Items where Community is "Muthuswamy lab"

Ramesh, M., Krishnan, N., Muthuswamy, S. K., Tonks, N. K. (April 2015) A Novel Phosphatidic Acid-Protein Tyrosine Phosphatase D2 Axis is Essential for ERBB2 Signaling in Mammary Epithelial Cells. Journal of Biological Chemistry, 290 (15). pp. 9646-9659. ISSN 0021-9258

Krishnan, N., Koveal, D., Miller, D. H., Xue, B., Akshinthala, S. D., Kragelj, J., Jensen, M. R., Gauss, C. M., Page, R., Blackledge, M., Muthuswamy, S. K., Peti, W., Tonks, N. K. (May 2014) Targeting the disordered C terminus of PTP1B with an allosteric inhibitor. Nature Chemical Biology, 10 (7). pp. 558-566. ISSN 15524450

Feigin, M. E., Akshinthala, S. D., Araki, K., Rosenberg, A. Z., Muthuswamy, L. B., Martin, B., Lehmann, B. D., Berman, H. K., Pietenpol, J. A., Cardiff, R. D., Muthuswamy, S. K. (March 2014) Mislocalization of the cell polarity protein Scribble promotes mammary tumorigenesis and is associated with basal breast cancer. Cancer Research, 74 (11). pp. 3180-3194. ISSN 0008-5472

Feigin, M. E., Xue, B., Hammell, M. C., Muthuswamy, S. K. (March 2014) G-protein-coupled receptor GPR161 is overexpressed in breast cancer and is a promoter of cell proliferation and invasion. Proceedings of the National Academy of Sciences of the United States of America, 111 (11). pp. 4191-6. ISSN 0027-8424

Feigin, M. E. (August 2013) Harnessing the genome for characterization of G-protein coupled receptors in cancer pathogenesis. FEBS J, 280 (19). pp. 4729-38. ISSN 1742-4658 (Electronic)1742-464X (Linking)

Wang, H., Lacoche, S., Huang, L., Xue, B., Muthuswamy, S. K. (January 2013) Rotational motion during three-dimensional morphogenesis of mammary epithelial acini relates to laminin matrix assembly. Proceedings of the National Academy of Sciences of the United States of America, 110 (1). pp. 163-168. ISSN 00278424

Xue, B., Krishnamurthy, K., Allred, D. C., Muthuswamy, S. K. (2013) Loss of Par3 promotes breast cancer metastasis by compromising cell-cell cohesion. Nature Cell Biology, 15 (2). pp. 189-200. ISSN 1465-7392

Xue, B., Krishnamurthy, K., Allred, D. C., Muthuswamy, S. K. (December 2012) Loss of Par3 promotes breast cancer metastasis by compromising cell-cell cohesion. Nat Cell Biol. ISSN 1476-4679 (Electronic)1465-7392 (Linking)

Muthuswamy, S. K. (October 2012) Autocrine prolactin: an emerging market for homegrown (prolactin) despite the imports. Genes Dev, 26 (20). pp. 2253-8. ISSN 1549-5477 (Electronic)0890-9369 (Linking)

Yu, M., Lin, G., Arshadi, N., Kalatskaya, I., Xue, B., Haider, S., Nguyen, F., Boutros, P. C., Elson, A., Muthuswamy, L. B., Tonks, N. K., Muthuswamy, S. K. (October 2012) Expression profiling during mammary epithelial cell 3D morphogenesis identifies PTPRO as a novel regulator of morphogenesis and ErbB2 mediated transformation. Mol Cell Biol, 32 (19). pp. 3913-3924. ISSN 1098-5549 (Electronic)0270-7306 (Linking)

Yang, Z., Xue, B., Umitsu, M., Ikura, M., Muthuswamy, S. K., Neel, B. G. (August 2012) The Signaling Adaptor Gab1 Regulates Cell Polarity by Acting as a PAR Protein Scaffold. Molecular Cell, 47 (3). pp. 469-483.

Muthuswamy, S. K., Xue, B. (August 2012) Cell Polarity as a Regulator of Cancer Cell Behavior Plasticity. Annu Rev Cell Dev Biol, 28 (28). pp. 599-625. ISSN 1530-8995 (Electronic)1081-0706 (Linking)

Chatterjee, S., Seifried, L., Feigin, M. E., Gibbons, D. L., Scuoppo, C., Lin, W., Rizvi, Z. H., Lind, E., Dissanayake, D., Kurie, J., Ohashi, P., Muthuswamy, S. K. (April 2012) Dysregulation of Cell Polarity Proteins Synergize with Oncogenes or the Microenvironment to Induce Invasive Behavior in Epithelial Cells. PLoS ONE, 7 (4). ISSN 1932-6203

Anczukow, O., Rosenberg, A. Z., Akerman, M., Das, S., Zhan, L., Karni, R., Muthuswamy, S. K., Krainer, A. R. (January 2012) The splicing factor SRSF1 regulates apoptosis and proliferation to promote mammary epithelial cell transformation. Nature Structural Molecular Biology, 19 (2). pp. 220-228. ISSN 1545-9985 (Electronic)1545-9985 (Linking)

