Items where Community is "Joshua-Tor lab"

Paper

Garg, Ankur, Shang, Renfu, Cvetanovic, Todor, Lai, Eric C, Joshua-Tor, Leemor (October 2024) The structural landscape of Microprocessor-mediated processing of pri-let-7 miRNAs. Molecular Cell. S1097-2765(24)00741. ISSN 1097-2765

Garg, Ankur, On, Kin Fan, Xiao, Yang, Elkayam, Elad, Cifani, Paolo, David, Yael, Joshua-Tor, Leemor (August 2024) The molecular basis of Human FN3K mediated phosphorylation of glycated substrate. bioRxiv. (Public Dataset) (Submitted)

Segovia, Danilo, Adams, Dexter W, Hoffman, Nickolas, Safaric Tepes, Polona, Wee, Tse-Luen, Cifani, Paolo, Joshua-Tor, Leemor, Krainer, Adrian R (May 2024) SRSF1 interactome determined by proximity labeling reveals direct interaction with spliceosomal RNA helicase DDX23. Proceedings of the National Academy of Sciences of the United States of America, 121 (21). e2322974121. ISSN 0027-8424 (Public Dataset)

Garg, Ankur, Shang, Renfu, Cvetanovic, Todor, Lai, Eric C, Joshua-Tor, Leemor (May 2024) The structural landscape of Microprocessor Mediated pri-let-7 miRNAs processing. bioRxiv. (Submitted)

Kotagama, Kasuen, Grimme, Acadia L, Braviner, Leah, Yang, Bing, Sakhawala, Rima M, Yu, Guoyun, Benner, Lars Kristian, Joshua-Tor, Leemor, McJunkin, Katherine (March 2024) Catalytic residues of microRNA Argonautes play a modest role in microRNA star strand destabilization in C. elegans. Nucleic Acids Research (NAR). gkae170. ISSN 0305-1048 (Public Dataset)

Kotagama, Kasuen, Grimme, Acadia L, Braviner, Leah, Yang, Bing, Sakhawala, Rima M, Yu, Guoyun, Benner, Lars Kristian, Joshua-Tor, Leemor, McJunkin, Katherine (January 2024) The catalytic activity of microRNA Argonautes plays a modest role in microRNA star strand destabilization in C. elegans. bioRxiv. (Submitted)

Qian, Zhe, Song, Dongyan, Ipsaro, Jonathan J, Bautista, Carmelita, Joshua-Tor, Leemor, Yeh, Johannes T-H, Tonks, Nicholas K (September 2023) Manipulating PTPRD function with ectodomain antibodies. Genes and Development. ISSN 0890-9369

Lee, Seung Cho, Adams, Dexter W, Ipsaro, Jonathan J, Cahn, Jonathan, Lynn, Jason, Kim, Hyun-Soo, Berube, Benjamin, Major, Viktoria, Calarco, Joseph P, LeBlanc, Chantal, Bhattacharjee, Sonali, Ramu, Umamaheswari, Grimanelli, Daniel, Jacob, Yannick, Voigt, Philipp, Joshua-Tor, Leemor, Martienssen, Robert A (August 2023) Chromatin remodeling of histone H3 variants by DDM1 underlies epigenetic inheritance of DNA methylation. Cell, 186 (19). 4100-4116.e15. ISSN 0092-8674 (Public Dataset)

Kinney, Brian, Sahu, Shubham, Stec, Natalia, Hills-Muckey, Kelly, Adams, Dexter W, Wang, Jing, Jaremko, Matt, Joshua-Tor, Leemor, Keil, Wolfgang, Hammell, Christopher M (August 2023) A circadian-like gene network programs the timing and dosage of heterochronic miRNA transcription during C. elegans development. Developmental Cell. S1534-5807(23)00402. ISSN 1534-5807

Lee, Seung Cho, Adams, Dexter W, Ipsaro, Jonathan J, Cahn, Jonathan, Lynn, Jason, Kim, Hyun-Soo, Berube, Benjamin, Major, Viktoria, Calarco, Joseph P, LeBlanc, Chantal, Bhattacharjee, Sonali, Ramu, Umamaheswari, Grimanelli, Daniel, Jacob, Yannick, Voigt, Philipp, Joshua-Tor, Leemor, Martienssen, Robert A (August 2023) Chromatin remodeling of histone H3 variants underlies epigenetic inheritance of DNA methylation. bioRxiv. (Submitted)

Meze, Katarina, Axhemi, Armend, Thomas, Dennis R, Doymaz, Ahmet, Joshua-Tor, Leemor (February 2023) A shape-shifting nuclease unravels structured RNA. Nature Structural and Molecular Biology. ISSN 1545-9993 (Public Dataset)

Gao, Yuan, He, Xue-Yan, Wu, Xiaoli S, Huang, Yu-Han, Toneyan, Shushan, Ha, Taehoon, Ipsaro, Jonathan J, Koo, Peter K, Joshua-Tor, Leemor, Bailey, Kelly M, Egeblad, Mikala, Vakoc, Christopher R (January 2023) ETV6 dependency in Ewing sarcoma by antagonism of EWS-FLI1-mediated enhancer activation. Nature Cell Biology. ISSN 1465-7392 (Public Dataset)

