Huang, C., Wang, P., Xie, Z., Wang, L., Zhong, Y. (July 2013) The differential requirement of mushroom body α/β subdivisions in long-term memory retrieval in Drosophila. Protein and Cell, 4 (7). pp. 512-519. ISSN 1674800X
Abstract
The mushroom body (MB), a bilateral brain structure possessing about 2000-2500 neurons per hemisphere, plays a central role in olfactory learning and memory in Drosophila melanogaster. Extensive studies have demonstrated that three major types of MB neurons (α/β, α′/β′ and Γ) exhibit distinct functions in memory processing, including the critical role of approximately 1000 MB α/β neurons in retrieving long-term memory. Inspired by recent findings that MB α/β neurons can be further divided into three subdivisions (surface, posterior and core) and wherein the α/β core neurons play an permissive role in long-term memory consolidation, we examined the functional differences of all the three morphological subdivisions of MB α/β by temporally precise manipulation of their synaptic outputs during long-term memory retrieval. We found the normal neurotransmission from a combination of MB α/β surface and posterior neurons is necessary for retrieving both aversive and appetitive long-term memory, whereas output from MB α/β posterior or core subdivision alone is dispensable. These results imply a specific requirement of about 500 MB α/β neurons in supporting long-term memory retrieval and a further functional partitioning for memory processing within the MB α/β region. © 2013 Higher Education Press and Springer-Verlag Berlin Heidelberg.
| Item Type: | Paper |
|---|---|
| Uncontrolled Keywords: | appetitive olfactory conditioning aversive olfactory conditioning memory retrieval mushroom body neural circuits |
| Subjects: | organism description > animal > insect > Drosophila organism description > animal behavior > memory organs, tissues, organelles, cell types and functions > tissues types and functions > mushroom body organs, tissues, organelles, cell types and functions organs, tissues, organelles, cell types and functions > tissues types and functions |
| CSHL Authors: | |
| Communities: | CSHL labs > Zhong lab |
| Depositing User: | Matt Covey |
| Date: | July 2013 |
| Date Deposited: | 16 Aug 2013 19:10 |
| Last Modified: | 19 Jul 2021 13:48 |
| PMCID: | PMC4875512 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/28540 |
Actions (login required)
 |
Administrator's edit/view item |