Krainer, Adrian R. Publications

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Krainer, Adrian R.

http://orcid.org/0000-0001-9024-9501

Number of items at this level: 222.

Scharner, J., Qi, S., Rigo, F., Bennett, C. F., Krainer, A. R. (March 2019) Delivery of GalNAc-Conjugated Splice-Switching ASOs to Non-hepatic Cells through Ectopic Expression of Asialoglycoprotein Receptor. Mol Ther Nucleic Acids, 16. pp. 313-325. ISSN 2162-2531 (Print)

Wang, E., Lu, S. X., Pastore, A., Chen, X., Imig, J., Chun-Wei Lee, S., Hockemeyer, K., Ghebrechristos, Y. E., Yoshimi, A., Inoue, D., Ki, M., Cho, H., Bitner, L., Kloetgen, A., Lin, K. T., Uehara, T., Owa, T., Tibes, R., Krainer, A. R., Abdel-Wahab, O., Aifantis, I. (February 2019) Targeting an RNA-Binding Protein Network in Acute Myeloid Leukemia. Cancer Cell, 35 (3). 359-384.e7. ISSN 1535-6108

Lu, S. X., Wang, E., Pastore, A., Chen, X. F., Imig, J., Lee, S. C., Ghebrechristos, Y., Yoshimi, A., Bitner, L. E., Ki, M., Kloetgen, A., Lin, K. T., Tibes, R., Krainer, A. R., Uehara, T., Owa, T., Aifantis, I., Abdel-Wahab, O. I. (November 2018) Therapeutic Targeting of an RNA Splicing Factor Network for the Treatment of Myeloid Neoplasms. Blood, 132 (Supple). Meeting Abstract 427. ISSN 0006-4971

Wong, M. S., Kinney, J. B., Krainer, A. R. (August 2018) Quantitative Activity Profile and Context Dependence of All Human 5' Splice Sites. Mol Cell, 71 (6). 1012-1026.e3. ISSN 1097-2765

Sinha, R., Kim, Y. J., Nomakuchi, T., Sahashi, K., Hua, Y., Rigo, F., Bennett, C. F., Krainer, A. R. (June 2018) Antisense oligonucleotides correct the familial dysautonomia splicing defect in IKBKAP transgenic mice. Nucleic Acids Res, 46 (10). pp. 4833-4844. ISSN 0305-1048

Aznarez, Isabel, Nomakuchi, Tomoki T., Tetenbaum-Novatt, Jaclyn, Rahman, Mohammad Alinoor, Fregoso, Oliver, Rees, Holly, Krainer, Adrian R. (May 2018) Mechanism of Nonsense-Mediated mRNA Decay Stimulation by Splicing Factor SRSF1. Cell Reports, 23 (7). pp. 2186-2198. ISSN 2211-1247

Lin, K. T., Ma, W. K., Scharner, J., Liu, Y. R., Krainer, A. R. (February 2018) A human-specific switch of alternatively spliced AFMID isoforms contributes to TP53 mutations and tumor recurrence in hepatocellular carcinoma. Genome Res. ISSN 1088-9051

Sheng, L., Wan, B., Feng, P., Sun, J., Rigo, F., Bennett, C. F., Akerman, M., Krainer, A. R., Hua, Y. (February 2018) Downregulation of Survivin contributes to cell-cycle arrest during postnatal cardiac development in a severe spinal muscular atrophy mouse model. Hum Mol Genet, 27 (3). pp. 486-498. ISSN 0964-6906

Sivaramakrishnan, M., McCarthy, K. D., Campagne, S., Huber, S., Meier, S., Augustin, A., Heckel, T., Meistermann, H., Hug, M. N., Birrer, P., Moursy, A., Khawaja, S., Schmucki, R., Berntenis, N., Giroud, N., Golling, S., Tzouros, M., Banfai, B., Duran-Pacheco, G., Lamerz, J., Hsiu Liu, Y., Luebbers, T., Ratni, H., Ebeling, M., Clery, A., Paushkin, S., Krainer, A. R., Allain, F. H., Metzger, F. (November 2017) Binding to SMN2 pre-mRNA-protein complex elicits specificity for small molecule splicing modifiers. Nat Commun, 8 (1). p. 1476. ISSN 2041-1723

Munoz, Adriana, Yamrom, Boris, Lee, Yoon-ha, Andrews, Peter, Marks, Steven, Lin, Kuan-Ting, Wang, Zihua, Krainer, Adrian R., Darnell, Robert B., Wigler, Michael, Iossifov, Ivan (May 2017) De novo indels within introns contribute to ASD incidence. bioRxiv. p. 137471. (Unpublished)

Wu, X., Wang, S. H., Sun, J., Krainer, A. R., Hua, Y., Prior, T. W. (April 2017) A-44G transition in SMN2 intron 6 protects patients with spinal muscular atrophy. Hum Mol Genet. ISSN 0964-6906

Jangi, M., Fleet, C., Cullen, P., Gupta, S. V., Mekhoubad, S., Chiao, E., Allaire, N., Bennett, C. F., Rigo, F., Krainer, A. R., Hurt, J. A., Carulli, J. P., Staropoli, J. F. (March 2017) SMN deficiency in severe models of spinal muscular atrophy causes widespread intron retention and DNA damage. Proc Natl Acad Sci U S A, 114 (12). E2347-2356. ISSN 0027-8424

Doktor, T. K., Hua, Y., Andersen, H. S., Broner, S., Liu, Y. H., Wieckowska, A., Dembic, M., Bruun, G. H., Krainer, A. R., Andresen, B. S. (January 2017) RNA-sequencing of a mouse-model of spinal muscular atrophy reveals tissue-wide changes in splicing of U12-dependent introns. Nucleic Acids Res, 45 (1). pp. 395-416. ISSN 1362-4962 (Electronic)0305-1048 (Linking)

Allemand, E., Myers, M. P., Garcia-Bernardo, J., Harel-Bellan, A., Krainer, A. R., Muchardt, C. (September 2016) A Broad Set of Chromatin Factors Influences Splicing. PLoS Genet, 12 (9). e1006318. ISSN 1553-7404 (Electronic)1553-7390 (Linking)

Anczukow, O., Krainer, A. R. (September 2016) Splicing-factor alterations in cancers. RNA, 22 (9). pp. 1285-301. ISSN 1469-9001 (Electronic)1355-8382 (Linking)

Bruun, G. H., Doktor, T. K., Borch-Jensen, J., Masuda, A., Krainer, A. R., Ohno, K., Andresen, B. S. (July 2016) Global identification of hnRNP A1 binding sites for SSO-based splicing modulation. BMC Biol, 14 (1). p. 54. ISSN 1741-7007 (Electronic)1741-7007 (Linking)

Arun, G., Diermeier, S., Akerman, M., Chang, K. C., Wilkinson, J. E., Hearn, S., Kim, Y., MacLeod, A. R., Krainer, A. R., Norton, L., Brogi, E., Egeblad, M., Spector, D. L. (March 2016) Differentiation of mammary tumors and reduction in metastasis upon Malat1 LncRNA loss. Cancer Research, 76 (Supple). ISSN 0008-5472

Nomakuchi, T. T., Rigo, F., Aznarez, I., Krainer, A. R. (February 2016) Antisense oligonucleotide-directed inhibition of nonsense-mediated mRNA decay. Nat Biotechnol, 34 (2). pp. 164-166. ISSN 1546-1696 (Electronic)1087-0156 (Linking)

Hua, Y., Krainer, A. R. (2016) Antisense-Oligonucleotide Modulation of SMN2 Pre-mRNA Splicing. In: Spinal Muscular Atrophy: Disease Mechanisms and Therapy. Elsevier, pp. 301-311. ISBN 978-012803686-0978-012803685-3

Anczukow, O., Krainer, A. R. (October 2015) The spliceosome, a potential Achilles heel of MYC-driven tumors. Genome Med, 7 (1). p. 107. ISSN 1756-994X (Electronic)1756-994X (Linking)

Anczukow, O., Akerman, M., Clery, A., Wu, J., Shen, C., Shirole, N. H., Raimer, A., Sun, S., Jensen, M. A., Hua, Y., Allain, F. H., Krainer, A. R. (October 2015) SRSF1-Regulated Alternative Splicing in Breast Cancer. Mol Cell, 60 (1). pp. 105-17. ISSN 1097-4164 (Electronic)1097-2765 (Linking)

Akerman, M., Fregoso, O. I., Das, S., Ruse, C., Jensen, M. A., Pappin, D. J., Zhang, M. Q., Krainer, A. R. (June 2015) Differential connectivity of splicing activators and repressors to the human spliceosome. Genome Biol, 16 (1). p. 119. ISSN 1465-6914 (Electronic)1465-6906 (Linking)

Krainer, A. R. (April 2015) Splicing: still so much to learn. RNA, 21 (4). pp. 500-1. ISSN 1355-8382