Bibel, Brianna, Elkayam, Elad, Silletti, Steve, Komives, Elizabeth A, Joshua-Tor, Leemor (May 2022) Target binding triggers hierarchical phosphorylation of human Argonaute-2 to promote target release. eLife, 11. ISSN 2050-084X

Wu, Xiaoli S, He, Xue-Yan, Ipsaro, Jonathan J, Huang, Yu-Han, Preall, Jonathan B, Ng, David, Shue, Yan Ting, Sage, Julien, Egeblad, Mikala, Joshua-Tor, Leemor, Vakoc, Christopher R (May 2022) OCA-T1 and OCA-T2 are coactivators of POU2F3 in the tuft cell lineage. Nature. ISSN 0028-0836

Ipsaro, Jonathan J, Joshua-Tor, Leemor (February 2022) Developmental roles and molecular mechanisms of Asterix/GTSF1. Wiley Interdisciplinary Reviews: RNA. e1716. ISSN 1757-7004

Bibel, Brianna, Elkayam, Elad, Silletti, Steve, Komives, Elizabeth, Joshua-Tor, Leemor (January 2022) Target binding triggers hierarchical phosphorylation of human Argonaute-2 to promote target release. Elife, 11 (e76908). ISSN 2050-084x

Connelly, Carla J, Vidal-Cardenas, Sofia, Goldsmith, Stephanie, Greider, Carol W (November 2021) The Bur1 cyclin-dependent kinase regulates telomere length in Saccharomyces cerevisiae. Yeast. ISSN 0749-503X

Garg, Ankur, Roske, Yvette, Yamada, Shinnosuke, Uehata, Takuya, Takeuchi, Osamu, Heinemann, Udo (May 2021) PIN and CCCH Zn-finger domains coordinate RNA targeting in ZC3H12 family endoribonucleases. Nucleic Acids Research, 49 (9). pp. 5369-5381. ISSN 0305-1048

Ipsaro, Jonathan J, O'Brien, Paul A, Bhattacharya, Shibani, Palmer, Arthur G, Joshua-Tor, Leemor (March 2021) Asterix/Gtsf1 links tRNAs and piRNA silencing of retrotransposons. Cell Reports, 34 (13). p. 108914. ISSN 2211-1247

Meze, Katarina, Axhemi, Armend, Thomas, Dennis, Doymaz, Ahmet, Joshua-Tor, Leemor (2021) A shape-shifting nuclease unravels structured RNA. bioRxiv. (Submitted)

Wang, Pengfei, Liu, Lihong, Nair, Manoj S, Yin, Michael T, Luo, Yang, Wang, Qian, Yuan, Ting, Mori, Kanako, Solis, Axel Guzman, Yamashita, Masahiro, Garg, Ankur, Purpura, Lawrence J, Laracy, Justin C, Yu, Jian, Joshua-Tor, Leemor, Sodroski, Joseph, Huang, Yaoxing, Ho, David D (December 2020) SARS-CoV-2 neutralizing antibody responses are more robust in patients with severe disease. Emerging Microbes and Infections, 9 (1). pp. 2091-2093. ISSN 2222-1751

Hu, Y, Tareen, A., Sheu, Y. J., Ireland, W. T., Speck, C., Li, H., Joshua-Tor, L., Kinney, J. B., Stillman, B. (October 2020) Evolution of DNA replication origin specification and gene silencing mechanisms. Nature Communications, 11 (1). p. 5175. ISSN 2041-1723

Jaremko, M. J., On, K. F., Thomas, D. R., Stillman, B., Joshua-Tor, L. (August 2020) The dynamic nature of the human origin recognition complex revealed through five cryoEM structures. Elife, 9. e58622. ISSN 2050-084x

Ipsaro, Jonathan J, O’Brien, Paul A, Bhattacharya, Shibani, Palmer, Arthur G, Joshua-Tor, Leemor (August 2020) Asterix/Gtsf1 links tRNAs and piRNA silencing of retrotransposons. BioRxiv. (Unpublished)

Hu, Y, Tareen, A, Sheu, Y-J, Ireland, WT, Speck, C, Li, H, Joshua-Tor, L, Kinney, JB, Stillman, B (July 2020) Evolution of DNA Replication Origin Specification and Gene Silencing Mechanisms. BioRxiv. (Unpublished)

Garg, Ankur, Liu, Lihong, Ho, David, Joshua-Tor, Leemor (2020) Heterologous Expression and Purification of SARS-CoV2 Nucleocapsid Protein. Bio-protocol, 10 (8). ISSN 2331-8325

Greider, Carol W, Sheltzer, Jason M, Cantalupo, Nancy C, Copeland, Wilbert B, Dasgupta, Nilanjana, Hopkins, Nancy, Jansen, Jaclyn M, Joshua-Tor, Leemor, McDowell, Gary S, Metcalf, Jessica L, McLaughlin, BethAnn, Olivarius, Ann, O'Shea, Erin K, Raymond, Jennifer L, Ruebain, David, Steitz, Joan A, Stillman, Bruce, Tilghman, Shirley M, Valian, Virginia, Villa-Komaroff, Lydia, Wong, Joyce Y (November 2019) Increasing gender diversity in the STEM research workforce. Science, 366 (6466). pp. 692-695. ISSN 0036-8075

