Shao, L., Lu, B., Wen, Z., Teng, S., Wang, L., Zhao, Y., Wang, L., Ishizuka, K., Xu, X., Sawa, A., Song, H., Ming, G., Zhong, Y. (July 2017) Disrupted-in-Schizophrenia-1 (DISC1) protein disturbs neural function in multiple disease-risk pathways. Hum Mol Genet, 26 (14). pp. 2634-2648. ISSN 0964-6906
Abstract
Although the genetic contribution is under debate, biological studies in multiple mouse models have suggested that the Disrupted-in-Schizophrenia-1 (DISC1) protein may contribute to susceptibility to psychiatric disorders. In the present study, we took the advantages of Drosophila model to dissect molecular pathways that can be affected by DISC1 in the context of pathology-related phenotypes. We found that three pathways that include the homologs of Drosophila Dys, Trio, and Shot were downregulated by introducing a C-terminal truncated mutant DISC1. Consistently, these three molecules were downregulated in the induced pluripotent stem cell-derived forebrain neurons from the subjects carrying a frameshift deletion in DISC1 C-terminus. Importantly, the three pathways were underscored in the pathophysiology of psychiatric disorders in bioinformatics analysis. Taken together, our findings are in line with the polygenic theory of psychiatric disorders.
| Item Type: | Paper |
|---|---|
| Subjects: | diseases & disorders > mental disorders > schizophrenia organs, tissues, organelles, cell types and functions > tissues types and functions > neural networks bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > genes: types > DISC1 |
| CSHL Authors: | |
| Communities: | CSHL labs > Zhong lab |
| Depositing User: | Matt Covey |
| Date: | 15 July 2017 |
| Date Deposited: | 11 May 2017 16:30 |
| Last Modified: | 07 Jul 2021 14:02 |
| PMCID: | PMC5886174 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/34734 |
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