Staropoli, John F., Li, Huo, Chun, Seung J., Allaire, Norm, Cullen, Patrick, Thai, Alice, Fleet, Christina M., Hua, Yimin, Bennett, C. Frank, Krainer, Adrian R., Kerr, Doug, McCampbell, Alexander, Rigo, Frank, Carulli, John P. (January 2015) Rescue of gene-expression changes in an induced mouse model of spinal muscular atrophy by an antisense oligonucleotide that promotes inclusion of SMN2 exon 7. Genomics, 105 (4). pp. 220-228. ISSN 0888-7543

Hua, Y., Liu, Y. H., Sahashi, K., Rigo, F., Bennett, C. F., Krainer, A. R. (January 2015) Motor neuron cell-nonautonomous rescue of spinal muscular atrophy phenotypes in mild and severe transgenic mouse models. Genes Dev, 29 (3). pp. 288-297. ISSN 0890-9369

Guo, Ya, Xu, Quan, Canzio, Daniele, Shou, Jia, Li, Jinhuan, Gorkin, David U, Jung, Inkyung, Wu, Haiyang, Zhai, Yanan, Tang, Yuanxiao, Lu, Yichao, Wu, Yonghu, Jia, Zhilian, Li, Wei, Zhang, Michael Q, Ren, Bing, Krainer, Adrian R, Maniatis, Tom, Wu, Qiang (2015) CRISPR Inversion of CTCF Sites Alters Genome Topology and Enhancer/Promoter Function. Cell, 162 (4). pp. 900-910. ISSN 0092-8674

Xiong, H. Y., Alipanahi, B., Lee, L. J., Bretschneider, H., Merico, D., Yuen, R. K., Hua, Y., Gueroussov, S., Najafabadi, H. S., Hughes, T. R., Morris, Q., Barash, Y., Krainer, A. R., Jojic, N., Scherer, S. W., Blencowe, B. J., Frey, B. J. (December 2014) RNA splicing. The human splicing code reveals new insights into the genetic determinants of disease. Science, 347 (6218). ISSN 0036-8075

Paz, S., Krainer, A. R., Caputi, M. (November 2014) HIV-1 transcription is regulated by splicing factor SRSF1. Nucleic Acids Research, 42 (22). pp. 13812-13823. ISSN 0305-1048

Chen, Hsu-Hsin, Welling, Maaike, Bloch, Donald B, Muñoz, Javier, Mientjes, Edwin, Chen, Xinjie, Tramp, Cody, Wu, Jie, Yabuuchi, Akiko, Chou, Yu-Fen, Buecker, Christa, Krainer, Adrian, Willemsen, Rob, Heck, Albert J, Geijsen, Niels (October 2014) DAZL Limits Pluripotency, Differentiation, and Apoptosis in Developing Primordial Germ Cells. Stem Cell Reports, 3 (5). pp. 892-904. ISSN 2213-6711

Senturk, S., Yao, Z., Camiolo, M., Stiles, B., Rathod, T., Walsh, A. M., Nemajerova, A., Lazzara, M. J., Altorki, N. K., Krainer, A., Moll, U. M., Lowe, S. W., Cartegni, L., Sordella, R. (July 2014) p53Psi is a transcriptionally inactive p53 isoform able to reprogram cells toward a metastatic-like state. Proceedings of the National Academy of Sciences of the United States of America, 111 (32). E3287-E3296. ISSN 0027-8424

Rigo, F., Chun, S. J., Norris, D. A., Hung, G., Lee, S., Matson, J., Fey, R. A., Gaus, H., Hua, Y., Grundy, J. S., Krainer, A. R., Henry, S. P., Bennett, C. F. (July 2014) Pharmacology of a central nervous system delivered 2′-O-methoxyethyl- modified survival of motor neuron splicing oligonucleotide in mice and nonhuman primates. Journal of Pharmacology and Experimental Therapeutics, 350 (1). pp. 46-55. ISSN 15210103

Das, S., Krainer, A. R. (May 2014) Emerging functions of SRSF1, splicing factor and oncoprotein, in RNA metabolism and cancer. Molecular Cancer Research, 12 (9). pp. 1195-1204. ISSN 1541-7786

Weyn-Vanhentenryck, Sebastien M., Mele, A., Yan, Q., Sun, S., Farny, N., Zhang, Z., Xue, C., Herre, M., Silver, Pamela A., Zhang, Michael Q., Krainer, Adrian R., Darnell, Robert B., Zhang, C. (March 2014) HITS-CLIP and Integrative Modeling Define the Rbfox Splicing-Regulatory Network Linked to Brain Development and Autism. Cell Reports, 6 (6). pp. 1139-1152. ISSN 22111247 (ISSN)

Jensen, M. A., Wilkinson, J. E., Krainer, A. R. (January 2014) Splicing factor SRSF6 promotes hyperplasia of sensitized skin. Nature Structural and Molecular Biology, 21. pp. 189-197. ISSN 15459993 (ISSN)

Sahashi, K., Ling, K. K., Hua, Y., Wilkinson, J. E., Nomakuchi, T., Rigo, F., Hung, G., Xu, D., Jiang, Y. P., Lin, R. Z., Ko, C. P., Bennett, C. F., Krainer, A. R. (September 2013) Pathological impact of SMN2 mis-splicing in adult SMA mice. EMBO Molecular Medicine, 5 (10). pp. 1586-1601. ISSN 17574676 (ISSN)

Cléry, A., Sinha, R., Anczuków, O., Corrionero, A., Moursy, A., Daubner, G. M., Valcárcel, J., Krainer, A. R., Allain, F. H. T. (July 2013) Isolated pseudo-RNA-recognition motifs of SR proteins can regulate splicing using a noncanonical mode of RNA recognition. Proceedings of the National Academy of Sciences of the United States of America, 110 (30). E2802-E2811. ISSN 00278424

Fregoso, O. I., Das, S., Akerman, M., Krainer, A. R. (March 2013) Splicing-Factor Oncoprotein SRSF1 Stabilizes p53 via RPL5 and Induces Cellular Senescence. Molecular Cell, 50 (1). pp. 56-66. ISSN 1097-2765

Roca, X., Krainer, A. R., Eperon, I. C. (January 2013) Pick one, but be quick: 5′ splice sites and the problems of too many choices. Genes and Development, 27 (2). pp. 129-144. ISSN 08909369 (ISSN)

Ben-Hur, V., Denichenko, P., Siegfried, Z., Maimon, A., Krainer, A., Davidson, B., Karni, R. (January 2013) S6K1 Alternative Splicing Modulates Its Oncogenic Activity and Regulates mTORC1. Cell Reports, 3 (1). pp. 103-115. ISSN 22111247

Hua, Yimin, Sahashi, Kentaro, Rigo, Frank, Hung, Gene, Bennett, C. Frank, Krainer, AdrianR (2013) Correction of RNA Splicing with Antisense Oligonucleotides as a Therapeutic Strategy for a Neurodegenerative Disease. In: Chembiomolecular Science. Springer Japan, pp. 301-313. ISBN 978-4-431-54037-3

Wu, J., Anczukow, O., Krainer, A. R., Zhang, M. Q., Zhang, C. (2013) OLego: fast and sensitive mapping of spliced mRNA-Seq reads using small seeds. Nucleic Acids Research, 41 (10). pp. 5149-5163. ISSN 03051048 (ISSN)

Roca, X., Krainer, A. R. (2013) RNA Splicing. In: Brenner's Encyclopedia of Genetics. Elsevier Science. ISBN 9780080961569

Das, S., Fregoso, O. I., Krainer, A. R. (2013) A new path to oncogene-induced senescence: At the cross-roads of splicing and translation. Cell Cycle, 12 (10). ISSN 1551-4005 (Electronic)1551-4005 (Linking)

Krainer, A. (November 2012) Pre-mRNA Splicing Mechanisms, Misregulation in Disease, and Therapeutic Strategies. Blood, 120 (21). ISSN 0006-4971

Rigo, F., Hua, Y. M., Krainer, A. R., Bennett, C. F. (October 2012) Antisense-based therapy for the treatment of spinal muscular atrophy. Journal of Cell Biology, 199 (1). pp. 21-25. ISSN 0021-9525

Wang, Z., Jeon, H. Y., Rigo, F., Bennett, C. F., Krainer, A. R. (October 2012) Manipulation of PK-M mutually exclusive alternative splicing by antisense oligonucleotides. Open Biol, 2 (10). p. 120133. ISSN 2046-2441 (Electronic)2046-2441 (Linking)

Sahashi, K., Hua, Y., Ling, K. K., Hung, G., Rigo, F., Horev, G., Katsuno, M., Sobue, G., Ko, C. P., Bennett, C. F., Krainer, A. R. (August 2012) TSUNAMI: an antisense method to phenocopy splicing-associated diseases in animals. Genes Dev, 26 (16). pp. 1874-84. ISSN 1549-5477 (Electronic)0890-9369 (Linking)

