Regulation of PTP1B activation through disruption of redox-complex formation

Londhe, A. D., Bergeron, A., Curley, S. M., Zhang, F., Rivera, K. D., Kannan, A., Coulis, G., Rizvi, S. H. M., Kim, S. J., Pappin, D. J., Tonks, N. K., Linhardt, R. J., Boivin, B. (December 2019) Regulation of PTP1B activation through disruption of redox-complex formation. Nat Chem Biol, 16 (2). pp. 122-125. ISSN 1552-4450

URL: https://www.ncbi.nlm.nih.gov/pubmed/31873221
DOI: 10.1038/s41589-019-0433-0

Abstract

We have identified a molecular interaction between the reversibly oxidized form of protein tyrosine phosphatase 1B (PTP1B) and 14-3-3zeta that regulates PTP1B activity. Destabilizing the transient interaction between 14-3-3zeta and PTP1B prevented PTP1B inactivation by reactive oxygen species and decreased epidermal growth factor receptor phosphorylation. Our data suggest that destabilizing the interaction between 14-3-3zeta and the reversibly oxidized and inactive form of PTP1B may establish a path to PTP1B activation in cells.

Item Type: Paper
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > epidermal growth factor
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein expression > phosphorylation
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > enzymes > protein tyrosine phosphatase
CSHL Authors:
Communities: CSHL Cancer Center Program > Cellular Communication in Cancer Program
CSHL labs > Pappin lab
CSHL labs > Tonks lab
Depositing User: Adrian Gomez
Date: 23 December 2019
Date Deposited: 06 Jan 2020 18:41
Last Modified: 29 Jun 2021 19:53
PMCID: PMC6982540
Related URLs:
URI: https://repository.cshl.edu/id/eprint/38868

Actions (login required)

Administrator's edit/view item Administrator's edit/view item
CSHL HomeAbout CSHLResearchEducationNews & FeaturesCampus & Public EventsCareersGiving