Muthuswamy, S. K. (August 2006) ErbB2 makes beta 4 integrin an accomplice in tumorigenesis. Cell, 126 (3). pp. 443-5. ISSN 0092-8674 (Print)
Abstract
Integrins modulate signaling by growth factor receptors, but their role during tumorigenesis is not clear. Guo et al. (2006) now demonstrate that alpha 6 beta 4 integrin cooperates with ErbB2 in the formation of mammary tumors and discover distinct pathways that regulate cellular proliferation and adhesion downstream of the ErbB2-integrin complex.
| Item Type: | Paper |
|---|---|
| Uncontrolled Keywords: | Animals Carcinoma metabolism physiopathology Cell Adhesion/physiology Cell Polarity physiology Cell Proliferation Cell Transformation Neoplastic genetics metabolism Epithelial Cells metabolism pathology Humans Integrin alpha6beta4 metabolism Receptor erbB-2 metabolism Signal Transduction physiology Tight Junctions metabolism |
| Subjects: | diseases & disorders > cancer diseases & disorders > cancer > cancer types > breast cancer |
| CSHL Authors: | |
| Communities: | CSHL labs > Muthuswamy lab |
| Depositing User: | CSHL Librarian |
| Date: | 11 August 2006 |
| Date Deposited: | 13 Dec 2011 14:20 |
| Last Modified: | 19 Apr 2018 19:01 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/22866 |
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