Characterization of Ros1 cDNA from a Human Glioblastoma Cell Line

Birchmeier, C., O'Neill, K., Riggs, M., Wigler, M. H. (1990) Characterization of Ros1 cDNA from a Human Glioblastoma Cell Line. Proceedings of the National Academy of Sciences of the United States of America, 87 (12). pp. 4799-4803.

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URL: https://www.ncbi.nlm.nih.gov/pubmed/2352949

DOI: 10.1073/pnas.87.12.4799

Abstract

We have isolated and characterized a human ROS1 cDNA from the glioblastoma cell line SW-1088. The cDNA, 8.3 kilobases long, has the potential to encode a transmembrane tyrosine-specific protein kinase with a predicted molecular mass of 259 kDa. The putative extracellular domain of ROS1 is homologous to the extracellular domain of the sevenless gene product from Drosophila. No comparable similarites in the extracellular domains were found between ROS1 and other receptor-type tyrosine kinases. Together, ROS1 and sevenless gene products define a distinct subclass of transmembrane tyrosine kinases.

Item Type:	Paper
Subjects:	bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > cDNA bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > gene expression bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein characterization bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > enzymes > kinase > tyrosine kinase
CSHL Authors:	Wigler, Michael H.
Communities:	CSHL labs > Wigler lab
Depositing User:	CSHL Librarian
Date:	1990
Date Deposited:	19 Apr 2012 14:58
Last Modified:	30 Sep 2019 16:35
PMCID:	PMC54205
Related URLs:	Publisher
URI:	https://repository.cshl.edu/id/eprint/26159

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