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Krishnan, N., Krishnan, K., Connors, C. R., Choy, M. S., Page, R., Peti, W., Van Aelst, L., Shea, S. D., Tonks, N. K. (2015) PTP1B inhibition suggests a therapeutic strategy for Rett syndrome. J Clin Invest, 125 (8). pp. 3163-3177. ISSN 1558-8238 (Electronic)0021-9738 (Linking)

Penzo, M. A., Robert, V., Tucciarone, J., De Bundel, D., Wang, M., Van Aelst, L., Darvas, M., Parada, L. F., Palmiter, R. D., He, M., Huang, Z. J., Li, B. (2015) The paraventricular thalamus controls a central amygdala fear circuit. Nature, 519 (7544). pp. 455-459. ISSN 0028-0836

Yu, J. R., Tai, Y., Jin, Y., Hammell, M. C., Wilkinson, J. E., Roe, J. S., Vakoc, C. R., Van Aelst, L. (2015) TGF-beta/Smad signaling through DOCK4 facilitates lung adenocarcinoma metastasis. Genes Dev, 29 (3). pp. 250-61. ISSN 0890-9369

Nakano-Kobayashi, A., Tai, Y., Nadif Kasri, N., Van Aelst, L. (2014) The X-linked Mental Retardation Protein OPHN1 Interacts with Homer1b/c to Control Spine Endocytic Zone Positioning and Expression of Synaptic Potentiation. Journal of Neuroscience, 34 (26). pp. 8665-71. ISSN 0270-6474

Murray, D. W., Didier, S., Chan, A., Paulino, V., Van Aelst, L., Ruggieri, R., Tran, N. L., Byrne, A. T., Symons, M. (2014) Guanine nucleotide exchange factor Dock7 mediates HGF-induced glioblastoma cell invasion via Rac activation. British Journal of Cancer, 110 (5). pp. 1307-1315. ISSN 0007-0920

Tai, Y., Janas, J. A., Wang, C. L., Van Aelst, L. (2014) Regulation of Chandelier Cell Cartridge and Bouton Development via DOCK7-Mediated ErbB4 Activation. Cell Reports, 6 (2). pp. 254-63. ISSN 22111247 (ISSN)

Boettner, B., Van Aelst, L. (2013) Introduction to the ECR special issue on the roles of small GTPases. Experimental Cell Research, 319 (15). p. 2309. ISSN 00144827

Hsu, H. C., Wang, C. L., Wang, M., Yang, N., Chen, Z., Sternglanz, R., Xu, R. M. (2013) Structural basis for allosteric stimulation of Sir2 activity by sir4 binding. Genes and Development, 27 (1). pp. 64-73. ISSN 08909369

Berger, A. H., Chen, M., Morotti, A., Janas, J. A., Niki, M., Bronson, R. T., Taylor, B. S., Ladanyi, M., Van Aelst, L., Politi, K., Varmus, H. E., Pandolfi, P. P. (2013) DOK2 inhibits EGFR-mutated lung adenocarcinoma. PLoS One, 8 (11). e79526. ISSN 1932-6203

Anne, S. L., Govek, E. E., Ayrault, O., Kim, J. H., Zhu, X., Murphy, D. A., Van Aelst, L., Roussel, M. F., Hatten, M. E. (2013) WNT3 inhibits cerebellar granule neuron progenitor proliferation and medulloblastoma formation via MAPK activation. PLoS ONE, 8 (11). ISSN 19326203 (ISSN)

Yang, Y. T., Wang, C. L., Van Aelst, L. (2012) DOCK7 interacts with TACC3 to regulate interkinetic nuclear migration and cortical neurogenesis. Nature Neuroscience, 15 (9). pp. 1201-10. ISSN 1097-6256

Zhang, X. C., Piccini, A., Myers, M. P., Van Aelst, L., Tonks, N. K. (2012) Functional analysis of the protein phosphatase activity of PTEN. Biochem J, 444 (3). pp. 457-64. ISSN 1470-8728 (Electronic)0264-6021 (Linking)

Hill, C. S., Van Aelst, L. (2012) Signaling and gradients: what's going down? Current Opinion in Cell Biology, 24 (2). pp. 155-157. ISSN 0955-0674