Lin, G., Aranda, V., Muthuswamy, S. K., Tonks, N. K. (July 2011) Identification of PTPN23 as a novel regulator of cell invasion in mammary epithelial cells from a loss-of-function screen of the 'PTP-ome'. Genes & Development, 25 (13). pp. 1412-1425. ISSN 0890-9369

Simpson, D. R., Yu, M., Zheng, S. Y., Zhao, Z. M., Muthuswamy, S. K., Tansey, W. P. (June 2011) Epithelial Cell Organization Suppresses Myc Function by Attenuating Myc Expression. Cancer Research, 71 (11). pp. 3822-3830. ISSN 0008-5472

Wang, G. H., Krishnamurthy, K., Tangpisuthipongsa, D. (May 2011) Protection of murine neural progenitor cells by the Hsp90 inhibitor 17-allylamino-17-demethoxygeldanamycin in the low nanomolar concentration range. Journal of Neurochemistry, 117 (4). pp. 703-711. ISSN 0022-3042

Muthuswamy, S. K. (April 2011) Trastuzumab resistance: all roads lead to SRC. Nature Medicine, 17 (4). pp. 416-8. ISSN 1078-8956

Keyes, W. M. , Pecoraro, M., Aranda, V., Vernersson-Lindahl, E., Li, W., Vogel, H., Guo, X., Garcia, E. L., Michurina, T. V., Enikolopov, G. N., Muthuswamy, S. K., Mills, A. A. (February 2011) DeltaNp63alpha Is an Oncogene that Targets Chromatin Remodeler Lsh to Drive Skin Stem Cell Proliferation and Tumorigenesis. Cell Stem Cell, 8 (2). pp. 164-76. ISSN 1875-9777 (Electronic)

Muthuswamy, S. K. (2011) 3D culture reveals a signaling network. Breast Cancer Research, 13 (1). ISSN 1465-542X

Arias-Romero, L. E., Villamar-Cruz, O., Pacheco, A., Kosoff, R., Huang, M., Muthuswamy, S. K., Chernoff, J. (October 2010) A Rac-Pak signaling pathway is essential for ErbB2-mediated transformation of human breast epithelial cancer cells. Oncogene, 29 (43). pp. 5839-49. ISSN 0950-9232

Cabodi, S., Tinnirello, A., Bisaro, B., Tornillo, G., Camacho-Leal, M. D., Forni, G., Cojoca, R., Iezzi, M., Amici, A., Montani, M., Eva, A., Di Stefano, P., Muthuswamy, S. K., Tarone, G., Turco, E., Defilippi, P. (October 2010) p130Cas is an essential transducer element in ErbB2 transformation. Faseb J, 24 (10). pp. 3796-3808. ISSN 1530-6860 (Electronic) 0892-6638 (Linking)

Huang, L., Muthuswamy, S. K. (February 2010) Polarity protein alterations in carcinoma: a focus on emerging roles for polarity regulators. Current Opinion in Genetics and Development, 20 (1). pp. 41-50.

Lucs, A. V., Muller, W. J., Muthuswamy, S. K. (January 2010) Shc is required for ErbB2-induced inhibition of apoptosis but is dispensable for cell proliferation and disruption of cell polarity. Oncogene, 29 (2). pp. 174-187. ISSN 0950-9232

Ling, C., Zuo, D., Xue, B., Muthuswamy, S. K., Muller, W. J. (2010) A novel role for 14-3-3σ in regulating epithelial cell polarity. Genes and Development, 24 (9). pp. 947-956.

Feigin, M. E., Muthuswamy, S. K. (October 2009) Polarity proteins regulate mammalian cell-cell junctions and cancer pathogenesis. Curr Opin Cell Biol, 21 (5). 694-700 .

Muthuswamy, S. K. (May 2009) A New Tumor Suppressor That Regulates Tissue Architecture. PLoS Medicine, 6 (5). e1000073.

Zavadil, J., Haley, J., Kalluri, R., Muthuswamy, S. K., Thompson, E. (December 2008) Epithelial-Mesenchymal Transition. Cancer Res, 68 (23). pp. 9574-9577.

Zhan, L., Rosenberg, A. , Bergami, K. C., Yu, M., Xuan, Z. Y., Jaffe, A. B., Allred, C., Muthuswamy, S. K. (November 2008) Deregulation of Scribble Promotes Mammary Tumorigenesis and Reveals a Role for Cell Polarity in Carcinoma. Cell, 135 (5). pp. 865-878.

Aranda, V., Nolan, M. E., Muthuswamy, S. K. (November 2008) Par complex in cancer: a regulator of normal cell polarity joins the dark side. Oncogene, 27 (55). pp. 6878-87.

Nolan, M. E., Aranda, V., Lee, S., Lakshmi, B., Basu, S., Allred, D. C., Muthuswamy, S. K. (October 2008) The polarity protein Par6 induces cell proliferation and is overexpressed in breast cancer. Cancer Res, 68 (20). pp. 8201-9.

