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Paper

Palm, W., Park, Y., Wright, K., Pavlova, N. N., Tuveson, D. A., Thompson, C. B. (July 2015) The Utilization of Extracellular Proteins as Nutrients Is Suppressed by mTORC1. Cell, 162 (2). pp. 259-270. ISSN 1097-4172 (Electronic)0092-8674 (Linking)

Trotman, L. C., Nowak, D. G., Cho, H., Herzka, T., Watrud, K., DeMarco, D. V., Wang, V. M., Senturk, S., Fellmann, C., Ding, D., Beinortas, T., Kleinman, D., Chen, M., Sordella, R., Wilkinson, J. E., Castillo-Martin, M., Cordon-Cardo, C., Robinson, B. D. (June 2015) Myc drives Pten/trp53-deficient proliferation and metastasis due to Il6-secretion and Akt-suppression via Phlpp2. Cancer Discovery, 5 (6). pp. 636-651. ISSN 21598274

Dos Santos, C. O., Dolzhenko, E., Hodges, E., Smith, A. D., Hannon, G. J. (May 2015) An Epigenetic Memory of Pregnancy in the Mouse Mammary Gland. Cell Reports. ISSN 2211-1247

Naguib, Adam, Bencze, Gyula, Cho, Hyejin, Zheng, Wu, Tocilj, Ante, Elkayam, Elad, Faehnle, Christopher R, Jaber, Nadia, Pratt, Christopher P, Chen, Muhan, Zong, Wei-Xing, Marks, Michael S, Joshua-Tor, Leemor, Pappin, Darryl J, Trotman, Lloyd C (April 2015) PTEN Functions by Recruitment to Cytoplasmic Vesicles. Molecular Cell, 58 (2). pp. 255-268. ISSN 1097-2765

Lee, J. H., Daugharthy, E. R., Scheiman, J., Kalhor, R., Ferrante, T. C., Terry, R., Turczyk, B. M., Yang, J. L., Lee, H. S., Aach, J., Zhang, K., Church, G. M. (March 2015) Fluorescent in situ sequencing (FISSEQ) of RNA for gene expression profiling in intact cells and tissues. Nat Protoc, 10 (3). pp. 442-58. ISSN 1750-2799

Stein, P., Rozhkov, N. V., Li, F., Cardenas, F. L., Davydenk, O., Vandivier, L. E., Gregory, B. D., Hannon, G. J., Schultz, R. M. (February 2015) Essential Role for Endogenous siRNAs during Meiosis in Mouse Oocytes. PLoS Genetics, 11 (2). e1005013. ISSN 1553-7390

Yu, J. R., Tai, Y., Jin, Y., Hammell, M. C., Wilkinson, J. E., Roe, J. S., Vakoc, C. R., Van Aelst, L. (February 2015) TGF-beta/Smad signaling through DOCK4 facilitates lung adenocarcinoma metastasis. Genes Dev, 29 (3). pp. 250-61. ISSN 0890-9369

Hua, Y., Liu, Y. H., Sahashi, K., Rigo, F., Bennett, C. F., Krainer, A. R. (January 2015) Motor neuron cell-nonautonomous rescue of spinal muscular atrophy phenotypes in mild and severe transgenic mouse models. Genes Dev, 29 (3). pp. 288-297. ISSN 0890-9369

Gampe, K., Stefani, J., Hammer, K., Brendel, P., Potzsch, A., Enikolopov, G., Enjyoji, K., Acker-Palmer, A., Robson, S. C., Zimmermann, H. (January 2015) NTPDase2 and Purinergic Signaling Control Progenitor Cell Proliferation in Neurogenic Niches of the Adult Mouse Brain. Stem Cells, 33 (1). pp. 253-64. ISSN 1066-5099

Boj, Sylvia F, Hwang, Chang-Il, Baker, Lindsey A, Chio, Iok In Christine, Engle, Dannielle D, Corbo, Vincenzo, Jager, Myrthe, Ponz-Sarvise, Mariano, Tiriac, Hervé, Spector, Mona S, Gracanin, Ana, Oni, Tobiloba, Yu, Kenneth H, van Boxtel, Ruben, Huch, Meritxell, Rivera, Keith D, Wilson, John P, Feigin, Michael E, Öhlund, Daniel, Handly-Santana, Abram, Ardito-Abraham, Christine M, Ludwig, Michael, Elyada, Ela, Alagesan, Brinda, Biffi, Giulia, Yordanov, Georgi N, Delcuze, Bethany, Creighton, Brianna, Wright, Kevin, Park, Youngkyu, Morsink, Folkert H M., Molenaar, I.  Quintus, Borel Rinkes, Inne H, Cuppen, Edwin, Hao, Yuan, Jin, Ying, Nijman, Isaac J, Iacobuzio-Donahue, Christine, Leach, Steven D, Pappin, Darryl J, Hammell, Molly, Klimstra, David S, Basturk, Olca, Hruban, Ralph H, Offerhaus, George Johan, Vries, Robert G J., Clevers, Hans, Tuveson, David A (January 2015) Organoid Models of Human and Mouse Ductal Pancreatic Cancer. Cell, 160 (1-2). pp. 324-338. ISSN 0092-8674

Naguib, A., Bencze, G., Engle, D. D., Chio, II, Herzka, T., Watrud, K., Bencze, S., Tuveson, D. A., Pappin, D. J., Trotman, L. C. (December 2014) P53 Mutations Change Phosphatidylinositol Acyl Chain Composition. Cell Reports, 10 (1). pp. 8-19. ISSN 2211-1247

Sherman, Mara H, Yu, Ruth T, Engle, Dannielle D, Ding, Ning, Atkins, Annette R, Tiriac, Herve, Collisson, Eric A, Connor, Frances, Van Dyke, Terry, Kozlov, Serguei, Martin, Philip, Tseng, Tiffany W, Dawson, David W, Donahue, Timothy R, Masamune, Atsushi, Shimosegawa, Tooru, Apte, Minoti V, Wilson, Jeremy S, Ng, Beverly, Lau, Sue Lynn, Gunton, Jenny E, Wahl, Geoffrey M, Hunter, Tony, Drebin, Jeffrey A, O’Dwyer, Peter J, Liddle, Christopher, Tuveson, David A, Downes, Michael, Evans, Ronald M (September 2014) Vitamin D Receptor-Mediated Stromal Reprogramming Suppresses Pancreatitis and Enhances Pancreatic Cancer Therapy. Cell, 159 (1). pp. 80-93. ISSN 0092-8674