Rigo, F., Hua, Y. M., Chun, S. J., Prakash, T. P., Krainer, A. R., Bennett, C. F. (June 2012) Synthetic oligonucleotides recruit ILF2/3 to RNA transcripts to modulate splicing. Nature Chemical Biology, 8 (6). pp. 555-561. ISSN 1552-4450

Beaulieu, C. L., Samuels, M. E., Ekins, S., McMaster, C. R., Edwards, A. M., Krainer, A. R., Hicks, G. G., Frey, B. J., Boycott, K. M., Mackenzie, A. E. (June 2012) A generalizable pre-clinical research approach for orphan disease therapy. Orphanet J Rare Dis, 7. pp. 1750-1172. ISSN 1750-1172 (Electronic)1750-1172 (Linking)

Roca, X., Akerman, M., Gaus, H., Berdeja, A., Bennett, C. F., Krainer, A. R. (May 2012) Widespread recognition of 5' splice sites by noncanonical base-pairing to U1 snRNA involving bulged nucleotides. Genes & Development, 26 (10). pp. 1098-109. ISSN 1549-5477 (Electronic)0890-9369 (Linking)

Sun, S. Y., Zhang, Z., Fregoso, O., Krainer, A. R. (February 2012) Mechanisms of activation and repression by the alternative splicing factors RBFOX1/2. RNA, 18 (2). pp. 274-283. ISSN 1355-8382

Kole, R., Krainer, A. R., Altman, S. (February 2012) RNA therapeutics: Beyond RNA interference and antisense oligonucleotides. Nature Reviews Drug Discovery, 11 (2). pp. 125-140. ISSN 14741776 (ISSN)

Anczukow, O., Rosenberg, A. Z., Akerman, M., Das, S., Zhan, L., Karni, R., Muthuswamy, S. K., Krainer, A. R. (January 2012) The splicing factor SRSF1 regulates apoptosis and proliferation to promote mammary epithelial cell transformation. Nature Structural Molecular Biology, 19 (2). pp. 220-228. ISSN 1545-9985 (Electronic)1545-9985 (Linking)

Hua, Y., Krainer, A. R. (2012) Antisense-mediated exon inclusion. Methods Mol Biol, 867. pp. 307-323. ISSN 1940-6029 (Electronic)1064-3745 (Linking)

Wang, Z. X., Chatterjee, D., Jeon, H. Y., Akerman, M., Vander Heiden, M. G., Cantley, L. C., Krainer, A. R. (2012) Exon-centric regulation of pyruvate kinase M alternative splicing via mutually exclusive exons. Journal of Molecular Cell Biology, 4 (2). pp. 79-87.

Mayeda, A., Krainer, A. R. (2012) In vitro splicing assays. In: Alternative pre-mRNA Splicing: Theory and Protocols. Wiley, pp. 321-330. ISBN 9783527636785

Das, S., Anczuków, O., Akerman, M., Krainer, A. R (2012) Oncogenic Splicing Factor SRSF1 Is a Critical Transcriptional Target of MYC. Cell Reports, 1 (2). pp. 110-117. ISSN 2211-1247

Wu, J., Akerman, M., Sun, S., McCombie, W. R., Krainer, A. R., Zhang, M. Q. (November 2011) SpliceTrap: a method to quantify alternative splicing under single cellular conditions. Bioinformatics, 27 (21). 3010-3016 . ISSN 1367-4803

Krainer, A. R. (November 2011) Talk from Adrian Krainer at the Cold Spring Harbor Laboratory In-House Symposium (2011). [Video] (Unpublished)

Hua, Y., Sahashi, K., Rigo, F., Hung, G., Horev, G., Bennett, C. F., Krainer, A. R. (October 2011) Peripheral SMN restoration is essential for long-term rescue of a severe spinal muscular atrophy mouse model. Nature, 478 (7367). pp. 123-6. ISSN 1476-4687 (Electronic) 0028-0836 (Linking)

Rigo, F., Hua, Y. M., Chun, S. J., Krainer, A. R., Bennett, C. F. (October 2011) Modulation of Gene Expression By Oligonucleotide Chemistry-Dependent Recruitment of Proteins to RNA Transcripts. Nucleic Acid Therapeutics, 21 (5). A53-A54. ISSN 2159-3337

Krainer, A. R., Hua, Y. M., Sahashi, K., Rigo, F., Hung, G. N., Horev, G., Bennett, C. F. (October 2011) Systemic Versus CNS Delivery Of MOE Antisense Oligonucleotide to Correct Defective Splicing in a Severe Mouse Model of Spinal Muscular Atrophy. Nucleic Acid Therapeutics, 21 (5). A57-A57. ISSN 2159-3337

Kubota, T., Roca, X., Kimura, T., Kokunai, Y., Nishino, I., Sakoda, S., Krainer, A. R., Takahashi, M. P. (July 2011) A mutation in a rare type of intron in a sodium-channel gene results in aberrant splicing and causes myotonia. Human Mutation, 32 (7). pp. 773-782. ISSN 10597794 (ISSN)

Krainer, A. R. (June 2011) Oligonucleotide therapeutics for correcting defective RNA splicing. FEBS Journal, 278 (Issue ). p. 11. ISSN 1742-464X

Cho, S. Y., Hoang, A., Sinha, R., Zhong, X. Y., Fu, X. D., Krainer, A. R., Ghosh, G. (May 2011) Interaction between the RNA binding domains of Ser-Arg splicing factor 1 and U1-70K snRNP protein determines early spliceosome assembly. Proceedings of the National Academy of Sciences of the United States of America, 108 (20). pp. 8233-8238. ISSN 0027-8424

Passini, M. A., Bu, J., Richards, A. M., Kinnecom, C., Sardi, S. P., Stanek, L. M., Hua,  Y., Rigo, F., Matson, J., Hung, G., Kaye, E. M., Shihabuddin, L. S., Krainer, A. R., Bennett, C. F., Cheng, S. H. (March 2011) Antisense oligonucleotides delivered to the mouse CNS ameliorate symptoms of severe spinal muscular atrophy. Science Translational Medicine, 3 (72). ISSN 19466234 (ISSN)

Thorsen, K., Mansilla, F., Schepeler, T., Oster, B., Rasmussen, M. H., Dyrskjot, L., Karni, R., Akerman, M., Krainer, A. R., Laurberg, S., Andersen, C. L., Orntoft, T. F. (January 2011) Alternative splicing of SLC39A14 in colorectal cancer is regulated by the Wnt pathway. Molecular and Cellular Proteomics, 10 (1).

Hua, Y., Sahashi, K., Hung, G., Rigo, F., Passini, M. A., Bennett, C. F., Krainer, A. R. (August 2010) Antisense correction of SMN2 splicing in the CNS rescues necrosis in a type III SMA mouse model. Genes and Development, 24 (15). pp. 1634-44. ISSN 08909369 (ISSN)

Wu, H., Sun, S., Tu, K., Gao, Y., Xie, B., Krainer, A. R., Zhu, J. (April 2010) A Splicing-Independent Function of SF2/ASF in MicroRNA Processing. Molecular Cell, 38 (1). pp. 67-77.

Kole, R., Krainer, A. R., Sullenger, B. (April 2010) RNA & OLIGONUCLEOTIDE THERAPEUTICS. In: 2010 meeting on RNA & OLIGONUCLEOTIDE THERAPEUTICS, April 7–April 10, 2010, Cold Spring Harbor.

Sinha, R., Allemand, E., Zhang, Z., Karni, R., Myers, M. P., Krainer, A. R. (March 2010) Arginine Methylation Controls the Subcellular Localization and Functions of the Oncoprotein Splicing Factor SF2/ASF. Molecular and Cellular Biology, 30 (11). pp. 2762-2774. ISSN 0270-7306

Sun, S., Zhang, Z., Sinha, R., Karni, R., Krainer, A. R. (February 2010) SF2/ASF autoregulation involves multiple layers of post-transcriptional and translational control. Nat Struct Mol Biol, 17 (3). pp. 306-12. ISSN 1545-9985 (Electronic) 1545-9985 (Linking)

Clower, C. V., Chatterjee, D., Wang, Z. X., Cantley, L. C., Heiden, M. G. V., Krainer, A. R. (February 2010) The alternative splicing repressors hnRNP A1/A2 and PTB influence pyruvate kinase isoform expression and cell metabolism. Proceedings of the National Academy of Sciences of the United States of America, 107 (5). pp. 1894-1899. ISSN 0027-8424

Manley, J. L., Krainer, A. R. (2010) A rational nomenclature for serine/arginine-rich protein splicing factors (SR proteins). Genes and Development, 24 (11). pp. 1073-1074.

