Joshua-Tor, Leemor Publications

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Joshua-Tor, Leemor

http://joshua-torlab.cshl.edu/
Number of items at this level: 77.

Paper

Elkayam, Elad, Faehnle, Christopher R., Morales, Marjorie, Sun, Jingchuan, Li, Huilin, Joshua-Tor, Leemor (2017) Multivalent Recruitment of Human Argonaute by GW182. Molecular Cell, 67 (4). pp. 646-658. ISSN 1097-2765

Faehnle, C. R., Walleshauser, J., Joshua-Tor, L. (2017) Multi-domain utilization by TUT4 and TUT7 in control of let-7 biogenesis. Nat Struct Mol Biol, 24 (8). pp. 658-665. ISSN 1545-9985

Elkayam, E., Parmar, R., Brown, C. R., Willoughby, J. L., Theile, C. S., Manoharan, M., Joshua-Tor, L. (2017) siRNA carrying an (E)-vinylphosphonate moiety at the 5' end of the guide strand augments gene silencing by enhanced binding to human Argonaute-2. Nucleic Acids Res, 45 (6). pp. 3528-3536. ISSN 1362-4962 (Electronic)0305-1048 (Linking)

Ipsaro, J. J., Shen, C., Arai, E., Xu, Y., Kinney, J. B., Joshua-Tor, L., Vakoc, C. R., Shi, J. (2017) Rapid generation of drug-resistance alleles at endogenous loci using CRISPR-Cas9 indel mutagenesis. PLoS One, 12 (2). e0172177. ISSN 1932-6203

Tocilj, A., On, K. F., Yuan, Z., Sun, J., Elkayam, E., Li, H., Stillman, B., Joshua-Tor, L. (2017) Structure of the active form of human Origin Recognition Complex and its ATPase motor module. Elife, 6. ISSN 2050-084X (Electronic)2050-084X (Linking)

Shen, Chen, Ipsaro, Jonathan J, Shi, Junwei, Milazzo, Joseph P, Wang, Eric, Roe, Jae-Seok, Suzuki, Yutaka, Pappin, Darryl J, Joshua-Tor, Leemor, Vakoc, Christopher R (2015) NSD3-Short Is an Adaptor Protein that Couples BRD4 to the CHD8 Chromatin Remodeler. Molecular Cell, 60 (6). pp. 847-859. ISSN 1097-2765

Kuhn, C. D., Wilusz, J. E., Zheng, Y., Beal, P. A., Joshua-Tor, L. (2015) On-enzyme refolding permits small RNA and tRNA surveillance by the CCA-adding enzyme. Febs Journal, 282 (Supple). p. 37. ISSN 1742-464X

Naguib, Adam, Bencze, Gyula, Cho, Hyejin, Zheng, Wu, Tocilj, Ante, Elkayam, Elad, Faehnle, Christopher R, Jaber, Nadia, Pratt, Christopher P, Chen, Muhan, Zong, Wei-Xing, Marks, Michael S, Joshua-Tor, Leemor, Pappin, Darryl J, Trotman, Lloyd C (2015) PTEN Functions by Recruitment to Cytoplasmic Vesicles. Molecular Cell, 58 (2). pp. 255-268. ISSN 1097-2765

Kuhn, C. D., Wilusz, J. E., Zheng, Y., Beal, P. A., Joshua-Tor, L. (2015) On-Enzyme Refolding Permits Small RNA and tRNA Surveillance by the CCA-Adding Enzyme. Cell, 160 (4). pp. 644-658. ISSN 0092-8674

Ipsaro, J. J., Joshua-Tor, L. (2015) From guide to target: molecular insights into eukaryotic RNA-interference machinery. Nat Struct Mol Biol, 22 (1). pp. 20-28. ISSN 1545-9985

Faehnle, C. R., Walleshauser, J., Joshua-Tor, L. (2014) Mechanism of Dis3l2 substrate recognition in the Lin28-let-7 pathway. Nature, 514 (7521). pp. 252-6. ISSN 0028-0836

