Additional materials of the author at
CSHL Institutional Repository

Shao, L., Lu, B., Wen, Z., Teng, S., Wang, L., Zhao, Y., Wang, L., Ishizuka, K., Xu, X., Sawa, A., Song, H., Ming, G. , Zhong, Y. (2017) Disrupted-in-Schizophrenia-1 (DISC1) protein disturbs neural function in multiple disease-risk pathways. Hum Mol Genet, 26(14) pp. 2634-2648.

Beshel, J., Dubnau, J. , Zhong, Y. (2017) A Leptin Analog Locally Produced in the Brain Acts via a Conserved Neural Circuit to Modulate Obesity-Linked Behaviors in Drosophila. Cell Metab, 25(1) pp. 208-217.

Shuai, Y., Hirokawa, A., Ai, Y., Zhang, M., Li, W. , Zhong, Y. (2015) Dissecting neural pathways for forgetting in Drosophila olfactory aversive memory. Proc Natl Acad Sci U S A, 112(48) pp. E6663-72.

Beshel, J. , Zhong, Y. (2015) Alterations in Brain-derived Leptin-homolog Unpaired 1 Lead to Obesity Phenotypes in Drosophila through Regulation of Food Odor Value Signaling. Chemical Senses, 40(7) pp. 549-550.

Lu, B. Y., Shao, L. S., Feng, S. X., Wang, T. , Zhong, Y. (2014) The beta-alanyl-monoamine synthase ebony is regulated by schizophrenia susceptibility gene dysbindin in Drosophila. Science China-Life Sciences, 57(1) pp. 46-51.

Beshel, J. , Zhong, Y. (2013) Graded Encoding of Food Odor Value in the Drosophila Brain. Journal of Neuroscience, 33(40) pp. 15693-15704.

Wang, L., Liang, B. , Zhong, Y. (2013) Reduced EGFR level potentially mediates the A beta 42-induced neuronal loss in transgenic fruit fly and mouse. Protein & Cell, 4(9) pp. 647-649.

Huang, C., Wang, P., Xie, Z., Wang, L. , Zhong, Y. (2013) The differential requirement of mushroom body α/β subdivisions in long-term memory retrieval in Drosophila. Protein and Cell, 4(7) pp. 512-519.

Zhao, J., Lu, Y., Zhao, X., Yao, X., Shuai, Y., Huang, C., Wang, L., Jeong, S. H. , Zhong, Y. (2013) Dissociation of rugose-dependent short-term memory component from memory consolidation in Drosophila. Genes, Brain and Behavior, 12(6) pp. 626-632.

Huang, C., Zheng, X., Zhao, H., Li, M., Wang, P., Xie, Z., Wang, L. , Zhong, Y. (2012) A Permissive Role of Mushroom Body α/β Core Neurons in Long-Term Memory Consolidation in Drosophila. Current Biology, 22(21) pp. 1981-1989.

Wang, L., Chiang, H. C., Wu, W. J., Liang, B., Xie, Z. L., Yao, X. S., Ma, W. W., Du, S. W. , Zhong, Y. (2012) Epidermal growth factor receptor is a preferred target for treating Amyloid-beta-induced memory loss. Proceedings of the National Academy of Sciences of the United States of America, 109(41) pp. 16743-16748.

Lang, M. L., Wang, L., Fan, Q. W., Xiao, G. R., Wang, X. X., Zhong, Y. , Zhou, B. (2012) Genetic Inhibition of Solute-Linked Carrier 39 Family Transporter 1 Ameliorates A beta Pathology in a Drosophila Model of Alzheimer's Disease. PLoS Genetics, 8(4) pp. 623-639.

Shuai, Y. C., Hu, Y., Qin, H. T., Campbell, R. A. A. , Zhong, Y. (2011) Distinct molecular underpinnings of Drosophila olfactory trace conditioning. Proceedings of the National Academy of Sciences of the United States of America, 108(50) pp. 20201-20206.