Reyes, G., Niederst, M., Cohen-Katsenelson, K., Stender, J. D., Kunkel, M. T., Chen, M., Brognard, J., Sierecki, E., Gao, T., Nowak, D. G., Trotman, L. C., Glass, C. K., Newton, A. C. (September 2014) Pleckstrin homology domain leucine-rich repeat protein phosphatases set the amplitude of receptor tyrosine kinase output. Proc Natl Acad Sci U S A, 111 (38). E3957-E3965. ISSN 0027-8424

Tschaharganeh, D. F., Xue, W., Calvisi, D. F., Evert, M., Michurina, T. V., Dow, L. E., Banito, A., Katz, S. F., Kastenhuber, E. R., Weissmueller, S., Huang, C. H., Lechel, A., Andersen, J. B., Capper, D., Zender, L., Longerich, T., Enikolopov, G., Lowe, S. W. (July 2014) p53-Dependent Nestin Regulation Links Tumor Suppression to Cellular Plasticity in Liver Cancer. Cell, 158 (3). pp. 579-92. ISSN 0092-8674

Krishnan, N., Koveal, D., Miller, D. H., Xue, B., Akshinthala, S. D., Kragelj, J., Jensen, M. R., Gauss, C. M., Page, R., Blackledge, M., Muthuswamy, S. K., Peti, W., Tonks, N. K. (May 2014) Targeting the disordered C terminus of PTP1B with an allosteric inhibitor. Nature Chemical Biology, 10 (7). pp. 558-566. ISSN 15524450

Li, W., Wu, J., Kim, S. Y., Zhao, M., Hearn, S. A., Zhang, M. Q., Meistrich, M. L., Mills, A. A. (May 2014) Chd5 orchestrates chromatin remodelling during sperm development. Nature Communications, 5. p. 3812. ISSN 20411723

Tai, Y., Janas, J. A., Wang, C. L., Van Aelst, L. (January 2014) Regulation of Chandelier Cell Cartridge and Bouton Development via DOCK7-Mediated ErbB4 Activation. Cell Reports, 6 (2). pp. 254-63. ISSN 22111247 (ISSN)

Cho, H., Herzka, T., Zheng, W., Qi, J., Wilkinson, J. E., Bradner, J. E., Robinson, B. D., Castillo-Martin, M., Cordon-Cardo, C., Trotman, L. C. (January 2014) RapidCaP, a novel GEM model for analysis and therapy of metastatic prostate cancer, reveals Myc as a driver of Pten-mutant metastasis. Cancer Discovery, 4 (3). pp. 318-33. ISSN 21598274

Streppel, M. M., Lata, S., Delabastide, M., Montgomery, E. A., Wang, J. S., Canto, M. I., Macgregor-Das, A. M., Pai, S., Morsink, F. H., Offerhaus, G. J., Antoniou, E., Maitra, A., McCombie, W. R. (January 2014) Next-generation sequencing of endoscopic biopsies identifies ARID1A as a tumor-suppressor gene in Barrett's esophagus. Oncogene, 33 (3). pp. 347-57. ISSN 0950-9232

Jensen, M. A., Wilkinson, J. E., Krainer, A. R. (January 2014) Splicing factor SRSF6 promotes hyperplasia of sensitized skin. Nature Structural and Molecular Biology, 21. pp. 189-197. ISSN 15459993 (ISSN)

Kovalenko, I. L., Galyamina, A. G., Smagin, D. A., Michurina, T. V., Kudryavtseva, N. N., Enikolopov, G. (2014) Extended effect of chronic social defeat stress in childhood on behaviors in adulthood. PLoS One, 9 (3). e91762. ISSN 1932-6203

Park, J. H., Lee, H., Makaryus, R., Yu, M., Smith, S. D., Sayed, K., Feng, T., Holland, E., Van der Linden, A., Bolwig, T. G., Enikolopov, G., Benveniste, H. (2014) Metabolic Profiling of Dividing Cells in Live Rodent Brain by Proton Magnetic Resonance Spectroscopy (1HMRS) and LCModel Analysis. PLoS One, 9 (5). e94755. ISSN 1932-6203

Labbé, D. P., Nowak, D. G., Deblois, G., Lessard, L., Giguère, V., Trotman, L. C., Tremblay, M. L. (2014) Prostate cancer genetic-susceptibility locus on chromosome 20q13 is amplified and coupled to androgen receptor-regulation in metastatic tumors. Molecular Cancer Research, 12 (2). pp. 184-189. ISSN 15417786 (ISSN)

Shi, J., Whyte, W. A., Zepeda-Mendoza, C. J., Milazzo, J. P., Shen, C., Roe, J. S., Minder, J. L., Mercan, F., Wang, E., Eckersley-Maslin, M. A., Campbell, A. E., Kawaoka, S., Shareef, S., Zhu, Z., Kendall, J., Muhar, M., Haslinger, C., Yu, M., Roeder, R. G., Wigler, M. A., Blobel, G. A., Zuber, J., Spector, D. L., Young, R. A., Vakoc, C. R. (November 2013) Role of SWI/SNF in acute leukemia maintenance and enhancer-mediated Myc regulation. Genes and Development, 27 (24). pp. 264-273. ISSN 08909369 (ISSN)

Cleary, S. P., Jeck, W. R., Zhao, X. B., Chen, K., Selitsky, S. R., Savich, G. L., Tan, T. X., Wu, M. C., Getz, G., Lawrence, M. S., Parker, J. S., Li, J. Y., Powers, S., Kim, H., Fischer, S., Guindi, M., Ghanekar, A., Chiang, D. Y. (November 2013) Identification of Driver Genes in Hepatocellular Carcinoma by Exome Sequencing. Hepatology, 58 (5). pp. 1693-1702. ISSN 0270-9139

