ErbB2 makes beta 4 integrin an accomplice in tumorigenesis

Muthuswamy, S. K. (August 2006) ErbB2 makes beta 4 integrin an accomplice in tumorigenesis. Cell, 126 (3). pp. 443-5. ISSN 0092-8674 (Print)

DOI: 10.1016/j.cell.2006.07.020


Integrins modulate signaling by growth factor receptors, but their role during tumorigenesis is not clear. Guo et al. (2006) now demonstrate that alpha 6 beta 4 integrin cooperates with ErbB2 in the formation of mammary tumors and discover distinct pathways that regulate cellular proliferation and adhesion downstream of the ErbB2-integrin complex.

Item Type: Paper
Uncontrolled Keywords: Animals Carcinoma metabolism physiopathology Cell Adhesion/physiology Cell Polarity physiology Cell Proliferation Cell Transformation Neoplastic genetics metabolism Epithelial Cells metabolism pathology Humans Integrin alpha6beta4 metabolism Receptor erbB-2 metabolism Signal Transduction physiology Tight Junctions metabolism
Subjects: diseases & disorders > cancer
diseases & disorders > cancer > cancer types > breast cancer
CSHL Authors:
Communities: CSHL labs > Muthuswamy lab
Depositing User: CSHL Librarian
Date: 11 August 2006
Date Deposited: 13 Dec 2011 14:20
Last Modified: 19 Apr 2018 19:01
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