Lowe, Scott W. Publications

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Lowe, Scott W.

Number of items at this level: 204.

Lee, C. S., Lee, L. C., Yuan, T. L., Chakka, S., Fellmann, C., Lowe, S. W., Caplen, N. J., McCormick, F., Luo, J. (February 2019) MAP kinase and autophagy pathways cooperate to maintain RAS mutant cancer cell survival. Proc Natl Acad Sci U S A. ISSN 0027-8424

Yuan, T. L., Amzallag, A., Bagni, R., Yi, M., Afghani, S., Burgan, W., Fer, N., Strathern, L. A., Powell, K., Smith, B., Waters, A. M., Drubin, D., Thomson, T., Liao, R., Greninger, P., Stein, G. T., Murchie, E., Cortez, E., Egan, R. K., Procter, L., Bess, M., Cheng, K. T., Lee, C. S., Lee, L. C., Fellmann, C., Stephens, R., Luo, J., Lowe, S. W., Benes, C. H., McCormick, F. (February 2018) Differential Effector Engagement by Oncogenic KRAS. Cell Rep, 22 (7). pp. 1889-1902.

Manchado, E., Weissmueller, S., Morris, J. P., Chen, C. C., Wullenkord, R., Lujambio, A., de Stanchina, E., Poirier, J. T., Gainor, J. F., Corcoran, R. B., Engelman, J. A., Rudin, C. M., Rosen, N., Lowe, S. W. (June 2016) A combinatorial strategy for treating KRAS-mutant lung cancer. Nature, 534. pp. 647-51. ISSN 1476-4687 (Electronic)0028-0836 (Linking)

Cifra, A., Lowe, S.W (November 2015) Exploring cell apoptosis and senescence to understand and treat cancer: an interview with Scott Lowe. Dis Model Mech, 8 (11). pp. 1345-8. ISSN 1754-8411 (Electronic)1754-8403 (Linking)

Chakraborty, A. A., Scuoppo, C., Dey, S., Thomas, L. R., Lorey, S. L., Lowe, S. W., Tansey, W. P. (July 2015) A common functional consequence of tumor-derived mutations within c-MYC. Oncogene, 34. pp. 2406-2409. ISSN 0950-9232

Li, J., Chanrion, M., Sawey, E., Wang, T., Chow, E., Tward, A., Su, Y., Xue, W., Lucito, R., Zender, L., Lowe, S. W., Bishop, J. M., Powers, S. (March 2015) Reciprocal Interaction of Wnt and RXR-alpha Pathways in Hepatocyte Development and Hepatocellular Carcinoma. PLoS One, 10 (3). e0118480. ISSN 1932-6203

Huang, C. H., Lujambio, A., Zuber, J., Tschaharganeh, D. F., Doran, M. G., Evans, M. J., Kitzing, T., Zhu, N., de Stanchina, E., Sawyers, C. L., Armstrong, S. A., Lewis, J. S., Sherr, C. J., Lowe, S. W. (August 2014) CDK9-mediated transcription elongation is required for MYC addiction in hepatocellular carcinoma. Genes and Development, 28 (16). pp. 1800-1814. ISSN 15495477 (ISSN)

Tschaharganeh, D. F., Xue, W., Calvisi, D. F., Evert, M., Michurina, T. V., Dow, L. E., Banito, A., Katz, S. F., Kastenhuber, E. R., Weissmueller, S., Huang, C. H., Lechel, A., Andersen, J. B., Capper, D., Zender, L., Longerich, T., Enikolopov, G., Lowe, S. W. (July 2014) p53-Dependent Nestin Regulation Links Tumor Suppression to Cellular Plasticity in Liver Cancer. Cell, 158 (3). pp. 579-92. ISSN 0092-8674

Zaiss, A. K., Zuber, J., Chu, C., Machado, H. B., Jiao, J., Catapang, A. B., Ishikawa, T. O., Gil, J. S., Lowe, S. W., Herschman, H. R. (July 2014) Reversible Suppression of Cyclooxygenase 2 (COX-2) Expression In Vivo by Inducible RNA Interference. PLoS One, 9 (7). e101263. ISSN 1932-6203

Miething, C., Scuoppo, C., Bosbach, B., Appelmann, I., Nakitandwe, J., Ma, J., Wu, G., Lintault, L., Auer, M., Premsrirut, P. K., Teruya-Feldstein, J., Hicks, J., Benveniste, H., Speicher, M. R., Downing, J. R., Lowe, S. W. (May 2014) PTEN action in leukaemia dictated by the tissue microenvironment. Nature, 510 (7505). p. 402. ISSN 0028-0836

Weissmueller, S., Manchado, E., Saborowski, M., Morris, J. P. th, Wagenblast, E., Davis, C. A., Moon, S. H., Pfister, N. T., Tschaharganeh, D. F., Kitzing, T., Aust, D., Markert, E. K., Wu, J., Grimmond, S. M., Pilarsky, C., Prives, C., Biankin, A. V., Lowe, S. W. (April 2014) Mutant p53 Drives Pancreatic Cancer Metastasis through Cell-Autonomous PDGF Receptor beta Signaling. Cell, 157 (2). pp. 382-94. ISSN 1097-4172 (Electronic)0092-8674 (Linking)

Saborowski, A., Saborowski, M., Davare, M. A., Druker, B. J., Klimstra, D. S., Lowe, S. W. (November 2013) Mouse model of intrahepatic cholangiocarcinoma validates FIG-ROS as a potent fusion oncogene and therapeutic target. Proceedings of the National Academy of Sciences of the United States of America, 110 (48). pp. 19513-19518. ISSN 00278424 (ISSN)

Rajaram, M., Zhang, J., Wang, T., Li, J., Kuscu, C., Qi, H., Kato, M., Grubor, V., Weil, R. J., Helland, A., Borrenson-Dale, A. L., Cho, K. R., Levine, D. A., Houghton, A. N., Wolchok, J. D., Myeroff, L., Markowitz, S. D., Lowe, S. W., Zhang, M., Krasnitz, A., Lucito, R., Mu, D., Powers, R. S. (June 2013) Two Distinct Categories of Focal Deletions in Cancer Genomes. PLoS ONE, 8 (6). e66264. ISSN 1932-6203 (Electronic)1932-6203 (Linking)

Tasdemir, N., Lowe, S. W. (June 2013) Senescent cells spread the word: non-cell autonomous propagation of cellular senescence. Embo Journal, 84 (1). pp. 114-127. ISSN 0261-4189

Mills, J. R., Malina, A., Lee, T., Di Paola, D., Larsson, O., Miething, C., Grosse, F., Tang, H. L., Zannis-Hadjopoulos, M., Lowe, S. W., Pelletier, J. (April 2013) RNAi screening uncovers Dhx9 as a modifier of ABT-737 resistance in an E mu-myc/Bcl-2 mouse model. Blood, 121 (17). pp. 3402-3412. ISSN 0006-4971

Sagiv, A., Biran, A., Yon, M., Simon, J., Lowe, S. W., Krizhanovsky, V. (April 2013) Granule exocytosis mediates immune surveillance of senescent cells. Oncogene, 32 (15). pp. 1971-7. ISSN 1476-5594 (Electronic)0950-9232 (Linking)

Wall, M., Poortinga, G., Stanley, K. L., Lindemann, R. K., Bots, M., Chan, C. J., Bywater, M. J., Kinross, K. M., Astle, M. V., Waldeck, K., Hannan, K. M., Shortt, J., Smyth, M. J., Lowe, S. W., Hannan, R. D., Pearson, R. B., Johnstone, R. W., McArthur, G. A. (January 2013) The mTORC1 inhibitor everolimus prevents and treats Eμ-Myc lymphoma by restoring oncogene-induced senescence. Cancer Discovery, 3 (1). pp. 82-95. ISSN 21598274

Lujambio, A., Akkari, L., Simon, J., Grace, D., Tschaharganeh, D. F., Bolden, J. E., Zhao, Z., Thapar, V., Joyce, J. A., Krizhanovsky, V., Lowe, S. W. (2013) Non-cell-autonomous tumor suppression by p53. Cell, 153 (2). pp. 449-460.

