Birchmeier, C., Broek, D., Wigler, M. H. (December 1985) RAS proteins can induce meiosis in Xenopus oocytes. Cell, 43 (3 PART). pp. 615-622.
Abstract
Injection of human H-ras protein induces maturation of Xenopus oocytes; that is, progression from prophase to metaphase of meiosis. The oncogenic protein encoded by H-rasval12 is nearly a 100-fold more potent than the protein encoded by the wild-type gene. We do not observe any measurable increase or decrease in cyclic AMP concentration in injected oocytes, and the effects of H-ras protein are only partially blocked by cholera toxin. Our results suggest that not all, if any, of the effects of H-rasval12 protein in this system are mediated by adenylate cyclase.
| Item Type: | Paper |
|---|---|
| Subjects: | bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > genes: types > RAS organism description > animal > developmental stage > embryo bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein characterization bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein expression organism description > animal > Frog > xenopus |
| CSHL Authors: | |
| Communities: | CSHL labs > Wigler lab |
| Depositing User: | CSHL Librarian |
| Date: | December 1985 |
| Date Deposited: | 19 Apr 2012 14:55 |
| Last Modified: | 18 Nov 2016 16:46 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/26158 |
Actions (login required)
 |
Administrator's edit/view item |