Lee, S. J., Syed, S., Enemark, E. J., Schuck, S., Stenlund, A., Ha, T., Joshua-Tor, L. (2014) Dynamic look at DNA unwinding by a replicative helicase. Proceedings of the National Academy of Sciences of the United States of America, 111 (9). E827-35. ISSN 0027-8424

Faehnle, C. R., Elkayam, E., Haase, A. D., Hannon, G. J., Joshua-Tor, L. (2014) Slicer and the Argonautes. Biophysical Journal, 106 (2; Sup). 455A-455A. ISSN 0006-3495

Kuscu, C., Zaratiegui, M., Kim, H. S., Wah, D. A., Martienssen, R. A., Schalch, T., Joshua-Tor, L. (2014) CRL4-like Clr4 complex in Schizosaccharomyces pombe depends on an exposed surface of Dos1 for heterochromatin silencing. Proceedings of the National Academy of Sciences of the United States of America, 111 (5). pp. 1795-1800. ISSN 0027-8424

Faehnle, Christopher R, Elkayam, Elad, Haase, Astrid D, Hannon, Gregory J, Joshua-Tor, Leemor (2013) The Making of a Slicer: Activation of Human Argonaute-1. Cell Reports, 3 (6). pp. 1901-1909. ISSN 2211-1247

Clark, P., Cohen, M., Danziger, S., Eisner, L., Herz-Roiphe, R., Iwahara, Y., Kafka, O., Kiprovski, A., Koones, G., Milich, A., Mittal, S., Richardson, A., Rubenstein, J., Shapiro, J., Stern, A., Zhao, Y. G., Hackett, J., Joshua-Tor, L. (2013) Modeling the Structure and Function of Argonaute in RNAi. Faseb Journal, 27. ISSN 0892-6638

Naguib, A., Bencze, G., Faehnle, C. R., Schalch, T., Lazar, Z., Ruse, C. I., Joshua-Tor, L., Pappin, D. J., Trotman, L. C. (2013) Upstream activation of PTEN. Cancer Research, 73 (8 (Sup). p. 5156. ISSN 0008-5472

Kuhn, C. D., Joshua-Tor, L. (2013) Eukaryotic Argonautes come into focus. Trends in Biochemical Sciences, 38 (5). pp. 263-271. ISSN 09680004 (ISSN)

Paul, S., Kuo, A., Schalch, T., Vogel, H., Joshua-Tor, L., McCombie, W. R., Gozani, O., Hammell, M., Mills, A. A. (2013) Chd5 Requires PHD-Mediated Histone 3 Binding for Tumor Suppression. Cell Reports, 3 (1). pp. 92-102. ISSN 2211-1247

Wilusz, J. E., Jnbaptiste, C. K., Lu, L. Y., Kuhn, C. D., Joshua-Tor, L., Sharp, P. A. (2012) A triple helix stabilizes the 3' ends of long noncoding RNAs that lack poly(A) tails. Genes Dev, 26 (21). pp. 2392-407. ISSN 1549-5477 (Electronic)0890-9369 (Linking)

Lavy, T., Kumar, P. R., He, H. Z., Joshua-Tor, L. (2012) The Gal3p transducer of the GAL regulon interacts with the Gal80p repressor in its ligand-induced closed conformation. Genes & Development, 26 (3). pp. 294-303. ISSN 0890-9369

Ipsaro, J. J., Haase, A. D., Knott, S. R., Joshua-Tor, L., Hannon, G. J. (2012) The structural biochemistry of Zucchini implicates it as a nuclease in piRNA biogenesis. Nature, 491 (7423). pp. 279-282. ISSN 00280836 (ISSN)

Elkayam, E., Kuhn, C. D., Tocilj, A., Haase, A. D., Greene, E. M., Hannon, G. J., Joshua-Tor, L. (2012) The structure of human argonaute-2 in complex with miR-20a. Cell, 150 (1). pp. 100-110. ISSN 00928674 (ISSN)

