SYNPLA, a method to identify synapses displaying plasticity after learning

Dore, K., Pao, Y., Soria Lopez, J., Aronson, S., Zhan, H., Ghosh, S., Merrill, S., Zador, A. M., Malinow, R., Kebschull, J. M. (January 2020) SYNPLA, a method to identify synapses displaying plasticity after learning. Proc Natl Acad Sci U S A, 117 (6). pp. 3214-3219. ISSN 0027-8424 (Public Dataset)

Abstract

Which neural circuits undergo synaptic changes when an animal learns? Although it is widely accepted that changes in synaptic strength underlie many forms of learning and memory, it remains challenging to connect changes in synaptic strength at specific neural pathways to specific behaviors and memories. Here we introduce SYNPLA (synaptic proximity ligation assay), a synapse-specific, high-throughput, and potentially brain-wide method capable of detecting circuit-specific learning-induced synaptic plasticity.

Item Type:	Paper
Subjects:	organism description > animal organism description > animal behavior organs, tissues, organelles, cell types and functions > tissues types and functions > auditory cortex organs, tissues, organelles, cell types and functions > tissues types and functions > hippocampus organism description > animal behavior > learning organism description > animal > mammal organism description > animal > mammal > rodent > mouse organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > neural plasticity organs, tissues, organelles, cell types and functions organism description > animal > mammal > rodent > rat organism description > animal > mammal > rodent > rat organism description > animal > mammal > rodent organs, tissues, organelles, cell types and functions > sub-cellular tissues: types and functions organs, tissues, organelles, cell types and functions > sub-cellular tissues: types and functions > synapse organs, tissues, organelles, cell types and functions > tissues types and functions
CSHL Authors:	Zador, Anthony M. Kebschull, Justus Malinow, Roberto Ghosh, Sanchari Zhan, Huiqing Merrill, Sabina
Communities:	CSHL labs > Zador lab School of Biological Sciences > Publications
Depositing User:	Adrian Gomez
Date:	23 January 2020
Date Deposited:	31 Jan 2020 18:09
Last Modified:	29 Jan 2024 21:08
PMCID:	PMC7022215
Related URLs:	https://www.pnas.org/content/early/2020/...
Dataset ID:	All data relevant to this study are included in this paper or in the SI: https://www.pnas.org/content/suppl/2020/01/23/1919911117.DCSupplemental
URI:	https://repository.cshl.edu/id/eprint/38945

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