Expression and rearrangement of the ROS1 gene in human glioblastoma cells

Birchmeier, C., Sharma, S., Wigler, M. H. (December 1987) Expression and rearrangement of the ROS1 gene in human glioblastoma cells. Proc Natl Acad Sci U S A, 84 (24). pp. 9270-4. ISSN 0027-8424

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URL: https://www.ncbi.nlm.nih.gov/pubmed/2827175

DOI: 10.1073/pnas.84.24.9270

Abstract

The human ROS1 gene, which possibly encodes a growth factor receptor, was found to be expressed in human tumor cell lines. In a survey of 45 different human cell lines, we found ROS1 to be expressed in glioblastoma-derived cell lines at high levels and not to be expressed at all, or expressed at very low levels, in the remaining cell lines. The ROS1 gene was present in normal copy numbers in all cell lines that expressed the gene. However, in one particular glioblastoma line, we detected a potentially activating mutation at the ROS1 locus.

Item Type:	Paper
Additional Information:
Uncontrolled Keywords:	DNA Neoplasm genetics Gene Expression Regulation Genes Structural Glioblastoma genetics Glioma genetics Humans Oncogenes Protein Tyrosine Kinase genetics RNA Messenger genetics RNA Neoplasm genetics Tumor Cells Cultured
Subjects:	diseases & disorders > neoplasms bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification organs, tissues, organelles, cell types and functions > cell types and functions > cell types > cell line organs, tissues, organelles, cell types and functions > cell types and functions > cell types > cell line organs, tissues, organelles, cell types and functions > cell types and functions > cell types > cell line bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > gene expression bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein characterization
CSHL Authors:	Wigler, Michael H. Birchmeier, Carmen
Communities:	CSHL labs > Wigler lab
Depositing User:	CSHL Librarian
Date:	December 1987
Date Deposited:	19 Apr 2012 15:03
Last Modified:	09 Nov 2017 20:49
PMCID:	PMC299735
Related URLs:	Publisher
URI:	https://repository.cshl.edu/id/eprint/26160

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