Shuai, Y. C., Zhang, Y. S., Gao, L. W. , Zhong, Y. (2011) Stress Resistance Conferred by Neuronal Expression of Dominant-Negative Rac in Adult Drosophila melanogaster. Journal of Neurogenetics, 25(1-2) pp. 35-39.

Shao, L., Shuai, Y., Wang, J., Feng, S., Lu, B., Li, Z., Zhao, Y., Wang, L. , Zhong, Y. (2011) Schizophrenia susceptibility gene dysbindin regulates glutamatergic and dopaminergic functions via distinctive mechanisms in Drosophila. Proceedings of the National Academy of Sciences of the United States of America, 108(46) pp. 18831-18836.

Shuai, Y. C. , Zhong, Y. (2010) Forgetting and small G protein Rac. Protein and Cell, 1(6) pp. 503-506.

Chiang, H-C., Wang, L., Xie, Z. L., Yau, A. , Zhong, Y. (2010) PI3 kinase signaling is involved in A beta-induced memory loss in Drosophila. Proceedings of the National Academy of Sciences of the United States of America, 107(15) pp. 7060-7065.

Shuai, Y. C., Lu, B., Hu, Y., Wang, L., Sun, K. , Zhong, Y. (2010) Forgetting Is Regulated through Rac Activity in Drosophila. Cell, 140(4) pp. 579-589.

Pagani, M. R., Oishi, K., Gelb, B. D. , Zhong, Y. (2009) The phosphatase SHP2 regulates the spacing effect for long-term memory induction. Cell, 139(1) pp. 186-98.

Song, Q., Sun, K., Shuai, Y. C., Lin, R., You, W., Wang, L. , Zhong, Y. (2009) Suppressor of hairless is required for long-term memory formation in drosophila. Journal of Neurogenetics, 23(4) pp. 405-411.

Chiang, H-C., Iijima, K., Hakker, I. , Zhong, Y. (2009) Distinctive roles of different {beta}-amyloid 42 aggregates in modulation of synaptic functions. FASEB J., 23(6) pp. 1969-1977.

de Bivort, B. L., Guo, H.- F. , Zhong, Y. (2009) Notch signaling is required for activity-dependent synaptic plasticity at the Drosophila neuromuscular junction. J Neurogenet, 23(4) pp. 395-404.

Zhao, H., Zheng, X., Yuan, X., Wang, L., Wang, X., Zhong, Y., Xie, Z. , Tully, T. (2009) ben Functions with Scamp during Synaptic Transmission and Long-Term Memory Formation in Drosophila. J Neurosci, 29(2) pp. 414-424.

Mamiya, A., Beshel, J., Xu, C. , Zhong, Y. (2008) Neural Representations of Airflow in Drosophila Mushroom Body. PLoS ONE, 3(12) pp. e4063.

Iijima-Ando, K., Hearn, S. A., Granger, L., Shenton, C., Gatt, A., Chiang, H. C., Hakker, I., Zhong, Y. , Iijima, K. (2008) Overexpression of neprilysin reduces Alzheimer amyloid-beta 42 (A beta 42)-induced neuron loss and intraneuronal A beta 42 deposits but causes a reduction in cAMP-responsive element-binding protein-mediated transcription, age-dependent axon pathology, and premature death in Drosophila. Journal of Biological Chemistry, 283(27) pp. 19066-19076.

Wang, Y., Mamiya, A., Chiang, A. S. , Zhong, Y. (2008) Imaging of an early memory trace in the Drosophila mushroom body. J Neurosci, 28(17) pp. 4368-76.

Iijima, K., Chiang, H. C., Hearn, S. A., Hakker, I., Gatt, A., Shenton, C., Granger, L., Leung, A., Iijima-Ando, K. , Zhong, Y. (2008) A beta 42 Mutants with Different Aggregation Profiles Induce Distinct Pathologies in Drosophila. PLoS ONE, 3(2) pp. e1703.