Joshua-Tor, L., Hannon, G. J. (2011) Ancestral Roles of Small RNAs: An Ago-Centric Perspective. Cold Spring Harb Perspect Biol, 3 (10). ISSN 1943-0264 (Electronic)

Schalch, T., Job, G., Shanker, S., Partridge, J. F., Joshua-Tor, L. (2011) The Chp1-Tas3 core is a multifunctional platform critical for gene silencing by RITS. Nature Structural and Molecular Biology, 18 (12). pp. 1351-1357. ISSN 15459993 (ISSN)

Schalch, T., Job, G., Shanker, S., Partridge, J., Joshua-Tor, L. (2011) The Chp1-Tas3 core is a multifunctional platform critical for gene silencing by RITS. Molecular Biology of the Cell, 22. ISSN 1059-1524

Faehnle, C. R., Joshua-Tor, L. (2010) Argonaute MID domain takes centre stage. Embo Reports, 11 (8). pp. 564-5. ISSN 1469-221X

Schalch, T., Job, G., Noffsinger, V. J., Shanker, S., Kuscu, C., Joshua-Tor, L., Partridge, J. F. (2009) High-affinity binding of Chp1 chromodomain to K9 methylated histone H3 is required to establish centromeric heterochromatin. Mol Cell, 34 (1). pp. 36-46. ISSN 1097-4164 (Electronic)

Kettner-Buhrow, D., Guenther, B., Kaelble, S., Joshua-Tor, L., Kracht, M. (2009) Measurement of in vivo RISC activity using an in vitro non-radioactive RISC assay. Naunyn-Schmiedebergs Archives of Pharmacology, 379 (281 Ab). p. 59. ISSN 0028-1298

Joshua-Tor, L., Enemark, E. J. (2008) Mechanism of DNA translocation in a replicative hexameric helicase. Faseb Journal, 22. ISSN 0892-6638

Enemark, E. J., Joshua-Tor, L. (2008) On helicases and other motor proteins. Curr Opin Struct Biol, 18 (2). 243-257 .

Kettner-Buhrow, D., Kaelble, S., Joshua-Tor, L., Kracht, M. (2008) Establishment of a non-radioactive assay to measure RISC (RNA-induced silencing complex) activity in vitro. Naunyn-Schmiedebergs Archives of Pharmacology, 377 (Supp 1). p. 64. ISSN 0028-1298

Kumar, P. R., Yu, Y., Sternglanz, R., Johnston, S. A., Joshua-Tor, L. (2008) NADP regulates the yeast GAL induction system. Science, 319 (5866). pp. 1090-2. ISSN 1095-9203 (Electronic)

Faehnle, Christopher R., Joshua-Tor, Leemor (2007) Argonautes confront new small RNAs. Current Opinion in Chemical Biology, 11 (5). pp. 569-577. ISSN 1367-5931 (Print)

O'Farrell, P. A., Joshua-Tor, L. (2007) Mutagenesis and crystallographic studies of the catalytic residues of the papain family protease bleomycin hydrolase: new insights into active-site structure. Biochem J, 401 (2). pp. 421-8. ISSN 0264-6021

Tolia, N. H., Joshua-Tor, L. (2007) Slicer and the Argonautes. Nature Chemical Biology, 3 (1). pp. 36-43. ISSN 1552-4450

Irvine, D. V., Zaratiegui, Mi., Tolia, N. H., Goto, D. B., Chitwood, D. H., Vaughn, M. W., Joshua-Tor, L., Martienssen, R. A. (2006) Argonaute slicing is required for heterochromatic silencing and spreading. Science, 313 (5790). pp. 1134-7. ISSN 1095-9203 (Electronic)

Enemark, E. J., Joshua-Tor, L. (2006) Mechanism of DNA translocation in a replicative hexameric helicase. Nature, 442 (7100). pp. 270-275. ISSN 1476-4687 (Electronic)

Song, J. J., Joshua-Tor, L. (2006) Argonaute and RNA--getting into the groove. Curr Opin Struct Biol, 16 (1). pp. 5-11. ISSN 0959-440X (Print)