Hastings, M. L., Berniac, J., Liu, Y. H., Abato, P., Jodelka, F. M., Barthel, L., Kumar, S., Dudley, C., Nelson, M., Larson, K., Edmonds, J., Bowser, T., Draper, M., Higgins, P., Krainer, A. R. (November 2009) Tetracyclines That Promote SMN2 Exon 7 Splicing as Therapeutics for Spinal Muscular Atrophy. Science Translational Medicine, 1 (5). ISSN 1946-6234

Okunola, H. L., Krainer, A. R. (October 2009) Cooperative-binding and splicing-repressive properties of hnRNP A1. Mol Cell Biol, 29 (20). pp. 5620-5631.

Prior, T. W., Krainer, A. R., Hua, Y., Swoboda, K. J., Snyder, P. C., Bridgeman, S. J., Burghes, A. H. M., Kissel, J. T. (September 2009) A Positive Modifier of Spinal Muscular Atrophy in the SMN2 Gene. The American Journal of Human Genetics, 85 (3). pp. 408-413.

De Araújo, M. M., Bonnal, S., Hastings, M. L., Krainer, A. R., Valcárcel, J. (April 2009) Differential 3′ splice site recognition of SMN1 and SMN2 transcripts by U2AF and U2 snRNP. RNA, 15 (4). pp. 515-523.

Khoo, B., Krainer, A. R. (April 2009) Splicing therapeutics in SMN2 and APOB. Current Opinion in Molecular Therapeutics, 11 (2). pp. 108-115. ISSN 1464-8431

Roca, X., Krainer, A. R. (March 2009) A splicing component adapted to gene silencing. Nat Biotechnol, 27 (3). pp. 250-1. ISSN 1546-1696 (Electronic)1087-0156 (Linking)

Roca, X., Krainer, A. R. (February 2009) Recognition of atypical 5' splice sites by shifted base-pairing to U1 snRNA. Nat Struct Mol Biol, 16 (2). pp. 176-182.

Andresen, B. S., Krainer, A. R. (2009) When the genetic code is not enough: How sequence variations can affect pre-mRNA splicing and cause (complex) disease. In: Genetics of Complex Human Diseases: A Laboratory Manual. Cold Spring Harbor Laboratory Press, pp. 165-182. ISBN 9780879698836

Karni, R., Hippo, Y., Lowe, S. W., Krainer, A. R. (October 2008) The splicing-factor oncoprotein SF2/ASF activates mTORC1. Proc Natl Acad Sci U S A, 105 (40). pp. 15323-7.

Zhang, C., Zhang, Z., Castle, J., Sun, S., Johnson, J., Krainer, A. R., Zhang, M. Q. (September 2008) Defining the regulatory network of the tissue-specific splicing factors Fox-1 and Fox-2. Genes Dev, 22 (18). pp. 2550-63.

Thorsen, K., Sorensen, K. D., Brems-Eskildsen, A. S., Modin, C., Gaustadnes, M., Hein, A. M. K., Kruhoffer, M., Laurberg, S., Borre, M., Wang, K., Brunak, S., Krainer, A. R., Torring, N., Dyrskjot, L., Andersen, C. L., Orntoft, T. F. (July 2008) Alternative splicing in colon, bladder, and prostate cancer identified by exon array analysis. Molecular & Cellular Proteomics, 7 (7). pp. 1214-1224. ISSN 1535-9476

Steitz, J. A., Dreyfuss, G., Krainer, A. R., Lamond, A. I., Matera, A. G., Padgett, R. A. (June 2008) Where in the cell is the minor spliceosome? Proc Natl Acad Sci U S A, 105 (25). pp. 8485-6.

Zhang, C., Li, W. H., Krainer, A. R., Zhang, M. Q. (April 2008) RNA landscape of evolution for optimal exon and intron discrimination. Proc Natl Acad Sci U S A, 105 (15). 5797-5802 .

Hua, Y., Vickers, T. A., Okunola, H. L., Bennett, C. F., Krainer, A. R. (April 2008) Antisense Masking of an hnRNP A1/A2 Intronic Splicing Silencer Corrects SMN2 Splicing in Transgenic Mice. Am J Hum Genet, 82 (4). pp. 834-48.

Majerciak, V., Yamanegi, K., Allemand, E., Kruhlak, M., Krainer, A. R., Zheng, Z. M. (March 2008) Kaposi sarcoma-associated herpesvirus ORF57 functions as a viral splicing factor and promotes the expression of intron-containing viral lytic genes in spliceosome-mediated RNA splicing. J Virol, 82 (6). pp. 2792-2801.

Chen, G., Li, W., Zhang, Q. S. , Regulski, M. R., Sinha, N., Barditch, J., Tully, T. , Krainer, A. R., Zhang, M. Q., Dubnau, J. T. (February 2008) Identification of Synaptic Targets of Drosophila Pumilio. PLoS Computational Biology, 4 (2). e1000026. ISSN 1553734X

Roca, X., Olson, A. J., Rao, A. R., Enerly, E., Kristensen, V. N., Borresen-Dale, A. L., Andresen, B. S., Krainer, A. R., Sachidanandam, R. (January 2008) Features of 5'-splice-site efficiency derived from disease-causing mutations and comparative genomics. Genome Res, 18 (1). pp. 77-87.

Zhang, C., Krainer, A. R., Zhang, M. Q. (October 2007) Evolutionary impact of limited splicing fidelity in mammalian genes. Trends Genet, 23 (10). pp. 484-488. ISSN 0168-9525 (Print)

Zhang, C. L., Hastings, M. L., Krainer, A. R., Zhang, M. Q. (September 2007) Dual-specificity splice sites function alternatively as 5 ' and 3 ' splice sites. Proceedings of the National Academy of Sciences of the United States of America, 104 (38). pp. 15028-15033. ISSN 0027-8424

Caceres, J. F., Krainer, A. R., Kornblihtt, A. R. (August 2007) The pathology of pre-mRNA splicing: a meeting in the Italian Alps - Workshop on pre-mRNA processing and disease. Embo Reports, 8 (8). pp. 730-734. ISSN 1469-221X

Zhang, Z., Krainer, A. R. (July 2007) Splicing remodels messenger ribonucleoprotein architecture via eIF4A3-dependent and -independent recruitment of exon junction complex components. Proc Natl Acad Sci U S A, 104 (28). pp. 11574-9. ISSN 0027-8424 (Print)

Allemand, E., Hastings, M. L., Murray, M. V., Myers, M. P., Krainer, A. R. (July 2007) Alternative splicing regulation by interaction of phosphatase PP2Cgamma with nucleic acid-binding protein YB-1. Nat Struct Mol Biol, 14 (7). pp. 630-638. ISSN 1545-9993 (Print)

Hastings, M. L., Allemand, E., Duelli, D. M., Myers, M. P., Krainer, A. R. (June 2007) Control of Pre-mRNA Splicing by the General Splicing Factors PUF60 and U2AF65. PLoS ONE, 2 (6). e538. ISSN 1932-6203 (Electronic)

Buratti, E., Chivers, M., Královičová, J., Romano, M., Baralle, M., Krainer, Adrian R., Vořechovský, I. (June 2007) Aberrant 5' splice sites in human disease genes: mutation pattern, nucleotide structure and comparison of computational tools that predict their utilization. Nucleic Acids Res, 35 (13). pp. 4250-4263. ISSN 1362-4962 (Electronic)

Wimmer, K., Roca, X., Beiglbock, H., Callens, T., Etzler, J., Rao, A. R., Krainer, A. R., Fonatsch, C., Messiaen, L. (June 2007) Extensive in silico analysis of NF1 splicing defects uncovers determinants for splicing outcome upon 5 ' splice-site disruption. Human Mutation, 28 (6). pp. 599-612. ISSN 1059-7794

Das, R., Yu, J., Zhang, Z., Gygi, M. P., Krainer, A. R., Gygi, S. P., Reed, R. (June 2007) SR proteins function in coupling RNAP II transcription to pre-mRNA splicing. Molecular Cell, 26 (6). pp. 867-881. ISSN 1097-2765

Hua, Y. M., Vickers, T. A., Baker, B. F., Bennett, C. F., Krainer, A. R. (April 2007) Enhancement of SMN2 Exon 7 inclusion by antisense oligonucleotides targeting the exon. PLoS Biology, 5 (4). e73. ISSN 1544-9173

Nielsen, K. B., Sorensen, S., Cartegni, L., Corydon, T. J., Doktor, T. K., Schroeder, L. D., Reinert, L. S., Elpeleg, O., Krainer, A. R., Gregersen, N., Kjems, J., Andresen, B. S. (March 2007) Seemingly neutral polymorphic variants may confer immunity to splicing-inactivating mutations: A synonymous SNP in exon 5 of MCAD protects from deleterious mutations in a flanking exonic splicing enhancer. American Journal of Human Genetics, 80 (3). pp. 416-432. ISSN 0002-9297

Karni, R., de Stanchina, E., Lowe, S. W., Sinha, R., Mu, D., Krainer, A. R. (March 2007) The gene encoding the splicing factor SF2/ASF is a proto-oncogene. Nat Struct Mol Biol, 14 (3). pp. 185-93. ISSN 1545-9993 (Print)