Kang, H., Davis-Dusenbery, B. N., Nguyen, P. H., Lal, A., Lieberman, J., Van Aelst, L., Lagna, G., Hata, A. (2012) Bone morphogenetic protein 4 promotes vascular smooth muscle contractility by activating microRNA-21 (miR-21), which down-regulates expression of family of dedicator of cytokinesis (DOCK) proteins. Journal of Biological Chemistry, 287 (6). pp. 3976-3986. ISSN 00219258 (ISSN)

Nadif Kasri, N., Nakano-Kobayashi, A., Van Aelst, L. (2011) Rapid Synthesis of the X-Linked Mental Retardation Protein OPHN1 Mediates mGluR-Dependent LTD through Interaction with the Endocytic Machinery. Neuron, 72 (2). pp. 300-315. ISSN 1097-4199 (Electronic)0896-6273 (Linking)

Govek, E. E., Hatten, M. E., Van Aelst, L. (2011) The role of Rho GTPase proteins in CNS neuronal migration. Developmental Neurobiology, 71 (6). pp. 528-553. ISSN 19328451 (ISSN)

Janas, J. A., Van Aelst, L. (2011) Oncogenic tyrosine kinases target Dok-1 for ubiquitin-mediated proteasomal degradation to promote cell transformation. Molecular and Cellular Biology, 31 (13). pp. 2552-2565. ISSN 0270-7306

Ren, J., Wang, C. L., Sternglanz, R. (2010) Promoter strength influences the S phase requirement for establishment of silencing at the Saccharomyces cerevisiae silent mating type loci. Genetics, 186 (2). pp. 551-560.

Van Aelst, L., Caroni, P. (2010) Signaling mechanisms. Curr Opin Neurobiol, 20. pp. 1-3. ISSN 1873-6882 (Electronic) 0959-4388 (Linking)

Boettner, B., Van Aelst, L. (2009) Control of cell adhesion dynamics by Rap1 signaling. Curr Opin Cell Biol, 21 (5). 684-693 .

Nakano-Kobayashi, A., Nadif Kasri, N., Newey, S. E., Van Aelst, L. (2009) The Rho-Linked Mental Retardation Protein OPHN1 Controls Synaptic Vesicle Endocytosis via Endophilin A1. Curr Biol, 19 (13). 1133-1139 .

Nadif Kasri, N., Nakano-Kobayashi, A., Malinow, R., Li, B., Van Aelst, L. (2009) The Rho-linked mental retardation protein oligophrenin-1 controls synapse maturation and plasticity by stabilizing AMPA receptors. Genes Dev, 23 (11). pp. 1289-1302. ISSN 0890-9369

Hu, H. L., Qin, Y., Bochorishvili, G., Zhu, Y. H., Van Aelst, L., Zhu, J. J. (2008) Ras signaling mechanisms underlying impaired GluR1-dependent plasticity associated with fragile X syndrome. Journal of Neuroscience, 28 (31). pp. 7847-7862. ISSN 0270-6474

Xue, W., Krasnitz, A., Lucito, R., Sordella, R., Van Aelst, L., Cordon-Cardo, C., Singer, S., Kuehnel, F., Wigler, M. H., Powers, S., Zender, L., Lowe, S. W. (2008) DLC1 is a chromosome 8p tumor suppressor whose loss promotes hepatocellular carcinoma. Genes & Development, 22 (11). pp. 1439-44. ISSN 0890-9369

Nadif Kasri, N., Govek, E. E., Van Aelst, L. (2008) Characterization of Oligophrenin -1, a RhoGAP Lost in Patients Affected with Mental Retardation: Lentiviral Injection in Organotypic Brain Slice Cultures. Methods Enzymol, 439. pp. 255-266.

Sordella, R., Van Aelst, L. (2008) Dialogue between RhoA/ROCK and Members of the Par Complex in Cell Polarity. Developmental Cell, 14 (2). pp. 150-2. ISSN 1534-5807

Nadif Kasri, N., Van Aelst, L. (2008) Rho-linked genes and neurological disorders. Pflügers Archiv European Journal of Physiology, 455 (5). pp. 787-797.