Tolia, N.H., Joshua-Tor, L. (2006) Strategies for protein coexpression in Escherichia coli. Nat Methods, 3 (1). pp. 55-64. ISSN 1548-7091 (Print)

Yigit, E., Batista, P. J., Bei, Y., Pang, K. M., Chen, C. C. G., Tolia, N. H., Joshua-Tor, L., Mitani, S., Simard, M. J., Mello, C. C. (2006) Analysis of the C. elegans Argonaute Family Reveals that Distinct Argonautes Act Sequentially during RNAi. Cell, 127 (4). pp. 747-757. ISSN 00928674

Joshua-Tor, L. (2006) The argonautes. Cold Spring Harb Symp Quant Biol, 71. pp. 67-72. ISSN 1943-4456 (Electronic) 0091-7451 (Linking)

Tolia, N. H., Enemark, E. J., Sim, B. K., Joshua-Tor, L. (2005) Structural basis for the EBA-175 erythrocyte invasion pathway of the malaria parasite Plasmodium falciparum. Cell, 122 (2). pp. 183-93. ISSN 0092-8674 (Print)

Rivas, Fabiola V., Tolia, Nirja H., Song, Ji-Joon, Aragon, Juan P., Liu, Jidong, Hannon, Gregory J., Joshua-Tor, Leemor (2005) Purified Argonaute2 and an siRNA form recombinant human RISC. Nat Struct Mol Biol, 12 (4). pp. 340-9. ISSN 1545-9993 (Print)

Liu, J., Carmell, M. A., Rivas, F. V., Marsden, C. G., Thomson, J. M., Song, J. J., Hammond, S. M., Joshua-Tor, L., Hannon, G. J. (2004) Argonaute2 is the catalytic engine of mammalian RNAi. Science, 305 (5689). pp. 1437-41. ISSN 1095-9203 (Electronic)

Song, J. J., Smith, S. K., Hannon, G. J., Joshua-Tor, L. (2004) Crystal structure of argonaute and its implications for RISC slicer activity. Science, 305 (5689). pp. 1434-1437. ISSN 0036-8075

Joshua-Tor, L. (2004) siRNAs at RISC. Structure, 12 (7). pp. 1120-1122. ISSN 0969-2126

Auster, A. S., Joshua-Tor, L. (2004) The DNA-binding domain of human papillomavirus type 18 E1. Crystal structure, dimerization, and DNA binding. J Biol Chem, 279 (5). pp. 3733-42. ISSN 0021-9258 (Print)

Song, J. J., Liu, J., Tolia, N. H., Schneiderman, J., Smith, S. K., Martienssen, R. A., Hannon, G. J., Joshua-Tor, L. (2003) The crystal structure of the Argonaute2 PAZ domain reveals an RNA binding motif in RNAi effector complexes. Nat Struct Biol, 10 (12). pp. 1026-32. ISSN 1072-8368 (Print)

Enemark, E. J., Stenlund, A., Joshua-Tor, L. (2002) Crystal structures of two intermediates in the assembly of the papillomavirus replication initiation complex. Embo Journal, 21 (6). pp. 1487-1496. ISSN 0261-4189

Messick, T. E., Chmiel, N. H., Golinelli, M. P., Langer, M. R., Joshua-Tor, L., David, S. S. (2002) Noncysteinyl coordination to the [4Fe-4S](2+) cluster of the DNA repair adenine glycosylase MutY introduced via site-directed mutagenesis. Structural characterization of an unusual histidinyl-coordinated cluster. Biochemistry, 41 (12). pp. 3931-3942. ISSN 0006-2960

van Aalten, D. M., Haker, A., Hendriks, J., Hellingwerf, K. J., Joshua-Tor, L., Crielaard, W. (2002) Engineering photocycle dynamics. Crystal structures and kinetics of three photoactive yellow protein hinge-bending mutants. J Biol Chem, 277 (8). pp. 6463-8. ISSN 0021-9258 (Print)

