Road Map to Defeat Pancreatic Cancer

Ferguson, L Paige, Tuveson, David A (April 2025) Road Map to Defeat Pancreatic Cancer. Annual Review of Cancer Biology, 9 (1). pp. 1-20. ISSN 2472-3428

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Abstract

Pancreatic cancer is a notoriously deadly disease characterized by many challenges in clinical management. Despite important advances in our understanding of pancreatic cancer progression and its underlying molecular biology over the last decades, there is a long road ahead if we aim to meaningfully improve patient outcomes in this difficult disease. Treatment options remain limited, and patient prognosis, although improving, remains bleak. As we build toward the future, we propose a framework for targeting the seven deadly hallmarks of pancreatic cancer in an effort to cure this disease. The high mortality and aggressive nature of pancreatic cancer can be largely ascribed to diagnostic deficiencies, chronic inflammation, desmoplastic stroma, early metastasis, KRAS signaling, metabolism, and rapid deconditioning. Here, we outline the challenges presented by each of these disease hallmarks and highlight ongoing research to tackle each one.

Item Type:	Paper
Subjects:	diseases & disorders > cancer diseases & disorders diseases & disorders > cancer > cancer types > pancreatic cancer diseases & disorders > cancer > cancer types
CSHL Authors:	Tuveson, David A. Ferguson, Lesley
Communities:	CSHL labs > Tuveson lab CSHL Cancer Center Program CSHL Cancer Center Program > Cellular Communication in Cancer Program
SWORD Depositor:	CSHL Elements
Depositing User:	CSHL Elements
Date:	April 2025
Date Deposited:	06 May 2025 12:13
Last Modified:	06 May 2025 12:13
Related URLs:	Publisher
URI:	https://repository.cshl.edu/id/eprint/41864

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