Shi, J., Wang, E., Zuber, J., Rappaport, A., Taylor, M., Johns, C., Lowe, S. W., Vakoc, C. R. (2013) The Polycomb complex PRC2 supports aberrant self-renewal in a mouse model of MLL-AF9;Nras(G12D) acute myeloid leukemia. Oncogene, 32 (7). pp. 930-938. ISSN 1476-5594 (Electronic)0950-9232 (Linking)

Miething, C., Scuoppo, C., Lindqvist, L., Reyes, J., Ruse, C., Appelmann, I., Yoon, S., Krasnitz, A., Teruya-Feldstein, J., Pappin, D., Pelletier, J., Lowe, S. (October 2012) An oncogenome-based RNAi screen identifies a tumour suppressor network in B-cell lymphoma relying on the polyamine-hypusine axis. Onkologie, 35. p. 104. ISSN 0378-584X

Bywater, M. J., Poortinga, G., Sanij, E., Hein, N., Peck, A., Cullinane, C., Wall, M., Cluse, L., Drygin, D., Anderes, K., Huser, N., Proffitt, C., Bliesath, J., Haddach, M., Schwaebe, M. K., Ryckman, D. M., Rice, W. G, Schmitt, C., Lowe, Scott W, Johnstone, R. W., Pearson, R. B., McArthur, G. A., Hannan, R. D. (July 2012) Inhibition of RNA Polymerase I as a Therapeutic Strategy to Promote Cancer-Specific Activation of p53. Cancer Cell, 22 (1). pp. 51-65. ISSN 1535-6108

Aksoy, O., Chicas, A., Zeng, T., Zhao, Z., McCurrach, M., Wang, X., Lowe, S. W. (July 2012) The atypical E2F family member E2F7 couples the p53 and RB pathways during cellular senescence. Genes Dev, 26 (14). pp. 1546-57. ISSN 1549-5477 (Electronic)0890-9369 (Linking)

Scuoppo, C., Miething, C., Lindqvist, L., Reyes, J., Ruse, C., Appelmann, I., Yoon, S., Krasnitz, A., Teruya-Feldstein, J., Pappin, D., Pelletier, J., Lowe, S. W. (July 2012) A tumour suppressor network relying on the polyamine-hypusine axis. Nature, 487 (7406). pp. 244-8. ISSN 1476-4687 (Electronic)0028-0836 (Linking)

Kitzing, T., Xue, W., Roessler, S., Krasnitz, A., Schultz, N., Wang, X. W., Wigler, M., Lowe, S. W. (July 2012) Cooperating Tumor Suppressor Genes on Chromosome 8p Predict Survival Outcome in Hepatocellular Carcinoma. European Journal of Cancer, 48. S139-S139. ISSN 0959-8049

Chicas, A., Kapoor, A., Wang, X. W., Aksoy, O., Evertts, A. G., Zhang, M. Q., Garcia, B. A., Bernstein, E., Lowe, S. W. (June 2012) H3K4 demethylation by Jarid1a and Jarid1b contributes to retinoblastoma-mediated gene silencing during cellular senescence. Proceedings of the National Academy of Sciences of the United States of America, 109 (23). pp. 8971-8976. ISSN 0027-8424

Spector, M. S., Iossifov, I., Kritharis, A., He, C., Kolitz, J. E., Lowe, S. W., Allen, S. L. (June 2012) Mast-cell leukemia exome sequencing reveals a mutation in the IgE mast-cell receptor beta chain and KIT V654A. Leukemia, 26 (6). pp. 1422-1425. ISSN 0887-6924

Bergerson, R. J., Collier, L. S., Sarver, A. L., Been, R. A., Lugthart, S., Diers, M. D., Zuber, J., Rappaport, A. R., Nixon, M. J., Silverstein, K. A. T., Fan, D. H., Lamblin, A. F. J., Wolff, L., Kersey, J. H., Delwel, R., Lowe, S. W., O'Sullivan, M. G., Kogan, S. C., Adams, D. J., Largaespada, D. A. (May 2012) An insertional mutagenesis screen identifies genes that cooperate with Mll-AF9 in a murine leukemogenesis model. Blood, 119 (19). pp. 4512-4523. ISSN 0006-4971

Xue, W., Kitzing, T., Roessler, S., Zuber, J., Krasnitz, A., Schultz, N., Revill, K., Weissmueller, S., Rappaport, A. R., Simon, J., Zhang, J., Luo, W. J., Hicks, J., Zender, L., Wang, X. W., Powers, S., Wigler, M., Lowe, S. W. (May 2012) A cluster of cooperating tumor-suppressor gene candidates in chromosomal deletions. Proceedings of the National Academy of Sciences of the United States of America, 109 (21). pp. 8212-8217. ISSN 0027-8424

Lin, C. J., Nasr, Z., Premsrirut, P. K., Porco Jr, J. A., Hippo, Y., Lowe, S. W., Pelletier, J. (April 2012) Targeting Synthetic Lethal Interactions between Myc and the eIF4F Complex Impedes Tumorigenesis. Cell Reports, 1 (4). pp. 325-333. ISSN 2211-1247

Bazarov, A. V., Jae Lee, W., Bazarov, I., Bosire, M., Hines, W. C., Stankovich, B., Chicas, A., Lowe, S. W., Yaswen, P. (March 2012) The specific role of pRb in p16(INK4A)-mediated arrest of normal and malignant human breast cell. Cell Cycle, 11 (5). ISSN 1551-4005 (Electronic)1551-4005 (Linking)

Glaser, S. P., Lee, E. F., Trounson, E., Bouillet, P., Wei, A., Fairlie, W. D., Izon, D. J., Zuber, J., Rappaport, A. R., Herold, M. J., Alexander, W. S., Lowe, S. W., Robb, L., Strasser, A. (January 2012) Anti-apoptotic mcl-1 is essential for the development and sustained growth of acute myeloid leukemia. Genes and Development, 26 (2). pp. 120-125. ISSN 08909369 (ISSN)

Freed-Pastor, W. A., Mizuno, H., Zhao, X., Langerød, A., Moon, S. H., Rodriguez-Barrueco, R., Barsotti, A., Chicas, A., Li, W., Polotskaia, A., Bissell, M. J., Osborne, T. F., Tian, B., Lowe, S. W., Silva, J. M., Børresen-Dale, A. L., Levine, A. J., Bargonetti, J., Prives, C. (January 2012) Mutant p53 disrupts mammary tissue architecture via the mevalonate pathway. Cell, 148 (1-2). pp. 244-258. ISSN 00928674 (ISSN)

Chandra, T., Kirschner, K., Thuret, J., Pope, B. D., Ryba, T., Newman, S., Ahmed, K., Samarajiwa, S. A., Salama, R., Carroll, T., Stark, R., Janky, R., Narita, M., Xue, L., Chicas, A., Nũnez, S., Janknecht, Ralf, Hayashi-Takanaka, Y., Wilson, M. D., Marshall, A., Odom, D. T, Babu, M.  M., Bazett-Jones, D. P., Tavaré, S., Edwards, P. A. W., Lowe, S. W., Kimura, H., Gilbert, D. M., Narita, M. (2012) Independence of Repressive Histone Marks and Chromatin Compaction during Senescent Heterochromatic Layer Formation. Molecular Cell, 47 (2). pp. 203-214. ISSN 1097-2765

Tan, X., Lu, Z. J., Gao, G., Xu, Q., Hu, L., Fellmann, C., Li, M. Z., Qu, H., Lowe, S. W., Hannon, G. J., Elledge, S. J. (2012) Tiling genomes of pathogenic viruses identifies potent antiviral shRNAs and reveals a role for secondary structure in shRNA efficacy. Proceedings of the National Academy of Sciences of the United States of America, 109 (3). pp. 869-874. ISSN 00278424 (ISSN)

Dow, L. E., Premsrirut, P. K., Zuber, J., Fellmann, C., McJunkin, K., Miething, C., Park, Y., Dickins, R. A., Hannon, G. J., Lowe, S. W. (2012) A pipeline for the generation of shRNA transgenic mice. Nature Protocols, 7 (2). pp. 374-393. ISSN 17542189 (ISSN)

Hein, N., Bywater, M. J., Stanley, K., Verbrugge, I., Cullinane, C., Baker, A., Zuber, H., Rappaport, A., Drygin, D., Huser, N., Bliesath, J., Ryckman, D. M., Rice, W. G., Lowe, S. W., Johnstone, R. W., Pearson, R. B., McArthur, G. A., Hannan, R. D. (November 2011) Inhibition of RNA Polymerase I Transcription by CX-5461 As a Therapeutic Strategy for the Cancer-Specific Activation of p53 in MLL-Rearranged Acute Myeloid Leukemias. Blood, 118 (21). p. 1548. ISSN 0006-4971

Herrmann, H., Blatt, K., Shi, J. W., Rappaport, A. R., Gleixner, K. V., Cerny-Reiterer, S., Peter, B., Wang, E., Sperr, W. R., Bradner, J. E., Lowe, S. W., Vakoc, C. R., Zuber, J., Valent, P. (November 2011) Small-Molecule Inhibition of BRD4 Is a Novel Promising Approach to Therapeutically Target Leukemia Stem Cells in AML. Blood, 118 (21). p. 3484. ISSN 0006-4971

Chien, Y., Scuoppo, C., Wang, X., Fang, X., Balgley, B., Bolden, J. E., Premsrirut, P., Luo, W., Chicas, A., Lee, C. S., Kogan, S. C., Lowe, S. W. (October 2011) Control of the senescence-associated secretory phenotype by NF-kappaB promotes senescence and enhances chemosensitivity. Genes Dev, 25 (20). pp. 2125-36. ISSN 1549-5477 (Electronic) 0890-9369 (Linking)

Zuber, J., Shi, J., Wang, E., Rappaport, A. R., Herrmann, H., Sison, E. A., Magoon, D., Qi, J., Blatt, K., Wunderlich, M., Taylor, M. J., Johns, C., Chicas, A., Mulloy, J. C., Kogan, S. C., Brown, P., Valent, P., Bradner, J. E., Lowe, S. W., Vakoc, C. R. (August 2011) RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia. Nature, 478 (7370). pp. 524-528. ISSN 0028-0836

Zuber, J., Rappaport, A. R., Luo, W., Wang, E., Chen, C., Vaseva, A. V., Shi, J., Weissmueller, S., Fellman, C., Taylor, M. J., Weissenboeck, M., Graeber, T. G., Kogan, S. C., Vakoc, C. R., Lowe, S. W. (August 2011) An integrated approach to dissecting oncogene addiction implicates a Myb-coordinated self-renewal program as essential for leukemia maintenance. Genes & Development, 25 (15). pp. 1628-1640. ISSN 0890-9369

