Metabolic partitioning in the brain and its hijacking by glioblastoma

de Ruiter Swain, Jed, Michalopoulou, Evdokia, Noch, Evan K, Lukey, Michael J, Van Aelst, Linda (August 2023) Metabolic partitioning in the brain and its hijacking by glioblastoma. Genes and Development, 37. pp. 681-702. ISSN 0890-9369

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URL: https://www.ncbi.nlm.nih.gov/pubmed/37648371

DOI: 10.1101/gad.350693.123

Abstract

The different cell types in the brain have highly specialized roles with unique metabolic requirements. Normal brain function requires the coordinated partitioning of metabolic pathways between these cells, such as in the neuron-astrocyte glutamate-glutamine cycle. An emerging theme in glioblastoma (GBM) biology is that malignant cells integrate into or "hijack" brain metabolism, co-opting neurons and glia for the supply of nutrients and recycling of waste products. Moreover, GBM cells communicate via signaling metabolites in the tumor microenvironment to promote tumor growth and induce immune suppression. Recent findings in this field point toward new therapeutic strategies to target the metabolic exchange processes that fuel tumorigenesis and suppress the anticancer immune response in GBM. Here, we provide an overview of the intercellular division of metabolic labor that occurs in both the normal brain and the GBM tumor microenvironment and then discuss the implications of these interactions for GBM therapy.

Item Type:	Paper
Subjects:	diseases & disorders > cancer diseases & disorders organs, tissues, organelles, cell types and functions > cell types and functions > cell types > astrocytes organs, tissues, organelles, cell types and functions > cell types and functions > cell types > astrocytes organs, tissues, organelles, cell types and functions > cell types and functions > cell types > astrocytes organs, tissues, organelles, cell types and functions > organs types and functions > brain organs, tissues, organelles, cell types and functions > cell types and functions > cell types organs, tissues, organelles, cell types and functions > cell types and functions > cell types organs, tissues, organelles, cell types and functions > cell types and functions > cell types organs, tissues, organelles, cell types and functions > cell types and functions diseases & disorders > cancer > cancer types > glioblastoma organs, tissues, organelles, cell types and functions > organs types and functions organs, tissues, organelles, cell types and functions Publication Type Publication Type > review diseases & disorders > cancer > cancer types
CSHL Authors:	Lukey, Michael Van Aelst, Linda de Ruiter-Swain, Jed Michalopoulou, Evdokia
Communities:	CSHL Cancer Center Program CSHL Cancer Center Program > Cellular Communication in Cancer Program CSHL labs > Van Aelst lab CSHL labs > Lukey lab School of Biological Sciences > Publications
SWORD Depositor:	CSHL Elements
Depositing User:	CSHL Elements
Date:	30 August 2023
Date Deposited:	21 Sep 2023 15:27
Last Modified:	29 Feb 2024 16:57
PMCID:	PMC10546978
Related URLs:	Publisher
URI:	https://repository.cshl.edu/id/eprint/40940

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