Jung, J., Grant, T., Thomas, D. R., Diehnelt, C. W., Grigorieff, N., Joshua-Tor, L. (June 2019) High-resolution cryo-EM structures of outbreak strain human norovirus shells reveal size variations. Proc Natl Acad Sci U S A, 116 (26). pp. 12828-12832. ISSN 0027-8424

Jung, James, Grant, Timothy, Thomas, Dennis, Diehnelt, Chris, Grigorieff, Nikolaus, Joshua-Tor, Leemor (March 2019) High-resolution cryo-EM structures of outbreak strain human norovirus shells reveal size variations. BioRxiv. (Unpublished)

Stein, C. B., Genzor, P., Mitra, S., Elchert, A. R., Ipsaro, J. J., Benner, L., Sobti, S., Su, Y., Hammell, M., Joshua-Tor, L., Haase, A. D. (February 2019) Decoding the 5' nucleotide bias of PIWI-interacting RNAs. Nat Commun, 10 (1). p. 828. ISSN 2041-1723

Ando, Y., Elkayam, E., McPherson, R. L., Dasovich, M., Cheng, S. J., Voorneveld, J., Filippov, D. V., Ong, S. E., Joshua-Tor, L., Leung, A. K. L. (January 2019) ELTA: Enzymatic Labeling of Terminal ADP-Ribose. Mol Cell, 73 (4). 845-856 e5. ISSN 1097-2765

On, Kin Fan, Jaremko, Matt, Stillman, Bruce, Joshua-Tor, Leemor (December 2018) A structural view of the initiators for chromosome replication. Current Opinion in Structural Biology, 53. pp. 131-139. ISSN 0959-440X

Zhang, T., Wu, Y. C., Mullane, P., Ji, Y. J., Liu, H., He, L., Arora, A., Hwang, H. Y., Alessi, A. F., Niaki, A. G., Periz, G., Guo, L., Wang, H., Elkayam, E., Joshua-Tor, L., Myong, S., Kim, J. K., Shorter, J., Ong, S. E., Leung, A. K. L., Wang, J. (March 2018) FUS Regulates Activity of MicroRNA-Mediated Gene Silencing. Mol Cell, 69 (5). 787-801.e8. ISSN 1097-2765 (Public Dataset)

Li, J., Wu, C., Wang, W., He, Y., Elkayam, E., Joshua-Tor, L., Hammond, P. T. (February 2018) Structurally modulated codelivery of siRNA and Argonaute 2 for enhanced RNA interference. Proc Natl Acad Sci U S A, 115 (12). E2696-E2705. ISSN 0027-8424

Krishnan, N., Bonham, C. A., Rus, I. A., Shrestha, O. K., Gauss, C. M., Haque, A., Tocilj, A., Joshua-Tor, L., Tonks, N. K. (January 2018) Harnessing insulin- and leptin-induced oxidation of PTP1B for therapeutic development. Nat Commun, 9 (1). p. 283. ISSN 2041-1723

Elkayam, Elad, Faehnle, Christopher R., Morales, Marjorie, Sun, Jingchuan, Li, Huilin, Joshua-Tor, Leemor (August 2017) Multivalent Recruitment of Human Argonaute by GW182. Molecular Cell, 67 (4). pp. 646-658. ISSN 1097-2765 (Public Dataset)

Faehnle, C. R., Walleshauser, J., Joshua-Tor, L. (August 2017) Multi-domain utilization by TUT4 and TUT7 in control of let-7 biogenesis. Nat Struct Mol Biol, 24 (8). pp. 658-665. ISSN 1545-9985 (Public Dataset)

Elkayam, E., Parmar, R., Brown, C. R., Willoughby, J. L., Theile, C. S., Manoharan, M., Joshua-Tor, L. (April 2017) siRNA carrying an (E)-vinylphosphonate moiety at the 5' end of the guide strand augments gene silencing by enhanced binding to human Argonaute-2. Nucleic Acids Res, 45 (6). pp. 3528-3536. ISSN 1362-4962 (Electronic)0305-1048 (Linking) (Public Dataset)

Ipsaro, J. J., Shen, C., Arai, E., Xu, Y., Kinney, J. B., Joshua-Tor, L., Vakoc, C. R., Shi, J. (February 2017) Rapid generation of drug-resistance alleles at endogenous loci using CRISPR-Cas9 indel mutagenesis. PLoS One, 12 (2). e0172177. ISSN 1932-6203

Tocilj, A., On, K. F., Yuan, Z., Sun, J., Elkayam, E., Li, H., Stillman, B., Joshua-Tor, L. (January 2017) Structure of the active form of human Origin Recognition Complex and its ATPase motor module. Elife, 6. ISSN 2050-084X (Electronic)2050-084X (Linking) (Public Dataset)

Shen, Chen, Ipsaro, Jonathan J, Shi, Junwei, Milazzo, Joseph P, Wang, Eric, Roe, Jae-Seok, Suzuki, Yutaka, Pappin, Darryl J, Joshua-Tor, Leemor, Vakoc, Christopher R (December 2015) NSD3-Short Is an Adaptor Protein that Couples BRD4 to the CHD8 Chromatin Remodeler. Molecular Cell, 60 (6). pp. 847-859. ISSN 1097-2765