Nikonenko, I., Nikonenko, A., Mendez, P., Michurina, T. V., Enikolopov, G., Muller, D. (October 2013) Nitric oxide mediates local activity-dependent excitatory synapse development. Proceedings of the National Academy of Sciences of the United States of America, 110 (44). E4142-E4151. ISSN 0027-8424

Mandal, S., Stanco, A., Buys, E. S., Enikolopov, G., Rubenstein, J. L. (October 2013) Soluble Guanylate Cyclase Generation of cGMP Regulates Migration of MGE Neurons. Journal of Neuroscience, 33 (43). pp. 16897-914. ISSN 1529-2401 (Electronic)0270-6474 (Linking)

Vestin, A., Mills, A. A. (October 2013) The tumor suppressor Chd5 is induced during neuronal differentiation, in the developing mouse brain. Gene Expression Patterns, 13 (8). pp. 482-489. ISSN 1872-7298 (Electronic)1567-133X (Linking)

Li, P., Du, F., Yuelling, L. W., Lin, T., Muradimova, R. E., Tricarico, R., Wang, J., Enikolopov, G., Bellacosa, A., Wechsler-Reya, R. J., Yang, Z. J (October 2013) A population of Nestin-expressing progenitors in the cerebellum exhibits increased tumorigenicity. Nature Neuroscience. ISSN 10976256 (ISSN)

Sahashi, K., Ling, K. K., Hua, Y., Wilkinson, J. E., Nomakuchi, T., Rigo, F., Hung, G., Xu, D., Jiang, Y. P., Lin, R. Z., Ko, C. P., Bennett, C. F., Krainer, A. R. (September 2013) Pathological impact of SMN2 mis-splicing in adult SMA mice. EMBO Molecular Medicine, 5 (10). pp. 1586-1601. ISSN 17574676 (ISSN)

Birbrair, A., Zhang, T., Wang, Z. M., Messi, M. L., Enikolopov, G. N., Mintz, A., Delbono, O. (August 2013) Role of pericytes in skeletal muscle regeneration and fat accumulation. Stem Cells and Development, 22 (16). pp. 2298-2314. ISSN 15473287

Ramsey, M. R., Wilson, C., Ory, B., Rothenberg, S. M., Faquin, W., Mills, A. A., Ellisen, L. W. (August 2013) FGFR2 signaling underlies p63 oncogenic function in squamous cell carcinoma. Journal of Clinical Investigation, 123 (8). pp. 3525-3538. ISSN 0021-9738

Kim, S. Y., Cordeiro, M. H., Serna, V. A., Ebbert, K., Butler, L. M., Sinha, S., Mills, A. A., Woodruff, T. K., Kurita, T. (August 2013) Rescue of platinum-damaged oocytes from programmed cell death through inactivation of the p53 family signaling network. Cell Death and Differentiation, 20 (8). pp. 987-997.

Laronda, Monica M., Unno, Kenji, Ishi, Kazutomo, Serna, Vanida A., Butler, Lindsey M., Mills, Alea A., Orvis, Grant D., Behringer, Richard R., Deng, Chuxia, Sinha, Satrajit, Kurita, Takeshi (July 2013) Diethylstilbestrol induces vaginal adenosis by disrupting SMAD/RUNX1-mediated cell fate decision in the Müllerian duct epithelium. Developmental Biology, 381 (1). pp. 5-16. ISSN 0012-1606

Park, E., Kim, H., Kim, J. M., Primack, B., Vidal-Cardenas, S., Xu, Y., Price, B. D., Mills, A. A., D’Andrea, A. D. (June 2013) FANCD2 Activates Transcription of TAp63 and Suppresses Tumorigenesis. Molecular Cell, 50 (6). pp. 908-918. ISSN 1097-2765

Vernersson Lindahl, E., Garcia, E. L., Mills, A. A. (June 2013) An allelic series of Trp63 mutations defines TAp63 as a modifier of EEC syndrome. American Journal of Medical Genetics Part A, 161 (8). pp. 1961-1971. ISSN 1552-4825

Park, J. H., Glass, Z., Sayed, K., Michurina, T. V., Lazutkin, A., Mineyeva, O., Velmeshev, D., Ward, W. F., Richardson, A., Enikolopov, G. (June 2013) Calorie restriction alleviates the age-related decrease in neural progenitor cell division in the aging brain. European Journal of Neuroscience, 37 (12). pp. 1987-93. ISSN 0953-816X

Flesken-Nikitin, A., Hwang, C. I., Cheng, C. Y., Michurina, T. V., Enikolopov, G., Nikitin, A. Yu (March 2013) Ovarian surface epithelium at the junction area contains a cancer-prone stem cell niche. Nature, 495 (7440). pp. 241-5. ISSN 00280836 (ISSN)

Wang, E., Kawaoka, S., Yu, M., Shi, J., Ni, T., Yang, W., Zhu, J., Roeder, R. G., Vakoc, C. R. (March 2013) Histone H2B ubiquitin ligase RNF20 is required for MLL-rearranged leukemia. Proceedings of the National Academy of Sciences of the United States of America, 110 (10). pp. 3901-6. ISSN 1091-6490 (Electronic)0027-8424 (Linking)

Paul, S., Kuo, A., Schalch, T., Vogel, H., Joshua-Tor, L., McCombie, W. R., Gozani, O., Hammell, M., Mills, A. A. (January 2013) Chd5 Requires PHD-Mediated Histone 3 Binding for Tumor Suppression. Cell Reports, 3 (1). pp. 92-102. ISSN 2211-1247 (Public Dataset)

Birbrair, A., Zhang, T., Wang, Z. M., Messi, M. L., Enikolopov, G. N., Mintz, A., Delbono, O. (January 2013) Skeletal muscle pericyte subtypes differ in their differentiation potential. Stem Cell Research, 10 (1). pp. 67-84. ISSN 1873-5061