McJunkin, K., Mazurek, A., Premsrirut, P. K., Zuber, J., Dow, L. E., Simon, J., Stillman, B., Lowe, S. W. (April 2011) Reversible suppression of an essential gene in adult mice using transgenic RNA interference. Proceedings of the National Academy of Sciences of the United States of America, 108 (17). pp. 7113-7118. ISSN 0027-8424

Pardee, T. S., Zuber, J., Lowe, S. W. (April 2011) Flt3-ITD alters chemotherapy response in vitro and in vivo in a p53-dependent manner. Exp Hematol, 39 (4). 473-485 e4. ISSN 1873-2399 (Electronic)0301-472X (Linking)

Premsrirut, P. K., Dow, L. E., Kim, S. Y., Camiolo, M., Malone, C. D., Miething, C., Scuoppo, C. , Zuber, J., Dickins, R. A., Kogan, Scott C, Shroyer, Kenneth R, Sordella, R., Hannon, G. J., Lowe, S. W. (March 2011) A Rapid and Scalable System for Studying Gene Function in Mice Using Conditional RNA Interference. Cell, 145 (1). pp. 145-158. ISSN 0092-8674

Fellmann, C., Zuber, J., McJunkin, K., Chang, K. , Malone, C. D., Dickins, R. A., Xu, Q., Hengartner, M. O., Elledge, S. J., Hannon, G. J., Lowe, S. W. (March 2011) Functional Identification of Optimized RNAi Triggers Using a Massively Parallel Sensor Assay. Molecular Cell, 41 (6). pp. 733-746. ISSN 1097-2765

Sawey, E. T., Chanrion, M., Cai, C., Wu, G., Zhang, J., Zender, L., Zhao, A., Busuttil, R. W., Yee, H., Stein, L. D., French, D. M., Finn, Richard S, Lowe, S. W., Powers, S. (March 2011) Identification of a Therapeutic Strategy Targeting Amplified FGF19 in Liver Cancer by Oncogenomic Screening. Cancer Cell, 19 (3). pp. 347-358. ISSN 1535-6108

Xu, M. Z., Chan, S. W., Liu, A. M., Wong, K. F., Fan, S. T., Chen, J., Poon, R. T., Zender, L., Lowe, S. W., Hong, W., Luk, J. M. (March 2011) AXL receptor kinase is a mediator of YAP-dependent oncogenic functions in hepatocellular carcinoma. Oncogene, 30 (10). pp. 1229-1240.

Zuber, J., McJunkin, K., Fellmann, C., Dow, L. E., Taylor, M. J., Hannon, G. J., Lowe, S. W. (January 2011) Toolkit for evaluating genes required for proliferation and survival using tetracycline-regulated RNA. Nature Biotechnology, 29 (1). pp. 79-85.

Karni-Schmidt, O., Castillo-Martin, M., HuaiShen, T., Gladoun, N., Domingo-Domenech, J., Sanchez-Carbayo, M., Li, Y., Lowe, S. W., Prives, C., Cordon-Cardo, C. (2011) Distinct Expression Profiles of p63 Variants during Urothelial Development and Bladder Cancer Progression. The American Journal of Pathology, 178 (3). pp. 1350-1360. ISSN 0002-9440

Fairfield, H., Gilbert, G. J., Barter, M., Corrigan, R. R., Curtain, M., Ding, Y. M., D'Ascenzo, M., Gerhardt, D. J., He, C., Huang, W. H., Richmond, T., Rowe, L., Probst, F. J., Bergstrom, D. E., Murray, S. A., Bult, C., Richardson, J., Kile, B. T., Gut, I., Hager, J., Sigurdsson, S., Mauceli, E., Di Palma, F., Lindblad-Toh, K., Cunningham, M. L., Cox, T. C., Justice, M. J., Spector, M. S., Lowe, S. W., Albert, T., Donahue, L. R., Jeddeloh, J., Shendure, J., Reinholdt, L. G. (2011) Mutation discovery in mice by whole exome sequencing. Genome Biology, 12 (9). ISSN 1474-7596

Gutmann, D. H., Stiles, C. D., Lowe, S. W., Bollag, G. E., Furnari, F. B., Charest, A. (2011) Report from the fifth national cancer institute mouse models of human cancers consortium nervous system tumors workshop. Neuro-Oncology, 13 (7). pp. 692-699. ISSN 15228517 (ISSN)

Takiguchi, M., James, C., Josefsson, E. C., Carmichael, C. L., Premsrirut, P. K., Lowe, S. W., Hamilton, J. R., Huang, D. C. S., Kile, B. T., Dickins, R. A. (December 2010) Transgenic, inducible RNAi in megakaryocytes and platelets in mice. J Thromb Haemost, 8 (12). pp. 2751-6. ISSN 1538-7836 (Electronic) 1538-7836 (Linking)

Jones, L., Wei, G., Sevcikova, S., Phan, V., Jain, S., Shieh, A., Wong, J. C., Li, M., Dubansky, J., Maunakea, M. L., Ochoa, R., Zhu, G., Tennant, T. R., Shannon, K. M., Lowe, S. W., Le Beau, M. M., Kogan, S. C. (November 2010) Gain of MYC underlies recurrent trisomy of the MYC chromosome in acute promyelocytic leukemia. J Exp Med, 207 (12). pp. 2581-94. ISSN 0022-1007

Newbold, A., Bots, M., Cluse, L., Lindemann, R., Lowe, S. W., Richon, V., Secrist, P., Miller, T., Hardwick, J., Johnstone, R. (November 2010) Mechanisms of action of histone deacetylase inhibitors (HDACi). Ejc Supplements, 8 (7). p. 46. ISSN 1359-6349

Vakoc, C. R., Zuber, J., Lowe, S., Wang, E., Rappaport, A. R., Shi, J. W. (November 2010) An RNA1 Screen Reveals a Pattern of Addiction to Epigenetic Pathways That Distinguishes MLL AF9 Leukemia From Normal Hematopoietic Cells. Blood, 116 (21). p. 35. ISSN 0006-4971

Ko, F. C. F., Chan, L. K., Tung, E. K. K., Lowe, S. W., Ng, I. O. L., Yam, J. W. P. (October 2010) Akt phosphorylation of deleted in liver cancer 1 abrogates its suppression of liver cancer tumorigenesis and metastasis. Gastroenterology, 139 (4).

Bazarov, A. V., van Sluis, M., Hines, W. C., Bassett, E., Beliveau, A., Campeau, E., Mukhopadhyay, R., Lee, W. J., Melodyev, S., Zaslavsky, Y., Lee, L., Rodier, F., Chicas, A., Lowe, S. W., Benhattar, J., Ren, B., Campisi, J., Yaswen, P. (October 2010) p16(INK4a)-mediated suppression of telomerase in normal and malignant human breast cells. Aging Cell, 9 (5). pp. 736-746. ISSN 1474-9718

Schreiber, S. L., Shamji, A. F., Clemons, P. A., Hon, C., Koehler, A. N., Munoz, B., Palmer, M., Stern, A. M., Wagner, B. K., Powers, S., Lowe, S. W., Guo, X., Krasnitz, A., Sawey, E. T., Sordella, R., Stein, L. D., Trotman, L. C., Califano, A., Dalla-Favera, R., Ferrando, A., Iavarone, A., Pasqualucci, L., Silva, J., Stockwell, B. R., Hahn, W. C., Chin, L., DePinho, R. A., Boehm, J. S., Gopal, S., Huang, A., Root, D. E., Weir, B. A., Gerhard, D. S., Zenklusen, J. C., Roth, M. G., White, M. A., Minna, J. D., MacMillan, J. B., Posner, B. A. (September 2010) Towards patient-based cancer therapeutics. Nature Biotechnology, 28 (9). pp. 904-906.

Zhao, Z., Zuber, J., Diaz-Flores, E., Lintault, L., Kogan, S. C., Shannon, K., Lowe, S. W. (July 2010) p53 loss promotes acute myeloid leukemia by enabling aberrant self-renewal. Genes Dev, 24 (13). pp. 1389-1402. ISSN 1549-5477 (Electronic) 0890-9369 (Linking)

Heyer, J., Kwong, L. N., Lowe, S. W., Chin, L. (July 2010) Non-germline genetically engineered mouse models for translational cancer research. Nature Reviews Cancer, 10 (7). pp. 470-480. ISSN 1474-175X

Sendoel, A., Kohler, I., Fellmann, C., Lowe, S. W., Hengartner, M. O. (June 2010) HIF-1 antagonizes p53-mediated apoptosis through a secreted neuronal tyrosinase. Nature, 465 (7298). 577-U69. ISSN 0028-0836

Lowe, S. W. (June 2010) Roles and regulation of cellular senescence. Ejc Supplements, 8 (5). p. 20. ISSN 1359-6349

Chicas, A., Wang, X., Zhang, C., McCurrach, M. E., Zhao, Z., Mert, O., Dickins, R. A., Narita, M., Zhang, M. Q., Lowe, S. W. (April 2010) Dissecting the Unique Role of the Retinoblastoma Tumor Suppressor during Cellular Senescence. Cancer Cell, 17 (4). pp. 376-387.

