Cancer immunotherapy trial registrations increase exponentially but chronic immunosuppressive glucocorticoid therapy may compromise outcomes

Connell, C. M., Raby, S., Beh, I., Flint, T., Williams, E., Fearon, D. T., Jodrell, D. I., Janowitz, T. (July 2017) Cancer immunotherapy trial registrations increase exponentially but chronic immunosuppressive glucocorticoid therapy may compromise outcomes. Ann Oncol, 28 (7). pp. 1678-1679. ISSN 0923-7534

URL: https://www.ncbi.nlm.nih.gov/pubmed/28430855
DOI: 10.1093/annonc/mdx181

Abstract

T cell checkpoint-targeted immunotherapy is effective in multiple cancers, but only in subsets of patients [1]. Failure of immunotherapy may be secondary to tumour intrinsic and/or systemic factors that impair immune response. Glucocorticoid administration has known systemic immunosuppressive effects [2] with potential to impair immunotherapy outcome [3], and should therefore be regulated at patient enrolment. We performed a cross-sectional analysis of T cell checkpoint-targeted cancer immunotherapy trials in solid malignancies registered on the U.S. National Institutes of Health (NIH) trial registry (clinicaltrials.gov) by October 7, 2016. Trials were searched by study type, condition, and interventions targeting the T cell checkpoint proteins CTLA-4, PD-1, PD-L1, PD-L2, LAG3, B7-H3, CD137, OX40, CD27 and GITR. Trials were reviewed manually and independently by two clinicians and registered data on glucocorticoid administration within enrolment criteria recorded.

Item Type: Paper
Uncontrolled Keywords: Cancer immunotherapy T cell checkpoint inhibitor clinical trial glucocorticoid immunomodulation immunosuppression
Subjects: diseases & disorders > cancer
diseases & disorders > cancer > drugs and therapies > Immunotherapy
CSHL Authors:
Communities: CSHL Cancer Center Program > Signal Transduction
CSHL labs > Fearon lab
CSHL labs > Janowitz lab
Highlight: Janowitz, Tobias
Depositing User: Matt Covey
Date: 1 July 2017
Date Deposited: 28 Apr 2017 16:19
Last Modified: 10 Oct 2018 16:26
PMCID: PMC5834107
Related URLs:
URI: http://repository.cshl.edu/id/eprint/34650

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