Nakasone, E. S., Askautrud, H. A., Egeblad, M. (2013) Live imaging of drug responses in the tumor microenvironment in mouse models of breast cancer. Journal of Visualized Experiments (73). ISSN 1940-087X (Electronic)1940-087X (Linking)

Xue, B., Krishnamurthy, K., Allred, D. C., Muthuswamy, S. K. (2013) Loss of Par3 promotes breast cancer metastasis by compromising cell-cell cohesion. Nature Cell Biology, 15 (2). pp. 189-200. ISSN 1465-7392

Naguib, A., Trotman, L. C. (2013) PTEN plasticity: how the taming of a lethal gene can go too far. Trends In Cell Biology, 23 (8). pp. 374-379. ISSN 0962-8924

Shi, J., Wang, E., Zuber, J., Rappaport, A., Taylor, M., Johns, C., Lowe, S. W., Vakoc, C. R. (2013) The Polycomb complex PRC2 supports aberrant self-renewal in a mouse model of MLL-AF9;Nras(G12D) acute myeloid leukemia. Oncogene, 32 (7). pp. 930-938. ISSN 1476-5594 (Electronic)0950-9232 (Linking)

Herrmann, H., Blatt, K., Shi, J., Gleixner, K. V., Cerny-Reiterer, S., Mullauer, L., Vakoc, C. R., Sperr, W. R., Horny, H. P., Bradner, J. E., Zuber, J., Valent, P. (December 2012) Small-molecule inhibition of BRD4 as a new potent approach to eliminate leukemic stem- and progenitor cells in acute myeloid leukemia AML. Oncotarget, 3 (12). pp. 1588-99. ISSN 1949-2553

Kerr, J. B., Hutt, K. J, Michalak, E. M., Cook, M., Vandenberg, C. J., Liew, S. H., Bouillet, P., Mills, A., Scott, C. L., Findlay, J. K., Strasser, A. (November 2012) DNA Damage-Induced Primordial Follicle Oocyte Apoptosis and Loss of Fertility Require TAp63-Mediated Induction of Puma and Noxa. Molecular Cell, 48 (3). pp. 343-352. ISSN 1097-2765

Wang, Z., Jeon, H. Y., Rigo, F., Bennett, C. F., Krainer, A. R. (October 2012) Manipulation of PK-M mutually exclusive alternative splicing by antisense oligonucleotides. Open Biol, 2 (10). p. 120133. ISSN 2046-2441 (Electronic)2046-2441 (Linking)

Sahashi, K., Hua, Y., Ling, K. K., Hung, G., Rigo, F., Horev, G., Katsuno, M., Sobue, G., Ko, C. P., Bennett, C. F., Krainer, A. R. (August 2012) TSUNAMI: an antisense method to phenocopy splicing-associated diseases in animals. Genes Dev, 26 (16). pp. 1874-84. ISSN 1549-5477 (Electronic)0890-9369 (Linking)

Yang, Y. T., Wang, C. L., Van Aelst, L. (August 2012) DOCK7 interacts with TACC3 to regulate interkinetic nuclear migration and cortical neurogenesis. Nature Neuroscience, 15 (9). pp. 1201-10. ISSN 1097-6256

Nandi, S., Gokhan, S., Dai, X. M., Wei, S. W., Enikolopov, G., Lin, H. S., Mehler, M. F., Stanley, E. R. (July 2012) The CSF-1 receptor ligands IL-34 and CSF-1 exhibit distinct developmental brain expression patterns and regulate neural progenitor cell maintenance and maturation. Developmental Biology, 367 (2). pp. 100-113. ISSN 0012-1606

Zhang, X. C., Piccini, A., Myers, M. P., Van Aelst, L., Tonks, N. K. (June 2012) Functional analysis of the protein phosphatase activity of PTEN. Biochem J, 444 (3). pp. 457-64. ISSN 1470-8728 (Electronic)0264-6021 (Linking)

Spector, M. S., Iossifov, I., Kritharis, A., He, C., Kolitz, J. E., Lowe, S. W., Allen, S. L. (June 2012) Mast-cell leukemia exome sequencing reveals a mutation in the IgE mast-cell receptor beta chain and KIT V654A. Leukemia, 26 (6). pp. 1422-1425. ISSN 0887-6924

Bergerson, R. J., Collier, L. S., Sarver, A. L., Been, R. A., Lugthart, S., Diers, M. D., Zuber, J., Rappaport, A. R., Nixon, M. J., Silverstein, K. A. T., Fan, D. H., Lamblin, A. F. J., Wolff, L., Kersey, J. H., Delwel, R., Lowe, S. W., O'Sullivan, M. G., Kogan, S. C., Adams, D. J., Largaespada, D. A. (May 2012) An insertional mutagenesis screen identifies genes that cooperate with Mll-AF9 in a murine leukemogenesis model. Blood, 119 (19). pp. 4512-4523. ISSN 0006-4971

Nakasone, E. S., Askautrud, H. A., Kees, T., Park, J. H., Plaks, V., Ewald, A. J., Fein, M., Rasch, M. G., Tan, Y. X., Qiu, J., Park, J., Sinha, P., Bissell, M. J., Frengen, E., Werb, Z., Egeblad, M. (April 2012) Imaging Tumor-Stroma Interactions during Chemotherapy Reveals Contributions of the Microenvironment to Resistance. Cancer Cell, 21 (4). pp. 488-503. ISSN 1535-6108

Gineau, L., Cognet, C., Kara, N., Lach, F. P., Dunne, J., Veturi, U., Picard, C., Trouillet, C., Eidenschenk, C., Aoufouchi, S., Alcaïs, A., Smith, O., Geissmann, F., Feighery, C., Abel, L., Smogorzewska, A., Stillman, B., Vivier, E., Casanova, J. L., Jouanguy, E. (March 2012) Partial MCM4 deficiency in patients with growth retardation, adrenal insufficiency, and natural killer cell deficiency. Journal of Clinical Investigation, 122 (3). pp. 821-832. ISSN 00219738 (ISSN)