Boettner, B., Van Aelst, L. (2007) The Rap GTPase Activator Drosophila PDZ-GEF Regulates Cell Shape in Epithelial Migration and Morphogenesis. Mol Cell Biol, 27 (22). pp. 7966-7980. ISSN 0270-7306 (Print)

Watabe-Uchida, M., Govek, E. E., Van Aelst, L. (2006) Regulators of Rho GTPases in neuronal development. J Neurosci, 26 (42). pp. 10633-5. ISSN 1529-2401 (Electronic)

Watabe-Uchida, M., John, K. A., Janas, J. A., Newey, S. E., Van Aelst, L. (2006) The Rac activator DOCK7 regulates neuronal polarity through local phosphorylation of stathmin/Op18. Neuron, 51 (6). pp. 727-39. ISSN 0896-6273 (Print)

Zhao, M., Janas, J. A. , Niki, M., Pandolfi, P. P., Van Aelst, L. (2006) Dok-1 independently attenuates Ras/mitogen-activated protein kinase and Src/c-myc pathways to inhibit platelet-derived growth factor-induced mitogenesis. Mol Cell Biol, 26 (7). pp. 2479-89. ISSN 0270-7306 (Print)

Sordella, R., Van Aelst, L. (2006) Driving Actin Dynamics under the Influence of Alcohol. Cell, 127 (1). pp. 37-39. ISSN 00928674

Janas, J. A., Skowronski, J., Van Aelst, L. (2006) Lentiviral delivery of RNAi in hippocampal neurons. Methods Enzymol, 406. pp. 593-605. ISSN 0076-6879 (Print)

Yasuda, Ryohei, Harvey, Christopher D., Zhong, Haining, Sobczyk, Aleksander, Van Aelst, Linda, Svoboda, Karel (2006) Supersensitive Ras activation in dendrites and spines revealed by two-photon fluorescence lifetime imaging. Nature Neuroscience, 9 (2). pp. 283-291. ISSN 10976256

Qin, Y., Zhu, Y. H., Baumgart, J. P., Stornetta, R. L., Seidenman, K., Mack, V., van Aelst, L., Zhu, J. J. (2005) State-dependent Ras signaling and AMPA receptor trafficking. Genes & Development, 19 (17). pp. 2000-2015. ISSN 0890-9369

Newey, S. E., Velamoor, V., Govek, E.-E., Van Aelst, L. (2005) Rho GTPases, dendritic structure, and mental retardation. J Neurobiol, 64 (1). pp. 58-74. ISSN 0022-3034 (Print)

Govek, E. E., Newey, S. E., Van Aelst, L. (2005) The role of the Rho GTPases in neuronal development. Genes Dev, 19 (1). pp. 1-49. ISSN 0890-9369 (Print)

Zhu, Y., Pak, D., Qin, Y., McCormack, S. G., Kim, M. J., Baumgart, J. P., Velamoor, V., Auberson, Y. P., Osten, P., Van Aelst, L., Sheng, M., Zhu, J. J. (2005) Rap2-JNK removes synaptic AMPA receptors during depotentiation. Neuron, 46 (6). pp. 905-916. ISSN 08966273 (ISSN)

Niki, M., Di Cristofano, A., Zhao, M., Honda, H., Hirai, H., Van Aelst, L., Cordon-Cardo, C., Pandolfi, P. P. (2004) Role of Dok-1 and Dok-2 in leukemia suppression. J Exp Med, 200 (12). pp. 1689-95.

Benitah, S. A., Valeron, P. F., Van Aelst, L., Marshall, C. J., Lacal, J. C. (2004) Rho GTPases in human cancer: an unresolved link to upstream and downstream transcriptional regulation. Biochimica Et Biophysica Acta-Reviews on Cancer, 1705 (2). pp. 121-132. ISSN 0304-419X

Niki, M., Di Cristofano, A., Zhao, M. M., Honda, H., Hirai, H., Van Aelst, L., Cordon-Cardo, C., Pandolfi, P. P. (2004) Role of Dok-1 and Dok-2 in leukemia suppression. Journal of Experimental Medicine, 200 (12). pp. 1689-1695. ISSN 0022-1007

Niki, M., Di Cristofano, A., Zhao, M. M., Hirai, H., Van Aelst, L., Cordon-Cardo, C., Pandolfi, P. P. (2004) Critical role of Dok-1 and Dok-2 in leukemia suppression. Blood, 104 (11). 807A-807A. ISSN 0006-4971

