Londhe, A. D., Bergeron, A., Curley, S. M., Zhang, F., Rivera, K. D., Kannan, A., Coulis, G., Rizvi, S. H. M., Kim, S. J., Pappin, D. J., Tonks, N. K., Linhardt, R. J., Boivin, B.
(December 2019)
Regulation of PTP1B activation through disruption of redox-complex formation.
Nat Chem Biol, 16 (2).
pp. 122-125.
ISSN 1552-4450
Abstract
We have identified a molecular interaction between the reversibly oxidized form of protein tyrosine phosphatase 1B (PTP1B) and 14-3-3zeta that regulates PTP1B activity. Destabilizing the transient interaction between 14-3-3zeta and PTP1B prevented PTP1B inactivation by reactive oxygen species and decreased epidermal growth factor receptor phosphorylation. Our data suggest that destabilizing the interaction between 14-3-3zeta and the reversibly oxidized and inactive form of PTP1B may establish a path to PTP1B activation in cells.
| Item Type: |
Paper
|
| Subjects: |
bioinformatics
bioinformatics > genomics and proteomics > genetics & nucleic acid processing
bioinformatics > genomics and proteomics
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > enzymes
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > epidermal growth factor
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein expression > phosphorylation
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > enzymes > protein tyrosine phosphatase |
| CSHL Authors: |
|
| Communities: |
CSHL Cancer Center Program > Cellular Communication in Cancer Program
CSHL labs > Pappin lab
CSHL labs > Tonks lab
CSHL Cancer Center Program |
| Depositing User: |
Adrian Gomez
|
| Date: |
23 December 2019 |
| Date Deposited: |
06 Jan 2020 18:41 |
| Last Modified: |
13 Feb 2024 21:30 |
| PMCID: |
PMC6982540 |
| Related URLs: |
|
| URI: |
https://repository.cshl.edu/id/eprint/38868 |
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