Kuhn, C. D., Wilusz, J. E., Zheng, Y., Beal, P. A., Joshua-Tor, L. (July 2015) On-enzyme refolding permits small RNA and tRNA surveillance by the CCA-adding enzyme. Febs Journal, 282 (Supple). p. 37. ISSN 1742-464X

Naguib, Adam, Bencze, Gyula, Cho, Hyejin, Zheng, Wu, Tocilj, Ante, Elkayam, Elad, Faehnle, Christopher R, Jaber, Nadia, Pratt, Christopher P, Chen, Muhan, Zong, Wei-Xing, Marks, Michael S, Joshua-Tor, Leemor, Pappin, Darryl J, Trotman, Lloyd C (April 2015) PTEN Functions by Recruitment to Cytoplasmic Vesicles. Molecular Cell, 58 (2). pp. 255-268. ISSN 1097-2765

Kuhn, C. D., Wilusz, J. E., Zheng, Y., Beal, P. A., Joshua-Tor, L. (January 2015) On-Enzyme Refolding Permits Small RNA and tRNA Surveillance by the CCA-Adding Enzyme. Cell, 160 (4). pp. 644-658. ISSN 0092-8674 (Public Dataset)

Ipsaro, J. J., Joshua-Tor, L. (January 2015) From guide to target: molecular insights into eukaryotic RNA-interference machinery. Nat Struct Mol Biol, 22 (1). pp. 20-28. ISSN 1545-9985 (Public Dataset)

Faehnle, C. R., Walleshauser, J., Joshua-Tor, L. (October 2014) Mechanism of Dis3l2 substrate recognition in the Lin28-let-7 pathway. Nature, 514 (7521). pp. 252-6. ISSN 0028-0836 (Public Dataset)

Lazarev, D., Miller, R. L., Dimango, E., Fu, X. D., Li, H. R., Logan, C. J., Manley, J. L. (May 2014) CFLIP expression is altered in severe corticosteroid-resistant asthma. Genomics Data, 2. pp. 99-104. ISSN 22135960

Lee, S. J., Syed, S., Enemark, E. J., Schuck, S., Stenlund, A., Ha, T., Joshua-Tor, L. (March 2014) Dynamic look at DNA unwinding by a replicative helicase. Proceedings of the National Academy of Sciences of the United States of America, 111 (9). E827-35. ISSN 0027-8424

Faehnle, C. R., Elkayam, E., Haase, A. D., Hannon, G. J., Joshua-Tor, L. (January 2014) Slicer and the Argonautes. Biophysical Journal, 106 (2; Sup). 455A-455A. ISSN 0006-3495

Kuscu, C., Zaratiegui, M., Kim, H. S., Wah, D. A., Martienssen, R. A., Schalch, T., Joshua-Tor, L. (January 2014) CRL4-like Clr4 complex in Schizosaccharomyces pombe depends on an exposed surface of Dos1 for heterochromatin silencing. Proceedings of the National Academy of Sciences of the United States of America, 111 (5). pp. 1795-1800. ISSN 0027-8424 (Public Dataset)

Faehnle, Christopher R, Elkayam, Elad, Haase, Astrid D, Hannon, Gregory J, Joshua-Tor, Leemor (June 2013) The Making of a Slicer: Activation of Human Argonaute-1. Cell Reports, 3 (6). pp. 1901-1909. ISSN 2211-1247 (Public Dataset)

Clark, P., Cohen, M., Danziger, S., Eisner, L., Herz-Roiphe, R., Iwahara, Y., Kafka, O., Kiprovski, A., Koones, G., Milich, A., Mittal, S., Richardson, A., Rubenstein, J., Shapiro, J., Stern, A., Zhao, Y. G., Hackett, J., Joshua-Tor, L. (April 2013) Modeling the Structure and Function of Argonaute in RNAi. Faseb Journal, 27. ISSN 0892-6638

Naguib, A., Bencze, G., Faehnle, C. R., Schalch, T., Lazar, Z., Ruse, C. I., Joshua-Tor, L., Pappin, D. J., Trotman, L. C. (April 2013) Upstream activation of PTEN. Cancer Research, 73 (8 (Sup). p. 5156. ISSN 0008-5472

Kuhn, C. D., Joshua-Tor, L. (March 2013) Eukaryotic Argonautes come into focus. Trends in Biochemical Sciences, 38 (5). pp. 263-271. ISSN 09680004 (ISSN)

Paul, S., Kuo, A., Schalch, T., Vogel, H., Joshua-Tor, L., McCombie, W. R., Gozani, O., Hammell, M., Mills, A. A. (January 2013) Chd5 Requires PHD-Mediated Histone 3 Binding for Tumor Suppression. Cell Reports, 3 (1). pp. 92-102. ISSN 2211-1247 (Public Dataset)

Wilusz, J. E., Jnbaptiste, C. K., Lu, L. Y., Kuhn, C. D., Joshua-Tor, L., Sharp, P. A. (November 2012) A triple helix stabilizes the 3' ends of long noncoding RNAs that lack poly(A) tails. Genes Dev, 26 (21). pp. 2392-407. ISSN 1549-5477 (Electronic)0890-9369 (Linking)

