Neuronal activity and adenylyl cyclase in environment-dependent plasticity of axonal outgrowth in Drosophila

Zhong, Y., Wu, C. F. (February 2004) Neuronal activity and adenylyl cyclase in environment-dependent plasticity of axonal outgrowth in Drosophila. Journal of Neuroscience, 24 (6). pp. 1439-1445. ISSN 0270-6474

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Abstract

The development of the nervous system is influenced by environmental factors. Among all environmental factors, temperature belongs to a unique category. Besides activating some specific sensory pathways, it exerts nonspecific, pervasive effects directly on the entire nervous system, especially in exothermic species. This study uses mutants to genetically discover how temperature affects nerve terminal arborization at larval neuromuscular junctions of Drosophila. It is known that hyperexcitability in K+ channel mutants leads to enhanced ramification of larval nerve terminals. Elevated cAMP levels in dunce mutants with reduced phosphodiesterase activity also cause enhanced arborization. These genetic alterations are thought to perturb mechanisms relevant to activity-dependent neural plasticity, in which neuronal activity activates the cAMP pathway, and consequently affect nerve terminal arborization by regulating expression of adhesion molecules. Here we demonstrate the robust influence of rearing temperature on motor nerve terminal arborization. Analysis of ion channel and cAMP pathway mutants indicates that this temperature-dependent plasticity is mediated via neuronal activity changes linked to mechanisms controlled by the rutabaga-encoded adenylyl cyclase.

Item Type:	Paper
Uncontrolled Keywords:	environment dependent plasticity cAMP mutants Drosophila excitability adenylyl cyclase CAT VISUAL-CORTEX Cat visual cortex SYNAPTIC PLASTICITY synaptic plasticity POTASSIUM CHANNEL potassium channel MEMBRANE membrane EXCITABILITY excitability FUNCTIONAL COMPONENTS functional components GENETIC DISSECTION genetic dissection MOLECULAR ANALYSIS MEMORY MUTANTS memory mutants CELL-ADHESION cell adhesion CAMP CASCADE CAMP Camp cascade
Subjects:	organs, tissues, organelles, cell types and functions > cell types and functions > cell types > dendritic cells > dendritic arbors organs, tissues, organelles, cell types and functions > cell types and functions > cell types > dendritic cells > dendritic arbors organs, tissues, organelles, cell types and functions > cell types and functions > cell types > dendritic cells > dendritic arbors organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons
CSHL Authors:	Zhong, Yi
Depositing User:	CSHL Librarian
Date:	February 2004
Date Deposited:	17 Jan 2012 14:43
Last Modified:	20 Apr 2012 20:27
URI:	https://repository.cshl.edu/id/eprint/22524

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