Griffith, L. C., Wang, J., Zhong, Y., Wu, C. F., Greenspan, R. J. (1994) Calcium/calmodulin-dependent protein kinase II and potassium channel subunit Eag similarly affect plasticity in Drosophila. Proceedings of the National Academy of Sciences of the United States of America, 91 (21). pp. 10044-10048. ISSN 00278424 (ISSN)
Abstract
Similar defects in both synaptic transmission and associative learning are produced in Drosophila melanogaster by inhibition of calcium/calmodulin- dependent protein kinase II and mutations in the potassium channel subunit gene eag. These behavioral and synaptic defects are not simply additive in animals carrying both an eag mutation and a transgene for a protein kinase inhibitor, raising the possibility that the phenotypes share a common pathway. At the molecular level, a portion of the putative cytoplasmic domain of Eag is a substrate of calcium/calmodulin-dependent protein kinase II. These similarities in behavior and synaptic physiology, the genetic interaction, and the in vitro biochemical interaction of the two molecules suggest that an important component of neural and behavioral plasticity may be mediated by modulation of Eag function by calcium/calmodulin-dependent protein kinase II.
| Item Type: | Paper |
|---|---|
| Additional Information: | PubMed ID: 7937834 |
| Uncontrolled Keywords: | learning memory protein phosphorylation synaptic physiology potassium channel potassium ion protein kinase (calcium,calmodulin) II protein kinase inhibitor animal cell animal experiment article controlled study Drosophila melanogaster female gene mutation male nerve cell plasticity neuromuscular synapse nonhuman priority journal state dependent learning synaptic transmission Amino Acid Sequence Animal Ca(2+) Calmodulin Dependent Protein Kinase Electric Stimulation Genotype Heat Larva Macromolecular Systems Molecular Sequence Data Neuromuscular Junction Neuronal Plasticity Phosphorylation Potassium Channels Recombinant Fusion Proteins Sex Behavior, Animal Animalia Melanogaster |
| Subjects: | organism description > animal > insect > Drosophila organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > neural plasticity organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > synaptic transmission |
| CSHL Authors: | |
| Communities: | CSHL labs > Zhong lab |
| Depositing User: | CSHL Librarian |
| Date: | 1994 |
| Date Deposited: | 30 Mar 2012 18:21 |
| Last Modified: | 30 Mar 2012 18:21 |
| URI: | https://repository.cshl.edu/id/eprint/25571 |
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