Lee, S. J., Lee, S. K., Yoon, H. J., Lee, H. H., Kim, K. K., Lee, B. J., Il Lee, B., Suh, S. W. (July 2012) Structures of Staphylococcus aureus peptide deformylase in complex with two classes of new inhibitors. Acta Crystallographica Section D-Biological Crystallography, 68 (Part 7). pp. 784-793. ISSN 0907-4449

Yasunaga, Mai, Ipsaro, Jonathan J., Mondragón, Alfonso (April 2012) Structurally Similar but Functionally Diverse ZU5 Domains in Human Erythrocyte Ankyrin. Journal of Molecular Biology, 417 (4). pp. 336-350. ISSN 0022-2836

Lavy, T., Kumar, P. R., He, H. Z., Joshua-Tor, L. (February 2012) The Gal3p transducer of the GAL regulon interacts with the Gal80p repressor in its ligand-induced closed conformation. Genes & Development, 26 (3). pp. 294-303. ISSN 0890-9369 (Public Dataset)

Pavlovsky, A. G., Liu, X., Faehnle, C. R., Potente, N., Viola, R. E. (January 2012) Structural characterization of inhibitors with selectivity against members of a homologous enzyme family. Chemical Biology and Drug Design, 79 (1). pp. 128-136. ISSN 17470277 (ISSN)

Ipsaro, J. J., Haase, A. D., Knott, S. R., Joshua-Tor, L., Hannon, G. J. (2012) The structural biochemistry of Zucchini implicates it as a nuclease in piRNA biogenesis. Nature, 491 (7423). pp. 279-282. ISSN 00280836 (ISSN) (Public Dataset)

Elkayam, E., Kuhn, C. D., Tocilj, A., Haase, A. D., Greene, E. M., Hannon, G. J., Joshua-Tor, L. (2012) The structure of human argonaute-2 in complex with miR-20a. Cell, 150 (1). pp. 100-110. ISSN 00928674 (ISSN) (Public Dataset)

Joshua-Tor, L., Hannon, G. J. (October 2011) Ancestral Roles of Small RNAs: An Ago-Centric Perspective. Cold Spring Harb Perspect Biol, 3 (10). ISSN 1943-0264 (Electronic)

Schalch, T., Job, G., Shanker, S., Partridge, J. F., Joshua-Tor, L. (2011) The Chp1-Tas3 core is a multifunctional platform critical for gene silencing by RITS. Nature Structural and Molecular Biology, 18 (12). pp. 1351-1357. ISSN 15459993 (ISSN) (Public Dataset)

Schalch, T., Job, G., Shanker, S., Partridge, J., Joshua-Tor, L. (2011) The Chp1-Tas3 core is a multifunctional platform critical for gene silencing by RITS. Molecular Biology of the Cell, 22. ISSN 1059-1524

Faehnle, C. R., Joshua-Tor, L. (August 2010) Argonaute MID domain takes centre stage. Embo Reports, 11 (8). pp. 564-5. ISSN 1469-221X

Schalch, T., Job, G., Noffsinger, V. J., Shanker, S., Kuscu, C., Joshua-Tor, L., Partridge, J. F. (April 2009) High-affinity binding of Chp1 chromodomain to K9 methylated histone H3 is required to establish centromeric heterochromatin. Mol Cell, 34 (1). pp. 36-46. ISSN 1097-4164 (Electronic) (Public Dataset)

Kettner-Buhrow, D., Guenther, B., Kaelble, S., Joshua-Tor, L., Kracht, M. (April 2009) Measurement of in vivo RISC activity using an in vitro non-radioactive RISC assay. Naunyn-Schmiedebergs Archives of Pharmacology, 379 (281 Ab). p. 59. ISSN 0028-1298

Joshua-Tor, L., Enemark, E. J. (April 2008) Mechanism of DNA translocation in a replicative hexameric helicase. Faseb Journal, 22. ISSN 0892-6638

Enemark, E. J., Joshua-Tor, L. (April 2008) On helicases and other motor proteins. Curr Opin Struct Biol, 18 (2). 243-257 .

Kettner-Buhrow, D., Kaelble, S., Joshua-Tor, L., Kracht, M. (March 2008) Establishment of a non-radioactive assay to measure RISC (RNA-induced silencing complex) activity in vitro. Naunyn-Schmiedebergs Archives of Pharmacology, 377 (Supp 1). p. 64. ISSN 0028-1298

Kumar, P. R., Yu, Y., Sternglanz, R., Johnston, S. A., Joshua-Tor, L. (February 2008) NADP regulates the yeast GAL induction system. Science, 319 (5866). pp. 1090-2. ISSN 1095-9203 (Electronic) (Public Dataset)

Faehnle, Christopher R., Joshua-Tor, Leemor (October 2007) Argonautes confront new small RNAs. Current Opinion in Chemical Biology, 11 (5). pp. 569-577. ISSN 1367-5931 (Print)

O'Farrell, P. A., Joshua-Tor, L. (January 2007) Mutagenesis and crystallographic studies of the catalytic residues of the papain family protease bleomycin hydrolase: new insights into active-site structure. Biochem J, 401 (2). pp. 421-8. ISSN 0264-6021 (Public Dataset)

Tolia, N. H., Joshua-Tor, L. (January 2007) Slicer and the Argonautes. Nature Chemical Biology, 3 (1). pp. 36-43. ISSN 1552-4450