Pineau, P., Volinia, S., McJunkin, K., Marchio, A., Battiston, C., Terris, B., Mazzaferro, V., Lowe, S. W., Croce, C. M., Dejean, A. (January 2010) miR-221 overexpression contributes to liver tumorigenesis. Proceedings of the National Academy of Sciences of the United States of America, 107 (1). pp. 264-269. ISSN 0027-8424

Olive, V., Bennett, M. J., Walker, J. C., Ma, C., Jiang, I., Cordon-Cardo, C., Li, Q. J., Lowe, S. W., Hannon, G. J., He, L. (December 2009) miR-19 is a key oncogenic component of mir-17-92. Genes & Development, 23 (24). pp. 2839-2849. ISSN 0890-9369

Guo, X., Keyes, W. M., Papazoglu, C., Zuber, J., Li, W., Lowe, S. W., Vogel, H., Mills, A. A. (December 2009) TAp63 induces senescence and suppresses tumorigenesis in vivo. Nat Cell Biol, 11 (12). 1451–1457.

Pardee, T., Zuber, J., Lowe, S. W. (November 2009) The Flt3 ITD Accelerates An Already Established Myeloid Leukemia and Alters Chemotherapy Response In Vitro and In Vivo in a p53 Dependent Manner. Blood, 114 (22). p. 685. ISSN 0006-4971

Liu, L. X., Lee, N. P. , Chan, V. W. , Xue, W., Zender, L., Zhang, C., Mao, M., Dai, H., Wang, X. L., Xu, M. Z. , Lee, T. K. , Ng, I. O. , Chen, Y., Kung, H.-f. , Lowe, S. W. , Poon, R. T. P. , Wang, J. H., Luk, J. M. (November 2009) Targeting cadherin-17 inactivates Wnt signaling and inhibits tumor growth in liver carcinoma. Hepatology, 50 (5). pp. 1453-1463. ISSN 1527-3350

Bric, A., Miething, C., Bialucha, C. U., Scuoppo, C., Zender, L., Krasnitz, A., Xuan, Z., Zuber, J., Wigler, M. H., Hicks, J. B., McCombie, W. R., Hemann, M. T., Hannon, G. J., Powers, S., Lowe, S. W. (October 2009) Functional identification of tumor-suppressor genes through an in vivo RNA interference screen in a mouse lymphoma model. Cancer Cell, 16 (4). pp. 324-35. ISSN 1535-6108

Xu, M. Z., Yao, T. J., Lee, N. P. Y., Ng, I. O. L., Chan, Y. T., Zender, L., Lowe, S. W., Poon, R. T. P., Luk, J. M. (October 2009) Yes-Associated Protein Is an Independent Prognostic Marker in Hepatocellular Carcinoma. Cancer, 115 (19). pp. 4576-4585. ISSN 0008-543X

Laska, M. J., Lowe, S. W., Zender, L., Hearn, S. A., Vogel, U., Jensen, U. B., Bric, A., Nexo, B. A. (September 2009) Enforced expression of PPP1R13L increases tumorigenesis and invasion through p53-dependent and p53-independent mechanisms. Mol Carcinog, 48 (9). pp. 832-42.

Ellis, L., Bots, M., Lindemann, R. K., Bolden, J. E., Newbold, A., Cluse, L. A., Scott, C. L., Strasser, A., Atadja, P., Lowe, S. W., Johnstone, R. W. (July 2009) The histone deacetylase inhibitors LAQ824 and LBH589 do not require death receptor signaling or a functional apoptosome to mediate tumor cell death or therapeutic efficacy. Blood, 114 (2). pp. 380-393.

Pardee, T. S., Zuber, J., Lowe, S. W. (May 2009) Effects of the Flt3 ITD on response to chemotherapy in a murine model of acute myeloid leukemia. Journal of Clinical Oncology, 27 (15). p. 7060. ISSN 0732-183X

Robert, F., Carrier, M., Rawe, S., Chen, S., Lowe, S. W., Pelletier, J. (May 2009) Altering chemosensitivity by modulating translation elongation. PLoS ONE, 4 (5). e5428.

Zuber, J., Radtke, I., Pardee, T. S., Zhao, Z., Rappaport, A. R., Luo, W., McCurrach, M. E., Yang, M. M., Dolan, M. E., Kogan, S. C., Downing, J. R., Lowe, S. W. (April 2009) Mouse models of human AML accurately predict chemotherapy response. Genes Dev, 23 (7). pp. 877-89.

White, E., Lowe, S. W. (April 2009) Eating to exit: autophagy-enabled senescence revealed. Genes Dev, 23 (7). pp. 784-787. ISSN 0890-9369

Ma, O., Cai, W. W., Zender, L., Dayaram, T., Shen, J. H., Herron, A. J., Lowe, S. W., Man, T. K., Lau, C. C., Donehower, L. A. (March 2009) MMP13, Birc2 (cIAP1), and Birc3 (cIAP2), Amplified on Chromosome 9, Collaborate with p53 Deficiency in Mouse Osteosarcoma Progression. Cancer Res, 69 (6). pp. 2559-2567. ISSN 0008-5472

Premsrirut, P. K., Miething, C., Zuber, J., Yong, K. S., Hannon, G. J., Lowe, S. W. (March 2009) Conditional Regulation of Tumor Suppressor Genes in Vivo Using Rna Interference. Journal of Investigative Medicine, 57 (3). ISSN 1081-5589

Keng, V. W., Villanueva, A., Chiang, D. Y., Dupuy, A. J., Ryan, B. J., Matise, I., Silverstein, K. A. T., Sarver, A., Starr, T. K., Akagi, K., Tessarollo, L., Collier, L. S., Powers, S., Lowe, S. W., Jenkins, N. A., Copeland, N. G., Llovet, J. M., Largaespada, D. A. (March 2009) A conditional transposon-based insertional mutagenesis screen for genes associated with mouse hepatocellular carcinoma. Nature Biotechnology, 27 (3). pp. 264-274. ISSN 1087-0156

Ghafoori, A., Lee, C., Perez, B., Johnston, S., Rodrigues, R., Badea, C., Kim, Y., Lowe, S. W., Kirsch, D. G. (2009) In Vivo shRNA to Study the Molecular Mechanisms of Radiation Response of Primary Cancers in Mice. International Journal of Radiation Oncology Biology Physics, 75 (3). S171-S172. ISSN 0360-3016

Krizhanovsky, V., Lowe, S. W. (2009) Stem cells: The promises and perils of p53. Nature, 460 (7259). pp. 1085-1086.

Zender, L., Xue, W., Zuber, J., Semighini, C. P., Krasnitz, A., Ma, B., Zender, P., Kubicka, S., Luk, J. M., Schirmacher, P., McCombie, W. R., Wigler, M. H., Hicks, J. B., Hannon, G. J., Powers, S., Lowe, S. W. (November 2008) An Oncogenomics-Based In Vivo RNAi Screen Identifies Tumor Suppressors in Liver Cancer. Cell, 135 (5). pp. 852-864. ISSN 0092-8674

Gyrd-Hansen, M., Darding, M., Miasari, M., Santoro, M. M., Zender, L., Xue, W., Tenev, T., da Fonseca, P. C., Zvelebil, M., Bujnicki, J. M., Lowe, S. W., Silke, J., Meier, P. (November 2008) IAPs contain an evolutionarily conserved ubiquitin-binding domain that regulates NF-kappaB as well as cell survival and oncogenesis. Nat Cell Biol, 10 (11). pp. 1309-17.

Jones, L., Sevcikova, S., Phan, V., Jain, S., Shieh, A., Dubansky, J., Li, M., Maunakea, M. L., Zhu, G., Tennant, T. R., Lowe, S. W., Le Beau, M. M., Kogan, S. C. (November 2008) Myc Drives Chromosomal Gain in Acute Myeloid Leukemia. Blood, 112 (11). p. 294. ISSN 0006-4971

Karni, R., Hippo, Y., Lowe, S. W., Krainer, A. R. (October 2008) The splicing-factor oncoprotein SF2/ASF activates mTORC1. Proc Natl Acad Sci U S A, 105 (40). pp. 15323-7.

Krizhanovsky, V., Yon, M., Dickens, R. A., Hearn, S. A., Simon, J., Ma, B., Miething, C., Zender, L., Lowe, S. W. (August 2008) Senescence of activated stellate cells limits liver fibrosis. Cell, 134 (4). 657-667 .

Mavrakis, K. J., Zhu, H., Silva, R. L., Mills, J. R., Teruya-Feldstein, J., Lowe, S. W., Tam, W., Pelletier, J., Wendel, H. G. (August 2008) Tumorigenic activity and therapeutic inhibition of Rheb GTPase. Genes Dev, 22 (16). pp. 2178-88.

Mills, J. R., Hippo, Y., Robert, F., Chen, S. M. H., Malina, A., Lin, C. J., Trojahn, U., Wendel, H. G., Charest, A., Bronson, R. T., Kogan, S. C., Nadon, R., Housman, D. E., Lowe, S. W., Pelletier, J. (August 2008) mTORC1 promotes survival through translational control of Mcl-1. Proc Natl Acad Sci U S A, 105 (31). pp. 10853-10858.