Van Aalten, D. M. F., Crielaard, W., Hellingwerf, K. J., Joshua-Tor, L. (2002) Structure of the photoactive yellow protein reconstituted with caffeic acid at 1.16 Å resolution. Acta Crystallographica Section D: Biological Crystallography, 58 (4). pp. 585-590. ISSN 09074449 (ISSN)

Russell, S. J., Gonzalez, F., Joshua-Tor, L., Johnston, S. A. (2001) Selective chemical inactivation of AAA proteins reveals distinct functions of proteasomal ATPases. Chemistry & Biology, 8 (10). pp. 941-950. ISSN 1074-5521

David, S. S., Golinelli, M. P., Chmiel, N. H., Langer, M. R., Chepanoske, C. L., Messick, T. R., Joshua-Tor, L. (2001) Participation of the iron-sulfur cluster loop (FCL) motif of the adenine glycosylase MutY in DNA damage recognition and repair. Abstracts of Papers of the American Chemical Society, 222. U578-U578. ISSN 0065-7727

van Aalten, D. M. F., Chong, C. R., Joshua-Tor, L. (2000) Crystal structure of carboxypeptidase A complexed with D-cysteine at 1.75 A - inhibitor-induced conformational changes. Biochemistry, 39 (33). pp. 10082-10089. ISSN 0006-2960

Enemark, E. J., Chen, G., Vaughn, D. E., Stenlund, A., Joshua-Tor, L. (2000) Crystal structure of the DNA binding domain of the replication initiation protein E1 from papillomavirus. Molecular Cell, 6 (1). pp. 149-158. ISSN 1097-2765

Van Aalten, D. M. F., Crielaard, W., Hellingwerf, K. J., Joshua-Tor, L. (2000) Conformational substates in different crystal forms of the photoactive yellow protein - Correlation with theoretical and experimental flexibility. Protein Science, 9 (1). pp. 64-72. ISSN 0961-8368

van Aalten, D. M., Erlanson, D. A., Verdine, G. L., Joshua-Tor, L. (1999) A structural snapshot of base-pair opening in DNA. Proc Natl Acad Sci U S A, 96 (21). pp. 11809-14. ISSN 0027-8424 (Print)

O'Farrell, P. A., Gonzalez, F., Zheng, W., Johnston, S. A., Joshua-Tor, L. (1999) Crystal structure of human bleomycin hydrolase, a self-compartmentalizing cysteine protease. Structure, 7 (6). pp. 619-27. ISSN 0969-2126

Vaughn, D. E., Rodriguez, J., Lazebnik, Y., Joshua-Tor, L. (1999) Crystal structure of Apaf-1 caspase recruitment domain: an alpha-helical Greek key fold for apoptotic signaling. Journal of Molecular Biology, 293 (3). pp. 439-447. ISSN 0022-2836

Zheng, W., Johnston, S. A., Joshua-Tor, L. (1998) The unusual active site of Gal6/bleomycin hydrolase can act as a carboxypeptidase, aminopeptidase, and peptide ligase. Cell, 93 (1). pp. 103-9. ISSN 0092-8674 (Print)0092-8674 (Linking)

Van Aalten, D. M. F., Grotewold, E., Joshua-Tor, L. (1998) Essential dynamics from NMR clusters: Dynamic properties of the Myb DNA-binding domain and a hinge-bending enhancing variant. Methods, 14 (3). pp. 318-328. ISSN 10462023 (ISSN)

Schlessman, J. L., Woo, D., Joshua-Tor, L., Howard, J. B., Rees, D. C. (1998) Conformational variability in structures of the nitrogenase iron proteins from Azotobacter vinelandii and Clostridium pasteurianum. Journal of Molecular Biology, 280 (4). pp. 669-685. ISSN 00222836 (ISSN)

Zheng, W., Joshua-Tor, L., Johnston, S. A. (1997) Bleomycin hydrolase, a new family of cysteine peptidases reveal a novel mechanism of peptide degradation. Faseb Journal, 11 (9). A1395-A1395. ISSN 0892-6638