Khoo, B., Roca, X., Chew, S. L., Krainer, A. R. (January 2007) Antisense oligonucleotide-induced alternative splicing of the APOB mRNA generates a novel isoform of APOB. BMC Molecular Biology, 8. ISSN 1471-2199

Shaw, S. D., Chakrabarti, S., Ghosh, G., Krainer, A. R. (2007) Deletion of the N-terminus of SF2/ASF permits RS-domain-independent pre-mRNA splicing. PLoS ONE, 2 (9). e854. ISSN 1932-6203 (Electronic)

Smith, P. J., Zhang, C., Wang, J., Chew, S. L., Zhang, M. Q., Krainer, A. R. (August 2006) An increased specificity score matrix for the prediction of SF2/ASF-specific exonic splicing enhancers. Hum Mol Genet, 15 (16). pp. 2490-508. ISSN 0964-6906 (Print)

Zhang, Q. S. , Manche, L., Xu, R. M. , Krainer, A. R. (June 2006) hnRNP A1 associates with telomere ends and stimulates telomerase activity. RNA, 12 (6). pp. 1116-28. ISSN 1355-8382 (Print)

Krainer, A. R., Karni, R. (March 2006) Oncogenic activity of alternative splicing factors. Faseb Journal, 20 (4). A456-A456. ISSN 0892-6638

Cartegni, L., Hastings, M. L., Calarco, J. A., de Stanchina, E., Krainer, A. R. (January 2006) Determinants of exon 7 splicing in the spinal muscular atrophy genes, SMN1 and SMN2. Am J Hum Genet, 78 (1). pp. 63-77. ISSN 0002-9297 (Print)

Sheth, N., Roca, X., Hastings, M. L., Roeder, T., Krainer, A. R., Sachidanandam, R. (2006) Comprehensive splice-site analysis using comparative genomics. Nucleic Acids Res, 34 (14). pp. 3955-3967. ISSN 1362-4962 (Electronic)

Zhang, Z., Krainer, A. R. (2006) Nonsense-Mediated Alternative Splicing. In: Nonsense-mediated mRNA decay. Landes Bioscience, Georgetown, TX, pp. 250-359. ISBN 9781587062964

Madsen, P. P., Kibæk, M., Roca, X., Sachidanandam, R., Krainer, A. R., Christensen, E., Steiner, R. D., Gibson, K. M., Corydon, T. J., Knudsen, I., Wanders, R. J. A., Ruiter, J. P. N., Gregersen, N., Andresen, B. S. (2006) Short/branched-chain acyl-CoA dehydrogenase deficiency due to an IVS3+3A>G mutation that causes exon skipping. Human Genetics, 118 (6). pp. 680-690. ISSN 03406717

Kimura, H., Takizawa, N., Allemand, E., Hori, T., Iborra, F. J., Nozaki, N., Muraki, M., Hagiwara, M., Krainer, A. R., Fukagawa, T., Okawa, K. (2006) A novel histone exchange factor, protein phosphatase 2Cgamma, mediates the exchange and dephosphorylation of H2A-H2B. Journal of Cell Biology, 175 (3). pp. 389-400. ISSN 00219525

Tyson-Capper, A. J., Bailey, J., Krainer, A. R., Robson, S. C., Europe-Finner, G. N. (October 2005) The switch in alternative splicing of cyclic AMP-response element modulator protein CREM tau(2)alpha (activator) to CREM alpha (repressor) in human myometrial cells is mediated by SRp40. Journal of Biological Chemistry, 280 (41). pp. 34521-34529. ISSN 0021-9258

Roca, Xavier, Sachidanandam, Ravi, Krainer, Adrian R. (May 2005) Determinants of the inherent strength of human 5' splice sites. Rna, 11 (5). pp. 683-98. ISSN 1355-8382 (Print)

Allemand, E., Guil, S., Myers, M., Moscat, J., Caceres, J. F., Krainer, A. R. (March 2005) Regulation of heterogenous nuclear ribonucleoprotein A1 transport by phosphorylation in cells stressed by osmotic shock. Proc Natl Acad Sci U S A, 102 (10). pp. 3605-10. ISSN 0027-8424 (Print)

Hastings, M. L., Resta, N., Traum, D., Stella, A., Guanti, G., Krainer, A. R. (January 2005) An LKB1 AT-AC intron mutation causes Peutz-Jeghers syndrome via splicing at noncanonical cryptic splice sites. Nat Struct Mol Biol, 12 (1). pp. 54-9. ISSN 1545-9993 (Print)

Wang, J., Smith, P. J., Krainer, A. R., Zhang, M. Q. (2005) Distribution of SR protein exonic splicing enhancer motifs in human protein-coding genes. Nucleic Acids Res, 33 (16). pp. 5053-62. ISSN 1362-4962 (Electronic)

Coutinho, G., Xie, J. Y., Du, L. T., Brusco, A., Krainer, A. R., Gatti, R. A. (2005) Functional significance of deep intronic mutation in the ATM gene and evidence for an alternative Exon 28a. Human Mutation, 25 (2). pp. 118-124. ISSN 1059-7794

Zhang, Z., Krainer, A. R. (November 2004) Involvement of SR proteins in mRNA surveillance. Molecular Cell, 16 (4). pp. 597-607. ISSN 1097-2765

Muraki, M., Ohkawara, B., Hosoya, T., Onogi, H., Koizumi, J., Koizumi, T., Sumi, K., Jun-ichiro, Y., Murray, M. V., Kimura, H., Furuichi, K., Shibuya, H., Krainer, A. R., Suzuki, M., Hagiwara, M. (June 2004) Manipulation of alternative splicing by a newly developed inhibitor of Clks. Journal of Biological Chemistry, 279 (23). pp. 24246-24254. ISSN 0021-9258

Zatkova, A., Messiaen, L., Vandenbroucke, I., Wieser, R., Fonatsch, C., Krainer, A. R., Wimmer, K. (2004) Disruption of exonic splicing enhancer elements is the principal cause of exon skipping associated with seven nonsense or missense alleles of NF1. Human Mutation, 24 (6). pp. 491-501. ISSN 1059-7794

Muraki, M., Ohkawara, B., Hosoya, T., Onogi, H., Koizumi, J., Koizumi, T., Sumi, K., Yomoda, J., Murray, M. V., Kimura, H., Furuichi, K., Shibuya, H., Krainer, A. R., Suzuki, M., Hagiwara, M. (2004) Manipulation of alternative splicing by a novel inhibitor of Clks. Journal of Pharmacological Sciences, 94 (S(1)). 244P-244P. ISSN 1347-8613

Domsic, J. K., Wang, Y. B., Mayeda, A., Krainer, A. R., Stoltzfus, C. M. (December 2003) Human immunodeficiency virus type 1 hnRNP A/B-Dep endent exonic splicing silencer ESSV antagonizes binding of U2AF65 to viral polypyrimidine tracts. Molecular and Cellular Biology, 23 (23). pp. 8762-8772. ISSN 0270-7306

Roca, X., Sachidanandam, R., Krainer, A. R. (November 2003) Intrinsic differences between authentic and cryptic 5 ' splice sites. Nucleic Acids Research, 31 (21). pp. 6321-6333. ISSN 0305-1048

Cartegni, L., Wang, J. H., Zhu, Z. W., Zhang, M. Q., Krainer, A. R. (July 2003) ESEfinder: a web resource to identify exonic splicing enhancers. Nucleic Acids Research, 31 (13). pp. 3568-3571. ISSN 0305-1048

Cartegni, L., Krainer, A. R. (February 2003) Correction of disease-associated exon skipping by synthetic exon-specific activators. Nature Structural Biology, 10 (2). pp. 120-125. ISSN 1072-8368

Hou, V. C., Lersch, R., Gee, S. L., Ponthier, J. L., Lo, A. J., Wu, M., Turck, C. W., Koury, M., Krainer, A. R., Mayeda, A., Conboy, J. G. (November 2002) Decrease in hnRNP A/B expression during erythropoiesis mediates a pre-mRNA splicing switch. Embo Journal, 21 (22). pp. 6195-6204. ISSN 0261-4189

Cazalla, D., Zhu, J., Manche, L., Huber, E., Krainer, A. R., Caceres, J. F. (October 2002) Nuclear export and retention signals in the RS domain of SR proteins. Molecular and Cellular Biology, 22 (19). pp. 6871-6882. ISSN 0270-7306

Andresen, B. S., Nielsen, K. B., Madsen, P. P., Corydon, T. J., Kjems, J., Krainer, A. R., Elpeleg, O. N., Schroeder, L. D., Gregersen, N. (October 2002) Simple mutations in the coding region of three acyl-CoA dehydrogenase genes may lead to skipping of the constitutive exon due to disruption of potential splice enhancer sequences or mRNA secondary structures. American Journal of Human Genetics, 71 (4). p. 196. ISSN 0002-9297

