Transient elevation of adult hippocampal neurogenesis after dopamine depletion

Park, J. H., Enikolopov, G. N. (January 2010) Transient elevation of adult hippocampal neurogenesis after dopamine depletion. Experimental Neurology, 222 (2). pp. 267-276. ISSN 1090-2430 (Electronic) 1090-2430 (Linking)

DOI: 10.1016/j.expneurol.2010.01.004


Degeneration of the midbrain dopaminergic neurons during Parkinson's disease (PD) may affect remote regions of the brain that are innervated by the projections of these neurons. The dentate gyrus (DG), a site of continuous production of new neurons in the adult hippocampus, receives dopaminergic inputs from the neurons of the substantia nigra (SN). Thus, depletion of the SN neurons during disease or in experimental settings may directly affect adult hippocampal neurogenesis. We show that experimental ablation of dopaminergic neurons in the 1-methyl-4-phenyl-1,2,3,6-tetrahydopyridine (MPTP) mouse model of PD results in a transient increase in cell division in the subgranular zone (SGZ) of the DG. This increase is evident for the amplifying neural progenitors and for their postmitotic progeny; our results also indicate that MPTP treatment affects division of the normally quiescent stem cells in the SGZ. We also show that L-DOPA, used in the clinical treatment of PD, while attenuating the MPTP-induced death of dopaminergic neurons, does not alter the effect of MPTP on cell division in the DG. Our results suggest that a decrease in dopaminergic signaling in the hippocampus leads to a transient activation of stem and progenitor cells in the DG.

Item Type: Paper
Uncontrolled Keywords: Parkinson’s disease adult neurogenesis dentate gyrus stem cells MPTP
Subjects: diseases & disorders > nervous system diseases and disorders > Parkinson's disease
organism description > animal > developmental stage > adult
organism description > animal > mammal > rodent > mouse
therapies > stem cells
CSHL Authors:
Communities: CSHL Post Doctoral Fellows
CSHL labs > Enikopolov lab
CSHL Cancer Center Shared Resources > Animal Services
CSHL Cancer Center Shared Resources > Microscopy Service
Depositing User: CSHL Librarian
Date: 12 January 2010
Date Deposited: 05 Oct 2011 14:40
Last Modified: 30 Dec 2014 17:08
PMCID: PMC3042396
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