Molecular mechanisms of axo-axonic innervation.

Ango, Fabrice, Gallo, Nicholas Biron, Van Aelst, Linda (April 2021) Molecular mechanisms of axo-axonic innervation. Current Opinion in Neurobiology, 69. pp. 105-112. ISSN 0959-4388

URL: https://www.ncbi.nlm.nih.gov/pubmed/33862423
DOI: 10.1016/j.conb.2021.03.002

Abstract

One of the most intriguing features of inhibitory synapses is the precision by which they innervate their target, not only at the cellular level but also at the subcellular level (i.e. axo-dendritic, axo-somatic, or axo-axonic innervation). In particular, in the cerebellum, cortex, and spinal cord, distinct and highly specialized GABAergic interneurons, such as basket cells, chandelier cells, and GABApre interneurons, form precise axo-axonic synapses, allowing them to directly regulate neuronal output and circuit function. In this article, we summarize our latest knowledge of the cellular and molecular mechanisms that regulate the establishment and maintenance of axo-axonic synapses in these regions of the CNS. We also detail the key roles of the L1CAM family of cell adhesion molecules in such GABAergic subcellular target recognition.

Item Type: Paper
Subjects: organs, tissues, organelles, cell types and functions > sub-cellular tissues: types and functions > synapse > axo-axonic synapse
organs, tissues, organelles, cell types and functions > tissues types and functions > cerebellum
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > interneurons > GABAergic interneurons
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > interneurons > GABAergic interneurons
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > interneurons > GABAergic interneurons
CSHL Authors:
Communities: CSHL labs > Van Aelst lab
SWORD Depositor: CSHL Elements
Depositing User: CSHL Elements
Date: 13 April 2021
Date Deposited: 28 Apr 2021 19:12
Last Modified: 28 Apr 2021 19:12
URI: https://repository.cshl.edu/id/eprint/39943

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