Jakubiec, A., Notaise, J., Tournier, V., Hericourt, F., Block, M. A., Drugeon, G., van Aelst, L., Jupin, I. (2004) Assembly of turnip yellow mosaic virus replication complexes: Interaction between the proteinase and polymerase domains of the replication proteins. Journal of Virology, 78 (15). pp. 7945-7957. ISSN 0022-538X

Van Aelst, L., Cline, H. T. (2004) Rho GTPases and activity-dependent dendrite development. Curr Opin Neurobiol, 14 (3). pp. 297-304. ISSN 0959-4388 (Print)

Govek, E. E., Newey, S., Van Aelst, L. (2004) Knockdown of the X-linked mental retardation protein, oligophrenin-1, affects dendritic spine morphology. Faseb Journal, 18 (8). C310-C310. ISSN 0892-6638

Govek, E. E., Newey, S. E., Akerman, C. J., Cross, J. R., Van der Veken, L., Van Aelst, L. (2004) The X-linked mental retardation protein oligophrenin-1 is required for dendritic spine morphogenesis. Nat Neurosci, 7 (4). pp. 364-72. ISSN 1097-6256 (Print)

Boettner, B., Harjes, P., Ishimaru, S., Heke, M., Fan, H. Q., Qin, Y., Van Aelst, L., Gaul, U. (2003) The AF-6 homolog Canoe acts as a Rap1 effector during dorsal closure of the Drosophila embryo. Genetics, 165 (1). pp. 159-169. ISSN 0016-6731

Perreault, M. C., Qin, Y., Heggelund, P., Zhu, J. J. (2003) Postnatal development of GABAergic signalling in the rat lateral geniculate nucleus: presynaptic dendritic mechanisms. Journal of Physiology-London, 546 (1). pp. 137-148. ISSN 0022-3751

Boettner, B., Van Aelst, L. (2002) The RASputin effect. Genes & Development, 16 (16). pp. 2033-2038. ISSN 0890-9369

Zhu, J. J., Qin, Y., Zhao, M. M., Van Aelst, L., Malinow, R. (2002) Ras and Rap control AMPA receptor trafficking during synaptic plasticity. Cell, 110 (4). pp. 443-455. ISSN 0092-8674

Van Aelst, L., Symons, M. (2002) Role of Rho family GTPases in epithelial morphogenesis. Genes & Development, 16 (9). pp. 1032-1054. ISSN 0890-9369

Boettner, B., Van Aelst, L. (2002) The role of Rho GTPases in disease development. Gene, 286 (2). pp. 155-74. ISSN 0378-1119 (Print)

Schmitz, A. A., Lucito, R., Van Aelst, L. (2002) Using cDNA-representational difference analysis (cDNA-RDA) in combination with microarrays to identify Rac regulated genes. Methods Mol Biol, 189. pp. 25-43. ISSN 1940-6029 (Electronic)1064-3745 (Linking)

Boettner, B., Harjes, P., Gaul, U., Van Aelst, L. (2001) Functional interaction of the small Rap GTPase and the junctional Canoe protein during embryonic dorsal closure in Drosophila melanogaster. Molecular Biology of the Cell, 12. 370A-370A. ISSN 1059-1524

Gumienny, T. L., Brugnera, E., Tosello-Trampont, A. C., Kinchen, J. M., Haney, L. B., Nishiwaki, K., Walk, S. F., Nemergut, M. E., Macara, I. G., Francis, R., Schedl, T., Qin, Y., Van Aelst, L., Hengartner, M. O., Ravichandran, K. S. (2001) CED-12/ELMO, a novel member of the crkII/dock180/rac pathway, is required for phagocytosis and cell migration. Cell, 107 (1). pp. 27-41. ISSN 0092-8674

Zhao, M. M., Schmitz, A. A. P., Qin, Y., Di Cristofano, A., Pandolfi, P. P., Van Aelst, L. (2001) Phosphoinositide 3-kinase-dependent membrane recruitment of p62(dok) is essential for its negative effect on mitogen-activated protein (MAP) kinase activation. Journal of Experimental Medicine, 194 (3). pp. 265-274. ISSN 0022-1007