Fackenthal, J. D., Cartegni, L., Krainer, A. R., Olopade, O. I. (September 2002) BRCA2 T2722R is a deleterious allele that causes exon skipping. American Journal of Human Genetics, 71 (3). pp. 625-631. ISSN 0002-9297

Pollard, A. J., Krainer, A. R., Robson, S. C., Europe-Finner, G. N. (May 2002) Alternative splicing of the adenylyl cyclase stimulatory G-protein G alpha(s) is regulated by SF2/ASF and heterogeneous nuclear ribonucleoprotein A1 (hnRNPA1) and involves the use of an unusual TG 3'-splice Site. Journal of Biological Chemistry, 277 (18). pp. 15241-51. ISSN 0021-9258 (Print)0021-9258

Vitali, J., Ding, J. Z., Jiang, J. Z., Zhang, Y., Krainer, A. R., Xu, R. M. (April 2002) Correlated alternative side chain conformations in the RNA-recognition motif of heterogeneous nuclear ribonucleoprotein A1. Nucleic Acids Research, 30 (7). pp. 1531-1538. ISSN 0305-1048

Cartegni, L., Krainer, A. R. (April 2002) Disruption of an SF2/ASF-dependent exonic splicing enhancer in SMN2 causes spinal muscular atrophy in the absence of SMN1. Nature Genetics, 30 (4). pp. 377-384. ISSN 1061-4036

Cartegni, L., Chew, S. L., Krainer, A. R. (April 2002) Listening to silence and understanding nonsense: Exonic mutations that affect splicing. Nature Reviews Genetics, 3 (4). pp. 285-298. ISSN 1471-0056

Dance, G. S. C., Sowden, M. P., Cartegni, L., Cooper, E., Krainer, A. R., Smith, H. C. (April 2002) Two proteins essential for apolipoprotein B mRNA editing are expressed from a single gene through alternative splicing. Journal of Biological Chemistry, 277 (15). pp. 12703-12709. ISSN 0021-9258

Smith, P. J., Spurrell, E. L., Coakley, J., Hinds, C. J., Ross, R. J. M., Krainer, A. R., Chew, S. L. (January 2002) An exonic splicing enhancer in human IGF-I pre-mRNA mediates recognition of alternative exon 5 by the serine-arginine protein splicing factor-2/alternative splicing factor. Endocrinology, 143 (1). pp. 146-154. ISSN 0013-7227

Zhu, J., Mayeda, A., Krainer, A. R. (December 2001) Exon identity established through differential antagonism between exonic splicing silencer-bound hnRNP A1 and enhancer-bound SR proteins. Molecular Cell, 8 (6). pp. 1351-1361. ISSN 1097-2765

Hou, V. C., Gee, S. L., Wu, M., Turck, C. W., Koury, M., Krainer, A. R., Mayeda, A., Conboy, J. G. (November 2001) Characterization of a second hnRNP A/B-dependent exonic splicing silencer in protein 4.1R exon 16. Blood, 98 (11). 436A-436A. ISSN 0006-4971

Bilodeau, P. S., Domsic, J. K., Mayeda, A., Krainer, A. R., Stoltzfus, C. M. (September 2001) RNA splicing at human immunodeficiency virus type 1 3 ' splice site A2 is regulated by binding of hnRNP A/B proteins to an exonic splicing silencer element. Journal of Virology, 75 (18). pp. 8487-8497. ISSN 0022-538X

Hastings, M. L., Krainer, A. R. (June 2001) Pre-mRNA splicing in the new millennium. Current Opinion in Cell Biology, 13 (3). pp. 302-309. ISSN 0955-0674

Hastings, M. L., Krainer, A. R. (March 2001) Functions of SR proteins in the U12-dependent AT-AC pre-mRNA splicing pathway. RNA, 7 (3). pp. 471-482. ISSN 1355-8382

Nilsson, C. E., Petersen-Mahrt, S., Durot, C., Shtrichman, R., Krainer, A. R., Kleinberger, T., Akusjarvi, G. (February 2001) The adenovirus E4-ORF4 splicing enhancer protein interacts with a subset of phosphorylated SR proteins. EMBO Journal, 20 (4). pp. 864-871. ISSN 0261-4189

Liu, H. X., Cartegni, L., Zhang, M. Q., Krainer, A. R. (January 2001) A mechanism for exon skipping caused by nonsense or missense mutations in BRCA1 and other genes. Nature Genetics, 27 (1). pp. 55-58. ISSN 1061-4036

Zhu, J., Krainer, A. R. (December 2000) Pre-mRNA splicing in the absence of an SR protein RS domain. Genes & Development, 14 (24). pp. 3166-3178. ISSN 0890-9369

Eperon, I. C., Makarova, O. V., Mayeda, A., Munroe, S. H., Caceres, J. F., Hayward, D. G., Krainer, A. R. (November 2000) Selection of alternative 5 ' splice sites: Role of U1 snRNP and models for the antagonistic effects of SF2/ASF and hnRNP A1. Molecular and Cellular Biology, 20 (22). pp. 8303-8318. ISSN 0270-7306

Van Scoy, S., Watakabe, I., Krainer, A. R., Hearing, J. (September 2000) Human p32: A coactivator for Epstein-Barr virus nuclear antigen-1-mediated transcriptional activation and possible role in viral latent cycle DNA replication. Virology, 275 (1). pp. 145-157. ISSN 0042-6822

Dirksen, W. P., Li, X. L., Mayeda, A., Krainer, A. R., Rottman, F. M. (September 2000) Mapping the SF2/ASF binding sites in the bovine growth hormone exonic splicing enhancer. Journal of Biological Chemistry, 275 (37). pp. 29170-29177. ISSN 0021-9258

Boudrez, A., Beullens, M., Groenen, P., Van Eynde, A., Vulsteke, V., Jagiello, I., Murray, M., Krainer, A. R., Stalmans, W., Bollen, M. (August 2000) NIPP1-mediated interaction of protein phosphatase-1 with CDC5L, a regulator of pre-mRNA splicing and mitotic entry. Journal of Biological Chemistry, 275 (33). pp. 25411-25417. ISSN 0021-9258

Pollard, A. J., Sparey, C., Robson, S. C., Krainer, A. R., Europe-Finner, G. N. (May 2000) Spatio-temporal expression of the trans-acting splicing factors SF2/ASF and heterogeneous ribonuclear proteins A1/A1(B) in the myometrium of the pregnant human uterus: A molecular mechanism for regulating regional protein isoform expression in vivo. Journal of Clinical Endocrinology & Metabolism, 85 (5). pp. 1928-1936. ISSN 0021-972X

van Oordt, W. V., Diaz-Meco, M. T., Lozano, J., Krainer, A. R., Moscat, J., Caceres, J. F. (April 2000) The MKK3/6-p38-signaling cascade alters the subcellular distribution of hnRNP A1 and modulates alternative splicing regulation. Journal of Cell Biology, 149 (2). pp. 307-316. ISSN 0021-9525

Liu, H. X., Chew, S. L., Cartegni, L., Zhang, M. Q., Krainer, A. R. (February 2000) Exonic splicing enhancer motif recognized by human SC35 under splicing conditions. Molecular and Cellular Biology, 20 (3). pp. 1063-1071. ISSN 0270-7306

Burns, C. G., Ohi, R., Krainer, A. R., Gould, K. L. (November 1999) Evidence that Myb-related CDC5 proteins are required for pre-mRNA splicing. Proceedings of the National Academy of Sciences of the United States of America, 96 (24). pp. 13789-13794. ISSN 0027-8424

Chew, S. L., Liu, H. X., Mayeda, A., Krainer, A. R. (September 1999) Evidence for the function of an exonic splicing enhancer after the first catalytic step of pre-mRNA splicing. Proceedings of the National Academy of Sciences of the United States of America, 96 (19). pp. 10655-10660. ISSN 0027-8424

Mayeda, A., Badolato, J., Kobayashi, R., Zhang, M. Q., Gardiner, E. M., Krainer, A. R. (August 1999) Purification and characterization of human RNPS1: a general activator of pre-mRNA splicing. EMBO Journal, 18 (16). pp. 4560-4570. ISSN 0261-4189

Ismaili, N., Perez-Morga, D., Walsh, P., Mayeda, A., Pays, A., Tebabi, P., Krainer, A. R., Pays, E. (July 1999) Characterization of a SR protein from Trypanosoma brucei with homology to RNA-binding cis-splicing proteins. Molecular and Biochemical Parasitology, 102 (1). pp. 103-115. ISSN 0166-6851

Caputi, M., Mayeda, A., Krainer, A. R., Zahler, A. M. (July 1999) hnRNP A/B proteins are required for inhibition of HIV-1 pre-mRNA splicing. EMBO Journal, 18 (14). pp. 4060-4067. ISSN 0261-4189

Wu, Q., Krainer, A. R. (May 1999) AT-AC Pre-mRNA splicing mechanisms and conservation of minor introns in voltage-gated ion channel genes. Molecular and Cellular Biology, 19 (5). pp. 3225-3236. ISSN 0270-7306