Anczukow, O., Rosenberg, A. Z., Akerman, M., Das, S., Zhan, L., Karni, R., Muthuswamy, S. K., Krainer, A. R. (January 2012) The splicing factor SRSF1 regulates apoptosis and proliferation to promote mammary epithelial cell transformation. Nature Structural Molecular Biology, 19 (2). pp. 220-228. ISSN 1545-9985 (Electronic)1545-9985 (Linking)

Glaser, S. P., Lee, E. F., Trounson, E., Bouillet, P., Wei, A., Fairlie, W. D., Izon, D. J., Zuber, J., Rappaport, A. R., Herold, M. J., Alexander, W. S., Lowe, S. W., Robb, L., Strasser, A. (January 2012) Anti-apoptotic mcl-1 is essential for the development and sustained growth of acute myeloid leukemia. Genes and Development, 26 (2). pp. 120-125. ISSN 08909369 (ISSN)

Ding, L., Saunders, T. L., Enikolopov, G., Morrison, S. J. (January 2012) Endothelial and perivascular cells maintain haematopoietic stem cells. Nature, 481 (7382). pp. 457-465. ISSN 0028-0836

Howitt, J., Lackovic, J., Low, L. H., Naguib, A., Macintyre, A., Goh, C. P., Callaway, J. K., Hammond, V., Thomas, T., Dixon, M., Putz, U., Silke, J., Bartlett, P., Yang, B. L., Kumar, S., Trotman, L. C., Tan, S. S. (January 2012) Ndfip1 regulates nuclear Pten import in vivo to promote neuronal survival following cerebral ischemia. Journal of Cell Biology, 196 (1). pp. 29-36. ISSN 0021-9525

Mazurek, A., Luo, W., Krasnitz, A., Hicks, J., Powers, R. S., Stillman, B. (2012) DDX5 regulates DNA replication and is required for cell proliferation in a subset of breast cancer cells. Cancer Discovery, 2 (9). pp. 812-825. ISSN 21598274 (ISSN)

Van Stry, M., Oguin Iii, T. H., Cheloufi, S., Vogel, P., Watanabe, M., Pillai, M. R., Dash, P., Thomas, P. G., Hannon, G. J., Bix, M. (2012) Enhanced susceptibility of Ago1/3 double-null mice to influenza a virus infection. Journal of Virology, 86 (8). pp. 4151-4157. ISSN 0022538X (ISSN)

Wang, Z. X., Chatterjee, D., Jeon, H. Y., Akerman, M., Vander Heiden, M. G., Cantley, L. C., Krainer, A. R. (2012) Exon-centric regulation of pyruvate kinase M alternative splicing via mutually exclusive exons. Journal of Molecular Cell Biology, 4 (2). pp. 79-87.

Engelhardt, J. J., Boldajipour, B., Beemiller, P., Pandurangi, P., Sorensen, C., Werb, Z., Egeblad, M., Krummel, M. F (2012) Marginating Dendritic Cells of the Tumor Microenvironment Cross-Present Tumor Antigens and Stably Engage Tumor-Specific T Cells. Cancer Cell, 21 (3). pp. 402-417. ISSN 1535-6108

Zhang, B., Arun, G., Mao, Y. S., Lazar, Z., Hung, G., Bhattacharjee, G., Xiao, X., Booth, C. J., Wu, J., Zhang, C., Spector, D. L. (2012) The lncRNA Malat1 is dispensable for mouse development but its transcription plays a cis-regulatory role in the adult. Cell Reports, 2 (1). pp. 111-123. ISSN 2211-1247

Dow, L. E., Premsrirut, P. K., Zuber, J., Fellmann, C., McJunkin, K., Miething, C., Park, Y., Dickins, R. A., Hannon, G. J., Lowe, S. W. (2012) A pipeline for the generation of shRNA transgenic mice. Nature Protocols, 7 (2). pp. 374-393. ISSN 17542189 (ISSN)

Zaratiegui, M., Castel, S. E., Irvine, D. V., Kloc, A., Ren, J., Li, F., de Castro, E., Marin, L., Chang, A. Y., Goto, D., Cande, W. Z., Antequera, F., Arcangioli, B., Martienssen, R. A. (November 2011) RNAi promotes heterochromatic silencing through replication-coupled release of RNA Pol II. Nature, 479 (7371). pp. 135-8. ISSN 1476-4687 (Electronic)0028-0836 (Linking)

Nadif Kasri, N., Nakano-Kobayashi, A., Van Aelst, L. (October 2011) Rapid Synthesis of the X-Linked Mental Retardation Protein OPHN1 Mediates mGluR-Dependent LTD through Interaction with the Endocytic Machinery. Neuron, 72 (2). pp. 300-315. ISSN 1097-4199 (Electronic)0896-6273 (Linking)

Chien, Y., Scuoppo, C., Wang, X., Fang, X., Balgley, B., Bolden, J. E., Premsrirut, P., Luo, W., Chicas, A., Lee, C. S., Kogan, S. C., Lowe, S. W. (October 2011) Control of the senescence-associated secretory phenotype by NF-kappaB promotes senescence and enhances chemosensitivity. Genes Dev, 25 (20). pp. 2125-36. ISSN 1549-5477 (Electronic) 0890-9369 (Linking)

Hua, Y., Sahashi, K., Rigo, F., Hung, G., Horev, G., Bennett, C. F., Krainer, A. R. (October 2011) Peripheral SMN restoration is essential for long-term rescue of a severe spinal muscular atrophy mouse model. Nature, 478 (7367). pp. 123-6. ISSN 1476-4687 (Electronic) 0028-0836 (Linking)

Zuber, J., Shi, J., Wang, E., Rappaport, A. R., Herrmann, H., Sison, E. A., Magoon, D., Qi, J., Blatt, K., Wunderlich, M., Taylor, M. J., Johns, C., Chicas, A., Mulloy, J. C., Kogan, S. C., Brown, P., Valent, P., Bradner, J. E., Lowe, S. W., Vakoc, C. R. (August 2011) RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia. Nature, 478 (7370). pp. 524-528. ISSN 0028-0836