Lu, Y., Lv, Y., Ye, Y., Wang, Y., Hong, Y., Fortini, M. E., Zhong, Y. , Xie, Z. (2007) A role for presenilin in post-stress regulation: effects of presenilin mutations on Ca2+ currents in Drosophila. Faseb Journal, 21(10) pp. 2368-2378.

Ho, I. S., Hannan, F., Guo, H.-F., Hakker, I. , Zhong, Y. (2007) Distinct functional domains of neurofibromatosis type 1 regulate immediate versus long-term memory formation. J Neurosci, 27(25) pp. 6852-7.

Qian, M., Pan, G., Sun, L., Feng, C., Xie, Z., Tully, T. , Zhong, Y. (2007) Receptor-like tyrosine phosphatase PTP10D is required for long-term memory in Drosophila. Journal of Neuroscience, 27(16) pp. 4396-4402.

Wang, Yalin , Zhong, Yi (2006) Imaging of learning & memory associated changes in the mushroom body within the adult brain of Drosophila. Journal of Neurogenetics, 20(3-4) pp. 254-255.

Guo, H. F. , Zhong, Y. (2006) Requirement of Akt to mediate long-term synaptic depression in Drosophila. J Neurosci, 26(15) pp. 4004-14.

Hannan, F., Ho, I., Tong, J. J., Zhu, Y., Nurnberg, P. , Zhong, Y. (2006) Effect of neurofibromatosis type I mutations on a novel pathway for adenylyl cyclase activation requiring neurofibromin and Ras. Hum Mol Genet, 15(7) pp. 1087-98.

Ge, X. C., Hannan, F., Xie, Z. L., Feng, C. H., Tully, T., Zhou, H. M., Xie, Z. P. , Zhong, Y. (2004) Notch signaling in Drosophila long-term memory formation. Proceedings of the National Academy of Sciences of the United States of America, 101(27) pp. 10172-10176.

Wang, Y. L., Guo, H. F., Pologruto, T. A., Hannan, F., Hakker, I., Svoboda, K. , Zhong, Y. (2004) Stereotyped odor-evoked activity in the mushroom body of Drosophila revealed by green fluorescent protein-based Ca2+ imaging. Journal of Neuroscience, 24(29) pp. 6507-6514.

Iijima, K., Liu, H. P., Chiang, A. S., Hearn, S. A., Konsolaki, M. , Zhong, Y. (2004) Dissecting the pathological effects of human Abeta40 and Abeta42 in Drosophila: a potential model for Alzheimer's disease. Proc Natl Acad Sci U S A, 101(17) pp. 6623-8.

Wang, Y. , Zhong, Y. (2004) TARGETing "when" and "where". Sci STKE, 2004(220) pp. pe5.

Zhong, Y. , Wu, C. F. (2004) Neuronal activity and adenylyl cyclase in environment-dependent plasticity of axonal outgrowth in Drosophila. Journal of Neuroscience, 24(6) pp. 1439-1445.

Wang, Y. L., Chiang, A. S., Xia, S. Z., Kitamoto, T., Tully, T. , Zhong, Y. (2003) Blockade of neurotransmission in Drosophila mushroom bodies impairs odor attraction, but not repulsion. Current Biology, 13(21) pp. 1900-1904.

Tong, J. Y., Hannan, F., Zhu, Y. H., Bernards, A. , Zhong, Y. (2002) Neurofibromin regulates G protein-stimulated adenylyl cyclase activity. Nature Neuroscience, 5(2) pp. 95-96.

Wang, Y. L., Wright, N. J. D., Guo, H. F., Xie, Z. P., Svoboda, K., Malinow, R., Smith, D. P. , Zhong, Y. (2001) Genetic manipulation of the odor-evoked distributed neural activity in the Drosophila mushroom body. Neuron, 29(1) pp. 267-276.

Guo, H. F., Tong, J. Y., Hannan, F., Luo, L. , Zhong, Y. (2000) A neurofibromatosis-1-regulated pathway is required for learning in Drosophila. Nature, 403(6772) pp. 895-898.