Bordeleau, M. E., Robert, F., Gerard, B., Lindqvist, L., Chen, S. M., Wendel, H. G., Brem, B., Greger, H., Lowe, S. W., Porco, J. A., Pelletier, J. (July 2008) Therapeutic suppression of translation initiation modulates chemosensitivity in a mouse lymphoma model. J Clin Invest, 118 (7). 2651- 2660.

Burgess, D. J., Doles, J., Zender, L., Xue, W., Ma, B., McCombie, W. R., Hannon, G. J., Lowe, S. W., Hemann, M. T. (July 2008) Topoisomerase levels determine chemotherapy response in vitro and in vivo. Proc Natl Acad Sci U S A, 105 (25). pp. 9053-9058.

Lowe, S. W. (July 2008) Dissecting tumor suppressor gene networks in vivo. European Journal of Cancer Supplements, 6 (9). p. 7. ISSN 1359-6349

Xue, W., Krasnitz, A., Lucito, R., Sordella, R., Van Aelst, L., Cordon-Cardo, C., Singer, S., Kuehnel, F., Wigler, M. H., Powers, S., Zender, L., Lowe, S. W. (June 2008) DLC1 is a chromosome 8p tumor suppressor whose loss promotes hepatocellular carcinoma. Genes & Development, 22 (11). pp. 1439-44. ISSN 0890-9369

Tworkowski, K. A., Chakraborty, A. A., Samuelson, A. V., Seger, Y. R., Narita, M., Hannon, G. J., Lowe, S. W., Tansey, W. P. (April 2008) Adenovirus E1A targets p400 to induce the cellular oncoprotein Myc. Proc Natl Acad Sci U S A, 105 (16). pp. 6103-6108.

Lindemann, R., Newbold, A., Whitecross, K., Cluse, L., Frew, A., Ellis, L., Williams, S., Wiegmans, A., Dear, A., Scott, C., Pelligrini, M., Wei, A., Richon, V., Marks, P., Lowe, S. W., Smyth, M., Johnstone, R. (February 2008) Defining the apoptotic pathways underlying HDAC inhibitor-mediated tumor therapy in vivo. Onkologie, 31 (Suppl.). pp. 69-70. ISSN 0378-584X

Zender, L., Lowe, S. W. (January 2008) Integrative oncogenomic approaches for accelerated cancer-gene discovery. Curr Opin Oncol, 20 (1). pp. 72-6.

Krizhanovsky, V., Xue, W., Zender, L., Yon, M., Hernando, E., Lowe, S. W. (2008) Implications of cellular senescence in tissue damage response, tumor suppression, and stem cell biology. Cold Spring Harb Symp Quant Biol, 73. pp. 513-22.

Chien, Y., Lowe, S. W. (2008) Secreting tumor suppression. Cell, 132 (3). pp. 339-41. ISSN 0092-8674

Wendel, H. G., Silva, R. L., Malina, A., Mills, J. R., Zhu, H., Ueda, T., Watanabe-Fukunaga, R., Fukunaga, R., Teruya-Feldstein, J., Pelletier, J., Lowe, S. W. (December 2007) Dissecting eIF4E action in tumorigenesis. Genes Dev, 21 (24). pp. 3232-7.

Ellis, L., Lindemann, R., Newbold, A., Whitecross, K., Cluse, L., Pelligrini, M., Wei, A., Scott, C., Atadja, P., Lowe, S. W., Johnstone, R. W. (December 2007) Characterization of the apoptotic and therapeutic activities of the histone deacetylase inhibitors LAQ824 and LBH589 using a mouse model of B cell lymphoma. Molecular Cancer Therapeutics, 6 (11). 3475S-3476S. ISSN 1535-7163

He, L., He, X., Lowe, S. W., Hannon, G. J. (November 2007) microRNAs join the p53 network - another piece in the tumour-suppression puzzle. Nat Rev Cancer, 7 (11). pp. 819-822. ISSN 1474-1768 (Electronic)

Flinterman, M. B., Mymryk, J. S., Klanrit, P., Yousef, A. F., Lowe, S. W., Caldas, C., Gaken, J., Farzaneh, F., Tavassoli, M. (November 2007) p400 function is required for the adenovirus E1A-mediated suppression of EGFR and tumour cell killing. Oncogene, 26 (48). pp. 6863-6874. ISSN 0950-9232

Dickins, R. A., McJunkin, K., Hernando, E., Premsrirut, P. K., Krizhanovsky, V., Burgess, D. J., Kim, S. Y., Cordon-Cardo, C., Zender, L., Hannon, G. J., Lowe, S. W. (July 2007) Tissue-specific and reversible RNA interference in transgenic mice. Nat Genet, 39 (7). 914 - 921. ISSN 1061-4036 (Print)

He, L., He, X., Lim, L. P., De Stanchina, E., Xuan, Z., Liang, Y., Xue, W., Zender, L., Magnus, J., Ridzon, D., Jackson, A. L., Linsley, P. S., Chen, C., Lowe, S. W., Cleary, M. A., Hannon, G. J. (June 2007) A microRNA component of the p53 tumour suppressor network. Nature, 447 (7148). pp. 1130-4. ISSN 1476-4687 (Electronic)

Ha, L., Ichikawa, T., Anver, M., Dickins, R. A., Lowe, S. W., Sharpless, N E., Krimpenfort, P , DePinho, R. A., Bennett, D. C., Sviderskaya, E. V., Merlino, G. (June 2007) ARF functions as a melanoma tumor suppressor by inducing p53-independent senescence. Proc Natl Acad Sci U S A, 104 (26). 10968-10973 . ISSN 0027-8424 (Print)

Lindemann, R. K., Newbold, A., Whitecross, K. F., Cluse, L. A., Frew, A. J., Ellis, L., Williams, S., Wiegmans, A. P., Dear, A. E., Scott, C. L., Pellegrini, M., Wei, A., Richon, V. M., Marks, P. A., Lowe, S. W., Smyth, M. J., Johnstone, R. W. (May 2007) Analysis of the apoptotic and therapeutic activities of histone deacetylase inhibitors by using a mouse model of B cell lymphoma. Proc Natl Acad Sci U S A, 104 (19). pp. 8071-6. ISSN 0027-8424

Zender, L., Zuber, J., Lowe, S. W. (May 2007) SnapShot: Genetic mouse models of cancer. Cell, 129 (4). p. 838. ISSN 0092-8674

Feng, Z. H., Hu, W. W., De Stanchina, E., Teresky, A. K., Jin, S. K., Lowe, S. W., Levine, A. J. (April 2007) The regulation of AMPK beta 1, TSC2, and PTEN expression by p53: Stress, cell and tissue specificity, and the role of these gene products in modulating the IGF-1-AKT-mTOR pathways. Cancer Research, 67 (7). pp. 3043-3053. ISSN 0008-5472

Scott, C. L., Gil, J., Hernando, E., Teruya-Feldstein, J., Narita, M., Martinez, D., Visakorpi, T., Mu, D., Cordon-Cardo, C., Peters, G., Beach, D., Lowe, S. W. (March 2007) Role of the chromobox protein CBX7 in lymphomagenesis. Proc Natl Acad Sci U S A, 104 (13). pp. 5389-94. ISSN 0027-8424 (Print)

Karni, R., de Stanchina, E., Lowe, S. W., Sinha, R., Mu, D., Krainer, A. R. (March 2007) The gene encoding the splicing factor SF2/ASF is a proto-oncogene. Nat Struct Mol Biol, 14 (3). pp. 185-93. ISSN 1545-9993 (Print)

Xue, W., Zender, L., Miething, C., Dickins, R. A., Hernando, E., Krizhanovsky, V., Cordon-Cardo, C., Lowe, S. W. (February 2007) Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas. Nature, 445 (7128). pp. 656-660. ISSN 0028-0836

Bosco, E. E., Wang, Y., Xu, H., Zilfou, J. T., Knudsen, K. E., Aronow, B. J., Lowe, S. W., Knudsen, E. S. (January 2007) The retinoblastoma tumor suppressor modifies the therapeutic response of breast cancer. J Clin Invest, 117 (1). pp. 218-228. ISSN 0021-9738 (Print)

Sotillo, R., Hernando, E., Díaz-Rodríguez, E., Teruya-Feldstein, J., Cordón-Cardo, C., Lowe, S. W., Benezra, R. (January 2007) Mad2 overexpression promotes aneuploidy and tumorigenesis in mice. Cancer Cell, 11 (1). pp. 9-23. ISSN 1535-6108

Yin, Bin, Diers, M. D., Rathe, S. K., Lowe, S. W., Largaespada, D. A. (November 2006) Genetic mechanisms of cytarabine resistance in leukemia: cell culture and mouse transplantation models. ASH Annual Meeting Abstracts, 108 (11). p. 4374. ISSN 0006-4971

Zender, L., Xue, W., Cordon-Cardo, C., Lowe, S. W. (October 2006) P53 restoration in liver carcinomas induces cellular senescence and tumor clearance through an innate immune response. Hepatology, 44 (4). 694A-695A. ISSN 0270-9139

Narita, M., Narita, M., Krizhanovsky, V., Nunez, S., Chicas, A., Hearn, S. A., Myers, M. P., Lowe, S. W. (August 2006) A novel role for high-mobility group a proteins in cellular senescence and heterochromatin formation. Cell, 126 (3). pp. 503-14. ISSN 0092-8674 (Print)