Zuber, J., Rappaport, A. R., Luo, W., Wang, E., Chen, C., Vaseva, A. V., Shi, J., Weissmueller, S., Fellman, C., Taylor, M. J., Weissenboeck, M., Graeber, T. G., Kogan, S. C., Vakoc, C. R., Lowe, S. W. (August 2011) An integrated approach to dissecting oncogene addiction implicates a Myb-coordinated self-renewal program as essential for leukemia maintenance. Genes & Development, 25 (15). pp. 1628-1640. ISSN 0890-9369

Chen, M. H., Pratt, C. P., Zeeman, M. E., Schultz, N., Taylor, B. S., O'Neill, A., Castillo-Martin, M., Nowak, D. G., Naguib, A., Grace, D. M., Murn, J., Navin, N., Atwal, G. S., Sander, C., Gerald, W. L., Cordon-Cardo, C., Newton, A. C., Carver, B. S., Trotman, L. C. (August 2011) Identification of PHLPP1 as a Tumor Suppressor Reveals the Role of Feedback Activation in PTEN-Mutant Prostate Cancer Progression. Cancer Cell, 20 (2). pp. 173-186. ISSN 1535-6108

Encinas, J. M., Michurina, T. V., Peunova, N., Park, J.H., Tordo, J., Peterson, D. A., Fishell, G., Koulakov, A. A., Enikolopov, G. N. (May 2011) Division-Coupled Astrocytic Differentiation and Age-Related Depletion of Neural Stem Cells in the Adult Hippocampus. Cell Stem Cell, 8 (5). pp. 566-579. ISSN 1934-5909

McJunkin, K., Mazurek, A., Premsrirut, P. K., Zuber, J., Dow, L. E., Simon, J., Stillman, B., Lowe, S. W. (April 2011) Reversible suppression of an essential gene in adult mice using transgenic RNA interference. Proceedings of the National Academy of Sciences of the United States of America, 108 (17). pp. 7113-7118. ISSN 0027-8424

Pardee, T. S., Zuber, J., Lowe, S. W. (April 2011) Flt3-ITD alters chemotherapy response in vitro and in vivo in a p53-dependent manner. Exp Hematol, 39 (4). 473-485 e4. ISSN 1873-2399 (Electronic)0301-472X (Linking)

Premsrirut, P. K., Dow, L. E., Kim, S. Y., Camiolo, M., Malone, C. D., Miething, C., Scuoppo, C. , Zuber, J., Dickins, R. A., Kogan, Scott C, Shroyer, Kenneth R, Sordella, R., Hannon, G. J., Lowe, S. W. (March 2011) A Rapid and Scalable System for Studying Gene Function in Mice Using Conditional RNA Interference. Cell, 145 (1). pp. 145-158. ISSN 0092-8674

Sawey, E. T., Chanrion, M., Cai, C., Wu, G., Zhang, J., Zender, L., Zhao, A., Busuttil, R. W., Yee, H., Stein, L. D., French, D. M., Finn, Richard S, Lowe, S. W., Powers, S. (March 2011) Identification of a Therapeutic Strategy Targeting Amplified FGF19 in Liver Cancer by Oncogenomic Screening. Cancer Cell, 19 (3). pp. 347-358. ISSN 1535-6108

Keyes, W. M. , Pecoraro, M., Aranda, V., Vernersson-Lindahl, E., Li, W., Vogel, H., Guo, X., Garcia, E. L., Michurina, T. V., Enikolopov, G. N., Muthuswamy, S. K., Mills, A. A. (February 2011) DeltaNp63alpha Is an Oncogene that Targets Chromatin Remodeler Lsh to Drive Skin Stem Cell Proliferation and Tumorigenesis. Cell Stem Cell, 8 (2). pp. 164-76. ISSN 1875-9777 (Electronic)

Encinas, J. M., Hamani, C., Lozano, A. M., Enikolopov, G. N. (January 2011) Neurogenic hippocampal targets of deep brain stimulation. Journal of Comparative Neurology, 519 (1). pp. 6-20. ISSN 1096-9861 (Electronic) 0021-9967 (Linking)

Zuber, J., McJunkin, K., Fellmann, C., Dow, L. E., Taylor, M. J., Hannon, G. J., Lowe, S. W. (January 2011) Toolkit for evaluating genes required for proliferation and survival using tetracycline-regulated RNA. Nature Biotechnology, 29 (1). pp. 79-85.

Choi, Y. J., Lin, C. P., Ho, J. J., He, X., Okada, N., Bu, P., Zhong, Y., Kim, S. Y., Bennett, M. J., Chen, C., Ozturk, A., Hicks, G. G., Hannon, G. J., He, L. (2011) MiR-34 miRNAs provide a barrier for somatic cell reprogramming. Nature Cell Biology, 13 (11). pp. 1353-1360. ISSN 14657392 (ISSN)

Fairfield, H., Gilbert, G. J., Barter, M., Corrigan, R. R., Curtain, M., Ding, Y. M., D'Ascenzo, M., Gerhardt, D. J., He, C., Huang, W. H., Richmond, T., Rowe, L., Probst, F. J., Bergstrom, D. E., Murray, S. A., Bult, C., Richardson, J., Kile, B. T., Gut, I., Hager, J., Sigurdsson, S., Mauceli, E., Di Palma, F., Lindblad-Toh, K., Cunningham, M. L., Cox, T. C., Justice, M. J., Spector, M. S., Lowe, S. W., Albert, T., Donahue, L. R., Jeddeloh, J., Shendure, J., Reinholdt, L. G. (2011) Mutation discovery in mice by whole exome sequencing. Genome Biology, 12 (9). ISSN 1474-7596

Takiguchi, M., James, C., Josefsson, E. C., Carmichael, C. L., Premsrirut, P. K., Lowe, S. W., Hamilton, J. R., Huang, D. C. S., Kile, B. T., Dickins, R. A. (December 2010) Transgenic, inducible RNAi in megakaryocytes and platelets in mice. J Thromb Haemost, 8 (12). pp. 2751-6. ISSN 1538-7836 (Electronic) 1538-7836 (Linking)

Sierra, A., Encinas, J. M., Deudero, J. J. P., Chancey, J. H., Enikolopov, G. N., Overstreet-Wadiche, L. S., Tsirka, S. E., Maletic-Savatic, M. (October 2010) Microglia shape adult hippocampal neurogenesis through apoptosis-coupled phagocytosis. Cell Stem Cell, 7 (4). pp. 483-495.