Irvine, D. V., Zaratiegui, Mi., Tolia, N. H., Goto, D. B., Chitwood, D. H., Vaughn, M. W., Joshua-Tor, L., Martienssen, R. A. (August 2006) Argonaute slicing is required for heterochromatic silencing and spreading. Science, 313 (5790). pp. 1134-7. ISSN 1095-9203 (Electronic)

Enemark, E. J., Joshua-Tor, L. (July 2006) Mechanism of DNA translocation in a replicative hexameric helicase. Nature, 442 (7100). pp. 270-275. ISSN 1476-4687 (Electronic) (Public Dataset)

Song, J. J., Joshua-Tor, L. (February 2006) Argonaute and RNA--getting into the groove. Curr Opin Struct Biol, 16 (1). pp. 5-11. ISSN 0959-440X (Print)

Tolia, N.H., Joshua-Tor, L. (January 2006) Strategies for protein coexpression in Escherichia coli. Nat Methods, 3 (1). pp. 55-64. ISSN 1548-7091 (Print)

Yigit, E., Batista, P. J., Bei, Y., Pang, K. M., Chen, C. C. G., Tolia, N. H., Joshua-Tor, L., Mitani, S., Simard, M. J., Mello, C. C. (2006) Analysis of the C. elegans Argonaute Family Reveals that Distinct Argonautes Act Sequentially during RNAi. Cell, 127 (4). pp. 747-757. ISSN 00928674

Joshua-Tor, L. (2006) The argonautes. Cold Spring Harb Symp Quant Biol, 71. pp. 67-72. ISSN 1943-4456 (Electronic) 0091-7451 (Linking)

Tolia, N. H., Enemark, E. J., Sim, B. K., Joshua-Tor, L. (July 2005) Structural basis for the EBA-175 erythrocyte invasion pathway of the malaria parasite Plasmodium falciparum. Cell, 122 (2). pp. 183-93. ISSN 0092-8674 (Print) (Public Dataset)

Rivas, Fabiola V., Tolia, Nirja H., Song, Ji-Joon, Aragon, Juan P., Liu, Jidong, Hannon, Gregory J., Joshua-Tor, Leemor (April 2005) Purified Argonaute2 and an siRNA form recombinant human RISC. Nat Struct Mol Biol, 12 (4). pp. 340-9. ISSN 1545-9993 (Print) (Public Dataset)

Liu, J., Carmell, M. A., Rivas, F. V., Marsden, C. G., Thomson, J. M., Song, J. J., Hammond, S. M., Joshua-Tor, L., Hannon, G. J. (September 2004) Argonaute2 is the catalytic engine of mammalian RNAi. Science, 305 (5689). pp. 1437-41. ISSN 1095-9203 (Electronic)

Song, J. J., Smith, S. K., Hannon, G. J., Joshua-Tor, L. (September 2004) Crystal structure of argonaute and its implications for RISC slicer activity. Science, 305 (5689). pp. 1434-1437. ISSN 0036-8075 (Public Dataset)

Joshua-Tor, L. (July 2004) siRNAs at RISC. Structure, 12 (7). pp. 1120-1122. ISSN 0969-2126

Auster, A. S., Joshua-Tor, L. (January 2004) The DNA-binding domain of human papillomavirus type 18 E1. Crystal structure, dimerization, and DNA binding. J Biol Chem, 279 (5). pp. 3733-42. ISSN 0021-9258 (Print) (Public Dataset)

Song, J. J., Liu, J., Tolia, N. H., Schneiderman, J., Smith, S. K., Martienssen, R. A., Hannon, G. J., Joshua-Tor, L. (December 2003) The crystal structure of the Argonaute2 PAZ domain reveals an RNA binding motif in RNAi effector complexes. Nat Struct Biol, 10 (12). pp. 1026-32. ISSN 1072-8368 (Print) (Public Dataset)

Enemark, E. J., Stenlund, A., Joshua-Tor, L. (March 2002) Crystal structures of two intermediates in the assembly of the papillomavirus replication initiation complex. Embo Journal, 21 (6). pp. 1487-1496. ISSN 0261-4189 (Public Dataset)

Messick, T. E., Chmiel, N. H., Golinelli, M. P., Langer, M. R., Joshua-Tor, L., David, S. S. (March 2002) Noncysteinyl coordination to the [4Fe-4S](2+) cluster of the DNA repair adenine glycosylase MutY introduced via site-directed mutagenesis. Structural characterization of an unusual histidinyl-coordinated cluster. Biochemistry, 41 (12). pp. 3931-3942. ISSN 0006-2960 (Public Dataset)

van Aalten, D. M., Haker, A., Hendriks, J., Hellingwerf, K. J., Joshua-Tor, L., Crielaard, W. (February 2002) Engineering photocycle dynamics. Crystal structures and kinetics of three photoactive yellow protein hinge-bending mutants. J Biol Chem, 277 (8). pp. 6463-8. ISSN 0021-9258 (Print) (Public Dataset)

Van Aalten, D. M. F., Crielaard, W., Hellingwerf, K. J., Joshua-Tor, L. (2002) Structure of the photoactive yellow protein reconstituted with caffeic acid at 1.16 Å resolution. Acta Crystallographica Section D: Biological Crystallography, 58 (4). pp. 585-590. ISSN 09074449 (ISSN) (Public Dataset)

