Executing cell senescence

Narita, M., Lowe, S. W. (March 2004) Executing cell senescence. Cell Cycle, 3 (3). pp. 244-6. ISSN 1538-4101 (Print)

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Senescence is a permanent form of cell cycle arrest that limits the proliferation of damaged cells and may contribute to tumor suppression and aging. We recently demonstrated that some senescent cell types undergo dramatic changes in chromatin organization that are dependent on the retinoblastoma protein and are associated with the stable repression of some E2F target genes. Here we show how these changes might contribute to the stability of the senescent state.

Item Type: Paper
Uncontrolled Keywords: Animals Cell Aging physiology Chromatin genetics metabolism Genes Tumor Suppressor Humans Retinoblastoma Protein metabolism
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > Chromatin dynamics
organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > senescence
CSHL Authors:
Communities: CSHL labs > Lowe lab
Depositing User: CSHL Librarian
Date: March 2004
Date Deposited: 31 Jan 2012 16:38
Last Modified: 31 Jan 2012 16:38
URI: https://repository.cshl.edu/id/eprint/22448

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