Joshua-Tor, L., Xu, H., Johnston, S., Rees, D. (1995) Crystal structure of a conserved protease that binds DNA: the bleomycin hydrolase, Gal6. Science, 269 (5226). pp. 945-950. ISSN 0036-80751095-9203

Joshua-Tor, L., Sussman, J. L. (1993) The Coming of Age of DNA Crystallography. Current Opinion in Structural Biology, 3 (3). pp. 323-335. ISSN 0959-440X

Blake, P. R., Day, M. W., Hsu, B. T., Joshua-Tor, L., Park, J. B., Hare, D. R., Adams, M. W., Rees, D. C., Summers, M. F. (1992) Comparison of the X-ray structure of native rubredoxin from Pyrococcus furiosus with the NMR structure of the zinc-substituted protein. Protein Sci, 1 (11). pp. 1522-5. ISSN 0961-8368 (Print)0961-8368 (Linking)

Joshua-Tor, L., Frolow, F., Appella, E., Hope, H., Rabinovich, D., Sussman, J. L. (1992) Three-dimensional structures of bulge-containing DNA fragments. J Mol Biol, 225 (2). pp. 397-431. ISSN 0022-2836 (Print)0022-2836 (Linking)

Day, M. W., Hsu, B. T., Joshua-Tor, L., Park, J. B., Zhou, Z. H., Adams, M. W. W., Rees, D. C. (1992) X-ray crystal structures of the oxidized and reduced forms of the rubredoxin from the marine hyperthermophilic archaebacterium Pyrococcus furiosus. Protein Science, 1 (11). pp. 1494-1507. ISSN 09618368 (ISSN)

Berman, H. M., Sussman, J. L., Joshua-Tor, L., Revich, G. G., Ripley, L. S. (1992) A structural model for sequence-specific proflavin-DNA interactions during in vitro frameshift mutagenesis. Journal of Biomolecular Structure and Dynamics, 10 (2). pp. 317-331. ISSN 07391102 (ISSN)

Joshua-Tor, L., Rabinovich, D., Hope, H., Frolow, F., Appella, E., Sussman, J. L. (1988) The three-dimensional structure of a DNA duplex containing looped-out bases. Nature, 334 (6177). pp. 82-4. ISSN 0028-0836 (Print)0028-0836 (Linking)

Book Section

Joshua-Tor, L., Johnston, S. A. (2004) The Bleomycin Hydrolases. In: Handbook of Proteolytic Enzymes. Elsevier Academic Press, pp. 1197-1201. ISBN 9780120796120

Joshua-Tor, L., Johnston, S. A. (1998) The Bleomycin Hydrolases. In: Handbook of Proteolytic Enzymes. Elsevier Academic Press, London, pp. 634-638. ISBN 9780120796120

Rees, D. C., Kim, J., Georgiadis, M. M., Komiya, H., Chirino, A. J., Woo, D., Schlessman, J., Chan, M. K., Joshua-Tor, L., Santillan, G., Chakrabarti, P., Hsu, B. T. (1993) Crystal Structures of the Iron Protein and Molybdenum-Iron Protein of Nitrogenase. In: Molybdenum Enzymes, Cofactors, and Model Systems. ACS Symposium Series, 535 (535). American Chemical Society, pp. 170-185. ISBN 0-8412-2708-X

Sussman, J. L., Joshua-Tor, L., Hirshberg, M., Saper, M. A. , Frowlow, F. , Hope, H., Appella, E. (1988) A Kinked Model of a DNA Tridecamer with an Unpaired Adenosine: Energy Minimization and X-ray Structural Studies. In: Molecular Structure: Chemical Reactivity and Biological Activity. Oxford University Press, pp. 195-200.

Video

Joshua-Tor, L. (2011) Talk from Leemor Joshua-Tor at the Cold Spring Harbor Laboratory In-House Symposium (2011). [Video] (Unpublished)

This list was generated on Sat Sep 23 08:49:22 2017 EDT.
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