Secreting tumor suppression

Chien, Y., Lowe, S. W. (2008) Secreting tumor suppression. Cell, 132 (3). pp. 339-41. ISSN 0092-8674

DOI: 10.1016/j.cell.2008.01.022


Cellular senescence limits the proliferative capacity of damaged cells and thereby acts as an intrinsic mechanism of tumor suppression. In this issue, Wajapeyee et al. (2008) identify insulin growth factor binding protein 7 (IGFBP7) as a secreted factor that mediates senescence induced by oncogenic BRAF in normal melanocytes. In addition, IGFBP7 triggers apoptosis in cells that have progressed to melanoma, suggesting a new approach for melanoma treatment.

Item Type: Paper
Subjects: bioinformatics
diseases & disorders > cancer
diseases & disorders > cancer > cancer types > melanomas
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein expression
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > genes: types > tumor suppressor
CSHL Authors:
Communities: CSHL labs > Lowe lab
Depositing User: Tom Adams
Date: 2008
Date Deposited: 27 Jul 2011 17:18
Last Modified: 17 Dec 2014 21:25
PMCID: PMC3285252
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