Schreiber, S. L., Shamji, A. F., Clemons, P. A., Hon, C., Koehler, A. N., Munoz, B., Palmer, M., Stern, A. M., Wagner, B. K., Powers, S., Lowe, S. W., Guo, X., Krasnitz, A., Sawey, E. T., Sordella, R., Stein, L. D., Trotman, L. C., Califano, A., Dalla-Favera, R., Ferrando, A., Iavarone, A., Pasqualucci, L., Silva, J., Stockwell, B. R., Hahn, W. C., Chin, L., DePinho, R. A., Boehm, J. S., Gopal, S., Huang, A., Root, D. E., Weir, B. A., Gerhard, D. S., Zenklusen, J. C., Roth, M. G., White, M. A., Minna, J. D., MacMillan, J. B., Posner, B. A. (September 2010) Towards patient-based cancer therapeutics. Nature Biotechnology, 28 (9). pp. 904-906.

Méndez-Ferrer, S., Michurina, T. V., Ferraro, F., Mazloom, A. R., MacArthur, B. D., Lira, S. A., Scadden, D. T., Mag'Ayan, A., Enikolopov, G. N., Frenette, P. S. (August 2010) Mesenchymal and haematopoietic stem cells form a unique bone marrow niche. Nature, 466 (7308). pp. 829-834.

Hua, Y., Sahashi, K., Hung, G., Rigo, F., Passini, M. A., Bennett, C. F., Krainer, A. R. (August 2010) Antisense correction of SMN2 splicing in the CNS rescues necrosis in a type III SMA mouse model. Genes and Development, 24 (15). pp. 1634-44. ISSN 08909369 (ISSN)

Khoury, M., Bransky, A., Korin, N., Konak, L. C., Enikolopov, G. N., Tzchori, I., Levenberg, S. (July 2010) A microfluidic traps system supporting prolonged culture of human embryonic stem cells aggregates. Biomedical Microdevices, 12 (6). pp. 1001-1008.

Zhao, Z., Zuber, J., Diaz-Flores, E., Lintault, L., Kogan, S. C., Shannon, K., Lowe, S. W. (July 2010) p53 loss promotes acute myeloid leukemia by enabling aberrant self-renewal. Genes Dev, 24 (13). pp. 1389-1402. ISSN 1549-5477 (Electronic) 0890-9369 (Linking)

Fu, Y. Y., Lu, C. H., Lin, C. W., Juang, J. H., Enikolopov, G. N., Sibley, E., Chiang, A. S., Tang, S. C. (July 2010) Three-dimensional optical method for integrated visualization of mouse islet microstructure and vascular network with subcellular-level resolution. Journal of Biomedical Optics, 15 (4). ISSN 1083-3668

Cheloufi, S., Dos Santos, C. O., Chong, M. M. W., Hannon, G. J. (June 2010) A Dicer-independent miRNA biogenesis pathway that requires Ago catalysis. Nature, 465 (7298). 584-U76. ISSN 0028-0836

Bennett, L. B., Cai, J., Enikolopov, G. N., Iacovitti, L. (May 2010) Heterotopically transplanted CVO neural stem cells generate neurons and migrate with SVZ cells in the adult mouse brain. Neuroscience Letters, 475 (1). pp. 1-6.

Moretti, F., Marinari, B., Iacono, N. L., Botti, E., Giunta, A., Spallone, G., Garaffo, G., Vernersson-Lindahl, E., Merlo, G., Mills, A. A., Ballaro, C., Alema, S., Chimenti, S., Guerrini, L., Costanzo, A. (May 2010) A regulatory feedback loop involving p63 and IRF6 links the pathogenesis of 2 genetically different human ectodermal dysplasias. Journal of Clinical Investigation, 120 (5). pp. 1570-1577.

Clower, C. V., Chatterjee, D., Wang, Z. X., Cantley, L. C., Heiden, M. G. V., Krainer, A. R. (February 2010) The alternative splicing repressors hnRNP A1/A2 and PTB influence pyruvate kinase isoform expression and cell metabolism. Proceedings of the National Academy of Sciences of the United States of America, 107 (5). pp. 1894-1899. ISSN 0027-8424

Park, J. H., Enikolopov, G. N. (January 2010) Transient elevation of adult hippocampal neurogenesis after dopamine depletion. Experimental Neurology, 222 (2). pp. 267-276. ISSN 1090-2430 (Electronic) 1090-2430 (Linking)

Pineau, P., Volinia, S., McJunkin, K., Marchio, A., Battiston, C., Terris, B., Mazzaferro, V., Lowe, S. W., Croce, C. M., Dejean, A. (January 2010) miR-221 overexpression contributes to liver tumorigenesis. Proceedings of the National Academy of Sciences of the United States of America, 107 (1). pp. 264-269. ISSN 0027-8424

Olive, V., Bennett, M. J., Walker, J. C., Ma, C., Jiang, I., Cordon-Cardo, C., Li, Q. J., Lowe, S. W., Hannon, G. J., He, L. (December 2009) miR-19 is a key oncogenic component of mir-17-92. Genes & Development, 23 (24). pp. 2839-2849. ISSN 0890-9369

Guo, X., Keyes, W. M., Papazoglu, C., Zuber, J., Li, W., Lowe, S. W., Vogel, H., Mills, A. A. (December 2009) TAp63 induces senescence and suppresses tumorigenesis in vivo. Nat Cell Biol, 11 (12). 1451–1457.