Ding, J. Z., Hayashi, M. K., Zhang, Y., Manche, L., Krainer, A. R., Xu, R. M. (May 1999) Crystal structure of the two-RRM domain of hnRNP A1 (UP1) complexed with single-stranded telomeric DNA. Genes & Development, 13 (9). pp. 1102-1115. ISSN 0890-9369

Lopato, S., Kalyna, M., Dorner, S., Kobayashi, R., Krainer, A. R., Barta, A. (April 1999) atSRp30, one of two SF2/ASF-like proteins from Arabidopsis thaliana, regulates splicing of specific plant genes. Genes & Development, 13 (8). pp. 987-1001. ISSN 0890-9369

Koizumi, J., Okamoto, Y., Onogi, H., Mayeda, A., Krainer, A. R., Hagiwara, M. (April 1999) The subcellular localization of SF2/ASF is regulated by direct interaction with SR protein kinases (SRPKs). Journal of Biological Chemistry, 274 (16). pp. 11125-11131. ISSN 0021-9258

Jiang, J., Zhang, Y., Krainer, A. R., Xu, R. M. (March 1999) Crystal structure of human p32, a doughnut-shaped acidic mitochondrial matrix protein. Proceedings of the National Academy of Sciences of the United States of America, 96 (7). pp. 3572-7. ISSN 0027-8424 (Print)0027-8424

Mayeda, A., Screaton, G. R., Chandler, S. D., Fu, X. D., Krainer, A. R. (March 1999) Substrate specificities of SR proteins in constitutive splicing are determined by their RNA recognition motifs and composite pre-mRNA exonic elements. Molecular and Cellular Biology, 19 (3). pp. 1853-1863. ISSN 0270-7306

Murray, M. V., Kobayashi, R., Krainer, A. R. (January 1999) The type 2C Ser/Thr phosphatase PP2C gamma is a pre-mRNA splicing factor. Genes & Development, 13 (1). pp. 87-97. ISSN 0890-9369

Mayeda, A., Krainer, A. R. (1999) Mammalian in vitro splicing assays. Methods in Molecular Biology, 118. pp. 315-21. ISSN 1064-3745 (Print)1064-3745

Mayeda, A., Krainer, A. R. (1999) Preparation of HeLa cell nuclear and cytosolic S100 extracts for in vitro splicing. Methods in Molecular Biology, 118. pp. 309-14. ISSN 1064-3745 (Print)1064-3745

Wu, Q., Krainer, A. R. (December 1998) Purine-rich enhancers function in the AT-AC pre-mRNA splicing pathway and do so independently of intact U1 snRNP. RNA, 4 (12). pp. 1664-1673. ISSN 1355-8382

Mayeda, A., Munroe, S. H., Xu, R. M., Krainer, A. R. (September 1998) Distinct functions of the closely related tandem RNA-recognition motifs of hnRNP A1. RNA, 4 (9). pp. 1111-1123. ISSN 1355-8382

Liu, H. X., Zhang, M., Krainer, A. R. (July 1998) Identification of functional exonic splicing enhancer motifs recognized by individual SR proteins. Genes & Development, 12 (13). pp. 1998-2012. ISSN 0890-9369

Hanamura, A., Caceres, J. F., Mayeda, A., Franza, B. R., Krainer, A. R. (April 1998) Regulated tissue-specific expression of antagonistic pre-mRNA splicing factors. RNA, 4 (4). pp. 430-444. ISSN 1355-8382

Caceres, J. F., Screaton, G. R., Krainer, A. R. (January 1998) A specific subset of SR proteins shuttles continuously between the nucleus and the cytoplasm. Genes & Development, 12 (1). pp. 55-66. ISSN 0890-9369

Misteli, T., Cáceres, J. F., Clement, J. Q., Krainer, A. R., Wilkinson, M. F., Spector, D. L. (1998) Serine phosphorylation of SR proteins is required for their recruitment to sites of transcription in vivo. Journal of Cell Biology, 143 (2). pp. 297-307. ISSN 0021-9525

Horowitz, D. S., Kobayashi, R., Krainer, A. R. (December 1997) A new cyclophilin and the human homologues of yeast Prp3 and Prp4 form a complex associated with U4/U6 snRNPs. Rna-a Publication of the Rna Society, 3 (12). pp. 1374-1387. ISSN 1355-8382

Misteli, T., Cáceres, J. F., Krainer, A. R., Spector, D. L. (November 1997) The control of splicing factor recruitment to sites of transcription in-vivo. Molecular Biology of the Cell, 8. p. 597. ISSN 1059-1524

Jokhan, L., Dong, A. P., Mayeda, A., Krainer, A. R., Xu, R. M. (September 1997) Crystallization and preliminary X-ray diffraction studies of UP1, the two-RRM domain of hnRNP A1. Acta Crystallographica Section D-Biological Crystallography, 53. pp. 615-618. ISSN 0907-4449

Cáceres, J. F., Misteli, T., Screaton, G. R., Spector, D. L., Krainer, A. R. (July 1997) Role of the modular domains of SR proteins in subnuclear localization and alternative splicing specificity. Journal of Cell Biology, 138 (2). pp. 225-38. ISSN 0021-9525

Wu, Q., Krainer, A. R. (June 1997) Splicing of a divergent subclass of AT-AC introns requires the major spliceosomal snRNAs. RNA, 3 (6). pp. 586-601. ISSN 13558382 (ISSN)

Xu, R. M., Jokhan, L., Cheng, X., Mayeda, A., Krainer, A. R. (April 1997) Crystal structure of human UP1, the domain of hnRNP A1 that contains two RNA-recognition motifs. Structure, 5 (4). pp. 559-70. ISSN 0969-2126 (Print)0969-2126

Chandler, S. D., Mayeda, A., Yeakley, J. M., Krainer, A. R., Fu, X. D. (April 1997) RNA splicing specificity determined by the coordinated action of RNA recognition motifs in SR proteins. Proceedings of the National Academy of Sciences of the United States of America, 94 (8). pp. 3596-3601. ISSN 0027-8424

Basu, A., Dong, B., Krainer, A. R., Howe, C. C. (February 1997) The intracisternal A-particle proximal enhancer-binding protein activates transcription and is identical to the RNA- and DNA-binding protein p54nrb/NonO. Molecular and Cellular Biology, 17 (2). pp. 677-86. ISSN 0270-7306 (Print)0270-7306

Horowitz, D. S., Krainer, A. R. (January 1997) A human protein required for the second step of pre-mRNA splicing is functionally related to a yeast splicing factor. Genes & Development, 11 (1). pp. 139-151. ISSN 0890-9369

Krainer, Adrian (1997) Eukaryotic mRNA processing. IRL Press at Oxford University Press. ISBN 9780199634187

Caceres, J. F., Krainer, A. R. (1997) Mammalian pre-mRNA splicing factors. In: Eukaryotic mRNA processing. IRL Press at Oxford University Press. ISBN 9780199634187

Huang, S., Mayeda, A., Krainer, A. R., Spector, D. L. (1997) RCC1 and nuclear organization. Molecular Biology of the Cell, 8 (6). pp. 1143-1157. ISSN 1059-1524

Tseng, T. I., Krainer, A. R. (December 1996) Defining and characterizing the functions of RS domains in yeast. Molecular Biology of the Cell, 7. p. 3661. ISSN 1059-1524

Wu, Q., Krainer, A. R. (November 1996) U1-mediated exon definition interactions between AT-AC and GT-AG introns. Science, 274 (5289). pp. 1005-1008. ISSN 0036-8075

Lopato, S., Mayeda, A., Krainer, A. R., Barta, A. (April 1996) Pre-mRNA splicing in plants: Characterization of Ser Arg splicing factors. Proceedings of the National Academy of Sciences of the United States of America, 93 (7). pp. 3074-3079. ISSN 0027-8424

Screaton, G. R., Caceres, J. F., Mayeda, A., Bell, M. V., Plebanski, M., Jackson, D. G., Bell, J. I., Krainer, A. R. (September 1995) Identification and characterization of three members of the human SR family of pre-mRNA splicing factors. EMBO Journal, 14 (17). pp. 4336-4349. ISSN 0261-4189

Mayeda, A., Munroe, S. H., Caceres, J. F., Krainer, A. R. (November 1994) Function of conserved domains of hnRNP A1 and other hnRNP A/B proteins. EMBO Journal, 13 (22). pp. 5483-5495. ISSN 0261-4189

Caceres, J. F., Stamm, S., Helfman, D. M., Krainer, A. R. (September 1994) Regulation of alternative splicing in vivo by overexpression of antagonistic splicing factors. Science, 265 (5179). pp. 1706-9. ISSN 0036-8075 (Print)0036-8075

Horowitz, D. S., Krainer, A. R. (March 1994) Mechanisms for selecting 5' splice sites in mammalian pre-mRNA splicing. Trends in Genetics, 10 (3). pp. 100-106. ISSN 0168-9525