Wendel, H. G., Malina, A., Zhao, Z., Zender, L., Kogan, S. C., Cordon-Cardo, C., Pelletier, J., Lowe, S. W. (August 2006) Determinants of sensitivity and resistance to rapamycin-chemotherapy drug combinations in vivo. Cancer Res, 66 (15). pp. 7639-46. ISSN 0008-5472 (Print)

Hemann, M. T., Lowe, S. W. (August 2006) The p53-Bcl-2 connection. Cell Death Differ, 13 (8). pp. 1256-9. ISSN 1350-9047 (Print)

Lakshmi, B., Hall, I. M., Egan, C., Alexander, J., Leotta, A., Healy, J., Zender, L., Spector, M. S., Xue, W., Lowe, S. W., Wigler, M. H., Lucito, R. (July 2006) Mouse genomic representational oligonucleotide microarray analysis: detection of copy number variations in normal and tumor specimens. Proc Natl Acad Sci U S A, 103 (30). pp. 11234-9. ISSN 0027-8424 (Print)

Zender, L., Spector, M. S., Xue, W., Flemming, P., Cordon-Cardo, C., Silke, J., Fan, S. T., Luk, J. M., Wigler, M. H., Hannon, G. J., Mu, D., Lucito, R., Powers, S., Lowe, S. W. (June 2006) Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approach. Cell, 125 (7). pp. 1253-67. ISSN 0092-8674 (Print)

Wendel, Hans-Guido, de Stanchina, Elisa, Cepero, Enriqué, Ray, Sagarika, Emig, Michael, Fridman, Jordan S., Veach, Darren R., Bornmann, William G., Clarkson, Bayard, McCombie, W. Richard, Kogan, Scott C., Hochhaus, Andreas, Lowe, Scott W. (May 2006) Loss of p53 impedes the antileukemic response to BCR-ABL inhibition. Proceedings of the National Academy of Sciences of the United States of America, 103 (19). pp. 7444-9. ISSN 0027-8424

Ramiro, A. R., Jankovic, M., Callen, E., Difilippantonio, S., Chen, H. T., McBride, K. M., Eisenreich, T. R., Chen, J., Dickins, R. A., Lowe, S. W., Nussenzweig, A., Nussenzweig, M. C. (March 2006) Role of genomic instability and p53 in AID-induced c-myc-Igh translocations. Nature, 440 (7080). pp. 105-109. ISSN 00280836

Mason, D. X., Keppler, D., Zhang, J., Jackson, T. J., Seger, Y. R., Matsui, S., Abreo, F., Cowell, J. K., Hannon, G. J., Lowe, S. W., Lin, A. W. (February 2006) Defined genetic events associated with the spontaneous in vitro transformation of ElA/Ras-expressing human IMR90 fibroblasts. Carcinogenesis, 27 (2). pp. 350-359. ISSN 0143-3334 (Print)

Soengas, M. S., Gerald, W. L., Cordon-Cardo, C., Lazebnik, Y., Lowe, S. W. (2006) Apaf-1 expression in malignant melanoma. Cell Death and Differentiation, 13 (2). pp. 352-353. ISSN 13509047

Geurts, A. M., Collier, L. S., Geurts, J. L., Oseth, L. L., Bell, M. L., Mu, David, Lucito, R., Godbout, S. A., Green, L. E., Lowe, S. W., Hirsch, B. A., Leinwand, L. A., Largaespada, D. A. (2006) Gene mutations and genomic rearrangements in the mouse as a result of transposon mobilization from chromosomal concatemers. PLoS Genetics, 2 (9). pp. 1413-1423. ISSN 15537390

Hernando, E., Matushansky, I., Maki, R. G., Lowe, S. W., Cordon-Cardo, C. (2006) RNA interference against cancer associated genes. Annals of Oncology, 17 (Supp 9). p. 45. ISSN 0923-7534

Martinelli, S., Kostylina, G., Niggli, V., Baumann, C., Fey, M. F., Wendel, H. G., Lowe, S. W., Yousefi, S., Simon, H. U. (2006) Targeting survivin via PI3K but not c-akt/PKB by anticancer drugs in immature neutrophils. Oncogene, 25 (52). pp. 6915-6923. ISSN 09509232

Dickins, R. A., Premsrirut, P., McJunkin, K., Kim, S. Y., Hannon, G. J., Lowe, S. W. (2006) Tetracycline-regulated p53 knockdown in cells and transgenic mice. Toxicologic Pathology, 34 (7). p. 1006. ISSN 0192-6233

Yin, Bin, Kogan, Scott C., Dickins, Ross A., Lowe, Scott W., Largaespada, David A. (2006) Trp53 loss during in vitro selection contributes to acquired Ara-C resistance in acute myeloid leukemia. Experimental Hematology, 34 (5). pp. 631-641. ISSN 0301472X

Feng, Z., Jin, S., Zupnick, A., Hoh, J., De Stanchina, E., Lowe, S. W., Prives, C., Levine, A. J. (2006) p53 tumor suppressor protein regulates the levels of huntingtin gene expression. Oncogene, 25 (1). pp. 1-7. ISSN 09509232

Zilfou, J. T., Spector, M. S., Lowe, S. W. (November 2005) Slugging it out: fine tuning the p53-PUMA death connection. Cell, 123 (4). pp. 545-8. ISSN 0092-8674 (Print)

Dickins, R. A., Hemann, M. T., Zilfou, J. T., Simpson, D. R., Ibarra, I., Hannon, G. J., Lowe, S. W. (November 2005) Probing tumor phenotypes using stable and regulated synthetic microRNA precursors. Nat Genet, 37 (11). pp. 1289-95. ISSN 1061-4036 (Print)

Zender, L., Spector, M. S., Xue, W., Flemming, P., Mu, D., Cordon-Cardo, C., Powers, S., Hannon, G. J., Lucito, R., Lowe, S. W. (October 2005) Representational oligonucleotide microarray (ROMA) identifies cIAP1/cIAP2 as candidate oncogenes in mouse and human hepatocarcinogenesis-validation of cIAP1 as a therapeutic target in liver cancer in a new mouse model of hepatocellular carcinoma. Hepatology, 42 (4). 244A-244A. ISSN 0270-9139

Keyes, William M., Wu, Ying, Vogel, Hannes, Guo, Xuecui, Lowe, Scott W., Mills, Alea A. (September 2005) p63 deficiency activates a program of cellular senescence and leads to accelerated aging. Genes Dev, 19 (17). pp. 1986-99. ISSN 0890-9369 (Print)

Narita, M., Lowe, S. W. (September 2005) Senescence comes of age. Nature Medicine, 11 (9). pp. 920-922. ISSN 1078-8956

Hemann, M. T., Bric, A., Teruya-Feldstein, J., Herbst, A., Nilsson, J. A., Cordon-Cardo, C., Cleveland, J. L., Tansey, W. P., Lowe, S. W. (August 2005) Evasion of the p53 tumour surveillance network by tumour-derived MYC mutants. Nature, 436 (7052). pp. 807-11. ISSN 1476-4687 (Electronic)

Fernandez, Y., Verhaegen, M., Miller, T. P., Rush, J. L., Steiner, P., Opipari, A. W., Lowe, S. W., Soengas, M. S. (July 2005) Differential regulation of noxa in normal Melanocytes and melanoma cells by proteasome inhibition: Therapeutic implications. Cancer Research, 65 (14). pp. 6294-6304. ISSN 0008-5472

Samuelson, A. V., Narita, M., Chan, H. M., Jin, J., de Stanchina, E., McCurrach, M. E., Narita, M., Fuchs, M., Livingston, D. M., Lowe, S. W. (June 2005) p400 is required for E1A to promote apoptosis. J Biol Chem, 280 (23). pp. 21915-23. ISSN 0021-9258 (Print)

He, L., Thomson, J. M., Hemann, M. T., Hernando-Monge, E., Mu, D., Goodson, S., Powers, S., Cordon-Cardo, C., Lowe, S. W., Hannon, G. J., Hammond, S. M. (June 2005) A microRNA polycistron as a potential human oncogene. Nature, 435 (7043). pp. 828-33. ISSN 0028-0836

Helmrich, A., Lee, S., O'Brien, P., Dorken, B., Lowe, S. W., Schrock, E., Schmitt, C. A. (June 2005) Recurrent chromosomal aberrations in INK4a/ARF defective primary lymphomas predict drug responses in vivo. Oncogene, 24 (26). pp. 4174-4182. ISSN 0950-9232

Finnberg, N., Gruber, J. J., Fei, P. W., Rudolph, D., Bric, A., Kim, S. H., Burns, T. F., Ajuha, H., Page, R., Wu, G. S., Chen, Y. H., McKenna, W. G., Bernhard, E., Lowe, S., Mak, T., El-Deiry, W. S. (March 2005) DR5 knockout mice are compromised in radiation-induced apoptosis. Molecular and Cellular Biology, 25 (5). pp. 2000-2013. ISSN 0270-7306

Herbst, A., Hemann, M. T., Tworkowski, K. A., Salghetti, S. E., Lowe, S. W., Tansey, W. P. (February 2005) A conserved element in Myc that negatively regulates its proapoptotic activity. EMBO Rep, 6 (2). pp. 177-83. ISSN 1469-221X (Print)

Hall, P. A., Lowe, S. W. (January 2005) Molecular and cellular themes in cancer research: II. Journal of Pathology, 205 (2). pp. 121-122. ISSN 0022-3417

