Dore, K., Pao, Y., Soria Lopez, J., Aronson, S., Zhan, H., Ghosh, S., Merrill, S., Zador, A. M., Malinow, R., Kebschull, J. M.
(January 2020)
SYNPLA, a method to identify synapses displaying plasticity after learning.
Proc Natl Acad Sci U S A, 117 (6).
pp. 3214-3219.
ISSN 0027-8424
(Public Dataset)
Abstract
Which neural circuits undergo synaptic changes when an animal learns? Although it is widely accepted that changes in synaptic strength underlie many forms of learning and memory, it remains challenging to connect changes in synaptic strength at specific neural pathways to specific behaviors and memories. Here we introduce SYNPLA (synaptic proximity ligation assay), a synapse-specific, high-throughput, and potentially brain-wide method capable of detecting circuit-specific learning-induced synaptic plasticity.
| Item Type: |
Paper
|
| Subjects: |
organism description > animal
organism description > animal behavior
organs, tissues, organelles, cell types and functions > tissues types and functions > auditory cortex
organs, tissues, organelles, cell types and functions > tissues types and functions > hippocampus
organism description > animal behavior > learning
organism description > animal > mammal
organism description > animal > mammal > rodent > mouse
organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > neural plasticity
organs, tissues, organelles, cell types and functions
organism description > animal > mammal > rodent > rat
organism description > animal > mammal > rodent > rat
organism description > animal > mammal > rodent
organs, tissues, organelles, cell types and functions > sub-cellular tissues: types and functions
organs, tissues, organelles, cell types and functions > sub-cellular tissues: types and functions > synapse
organs, tissues, organelles, cell types and functions > tissues types and functions |
| CSHL Authors: |
|
| Communities: |
CSHL labs > Zador lab
School of Biological Sciences > Publications |
| Depositing User: |
Adrian Gomez
|
| Date: |
23 January 2020 |
| Date Deposited: |
31 Jan 2020 18:09 |
| Last Modified: |
29 Jan 2024 21:08 |
| PMCID: |
PMC7022215 |
| Related URLs: |
|
| Dataset ID: |
- All data relevant to this study are included in this paper or in the SI: https://www.pnas.org/content/suppl/2020/01/23/1919911117.DCSupplemental
|
| URI: |
https://repository.cshl.edu/id/eprint/38945 |
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