Senescence comes of age

Narita, M., Lowe, S. W. (September 2005) Senescence comes of age. Nature Medicine, 11 (9). pp. 920-922. ISSN 1078-8956

DOI: 10.1038/nm0905-920


Normal cells can respond to expression of activated oncogenes by initiating cellular senescence, a permanent state of proliferative arrest. But whether this process reflects a relevant anticancer mechanism has been debated. Several studies now show that oncogene- induced senescence can occur in vivo and provides a bona fide barrier to tumorigenesis.

Item Type: Paper
Uncontrolled Keywords: cellular senescence tumor suppression human fibroblasts in-vivo CELLS transformation P16(INK4A) oncogene pathway cancer
Subjects: diseases & disorders > cancer
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > genes: types > oncogene
CSHL Authors:
Communities: CSHL labs > Lowe lab
Depositing User: CSHL Librarian
Date: September 2005
Date Deposited: 06 Jan 2012 19:34
Last Modified: 06 Jan 2012 19:34

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