Hannan, F. , Zhong, Y. (1999) Second messenger systems underlying plasticity at the neuromuscular junction. Int Rev Neurobiol, 43 pp. 119-38.

Wright, N. J. , Zhong, Y. (1998) Serotonin-sensitive leakage channel in Drosophila central neurons. J Neurobiol, 34(1) pp. 83-95.

Guo, H. F., The, I., Hannan, F., Bernards, A. , Zhong, Y. (1997) Requirement of Drosophila NF1 for activation of adenylyl cyclase by PACAP38-like neuropeptides. Science, 276(5313) pp. 795-8.

The, I., Hannigan, G. E., Cowley, G. S., Reginald, S., Zhong, Y., Gusella, J. F., Hariharan, I. K. , Bernards, A. (1997) Rescue of a Drosophila NF1 mutant phenotype by protein kinase A. Science, 276(5313) pp. 791-794.

Zhong, Y. (1996) Genetic dissection of signal transduction mechanisms underlying PACAP-like neuropeptide transmission in Drosophila: synergy of cAMP and Ras/Raf pathways. Ann N Y Acad Sci, 805 pp. 67-79; discussion 79.

Zhong, Y. (1996) Behavior-specific genes?. Trends in Genetics, 12(3) pp. 116-117.

Zhong, Y. , Shanley, J. (1995) Altered nerve terminal arborization and synaptic transmission in Drosophila mutants of cell adhesion molecule fasciclin I. J Neurosci, 15(10) pp. 6679-87.

Zhong, Y. (1995) Mediation of PACAP-like neuropeptide transmission by coactivation of Ras/Raf and cAMP signal transduction pathways in Drosophila. Nature, 375(6532) pp. 588-92.

Zhong, Y. , Pena, L. A. (1995) A novel synaptic transmission mediated by a PACAP-like neuropeptide in Drosophila. Neuron, 14(3) pp. 527-36.

Wright, N. J. , Zhong, Y. (1995) Characterization of K+ currents and the cAMP-dependent modulation in cultured Drosophila mushroom body neurons identified by lacZ expression. J Neurosci, 15(2) pp. 1025-34.

Griffith, L. C., Wang, J., Zhong, Y., Wu, C. F. , Greenspan, R. J. (1994) Calcium/calmodulin-dependent protein kinase II and potassium channel subunit Eag similarly affect plasticity in Drosophila. Proceedings of the National Academy of Sciences of the United States of America, 91(21) pp. 10044-10048.

Zhong, Y. , Wu, C. F. (1993) Modulation of different K+ currents in Drosophila: a hypothetical role for the Eag subunit in multimeric K+ channels. J Neurosci, 13(11) pp. 4669-79.

Zhong, Y. , Wu Chun, F. (1993) Differential modulation of potassium currents by cAMP and its long-term and short-term effects: dunce and rutabaga mutants of Drosophila. J.NEUROGENET., 9(1) pp. 15-27.

Zhong, Y., Budnik, V. , Wu, C. F. (1992) Synaptic plasticity in Drosophila memory and hyperexcitable mutants: role of cAMP cascade. J Neurosci, 12(2) pp. 644-51.

Zhong, Y. , Wu, C. F. (1991) Alteration of four identified K+ currents in Drosophila muscle by mutations in eag. Science, 252(5012) pp. 1562-4.

Zhong, Y. , Wu, C. F. (1991) Altered synaptic plasticity in Drosophila memory mutants with a defective cyclic AMP cascade. Science, 251(4990) pp. 198-201.

Budnik, V., Zhong, Y. , Wu, C. F. (1990) Morphological plasticity of motor axons in Drosophila mutants with altered excitability. J Neurosci, 10(11) pp. 3754-68.

Wu, C. F., Tsai, M. C., Chen, M. L., Zhong, Y., Singh, S. , Lee, C. Y. (1989) Actions of dendrotoxin on K+ channels and neuromuscular transmission in Drosophila melanogaster, and its effects in synergy with K+ channel-specific drugs and mutations. J Exp Biol, 147(1) pp. 21-41.