Russell, S. J., Gonzalez, F., Joshua-Tor, L., Johnston, S. A. (October 2001) Selective chemical inactivation of AAA proteins reveals distinct functions of proteasomal ATPases. Chemistry & Biology, 8 (10). pp. 941-950. ISSN 1074-5521

David, S. S., Golinelli, M. P., Chmiel, N. H., Langer, M. R., Chepanoske, C. L., Messick, T. R., Joshua-Tor, L. (August 2001) Participation of the iron-sulfur cluster loop (FCL) motif of the adenine glycosylase MutY in DNA damage recognition and repair. Abstracts of Papers of the American Chemical Society, 222. U578-U578. ISSN 0065-7727

van Aalten, D. M. F., Chong, C. R., Joshua-Tor, L. (August 2000) Crystal structure of carboxypeptidase A complexed with D-cysteine at 1.75 A - inhibitor-induced conformational changes. Biochemistry, 39 (33). pp. 10082-10089. ISSN 0006-2960 (Public Dataset)

Enemark, E. J., Chen, G., Vaughn, D. E., Stenlund, A., Joshua-Tor, L. (July 2000) Crystal structure of the DNA binding domain of the replication initiation protein E1 from papillomavirus. Molecular Cell, 6 (1). pp. 149-158. ISSN 1097-2765 (Public Dataset)

Van Aalten, D. M. F., Crielaard, W., Hellingwerf, K. J., Joshua-Tor, L. (January 2000) Conformational substates in different crystal forms of the photoactive yellow protein - Correlation with theoretical and experimental flexibility. Protein Science, 9 (1). pp. 64-72. ISSN 0961-8368 (Public Dataset)

van Aalten, D. M., Erlanson, D. A., Verdine, G. L., Joshua-Tor, L. (October 1999) A structural snapshot of base-pair opening in DNA. Proc Natl Acad Sci U S A, 96 (21). pp. 11809-14. ISSN 0027-8424 (Print) (Public Dataset)

O'Farrell, P. A., Gonzalez, F., Zheng, W., Johnston, S. A., Joshua-Tor, L. (June 1999) Crystal structure of human bleomycin hydrolase, a self-compartmentalizing cysteine protease. Structure, 7 (6). pp. 619-27. ISSN 0969-2126 (Public Dataset)

Vaughn, D. E., Rodriguez, J., Lazebnik, Y., Joshua-Tor, L. (1999) Crystal structure of Apaf-1 caspase recruitment domain: an alpha-helical Greek key fold for apoptotic signaling. Journal of Molecular Biology, 293 (3). pp. 439-447. ISSN 0022-2836 (Public Dataset)

Zheng, W., Johnston, S. A., Joshua-Tor, L. (April 1998) The unusual active site of Gal6/bleomycin hydrolase can act as a carboxypeptidase, aminopeptidase, and peptide ligase. Cell, 93 (1). pp. 103-9. ISSN 0092-8674 (Print)0092-8674 (Linking) (Public Dataset)

Van Aalten, D. M. F., Grotewold, E., Joshua-Tor, L. (March 1998) Essential dynamics from NMR clusters: Dynamic properties of the Myb DNA-binding domain and a hinge-bending enhancing variant. Methods, 14 (3). pp. 318-328. ISSN 10462023 (ISSN)

Schlessman, J. L., Woo, D., Joshua-Tor, L., Howard, J. B., Rees, D. C. (1998) Conformational variability in structures of the nitrogenase iron proteins from Azotobacter vinelandii and Clostridium pasteurianum. Journal of Molecular Biology, 280 (4). pp. 669-685. ISSN 00222836 (ISSN) (Public Dataset)

Zheng, W., Joshua-Tor, L., Johnston, S. A. (July 1997) Bleomycin hydrolase, a new family of cysteine peptidases reveal a novel mechanism of peptide degradation. Faseb Journal, 11 (9). A1395-A1395. ISSN 0892-6638

Joshua-Tor, L., Xu, H., Johnston, S., Rees, D. (August 1995) Crystal structure of a conserved protease that binds DNA: the bleomycin hydrolase, Gal6. Science, 269 (5226). pp. 945-950. ISSN 0036-80751095-9203 (Public Dataset)

Joshua-Tor, L., Sussman, J. L. (June 1993) The Coming of Age of DNA Crystallography. Current Opinion in Structural Biology, 3 (3). pp. 323-335. ISSN 0959-440X

Blake, P. R., Day, M. W., Hsu, B. T., Joshua-Tor, L., Park, J. B., Hare, D. R., Adams, M. W., Rees, D. C., Summers, M. F. (November 1992) Comparison of the X-ray structure of native rubredoxin from Pyrococcus furiosus with the NMR structure of the zinc-substituted protein. Protein Sci, 1 (11). pp. 1522-5. ISSN 0961-8368 (Print)0961-8368 (Linking)

Joshua-Tor, L., Frolow, F., Appella, E., Hope, H., Rabinovich, D., Sussman, J. L. (May 1992) Three-dimensional structures of bulge-containing DNA fragments. J Mol Biol, 225 (2). pp. 397-431. ISSN 0022-2836 (Print)0022-2836 (Linking) (Public Dataset)

