Zhong, Y., Wu, C. F. (January 1991) Altered synaptic plasticity in Drosophila memory mutants with a defective cyclic AMP cascade. Science, 251 (4990). pp. 198-201. ISSN 0036-8075 (Print)
Abstract
Synaptic transmission was examined in Drosophila mutants deficient in memory function. These mutants, dunce and rutabaga, are defective in different steps of the cyclic adenosine 3',5'-monophosphate (cAMP) cascade. In both dunce and rutabaga larvae, voltage-clamp analysis of neuromuscular transmission revealed impaired synaptic facilitation and post-tetanic potentiation as well as abnormal responses to direct application of dibutyryl cAMP. In addition, the calcium dependence of transmitter release was shifted in dunce. The results suggest that the cAMP cascade plays a role in synaptic facilitation and potentiation and indicate that synaptic plasticity is altered in Drosophila memory mutants.
| Item Type: | Paper |
|---|---|
| Uncontrolled Keywords: | Action Potentials drug effects Animals Bucladesine pharmacology Calcium pharmacology Cyclic AMP physiology Drosophila genetics Electric Stimulation Larva physiology Memory physiology Muscle Contraction physiology Mutation Neuromuscular Junction physiology Neuronal Plasticity physiology Neurotransmitter Agents secretion Synapses physiology |
| Subjects: | organism description > animal > insect > Drosophila organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > neural plasticity organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > synaptic transmission |
| CSHL Authors: | |
| Communities: | CSHL labs > Zhong lab |
| Depositing User: | CSHL Librarian |
| Date: | 11 January 1991 |
| Date Deposited: | 30 Mar 2012 18:04 |
| Last Modified: | 30 Mar 2012 18:04 |
| URI: | https://repository.cshl.edu/id/eprint/25566 |
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