Di Cristofano, A., Niki, M., Zhao, M. M., Karnell, F. G., Clarkson, B., Pear, W. S., Van Aelst, L., Pandolfi, P. P. (2001) p62(dok), a negative regulator of Ras and mitogen-activated protein kinase (MAPK) activity, opposes leukemogenesis by p210(bcr-abl). Journal of Experimental Medicine, 194 (3). pp. 275-284. ISSN 0022-1007

Schmitz, A. A. P., Govek, E. E., Bottner, B., Van Aelst, L. (2000) Rho GTPases: Signaling, migration, and invasion. Experimental Cell Research, 261 (1). pp. 1-12. ISSN 0014-4827

Niki, M., Di Cristofano, A., Zhao, M., Karnell, F. G., Clarkson, B., Pear, W. S., Van Aelst, L., Pandolfi, P. P. (2000) Role of p65(dok) in leukemogenesis by p210(bcr-abl). Blood, 96 (11). 510A-510A. ISSN 0006-4971

Boettner, B., Govek, E. E., Cross, J., Van Aelst, L. (2000) The junctional multidomain protein AF-6 is a binding partner of the Rap1A GTPase and associates with the actin cytoskeletal regulator profilin. Proceedings of the National Academy of Sciences of the United States of America, 97 (16). pp. 9064-9069. ISSN 0027-8424

Boshans, R. L., Szanto, S., Van Aelst, L., D'Souza-Schorey, C. (2000) ADP-ribosylation factor 6 regulates actin cytoskeleton remodeling in coordination with Rac1 and RhoA. Molecular and Cellular Biology, 20 (10). pp. 3685-3694. ISSN 0270-7306

Chen, R. A., Michaeli, T., Van Aelst, L., Ballester, R. (2000) A role for the noncatalytic N terminus in the function of Cdc25, a Saccharomyces cerevisiae Ras-guanine nucleotide exchange factor. Genetics, 154 (4). pp. 1473-1484. ISSN 0016-6731

Li, Z., Van Aelst, L., Cline, H. T. (2000) Rho GTPases regulate distinct aspects of dendritic arbor growth in Xenopus central neurons in vivo. Nature Neuroscience, 3 (3). pp. 217-225. ISSN 1097-6256

Boettner, B., Van Aelst, L. (1999) Rac and Cdc42 effectors. Progress in molecular and subcellular biology, 22. pp. 135-58. ISSN 0079-6484 (Print)

Boettner, B., Govek, E., Van Aelst, L. (1998) AF6: A binding partner and putative effector of Ras oncoproteins. Molecular Biology of the Cell, 9. 462A-462A. ISSN 1059-1524

D'Souza-Schorey, C., Boettner, B., Van Aelst, L. (1998) Rac1 regulates integrin-mediated cell spreading and adhesion of T lymphocytes. Molecular Biology of the Cell, 9. 299A-299A. ISSN 1059-1524

Lin, A. W., Barradas, M., Stone, J. C., Van Aelst, L., Serrano, M., Lowe, S. W. (1998) Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling. Genes & Development, 12 (19). pp. 3008-3019. ISSN 0890-9369

Bagrodia, S., Taylor, S. J., Jordon, K. A., Van Aelst, L., Cerione, R. A. (1998) A novel regulator of p21-activated kinases. Journal of Biological Chemistry, 273 (37). pp. 23633-23636. ISSN 0021-9258

Webb, C. P., Van Aelst, L., Wigler, M. H., Woude, G. F. (1998) Signaling pathways in Ras-mediated tumorigenicity and metastasis. Proc Natl Acad Sci U S A, 95 (15). pp. 8773-8. ISSN 0027-8424 (Print)

D'Souza-Schorey, C., Boettner, B., Van Aelst, L. (1998) Rac regulates integrin-mediated spreading and increased adhesion of T lymphocytes. Molecular and Cellular Biology, 18 (7). pp. 3936-3946. ISSN 0270-7306

Antonarakis, S. E., Van Aelst, L. (1998) Mind the GAP, Rho, Rab and GDI. Nature Genetics, 19 (2). pp. 106-108. ISSN 1061-4036

Van Aelst, L. (1998) Two-hybrid analysis of Ras-Raf interactions. Methods in Molecular Biology, 84. pp. 201-22. ISSN 1064-3745 (Print)

Van Aelst, L., D'Souza-Schorey, C. (1997) Rho GTPases and signaling networks. Genes and Development, 11 (18). pp. 2295-322. ISSN 08909369 (ISSN)