Liu, L. X., Lee, N. P. , Chan, V. W. , Xue, W., Zender, L., Zhang, C., Mao, M., Dai, H., Wang, X. L., Xu, M. Z. , Lee, T. K. , Ng, I. O. , Chen, Y., Kung, H.-f. , Lowe, S. W. , Poon, R. T. P. , Wang, J. H., Luk, J. M. (November 2009) Targeting cadherin-17 inactivates Wnt signaling and inhibits tumor growth in liver carcinoma. Hepatology, 50 (5). pp. 1453-1463. ISSN 1527-3350

Hastings, M. L., Berniac, J., Liu, Y. H., Abato, P., Jodelka, F. M., Barthel, L., Kumar, S., Dudley, C., Nelson, M., Larson, K., Edmonds, J., Bowser, T., Draper, M., Higgins, P., Krainer, A. R. (November 2009) Tetracyclines That Promote SMN2 Exon 7 Splicing as Therapeutics for Spinal Muscular Atrophy. Science Translational Medicine, 1 (5). ISSN 1946-6234

Muller, D., Hida, B., Guidone, G., Speth, R. C., Michurina, T. V., Enikolopov, G. N., Middendorff, R. (October 2009) Expression of Guanylyl Cyclase (GC)-A and GC-B during Brain Development: Evidence for a Role of GC-B in Perinatal Neurogenesis. Endocrinology, 150 (12). pp. 5520-5529. ISSN 0013-7227

Bric, A., Miething, C., Bialucha, C. U., Scuoppo, C., Zender, L., Krasnitz, A., Xuan, Z., Zuber, J., Wigler, M. H., Hicks, J. B., McCombie, W. R., Hemann, M. T., Hannon, G. J., Powers, S., Lowe, S. W. (October 2009) Functional identification of tumor-suppressor genes through an in vivo RNA interference screen in a mouse lymphoma model. Cancer Cell, 16 (4). pp. 324-35. ISSN 1535-6108

Gao, X., Enikolopov, G. N., Chen, J. (October 2009) Moderate traumatic brain injury promotes proliferation of quiescent neural progenitors in the adult hippocampus. Experimental Neurology, 219 (2). pp. 516-523.

Xu, M. Z., Yao, T. J., Lee, N. P. Y., Ng, I. O. L., Chan, Y. T., Zender, L., Lowe, S. W., Poon, R. T. P., Luk, J. M. (October 2009) Yes-Associated Protein Is an Independent Prognostic Marker in Hepatocellular Carcinoma. Cancer, 115 (19). pp. 4576-4585. ISSN 0008-543X

Fu, Y.-Y., Lin, C.-W., Enikolopov, G. N., Sibley, E., Chiang, A.-S., Tang, S.-C. (August 2009) Microtome-Free 3-Dimensional Confocal Imaging Method for Visualization of Mouse Intestine With Subcellular-Level Resolution. Gastroenterology, 137 (2). pp. 453-465.

Nakano-Kobayashi, A., Nadif Kasri, N., Newey, S. E., Van Aelst, L. (July 2009) The Rho-Linked Mental Retardation Protein OPHN1 Controls Synaptic Vesicle Endocytosis via Endophilin A1. Curr Biol, 19 (13). 1133-1139 .

Ellis, L., Bots, M., Lindemann, R. K., Bolden, J. E., Newbold, A., Cluse, L. A., Scott, C. L., Strasser, A., Atadja, P., Lowe, S. W., Johnstone, R. W. (July 2009) The histone deacetylase inhibitors LAQ824 and LBH589 do not require death receptor signaling or a functional apoptosome to mediate tumor cell death or therapeutic efficacy. Blood, 114 (2). pp. 380-393.

Bennett, Lori, Yang, Ming, Enikolopov, G. N., Iacovitti, Lorraine (June 2009) Circumventricular organs: A novel site of neural stem cells in the adult brain. Molecular and Cellular Neuroscience, 41 (3). pp. 337-347.

Krishnan, N., Jeong, D. G., Jung, S.-k., Ryu, S. E., Xiao, A., Allis, C. D., Kim, S. J., Tonks, N. K. (June 2009) Dephosphorylation of the C-terminal tyrosyl residue of the DNA damage-related histone H2A.X is mediated by the protein phosphatase eyes absent. Journal of Biological Chemistry, 284 (24). pp. 16066-16070.

Nadif Kasri, N., Nakano-Kobayashi, A., Malinow, R., Li, B., Van Aelst, L. (June 2009) The Rho-linked mental retardation protein oligophrenin-1 controls synapse maturation and plasticity by stabilizing AMPA receptors. Genes Dev, 23 (11). pp. 1289-1302. ISSN 0890-9369

Robert, F., Carrier, M., Rawe, S., Chen, S., Lowe, S. W., Pelletier, J. (May 2009) Altering chemosensitivity by modulating translation elongation. PLoS ONE, 4 (5). e5428.

Sunwoo, H., Dinger, M. E., Wilusz, J. E., Amaral, P. P., Mattick, J. S., Spector, D. L. (March 2009) MEN epsilon/beta nuclear-retained non-coding RNAs are up-regulated upon muscle differentiation and are essential components of paraspeckles. Genome Research, 19 (3). pp. 347-359. ISSN 10889051 (ISSN)

Cai, J., Donaldson, A., Yang, M., German, M. S., Enikolopov, G. N., Iacovitti, L. (January 2009) The Role of Lmx1a in the Differentiation of Human Embryonic Stem Cells into Midbrain Dopamine Neurons in Culture and After Transplantation into a Parkinson's Disease Model. Stem Cells, 27 (1). pp. 220-229.

Rechavi, O., Erlich, Y., Amram, H., Flomenblit, L., Karginov, F. V., Goldstein, I., Hannon, G. J., Kloog, Y. (2009) Cell contact-dependent acquisition of cellular and viral nonautonomously encoded small RNAs. Genes and Development, 23 (16). pp. 1971-1979. ISSN 08909369 (ISSN)

Krizhanovsky, V., Lowe, S. W. (2009) Stem cells: The promises and perils of p53. Nature, 460 (7259). pp. 1085-1086.

This list was generated on Sat Dec 15 12:59:13 2018 EST.
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