Day, M. W., Hsu, B. T., Joshua-Tor, L., Park, J. B., Zhou, Z. H., Adams, M. W. W., Rees, D. C. (1992) X-ray crystal structures of the oxidized and reduced forms of the rubredoxin from the marine hyperthermophilic archaebacterium Pyrococcus furiosus. Protein Science, 1 (11). pp. 1494-1507. ISSN 09618368 (ISSN) (Public Dataset)

Berman, H. M., Sussman, J. L., Joshua-Tor, L., Revich, G. G., Ripley, L. S. (1992) A structural model for sequence-specific proflavin-DNA interactions during in vitro frameshift mutagenesis. Journal of Biomolecular Structure and Dynamics, 10 (2). pp. 317-331. ISSN 07391102 (ISSN)

Joshua-Tor, L., Rabinovich, D., Hope, H., Frolow, F., Appella, E., Sussman, J. L. (July 1988) The three-dimensional structure of a DNA duplex containing looped-out bases. Nature, 334 (6177). pp. 82-4. ISSN 0028-0836 (Print)0028-0836 (Linking)

Book Section

Joshua-Tor, L., Johnston, S. A. (2004) The Bleomycin Hydrolases. In: Handbook of Proteolytic Enzymes. Elsevier Academic Press, pp. 1197-1201. ISBN 9780120796120

Joshua-Tor, L., Johnston, S. A. (1998) The Bleomycin Hydrolases. In: Handbook of Proteolytic Enzymes. Elsevier Academic Press, London, pp. 634-638. ISBN 9780120796120

Rees, D. C., Kim, J., Georgiadis, M. M., Komiya, H., Chirino, A. J., Woo, D., Schlessman, J., Chan, M. K., Joshua-Tor, L., Santillan, G., Chakrabarti, P., Hsu, B. T. (1993) Crystal Structures of the Iron Protein and Molybdenum-Iron Protein of Nitrogenase. In: Molybdenum Enzymes, Cofactors, and Model Systems. ACS Symposium Series, 535 (535). American Chemical Society, pp. 170-185. ISBN 0-8412-2708-X

Sussman, J. L., Joshua-Tor, L., Hirshberg, M., Saper, M. A. , Frowlow, F. , Hope, H., Appella, E. (1988) A Kinked Model of a DNA Tridecamer with an Unpaired Adenosine: Energy Minimization and X-ray Structural Studies. In: Molecular Structure: Chemical Reactivity and Biological Activity. Oxford University Press, pp. 195-200.

Conference or Workshop Item

Meze, Katarina, Axhemi, Armend, Thomas, Dennis, Joshua-Tor, Leemor (October 2021) The 3 '-5 ' Exonuclease Dis3L2 Undergoes Conformational Dynamics During Structured RNA Degradation. In: Protein Science 35th Anniversary Symposium.

Bibel, Brianna, Elkayam, Elad, Joshua-Tor, Leemor (April 2020) Mechanisms of Phosphorylation-Mediated Regulation of the RNAi Effector Protein Argonaute 2. In: Annual Meeting on Experimental Biology.

Joshua-Tor, Leemor, Tocilj, Ante, On, Kenneth, Yuan, Zuanning, Sun, Jingchuan, Li, Huilin, Stillman, Bruce (April 2018) The Origin Recognition Complex: where it all begins. In: UNSPECIFIED.

Naguib, Adam, Bencze, Gylua, Cho, Hyejin, Zheng, Wu, Tocilj, Ante, Elkayam, Elad, Faehnle, Christopher R, Jaber, Nadia, Pratt, Christopher, Chen, Muhan, Zong, Wei-Xing, Marks, Michael S, Joshua-Tor, Leemor, Pappin, Darryl J, Trotman, Lloyd C (August 2015) PTEN function is controlled by recruitment to cytoplasmic vesicles. In: AACR 106th Annual Meeting 2015.

Lavy, Tali, Prakash, Rajesh K, He, Hongzhen, Joshua-Tor, Leemor (2011) The GAL regulon in S. CEREVISIAE: the Gal3p/Gal80p interaction. In: Acta Crystallographica.

Thesis

Bibel, Brianna L (October 2021) Regulating the regulator: Phosphorylation-mediated regulation of the RNAi effector protein Argonaute. PhD thesis, Cold Spring Harbor Laboratory.

Meze, Katarina (July 2021) Mechanism of Structured RNA Degradation by the Human Exonuclease Dis3L2. PhD thesis, Cold Spring Harbor Laboratory.

Song, J. J. (March 2005) STRUCTURAL AND BIOCHEMICAL STUDIES OF ARGONAUTE REVEAL THE SLICING MECHANISM OF RISC – RNAI EFFECTOR COMPLEX. PhD thesis, Cold Spring Harbor Laboratory.

Tolia, N. H. (2004) STRUCTURAL AND BIOCHEMICAL STUDIES OF EBA-175, A PROTEIN THAT MEDIATES ERYTHROCYTE INVASION BY THE MALARIA PARASITE PLASMODIUM FALCIPARUM. PhD thesis, Cold Spring Harbor Laboratory.

Video

Joshua-Tor, L. (November 2011) Talk from Leemor Joshua-Tor at the Cold Spring Harbor Laboratory In-House Symposium (2011). [Video] (Unpublished)