Joneson, T., McDonough, M., Bar-Sagi, D., Van Aelst, L. (1996) RAC regulation of actin polymerization and proliferation by a pathway distinct from Jun kinase. Science, 274 (5291). pp. 1374-1376. ISSN 0036-8075

Barr, M. M., Tu, H., Van Aelst, L., Wigler, M. H. (1996) Identification of Ste4 as a potential regulator of Byr2 in the sexual response pathway of Schizosaccharomyces pombe. Mol Cell Biol, 16 (10). pp. 5597-603. ISSN 0270-7306 (Print)

Van Aelst, L., Joneson, T., Bar-Sagi, D. (1996) Identification of a novel Rac1-interacting protein involved in membrane ruffling. Embo Journal, 15 (15). pp. 3778-86. ISSN 0261-4189

Khosravi-Far, R., White, M. A., Westwick, J. K., Solski, P. A., Chrzanowska-Wodnicka, M., Van Aelst, L., Wigler, M. H., Der, C. J. (1996) Oncogenic Ras activation of Raf/mitogen-activated protein kinase-independent pathways is sufficient to cause tumorigenic transformation. Mol Cell Biol, 16 (7). pp. 3923-33. ISSN 0270-7306 (Print)

White, M. A., Nicolette, C., Minden, A., Polverino, A., Van Aelst, L., Karin, M., Wigler, M. H. (1995) Multiple Ras functions can contribute to mammalian cell transformation. Cell, 80 (4). pp. 533-41. ISSN 0092-8674 (Print)

Jung, V., Wei, W., Ballester, R., Camonis, J., Mi, S., Van Aelst, L., Wigler, M. H., Broek, D. (1994) Two types of RAS mutants that dominantly interfere with activators of RAS. Mol Cell Biol, 14 (6). pp. 3707-18. ISSN 0270-7306 (Print)

Van Aelst, L., White, M., Wigler, M. H. (1994) Ras partners. Cold Spring Harbor Symposia on Quantitative Biology, 59. pp. 181-186. ISSN 00917451 (ISSN)

Van Aelst, L., Barr, M., Marcus, S., Polverino, A., Wigler, M. H. (1993) Complex formation between RAS and RAF and other protein kinases. Proc Natl Acad Sci U S A, 90 (13). pp. 6213-7. ISSN 0027-8424 (Print)

Chardin, P., Camonis, J. H., Gale, N. W., van Aelst, L., Schlessinger, J., Wigler, M. H., Bar-Sagi, D. (1993) Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2. Science, 260 (5112). pp. 1338-1343.

Van Aelst, L., Hohmann, S., Bulaya, B., Dekoning, W., Sierkstr, L., Neves, M. J., Luyten, K., Alijo, R., Ramos, J., Coccetti, P., Martegani, E., Demagalhaesrocha, N. M., Brandao, R. L., Vandijck, P., Vanhalewyn, M., Durnez, P., Jans, A. W. H., Thevelein, J. M. (1993) Molecular-Cloning of a Gene Involved in Glucose Sensing in the Yeast Saccharomyces-Cerevisiae. Molecular Microbiology, 8 (5). pp. 927-943. ISSN 0950-382X

Book Section

Soderling, S. H., Van Aelst, L. (2014) Principles driving the spatial organization of Rho GTPase signaling at synapses. In: Ras Superfamily Small G Proteins: Biology and Mechanisms 1: General Features, Signaling. Springer, pp. 395-419. ISBN 978-370911806-13709118050978-370911805-4S

Boettner, B., Herrmann, C., Van Aelst, L. (2001) Ras and Rap1 interaction with AF-6 effector target. In: Regulators and Effectors of Small Gtpases, Pt F, Ras Family I. Methods of Enzymology, 332 . Elsevier, pp. 151-168. ISBN 0076-6879

Thesis

John, K.A. (2009) Characterization of the role of DOCK7 in neuronal development. PhD thesis, Cold Spring Harbor Laboratory.

Video

Van Aelst, L. (2011) Talk from Linda Van Aelst at the Cold Spring Harbor Laboratory In-House Symposium (2011). [Video] (Unpublished)

This list was generated on Sat Mar 25 19:39:28 2017 EDT.
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