Chan, H. M., Narita, M., Lowe, S. W., Livingstone, D. M. (January 2005) The p400 E1A-associated protein is a novel component of the p53 -> p21 senescence pathway. Genes Dev, 19 (2). pp. 196-201. ISSN 0890-9369

Lowe, S. W. (2005) Evading p53 action during tumor development and therapy. Breast Cancer Research, 7. S12-S12. ISSN 1465-5411

Zender, L., Xue, W., Cordon-Cardo, C., Hannon, G. J., Lucito, R., Powers, S., Flemming, P., Spector, M. S., Lowe, S. W. (2005) Generation and Analysis of Genetically Defined Liver Carcinomas Derived from Bipotential Liver Progenitors. Cold Spring Harb Symp Quant Biol, 70 (1). pp. 251-261. ISSN 1943-4456 (Electronic) 0091-7451 (Linking)

Lowe, S. W. (2005) Special issue: Abstracts of ISCO 2005, Belfast, Northern Ireland, UK, 5-8 April 2005. Cellular Oncology, 27 (2). pp. 93-160. ISSN 1570-5870

Lowe, S. W., Cepero, E., Evan, G. (November 2004) Intrinsic tumour suppression. Nature, 432 (7015). pp. 307-15. ISSN 1476-4687 (Electronic)

Hernando, E., Nahle, Z., Juan, G., Diaz-Rodriguez, E., Alaminos, M., Hemann, M., Michel, L., Mittal, V., Gerald, W., Benezra, R., Lowe, S. W., Cordon-Cardo, C. (August 2004) Rb inactivation promotes genomic instability by uncoupling cell cycle progression from mitotic control. Nature, 430 (7001). pp. 797-802. ISSN 0028-0836

Wendel, H. G., Lowe, S. W. (July 2004) Reversing drug resistance in vivo. Cell Cycle, 3 (7). pp. 847-9. ISSN 1551-4005 (Electronic)

Hemann, M. T., Zilfou, J. T., Zhao, Z., Burgess, D. J., Hannon, G. J., Lowe, S. W. (June 2004) Suppression of tumorigenesis by the p53 target PUMA. Proc Natl Acad Sci U S A, 101 (25). pp. 9333-8. ISSN 0027-8424 (Print)

Wendel, H. G., De Stanchina, E., Fridman, J. S., Malina, A., Ray, S., Kogan, S., Cordon-Cardo, C., Pelletier, J., Lowe, S. W. (March 2004) Survival signalling by Akt and eIF4E in oncogenesis and cancer therapy. Nature, 428 (6980). pp. 332-7. ISSN 1476-4687 (Electronic)

Narita, M., Lowe, S. W. (March 2004) Executing cell senescence. Cell Cycle, 3 (3). pp. 244-6. ISSN 1538-4101 (Print)

de Stanchina, E., Querido, E., Narita, M., Davuluri, R. V., Pandolfi, P. P., Ferbeyre, G., Lowe, S. W. (February 2004) PML is a direct p53 target that modulates p53 effector functions. Mol Cell, 13 (4). pp. 523-35. ISSN 1097-2765 (Print)

Fridman, J. S., Lowe, S. W. (December 2003) Control of apoptosis by p53. Oncogene, 22 (56). pp. 9030-9040. ISSN 0950-9232

Rabinowicz, P. D., Palmer, L. E., May, B. P., Hemann, M. T., Lowe, S. W., McCombie, W. R., Martienssen, R. A. (December 2003) Genes and transposons are differentially methylated in plants, but not in mammals. Genome Research, 13 (12). pp. 2658-64. ISSN 1088-9051

Schmitt, C. A., Helmrich, A., Lee, S., Dorken, B., Lowe, S. W., Schrock, E. (November 2003) Impact of recurrent cytogenetic abnormalities in INK4a/ARF defective primary lymphomas on chemosensitivity in vivo. Blood, 102 (11). 68A-69A. ISSN 0006-4971

Fridman, J. S., Hernando, E., Hemann, M. T., de Stanchina, E., Cordon-Cardo, C., Lowe, S. W. (September 2003) Tumor promotion by Mdm2 splice variants unable to bind p53. Cancer Research, 63 (18). pp. 5703-5706. ISSN 0008-5472

Beausejour, C. M., Krtolica, A., Galimi, F., Narita, M., Lowe, S. W., Yaswen, P., Campisi, J. (August 2003) Reversal of human cellular senescence: roles of the p53 and p16 pathways. Embo Journal, 22 (16). pp. 4212-4222. ISSN 0261-4189

Narita, M., Nunez, S., Heard, E., Narita, M., Lin, A. W., Hearn, S. A., Spector, D. L., Hannon, G. J., Lowe, S. W. (June 2003) Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence. Cell, 113 (6). pp. 703-716. ISSN 0092-8674

Soengas, M. S., Lowe, S. W. (May 2003) Apoptosis and melanoma chemoresistance. Oncogene, 22 (20). pp. 3138-3151. ISSN 0950-9232

Kondo, S., Lu, Y., Debbas, M., Lin, A. W., Sarosi, I., Itie, A., Wakeham, A., Tuan, J., Saris, C., Elliott, G., Ma, W. L., Benchimol, S., Lowe, S. W., Mak, T. W., Thukral, S. K. (April 2003) Characterization of cells and gene-targeted mice deficient for the p53-binding kinase homeodomain-interacting protein kinase 1 (HIPK1). Proceedings of the National Academy of Sciences of the United States of America, 100 (9). pp. 5431-5436. ISSN 0027-8424

Hemann, M. T., Fridman, J. S., Zilfou, J. T., Hernando, E., Paddison, P. J., Cordon-Cardo, C., Hannon, G. J., Lowe, S. W. (March 2003) An epi-allelic series of p53 hypomorphs created by stable RNAi produces distinct tumor phenotypes in vivo. Nature Genetics, 33 (3). pp. 396-400. ISSN 1061-4036

Mu, D., Chen, L. Y., Zhang, X. P., See, L. H., Koch, C. M., Yen, C., Tong, J. J., Spiegel, L., Nguyen, K. C. Q., Servoss, A., Peng, Y., Pei, L., Marks, J. R., Lowe, S. W., Hoey, T., Jan, L. Y., McCombie, W. R., Wigler, M. H., Powers, S. (March 2003) Genomic amplification and oncogenic properties of the KCNK9 potassium channel gene. Cancer Cell, 3 (3). pp. 297-302. ISSN 1535-6108

Lowe, S. W., Sherr, C. J. (February 2003) Tumor suppression by Ink4a-Arf: progress and puzzles. Current Opinion in Genetics & Development, 13 (1). pp. 77-83. ISSN 0959-437X

de Stanchina, E., Lowe, S. W. (December 2002) Tumour suppression: something for nothing? Nature Cell Biology, 4 (12). E275-E276. ISSN 1465-7392

Lowe, S. (November 2002) Roles of oncogenes and tumor suppressor genes in apoptosis. European Journal of Cancer, 38. S15-S15. ISSN 0959-8049

Lowe, S. W. (October 2002) Premature senescence in tumor suppression. Cancer Epidemiology Biomarkers & Prevention, 11 (10). 1259S-1259S. ISSN 1055-9965

Hirao, A., Cheung, A., Duncan, G., Girard, P. M., Elia, A. J., Wakeham, A., Okada, H., Sarkissian, T., Wong, J. A., Sakai, T., de Stanchina, E., Bristow, R. G., Suda, T., Lowe, S. W., Jeggo, P. A., Elledge, S. J., Mak, T. W. (September 2002) Chk2 is a tumor suppressor that regulates apoptosis in both an ataxia telangiectasia mutated (ATM)-dependent and an ATM-independent manner. Molecular and Cellular Biology, 22 (18). pp. 6521-6532. ISSN 0270-7306

Li, J., Yang, Y., Peng, Y., Austin, R. J., van Eyndhoven, G., Nguyen, K. C. Q., Gabriele, T., McCurrach, M. E., Marks, J. R., Hoey, T., Lowe, S. W., Powers, S. (June 2002) Oncogenic properties of PPM1D located within a breast cancer amplification epicenter at 17q23. Nature Genetics, 31 (2). pp. 133-134. ISSN 1061-4036

Okada, H., Suh, W. K., Jin, J., Woo, M., Du, C., Elia, A., Duncan, G. S., Wakeham, A., Itie, A., Lowe, S. W., Wang, X., Mak, T. W. (May 2002) Generation and characterization of Smac/DIABLO-deficient mice. Molecular and Cellular Biology, 22 (10). pp. 3509-3517. ISSN 0270-7306

Schmitt, C. A., Fridman, J. S., Yang, M., Lee, S., Baranov, E., Hoffman, R. M., Lowe, S. W. (May 2002) A senescence program controlled by p53 and p16(INK4a) contributes to the outcome of cancer therapy. Cell, 109 (3). pp. 335-346. ISSN 0092-8674

Schmitt, C. A., Fridman, J. S., Yang, M., Baranov, E., Hoffman, R. M., Lowe, S. W. (April 2002) Dissecting p53 tumor suppressor functions in vivo. Cancer Cell, 1 (3). pp. 289-298. ISSN 1535-6108

Ferbeyre, G., Lowe, S. W. (January 2002) Ageing: The price of tumour suppression? Nature, 415 (6867). pp. 26-27. ISSN 0028-0836