Monroe, S. H., Mayeda, A., Krainer, A. R. (February 1994) Role of hnRNP A1 structural domains in messenger-RNA splicing and RNA-RNA annealing. Journal of Cellular Biochemistry. p. 116. ISSN 0730-2312

Huang, M., Rech, J. E., Northington, S. J., Flicker, P. F., Mayeda, A., Krainer, A. R., Lestourgeon, W. M. (January 1994) The C-protein tetramer binds 230 to 240 nucleotides of pre-mRNA and nucleates the assembly of 40S heterogeneous nuclear ribonucleoprotein particles. Molecular and Cellular Biology, 14 (1). pp. 518-533. ISSN 0270-7306

Stamm, S., Mulligan, G. J., Krainer, A. R., Helfman, D. M. (January 1994) Non-radioactive detection of m3G capped RNAs by immunoblotting. Nucleic Acids Research, 22 (2). pp. 252-253. ISSN 0305-1048

O'Keefe, R. T., Mayeda, A., Sadowski, C. L., Krainer, A. R., Spector, D. L. (1994) Disruption of pre-mRNA splicing in vivo results in reorganization of splicing factors. Journal of Cell Biology, 124 (3). pp. 249-260. ISSN 0021-9525

Eperon, I. C., Krainer, A. R. (1994) Splicing of mRNA precursors in mammalian cells. In: RNA Processing, a practical approach. IRL, Oxford, pp. 57-101. ISBN 9780199633432

Birney, E., Kumar, S., Krainer, A. R. (December 1993) Analysis of the RNA-recognition motif and RS and RGG domains: conservation in metazoan pre-mRNA splicing factors. Nucleic Acids Research, 21 (25). pp. 5803-5816. ISSN 0305-1048

Caceres, J. F., Krainer, A. R. (December 1993) Functional analysis of pre-mRNA splicing factor SF2/ASF structural domains. EMBO Journal, 12 (12). pp. 4715-4726. ISSN 0261-4189

Sun, Q., Mayeda, A., Hampson, R. K., Krainer, A. R., Rottman, F. M. (December 1993) General splicing factor SF2/ASF promotes alternative splicing by binding to an exonic splicing enhancer. Genes & Development, 7 (12b). pp. 2598-608. ISSN 0890-9369 (Print)0890-9369

Eperon, I. C., Ireland, D. C., Smith, R. A., Mayeda, A., Krainer, A. R. (September 1993) Pathways for selection of 5' splice sites by U1 snRNPs and SF2/ASF. EMBO Journal, 12 (9). pp. 3607-3617. ISSN 0261-4189

Dong, B. H., Horowitz, D. S., Kobayashi, R., Krainer, A. R. (August 1993) Purification and cDNA cloning of HeLa cell p54nrb, a nuclear protein with two RNA recognition motifs and extensive homology to human splicing factor PSF and Drosophila NONA/BJ6. Nucleic Acids Research, 21 (17). pp. 4085-4092. ISSN 0305-1048

Mayeda, A., Helfman, D. M., Krainer, A. R. (May 1993) Modulation of exon skipping and inclusion by heterogeneous nuclear ribonucleoprotein A1 and pre-mRNA splicing factor SF2/ASF. Molecular and Cellular Biology, 13 (5). pp. 2993-3001. ISSN 0270-7306 (Print)0270-7306

Fu, X. D., Mayeda, A., Maniatis, T., Krainer, A. R. (December 1992) General splicing factors SF2 and SC35 have equivalent activities in vitro, and both affect alternative 5' and 3' splice site selection. Proceedings of the National Academy of Sciences of the United States of America, 89 (23). pp. 11224-8. ISSN 0027-8424 (Print)0027-8424

Amero, S. A., Raychaudhuri, G., Cass, C. L., Vanvenrooij, W. J., Habets, W. J., Krainer, A. R., Beyer, A. L. (September 1992) Independent deposition of heterogeneous nuclear ribonucleoproteins and small nuclear ribonucleoprotein particles at sites of transcription. Proceedings of the National Academy of Sciences of the United States of America, 89 (18). pp. 8409-8413. ISSN 0027-8424

Birney, E., Kumar, S., Krainer, A. R. (September 1992) A putative homolog of U2AF65 in S. cerevisiae. Nucleic Acids Research, 20 (17). p. 4663. ISSN 0305-1048

Mayeda, A., Zahler, A. M., Krainer, A. R., Roth, M. B. (February 1992) Two members of a conserved family of nuclear phosphoproteins are involved in pre-mRNA splicing. Proceedings of the National Academy of Sciences of the United States of America, 89 (4). pp. 1301-1304. ISSN 0027-8424

Mayeda, A., Krainer, A. R. (January 1992) Regulation of alternative pre-mRNA splicing by hnRNP A1 and splicing factor SF2. Cell, 68 (2). pp. 365-75. ISSN 0092-8674 (Print)0092-8674

Krainer, A. R., Mayeda, A., Kozak, D., Binns, G. (July 1991) Functional expression of cloned human splicing factor SF2: homology to RNA-binding proteins, U1 70K, and Drosophila splicing regulators. Cell, 66 (2). pp. 383-394. ISSN 0092-8674

Mayeda, A., Krainer, A. R. (February 1991) Long-term storage of concentrated tris-borate-EDTA electrophoresis buffers without precipitation. Biotechniques, 10 (2). p. 182. ISSN 0736-6205

Krainer, A. R., Mayeda, A., Helfman, D., Conway, G. C., Kozak, D. (1991) Biochemistry of Mammalian Nuclear Pre-Messenger Rna Splicing and Splice Site Selection. Journal of Cellular Biochemistry, 47 (Suppl ). p. 45.

Krainer, A. R., Conway, G. C., Kozak, D. (July 1990) Purification and characterization of pre-mRNA splicing factor SF2 from HeLa cells. Genes & Development, 4 (7). pp. 1158-1171. ISSN 0890-9369

Krainer, A. R., Conway, G. C., Kozak, D. (July 1990) The essential pre-mRNA splicing factor SF2 influences 5' splice site selection by activating proximal sites. Cell, 62 (1). pp. 35-42. ISSN 0092-8674

Conway, G. C., Krainer, A. R., Spector, D. L., Roberts, R. J. (December 1989) Multiple splicing factors are released from endogenous complexes during in vitro pre-mRNA splicing. Molecular & Cellular Biology, 9 (12). pp. 5273-80. ISSN 0270-7306

Tschudi, C., Krainer, A. R., Ullu, E. (December 1988) The U6 small nuclear RNA from Trypanosoma brucei. Nucleic Acids Research, 16 (23). p. 11375. ISSN 0305-1048

Krainer, A. R. (October 1988) Pre-mRNA splicing by complementation with purified human U1, U2, U4/U6 and U5 snRNPs. Nucleic Acids Research, 16 (20). pp. 9415-9429. ISSN 0305-1048

Krainer, A. R., Maniatis, T. (1988) RNA splicing. In: Frontiers in Molecular Biology: Transcription and splicing. IRL Press, Oxford, pp. 131-206. ISBN 9781852210809

Krainer, A. R., Maniatis, T. (October 1985) Multiple factors including the small nuclear ribonucleoproteins U1 and U2 are necessary for pre-mRNA splicing in vitro. Cell, 42 (3). pp. 725-36. ISSN 0092-8674 (Print)0092-8674

Krainer, A. R., Reed, R., Maniatis, T. (1985) Mechanisms of human β-globin pre-mRNA splicing. In: Proceedings of the Robert A. Welch Foundation Conferences on Chemical Research. Robert A. Welch Foundation, pp. 353-378. ISBN 0557-1588

Krainer, A. R., Reed, R., Maniatis, T. (1985) Sequences and factors involved in pre-mRNA splicing in vitro. In: Sequence specificity in transcription and translation: proceedings of a conference from a UCLA symposium held in Steamboat Springs, Colorado, April, 1985. A.R. Liss, New York, pp. 461-473. ISBN 9780845126295

Ruskin, B., Krainer, A. R., Maniatis, T., Green, M. R. (August 1984) Excision of an intact intron as a novel lariat structure during pre-mRNA splicing in vitro. Cell, 38 (1). pp. 317-31. ISSN 0092-8674 (Print)0092-8674

Krainer, A. R., Maniatis, T., Ruskin, B., Green, M. R. (April 1984) Normal and mutant human beta-globin pre-mRNAs are faithfully and efficiently spliced in vitro. Cell, 36 (4). pp. 993-1005. ISSN 0092-8674 (Print)0092-8674

Squires, C., Krainer, A., Barry, G., Shen, W. F., Squires, C. L. (December 1981) Nucleotide sequence at the end of the gene for the RNA polymerase beta' subunit (rpoC). Nucleic Acids Research, 9 (24). pp. 6827-40. ISSN 0305-1048 (Print)0305-1048

This list was generated on Wed Apr 24 08:48:13 2019 EDT.
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