neoplasia and Adenocarcinoma

Benitz, Simone, Steep, Alec, Nasser, Malak M, Preall, Jonathan, Mahajan, Ujjwal Mukund, McQuithey, Holly, Loveless, Ian, Davis, Erick T, Wen, Hui-Ju, Long, Daniel W, Metzler, Thomas, Zwernik, Samuel, Louw, Michaela, Rempinski, Donald, Salas-Escabillas, Daniel J, Brender, Sydney M, Song, Linghao, Huang, Ling, Theisen, Brian K, Zhang, Zhenyu, Steele, Nina G, Regel, Ivonne, Bednar, Filip, Crawford, Howard C (July 2024) ROR2 Regulates Cellular Plasticity in Pancreatic Neoplasia and Adenocarcinoma. Cancer Discovery. ISSN 2159-8274 (Public Dataset)

[thumbnail of 10.1158.2159-8290.CD-24-0137.pdf] PDF
10.1158.2159-8290.CD-24-0137.pdf - Published Version
Available under License Creative Commons Attribution Non-commercial No Derivatives.

Download (22MB)

Abstract

Cellular plasticity is a hallmark of pancreatic ductal adenocarcinoma (PDAC) starting from the conversion of normal cells into precancerous lesions, to the progression of carcinoma subtypes associated with aggressiveness and therapeutic response. We discovered that normal acinar cell differentiation, maintained by the transcription factor Pdx1, suppresses a broad gastric cell identity that is maintained in metaplasia, neoplasia, and the classical subtype of PDAC in mouse and human. We have identified the receptor tyrosine kinase Ror2 as marker of a gastric metaplasia-like identity in pancreas neoplasms. Ablation of Ror2 in a mouse model of pancreatic tumorigenesis promoted a switch to a gastric pit cell identity that largely persisted through progression to the classical subtype of PDAC. In both human and mouse pancreatic cancer, ROR2 activity continued to antagonize the gastric pit cell identity, strongly promoting an epithelial to mesenchymal transition, conferring resistance to KRAS inhibition, and vulnerability to AKT inhibition.

Item Type: Paper
Subjects: diseases & disorders > cancer
diseases & disorders
diseases & disorders > cancer > cancer types > pancreatic cancer
diseases & disorders > cancer > cancer types
CSHL Authors:
Communities: CSHL Cancer Center Program
CSHL Cancer Center Program > Cellular Communication in Cancer Program
CSHL labs > Preall lab
SWORD Depositor: CSHL Elements
Depositing User: CSHL Elements
Date: 8 July 2024
Date Deposited: 15 Jul 2024 13:36
Last Modified: 01 Oct 2024 17:32
Related URLs:
Dataset ID:
URI: https://repository.cshl.edu/id/eprint/41602

Actions (login required)

Administrator's edit/view item Administrator's edit/view item