Johnstone, R. W., Ruefli, A. A., Lowe, S. W. (January 2002) Apoptosis: A link between cancer genetics and chemotherapy. Cell, 108 (2). pp. 153-164. ISSN 0092-8674

Nahle, Zaher, Polakoff, Julia, Davuluri, Ramana V., McCurrach, Mila E., Jacobson, Matthew D., Narita, Masashi, Zhang, Michael Q., Lazebnik, Yuri, Bar-Sagi, Dafna, Lowe, Scott W. (2002) Direct coupling of the cell cycle and cell death machinery by E2F. Nature Cell Biology, 4 (11). pp. 859-864. ISSN 1465-7392

Ferbeyre, G., De Stanchina, E., Lin, A. W., Querido, E., McCurrach, M. E., Hannon, G. J., Lowe, S. W. (2002) Oncogenic ras and p53 cooperate to induce cellular senescence. Molecular and Cellular Biology, 22 (10). pp. 3497-3508. ISSN 02707306 (ISSN)

Lowe, S. W., Schmitt, C., Fridman, J., Rosenthal, C. (November 2001) Genetics of drug sensitivity and resistance in a mouse lymphoma model. Clinical Cancer Research, 7 (11). 3828S-3829S. ISSN 1078-0432

Schmitt, C. A., Yang, M., Fridman, J. S., Baranov, E., Hoffman, R. M., Lowe, S. W. (November 2001) Myc-driven lymphomas respond with both apoptosis and senescence to anticancer treatment in vivo. Blood, 98 (11). 172B-172B. ISSN 0006-4971

Schmitt, C. A., Lowe, S. W. (April 2001) Apoptosis is critical for drug response in vivo. Drug Resistance Updates, 4 (2). pp. 132-134. ISSN 1368-7646

Lin, A. W., Lowe, S. W. (April 2001) Oncogenic ras activates the ARF-p53 pathway to suppress epithelial cell transformation. Proceedings of the National Academy of Sciences of the United States of America, 98 (9). pp. 5025-5030. ISSN 0027-8424

Koumenis, C., Alarcon, R., Hammond, E., Sutphin, P., Hoffman, W., Murphy, M., Derr, J., Taya, Y., Lowe, S. W., Kastan, M., Giaccia, A. (February 2001) Regulation of p53 by hypoxia: Dissociation of transcriptional repression and apoptosis from p53-dependent transactivation. Molecular and Cellular Biology, 21 (4). pp. 1297-1310. ISSN 0270-7306

Schmitt, C. A., Lowe, S. W. (January 2001) Bcl-2 mediates chemoresistance in matched pairs of primary E mu-myc lymphomas in vivo. Blood Cells Molecules and Diseases, 27 (1). pp. 206-216. ISSN 1079-9796

Soengas, M. S., Capodieci, P., Polsky, D., Mora, J., Esteller, M., Opitz-Araya, X., McCombie, R., Herman, J. G., Gerald, W. L., Lazebnik, Y. A., Cordon-Cardo, C., Lowe, S. W. (2001) Inactivation of the apoptosis effector Apaf-1 in malignant melanoma. Nature, 409 (6817). pp. 207-211. ISSN 0028-0836

McCurrach, M. E., Lowe, S. W. (2001) Methods for studying pro- and antiapoptotic genes in nonimmortal cells. In: Methods in Cell Biology. Methods in Cell Biology, 66 . Academic Press Inc, San Diego, pp. 197-227. ISBN 0091-679X

Nakaya, N., Lowe, S. W., Taya, Y., Chenchik, A., Enikolopov, G. (December 2000) Specific pattern of p53 phosphorylation during nitric oxide-induced cell cycle arrest. Oncogene, 19 (54). pp. 6369-6375. ISSN 0950-9232

Soengas, M. S., Lowe, S. W. (December 2000) p53 and p73: seeing double? Nature Genetics, 26 (4). pp. 391-392. ISSN 1061-4036

Schmitt, C. A., Rosenthal, C. T., Lowe, S. W. (September 2000) Genetic analysis of chemoresistance in primary murine lymphomas. Nature Medicine, 6 (9). pp. 1029-1035. ISSN 1078-8956

Rocha, S., Soengas, M. S., Lowe, S. W., Glanzmann, C., Fabbro, D., Winterhalter, K., Bodis, S., Pruschy, M. (September 2000) Protein kinase C inhibitor and irradiation-induced apoptosis: Relevance of the cytochrome c-mediated caspase-9 death pathway. Cell Growth & Differentiation, 11 (9). pp. 491-499. ISSN 1044-9523

Ferbeyre, G., de Stanchina, E., Querido, E., Baptiste, N., Prives, C., Lowe, S. W. (August 2000) PML is induced by oncogenic ras and promotes premature senescence. Genes & Development, 14 (16). pp. 2015-2027. ISSN 0890-9369

Schmitt, C. A., Fridman, J., Lowe, S. W. (July 2000) Molecular genetics of drug sensitivity and resistance in a mouse lymphoma model. British Journal of Cancer, 83. p. 4. ISSN 0007-0920

Lowe, S. W., Lin, A. W. (March 2000) Apoptosis in cancer. Carcinogenesis, 21 (3). pp. 485-495. ISSN 0143-3334

Attardi, L. D., Reczek, E. E., Cosmas, C., Demicco, E. G., McCurrach, M. E., Lowe, S. W., Jacks, T. (March 2000) PERP, an apoptosis-associated target of p53, is a novel member of the PMP-22/gas3 family. Genes & Development, 14 (6). pp. 704-718. ISSN 0890-9369

Yang, X. H., Sham, J. S. T., Ng, M. H., Tsao, S. W., Zhang, D. K., Lowe, S. W., Cao, L. (January 2000) LMP1 of Epstein-Barr virus induces proliferation of primary mouse embryonic fibroblasts and cooperatively transforms the cells with a p16-insensitive CDK4 oncogene. Journal of Virology, 74 (2). pp. 883-891. ISSN 0022-538X

Schmitt, C. A., Wallace-Brodeur, R. R., Rosenthal, C. T., McCurrach, M. E., Lowe, S. W. (2000) DNA damage responses and chemosensitivity in the E mu-myc mouse lymphoma model. Cold Spring Harbor Symposia on Quantitative Biology, 65. pp. 499-510. ISSN 0091-7451

Schmitt, C. A., McCurrach, M. E., de Stanchina, E., Wallace-Brodeur, R. R., Lowe, S. W. (October 1999) INK4a/ARF mutations accelerate lymphomagenesis and promote chemoresistance by disabling p53. Genes and Development, 13 (20). pp. 2670-7. ISSN 0890-9369 (Print)

Soengas, M. S., Alarcon, R. M., Yoshida, H., Giaccia, A. J., Hakem, R., Mak, T. W., Lowe, S. W. (April 1999) Apaf-1 and caspase-9 in p53-dependent apoptosis and tumor inhibition. Science, 284 (5411). pp. 156-9. ISSN 0036-8075 (Print)

Lowe, S. W. (March 1999) Activation of p53 by oncogenes. Endocr Relat Cancer, 6 (1). pp. 45-8. ISSN 1351-0088 (Print)

Schmitt, C. A., Lowe, S. W. (January 1999) Apoptosis and therapy. Journal of Pathology, 187 (1). pp. 127-37. ISSN 0022-3417 (Print)

Wallace-Brodeur, R. R., Lowe, S. W. (January 1999) Clinical implications of p53 mutations. Cellular and Molecular Life Sciences , 55 (1). pp. 64-75. ISSN 1420-682X (Print)

Lin, A. W., Barradas, M., Stone, J. C., Van Aelst, L., Serrano, M., Lowe, S. W. (October 1998) Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling. Genes & Development, 12 (19). pp. 3008-3019. ISSN 0890-9369

de Stanchina, E., McCurrach, M. E., Zindy, F., Shieh, S. Y., Ferbeyre, G., Samuelson, A. V., Prives, C., Roussel, M. F., Sherr, C. J., Lowe, S. W. (August 1998) E1A signaling to p53 involves the p19(ARF) tumor suppressor. Genes Dev, 12 (15). pp. 2434-42. ISSN 0890-9369 (Print)

Samuelson, A. V., Lowe, S. W. (October 1997) Selective induction of p53 and chemosensitivity in RB-deficient cells by E1A mutants unable to bind the RB-related proteins. Proceedings of the National Academy of Sciences, 94 (22). pp. 12094-9. ISSN 0027-8424 (Print)

McCurrach, M. E., Connor, T. M., Knudson, C. M., Korsmeyer, S. J., Lowe, S. W. (March 1997) bax-deficiency promotes drug resistance and oncogenic transformation by attenuating p53-dependent apoptosis. Proceedings of the National Academy of Sciences of the United States of America, 94 (6). pp. 2345-9. ISSN 0027-8424

Serrano, M., Lin, A. W., McCurrach, M. E., Beach, D., Lowe, S. W. (March 1997) Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a. Cell, 88 (5). pp. 593-602. ISSN 0092-8674 (Print)

Fearnhead, H. O., McCurrach, M. E., O'Neill, J., Zhang, K., Lowe, S. W., Lazebnik, Y. A. (1997) Oncogene-dependent apoptosis in extracts from drug-resistant cells. Genes Dev, 11 (10). pp. 1266-1276. ISSN 0890-9369

This list was generated on Sat Mar 23 04:17:00 2019 EDT.
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