Xiang, B., Chatti, K., Qiu, H., Lakshmi, B., Krasnitz, A., Hicks, J. B., Yu, M., Miller, W. T., Muthuswamy, S. K. (August 2008) Brk is coamplified with ErbB2 to promote proliferation in breast cancer. Proc Natl Acad Sci U S A, 105 (34). pp. 12463-8.

Guix, M., de Matos Granja, N., Meszoely, I., Adkins, T. B., Wieman, B. M., Frierson, K. E., Sanchez, V., Sanders, M. E., Grau, A. M., Mayer, I. A., Pestano, G., Shyr, Y., Muthuswamy, S., Calvo, B., Krontiras, H., Krop, I. E., Kelley, M. C., Arteaga, C. L. (February 2008) Short Preoperative Treatment With Erlotinib Inhibits Tumor Cell Proliferation in Hormone Receptor Positive Breast Cancers. J Clin Oncol, 26 (6). pp. 897-906.

Feigin, M. E., Muthuswamy, S. K. (February 2008) ErbB receptors and cell polarity: New pathways and paradigms for understanding cell migration and invasion. Experimental Cell Research, 315 (4). pp. 707-716. ISSN 0014-4827

Ibarra, I., Erlich, Y., Muthuswamy, S. K., Sachidanandam, R., Hannon, Gregory J. (December 2007) A role for microRNAs in maintenance of mouse mammary epithelial progenitor cells. Genes Dev, 21 (24). pp. 3238-43. ISSN 0890-9369 (Print)

Tonks, N. K., Muthuswamy, S. K. (March 2007) A Brake Becomes an Accelerator: PTP1B-A New Therapeutic Target for Breast Cancer. Cancer Cell, 11 (3). pp. 214-6. ISSN 1535-6108 (Print)

Aranda, V., Haire, T., Nolan, M. E., Calarco, J. P., Rosenberg, A. Z., Fawcett, J. P., Pawson, T., Muthuswamy, S. K. (November 2006) Par6-aPKC uncouples ErbB2 induced disruption of polarized epithelial organization from proliferation control. Nat Cell Biol, 8 (11). pp. 1235-45. ISSN 1465-7392 (Print)

Muthuswamy, S. K. (August 2006) ErbB2 makes beta 4 integrin an accomplice in tumorigenesis. Cell, 126 (3). pp. 443-5. ISSN 0092-8674 (Print)

Zhan, L., Xiang, B., Muthuswamy, S. K. (May 2006) Controlled activation of ErbB1/ErbB2 heterodimers promote invasion of three-dimensional organized epithelia in an ErbB1-dependent manner: implications for progression of ErbB2-overexpressing tumors. Cancer Res, 66 (10). pp. 5201-8. ISSN 0008-5472 (Print)

Wang, S. E., Narasanna, A., Perez-Torres, M., Xiang, B., Wu, F. Y., Yang, S., Carpenter, G., Gazdar, A. F., Muthuswamy, S. K., Arteaga, C. L. (2006) HER2 kinase domain mutation results in constitutive phosphorylation and activation of HER2 and EGFR and resistance to EGFR tyrosine kinase inhibitors. Cancer Cell, 10 (1). pp. 25-38. ISSN 15356108

Reginato, M. J., Muthuswamy, S. K. (2006) Illuminating the center: Mechanisms regulating lumen formation and maintenance in mammary morphogenesis. Journal of Mammary Gland Biology and Neoplasia, 11 (3-4). pp. 205-211. ISSN 10833021

Xiang, B., Muthuswamy, S. K. (2006) Using three-dimensional acinar structures for molecular and cell biological assays. Methods Enzymol, 406. pp. 692-701. ISSN 0076-6879 (Print)

Muthuswamy, S. K. (2005) Regulation of epithelial cell polarity during carcinogenesis. Breast Cancer Research, 7. S7-S7. ISSN 1465-5411

Debnath, J., Muthuswamy, S. K., Brugge, J. S. (July 2003) Morphogenesis and oncogenesis of MCF-10A mammary epithelial acini grown in three-dimensional basement membrane cultures. Methods, 30 (3). pp. 256-268. ISSN 1046-2023

Miranti, C. K., Bill, H. M., Modres, S. L., Rao, V. R., Knudsen, B., Muthuswamy, S. K., Brugge, J. S. (March 2003) Integrin-induced EGFR activation and control of the cell cycle in epithelial cells. Faseb Journal, 17 (5). A974-A974. ISSN 0892-6638

Reginato, M. J., Mills, K., Debnath, J., Paulus, J., Muthuswamy, S., Brugge, J. (November 2002) Bim regulation or lumen formation in epithelial acini is blocked by oncogenes. Molecular Biology of the Cell, 13. 4A-4A. ISSN 1059-1524

Muthuswamy, S. K., Li, D. M., Lelievre, S., Bissell, M. J., Brugge, J. S. (September 2001) ErbB2, but not ErbB1, reinitiates proliferation and induces luminal repopulation in epithelial acini. Nature Cell Biology, 3 (9). pp. 785-792. ISSN 1465-7392