Shuai, Y. C., Zhang, Y. S., Gao, L. W., Zhong, Y. (March 2011) Stress Resistance Conferred by Neuronal Expression of Dominant-Negative Rac in Adult Drosophila melanogaster. Journal of Neurogenetics, 25 (1-2). pp. 35-39. ISSN 0167-7063
Abstract
How does brain coordinate physiological and behavioral responses to achieve survival in adverse environment is intriguing yet complicated. During studies of the small G protein Rac's role in learning and memory, the authors unexpectedly observed that neuronal expression of dominant-negative Rac in adult Drosophila remarkably enhanced the survival of animals in various stress conditions, including oxidation, desiccation, starvation, and heat. The elevated stress resistance was not accompanied by a reduction in female fecundity or a change in whole-body lipid storage. The observation therefore implies the involvement of small G protein Rac in neuronal regulation of global stress responses.</.
| Item Type: | Paper |
|---|---|
| Uncontrolled Keywords: | Drosophila Rac stress resistance extended life longevity guidance gtpases span |
| Subjects: | organism description > animal > insect > Drosophila bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > Rac organs, tissues, organelles, cell types and functions > organs types and functions > brain bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein expression |
| CSHL Authors: | |
| Communities: | CSHL labs > Zhong lab CSHL Post Doctoral Fellows |
| Depositing User: | CSHL Librarian |
| Date: | March 2011 |
| Date Deposited: | 28 Mar 2012 19:21 |
| Last Modified: | 03 May 2013 14:55 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/25600 |
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