Connell, C. M., Raby, S., Beh, I., Flint, T., Williams, E., Fearon, D. T., Jodrell, D. I., Janowitz, T. (July 2017) Cancer immunotherapy trial registrations increase exponentially but chronic immunosuppressive glucocorticoid therapy may compromise outcomes. Ann Oncol, 28 (7). pp. 1678-1679. ISSN 0923-7534
Abstract
T cell checkpoint-targeted immunotherapy is effective in multiple cancers, but only in subsets of patients [1]. Failure of immunotherapy may be secondary to tumour intrinsic and/or systemic factors that impair immune response. Glucocorticoid administration has known systemic immunosuppressive effects [2] with potential to impair immunotherapy outcome [3], and should therefore be regulated at patient enrolment. We performed a cross-sectional analysis of T cell checkpoint-targeted cancer immunotherapy trials in solid malignancies registered on the U.S. National Institutes of Health (NIH) trial registry (clinicaltrials.gov) by October 7, 2016. Trials were searched by study type, condition, and interventions targeting the T cell checkpoint proteins CTLA-4, PD-1, PD-L1, PD-L2, LAG3, B7-H3, CD137, OX40, CD27 and GITR. Trials were reviewed manually and independently by two clinicians and registered data on glucocorticoid administration within enrolment criteria recorded.
| Item Type: | Paper |
|---|---|
| Uncontrolled Keywords: | Cancer immunotherapy T cell checkpoint inhibitor clinical trial glucocorticoid immunomodulation immunosuppression |
| Subjects: | diseases & disorders > cancer diseases & disorders > cancer > drugs and therapies > Immunotherapy |
| CSHL Authors: | |
| Communities: | CSHL Cancer Center Program > Signal Transduction CSHL labs > Fearon lab CSHL labs > Janowitz lab CSHL Cancer Center Program > Cellular Communication in Cancer Program |
| Highlight: | Janowitz, Tobias |
| Depositing User: | Matt Covey |
| Date: | 1 July 2017 |
| Date Deposited: | 28 Apr 2017 16:19 |
| Last Modified: | 26 Oct 2020 16:02 |
| PMCID: | PMC5834107 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/34650 |
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